JP2014518853A5 - - Google Patents
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- Publication number
- JP2014518853A5 JP2014518853A5 JP2014508573A JP2014508573A JP2014518853A5 JP 2014518853 A5 JP2014518853 A5 JP 2014518853A5 JP 2014508573 A JP2014508573 A JP 2014508573A JP 2014508573 A JP2014508573 A JP 2014508573A JP 2014518853 A5 JP2014518853 A5 JP 2014518853A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- cycloalkyl
- hydrogen
- aryl
- halo
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161479917P | 2011-04-28 | 2011-04-28 | |
| US61/479,917 | 2011-04-28 | ||
| PCT/US2012/035327 WO2012149236A1 (en) | 2011-04-28 | 2012-04-27 | Novel bicyclic nitrogen containing heteroaryl tgr5 receptor modulators |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2014518853A JP2014518853A (ja) | 2014-08-07 |
| JP2014518853A5 true JP2014518853A5 (https=) | 2015-06-18 |
Family
ID=46172887
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014508573A Pending JP2014518853A (ja) | 2011-04-28 | 2012-04-27 | 新規な二環式窒素含有ヘテロアリールｔｇｒ５受容体調節因子 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US9062028B2 (https=) |
| EP (1) | EP2702042A1 (https=) |
| JP (1) | JP2014518853A (https=) |
| CN (1) | CN103619817A (https=) |
| TW (1) | TW201247627A (https=) |
| WO (1) | WO2012149236A1 (https=) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103665043B (zh) | 2012-08-30 | 2017-11-10 | 江苏豪森药业集团有限公司 | 一种替诺福韦前药及其在医药上的应用 |
| JP6553632B2 (ja) | 2013-11-18 | 2019-07-31 | フォーマ セラピューティクス，インコーポレイテッド | Ｂｅｔブロモドメイン阻害剤としてのテトラヒドロキノリン組成物 |
| CN106029076B (zh) | 2013-11-18 | 2019-06-07 | 福马疗法公司 | 作为bet溴域抑制剂的苯并哌嗪组合物 |
| WO2015089800A1 (en) * | 2013-12-19 | 2015-06-25 | Eli Lilly And Company | Fluorophenyl pyrazol compounds |
| WO2016036633A1 (en) * | 2014-09-05 | 2016-03-10 | Merck Sharp & Dohme Corp. | Tetrahydroisoquinoline derivatives useful as inhibitors of diacylglyceride o-acyltransferase 2 |
| WO2016036638A1 (en) * | 2014-09-05 | 2016-03-10 | Merck Sharp & Dohme Corp. | Isoquinoline derivatives useful as inhibitors of diacylglyceride o-acyltransferase 2 |
| US9877957B2 (en) | 2014-09-05 | 2018-01-30 | Merck Sharp & Dohme Corp. | Tetrahydroisoquinoline derivatives useful as inhibitors of diacylglyceride O-acyltransferase 2 |
| JP6592512B2 (ja) | 2014-10-24 | 2019-10-16 | ブリストル−マイヤーズ スクイブ カンパニーＢｒｉｓｔｏｌ−Ｍｙｅｒｓ Ｓｑｕｉｂｂ Ｃｏｍｐａｎｙ | 三環式アトロプ異性体の化合物 |
| EA034931B1 (ru) | 2014-10-24 | 2020-04-08 | Бристол-Майерс Сквибб Компани | Индолкарбоксамидные соединения |
| US10654834B2 (en) * | 2016-07-01 | 2020-05-19 | Venenum Biodesign, LLC | Non-systemic TGR5 agonists |
| TW201840542A (zh) | 2017-03-22 | 2018-11-16 | 瑞士商先正達合夥公司 | 殺有害生物活性環丙基甲基醯胺衍生物 |
| JP2022552655A (ja) | 2019-10-07 | 2022-12-19 | キャリーオペ，インク． | Ｇｐｒ１１９アゴニスト |
| CA3166630A1 (en) | 2020-01-03 | 2021-07-08 | Berg Llc | Polycyclic amides as ube2k modulators for treating cancer |
