JP2013540114A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2013540114A5 JP2013540114A5 JP2013530690A JP2013530690A JP2013540114A5 JP 2013540114 A5 JP2013540114 A5 JP 2013540114A5 JP 2013530690 A JP2013530690 A JP 2013530690A JP 2013530690 A JP2013530690 A JP 2013530690A JP 2013540114 A5 JP2013540114 A5 JP 2013540114A5
- Authority
- JP
- Japan
- Prior art keywords
- solvate
- salt
- formula
- compound
- alkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 0 CC[C@](C)C([C@@](CC(N(CCC1)[C@@]1[C@@]([C@@](C)C(NC(*)(*)*)=O)OC)=O)OC)N(C)C([C@](C(C)C)NC([C@](C(C)C)N(C)IC(O)=O)=O)=O Chemical compound CC[C@](C)C([C@@](CC(N(CCC1)[C@@]1[C@@]([C@@](C)C(NC(*)(*)*)=O)OC)=O)OC)N(C)C([C@](C(C)C)NC([C@](C(C)C)N(C)IC(O)=O)=O)=O 0.000 description 28
- ZWDLQHBCEBFQKD-XYBOYREGSA-N CC[C@H](C)[C@H](CCC(C)C([C@H](C(C)C)NC([C@H](C(C)C)N(C)CCCC(O)=O)=O)=O)[C@@H](CC(N(CCC1)[C@@H]1[C@@H]([C@@H](C)C(C)=O)OC)=O)OC Chemical compound CC[C@H](C)[C@H](CCC(C)C([C@H](C(C)C)NC([C@H](C(C)C)N(C)CCCC(O)=O)=O)=O)[C@@H](CC(N(CCC1)[C@@H]1[C@@H]([C@@H](C)C(C)=O)OC)=O)OC ZWDLQHBCEBFQKD-XYBOYREGSA-N 0.000 description 2
- OLYPTCGBTWFWMB-IRXDYDNUSA-N CC(C)[C@@H](C(C)=O)NC([C@H](C(C)C)N(C)CCCCCC(O)=O)=O Chemical compound CC(C)[C@@H](C(C)=O)NC([C@H](C(C)C)N(C)CCCCCC(O)=O)=O OLYPTCGBTWFWMB-IRXDYDNUSA-N 0.000 description 1
- ZWDLQHBCEBFQKD-IOYRNSPRSA-N CC[C@H](C)C(CCC(C)C([C@H](C(C)C)NC([C@H](C(C)C)N(C)CCCC(O)=O)=O)=O)[C@@H](CC(N(CCC1)[C@@H]1[C@@H]([C@@H](C)C(C)=O)OC)=O)OC Chemical compound CC[C@H](C)C(CCC(C)C([C@H](C(C)C)NC([C@H](C(C)C)N(C)CCCC(O)=O)=O)=O)[C@@H](CC(N(CCC1)[C@@H]1[C@@H]([C@@H](C)C(C)=O)OC)=O)OC ZWDLQHBCEBFQKD-IOYRNSPRSA-N 0.000 description 1
- JAOIHPORDCWUCG-QMIZPITJSA-N CC[C@H](C)C(CCC(C)C([C@H](C(C)C)NC([C@H](C(C)C)N(C)CCCC(O)=O)=O)=O)[C@@H](CC(N(CCC1)[C@@H]1[C@@H]([C@@H](C)C(N[C@@H](Cc1c[nH]c2c1cccc2)C(O)=O)=O)OC)=O)OC Chemical compound CC[C@H](C)C(CCC(C)C([C@H](C(C)C)NC([C@H](C(C)C)N(C)CCCC(O)=O)=O)=O)[C@@H](CC(N(CCC1)[C@@H]1[C@@H]([C@@H](C)C(N[C@@H](Cc1c[nH]c2c1cccc2)C(O)=O)=O)OC)=O)OC JAOIHPORDCWUCG-QMIZPITJSA-N 0.000 description 1
- NGDNYJSFYCAFCY-QMIZPITJSA-N CC[C@H](C)C(CCC(C)C([C@H](C(C)C)NC([C@H](C(C)C)N(C)CCCC(O)=O)=O)=O)[C@@H](CC(N(CCC1)[C@@H]1[C@@H]([C@@H](C)C(N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O)=O)OC)=O)OC Chemical compound CC[C@H](C)C(CCC(C)C([C@H](C(C)C)NC([C@H](C(C)C)N(C)CCCC(O)=O)=O)=O)[C@@H](CC(N(CCC1)[C@@H]1[C@@H]([C@@H](C)C(N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O)=O)OC)=O)OC NGDNYJSFYCAFCY-QMIZPITJSA-N 0.000 description 1