| IL295825A (en) | 2020-02-28 | 2022-10-01 | Kallyope Inc | gpr40 agonists |
| WO2021236617A1 (en) | 2020-05-19 | 2021-11-25 | Kallyope, Inc. | Ampk activators |
| CA3183575A1 (en) | 2020-06-26 | 2021-12-30 | Iyassu Sebhat | Ampk activators |
| CN114199812A (zh) * | 2021-12-28 | 2022-03-18 | 南通联亚药业有限公司 | 一种盐酸美金刚缓释制剂中盐酸美金刚的检测方法 |
| KR20240161147A (ko) | 2022-03-14 | 2024-11-12 | 슬랩 파마슈티컬스 엘엘씨 | 다중 사이클릭 화합물 |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK0450097T3 (da) * | 1989-10-20 | 1996-05-20 | Otsuka Pharma Co Ltd | Benzoheterocykliske forbindelser |
| GB9307527D0 (en) * | 1993-04-13 | 1993-06-02 | Fujisawa Pharmaceutical Co | New venzamide derivatives,processes for the preparation thereof and pharmaceutical composition comprising the same |
| JP3362494B2 (ja) * | 1994-03-01 | 2003-01-07 | 三菱ウェルファーマ株式会社 | ベンゾオキサジン化合物 |
| JP2006063064A (ja) * | 2004-07-27 | 2006-03-09 | Takeda Chem Ind Ltd | 受容体作動剤 |
| US7989461B2 (en) * | 2005-12-23 | 2011-08-02 | Amgen Inc. | Substituted quinazolinamine compounds for the treatment of cancer |
| WO2008067222A1 (en) | 2006-11-28 | 2008-06-05 | Kalypsys, Inc. | Heterocyclic modulators of tgr5 |
| WO2008067219A2 (en) | 2006-11-29 | 2008-06-05 | Kalypsys, Inc. | Quinazolinone modulators of tgr5 |
| WO2008097976A1 (en) | 2007-02-09 | 2008-08-14 | Kalypsys, Inc. | Heterocyclic modulators of tgr5 for treatment of disease |
| US20090105124A1 (en) | 2007-08-23 | 2009-04-23 | Kalypsys, Inc. | Heterocyclic modulators of tgr5 |
| US20110136788A1 (en) * | 2008-08-07 | 2011-06-09 | Minoru Maruyama | Therapeutic agent for irritable bowel syndrome |
| WO2010016846A1 (en) | 2008-08-08 | 2010-02-11 | Kalypsys, Inc. | Heterocyclic modulators of tgr5 for treatment of disease |
| US8309734B2 (en) | 2008-10-29 | 2012-11-13 | Hoffmann-La Roche Inc. | Substituted pyridines as GPBAR1 agonists |
| ES2774368T3 (es) | 2008-11-19 | 2020-07-20 | Intercept Pharmaceuticals Inc | Moduladores de TGR5 y métodos de uso de los mismos |
| CN102395567A (zh) | 2009-02-12 | 2012-03-28 | 埃克塞利希斯股份有限公司 | 在治疗糖尿病和肥胖症中用作的tgr5激动剂的三唑和咪唑衍生物 |
| US20120022057A1 (en) * | 2009-03-18 | 2012-01-26 | Schering Corporation | Bicyclic compounds as inhibitors of diacyglycerol acyltransferase |
| CN102781922A (zh) | 2009-12-11 | 2012-11-14 | 埃克塞利希斯股份有限公司 | Tgr5激动剂 |
-
2012
- 2012-04-27 WO PCT/US2012/035327 patent/WO2012149236A1/en not_active Ceased
- 2012-04-27 TW TW101115262A patent/TW201247627A/zh unknown
- 2012-04-27 CN CN201280031836.7A patent/CN103619817A/zh active Pending
- 2012-04-27 US US14/113,593 patent/US9062028B2/en active Active
- 2012-04-27 JP JP2014508573A patent/JP2014518853A/ja active Pending
- 2012-04-27 EP EP12723982.0A patent/EP2702042A1/en not_active Withdrawn
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