- DDYWUFFJEBYXTA-GZOYZLNXSA-N CC[C@H](C)C(CCC(C)C([C@H](C(C)C)NC([C@H](C(C)C)N(C)CCCC(O)=O)=O)=O)[C@@H](CC(N(CCC1)[C@@H]1[C@@H]([C@@H](C)C(N[C@@H](Cc1ccccc1)C(N(C)Cc1ccccc1)=O)=O)OC)=O)OC Chemical compound CC[C@H](C)C(CCC(C)C([C@H](C(C)C)NC([C@H](C(C)C)N(C)CCCC(O)=O)=O)=O)[C@@H](CC(N(CCC1)[C@@H]1[C@@H]([C@@H](C)C(N[C@@H](Cc1ccccc1)C(N(C)Cc1ccccc1)=O)=O)OC)=O)OC DDYWUFFJEBYXTA-GZOYZLNXSA-N 0.000 description 1
- FBIWVCRQANCVRO-RLQGXUMZSA-N CC[C@H](C)C(CCC(C)C([C@H](C(C)C)NC([C@H](C(C)C)N(C)CCCC(O)=O)=O)=O)[C@@H](CC(N(CCC1)[C@@H]1[C@@H]([C@@H](C)C(N[C@@H](Cc1ccccc1)C(OC(C)(C)C)=O)=O)OC)=O)OC Chemical compound CC[C@H](C)C(CCC(C)C([C@H](C(C)C)NC([C@H](C(C)C)N(C)CCCC(O)=O)=O)=O)[C@@H](CC(N(CCC1)[C@@H]1[C@@H]([C@@H](C)C(N[C@@H](Cc1ccccc1)C(OC(C)(C)C)=O)=O)OC)=O)OC FBIWVCRQANCVRO-RLQGXUMZSA-N 0.000 description 1
- QKIRHMUPVCKBOP-ONNNRECGSA-N CC[C@H](C)C(CCC(C)C([C@H](C(C)C)NC([C@H](C(C)C)N(C)CCCC(O)=O)=O)=O)[C@@H](CC(N(CCC1)[C@@H]1[C@@H]([C@@H](C)C(N[C@@H]([C@@H](C)c1ccccc1)C(OCc1ccccc1)=O)=O)OC)=O)OC Chemical compound CC[C@H](C)C(CCC(C)C([C@H](C(C)C)NC([C@H](C(C)C)N(C)CCCC(O)=O)=O)=O)[C@@H](CC(N(CCC1)[C@@H]1[C@@H]([C@@H](C)C(N[C@@H]([C@@H](C)c1ccccc1)C(OCc1ccccc1)=O)=O)OC)=O)OC QKIRHMUPVCKBOP-ONNNRECGSA-N 0.000 description 1
- YXLPSSZGUQXPKX-IGCNILKZSA-N CC[C@H](C)[C@H](C)[C@@H](CC(N(CCC1)[C@@H]1[C@@H]([C@@H](C)C(CC([C@@H]([C@@H](C)O)C(NCc1ccccc1)=O)=N)=O)OC)=O)OC Chemical compound CC[C@H](C)[C@H](C)[C@@H](CC(N(CCC1)[C@@H]1[C@@H]([C@@H](C)C(CC([C@@H]([C@@H](C)O)C(NCc1ccccc1)=O)=N)=O)OC)=O)OC YXLPSSZGUQXPKX-IGCNILKZSA-N 0.000 description 1
- LPUCAZIAVVVSDS-FCWSTYBQSA-N CC[C@H](C)[C@H](C)[C@@H](CC(N(CCC1)[C@@H]1[C@@H]([C@@H](C)C(N[C@@H](Cc1c[nH]c2ccccc12)C(NCc1ccccc1)=O)=O)OC)=O)OC Chemical compound CC[C@H](C)[C@H](C)[C@@H](CC(N(CCC1)[C@@H]1[C@@H]([C@@H](C)C(N[C@@H](Cc1c[nH]c2ccccc12)C(NCc1ccccc1)=O)=O)OC)=O)OC LPUCAZIAVVVSDS-FCWSTYBQSA-N 0.000 description 1
- UORPSFYPZHGOGT-LZZUFOLASA-N CC[C@H](C)[C@H](CCC(C)C([C@H](C(C)C)NC([C@H](C(C)C)N(C)CCCC(O)=O)=O)=O)[C@@H](CC(N(CCC1)[C@@H]1[C@@H]([C@@H](C)C(N[C@@H](Cc1c[nH]c2ccccc12)C(NCc1ccccc1)=O)=O)OC)=O)OC Chemical compound CC[C@H](C)[C@H](CCC(C)C([C@H](C(C)C)NC([C@H](C(C)C)N(C)CCCC(O)=O)=O)=O)[C@@H](CC(N(CCC1)[C@@H]1[C@@H]([C@@H](C)C(N[C@@H](Cc1c[nH]c2ccccc12)C(NCc1ccccc1)=O)=O)OC)=O)OC UORPSFYPZHGOGT-LZZUFOLASA-N 0.000 description 1
- XPTIAPCETXADHD-FYVMMZCLSA-N CC[C@H](C)[C@H](CCC(C)C([C@H](C(C)C)NC([C@H](C(C)C)N(C)CCCC(O)=O)=O)=O)[C@@H](CC(N(CCC1)[C@@H]1[C@@H]([C@@H](C)C(N[C@@H](Cc1c[nH]c2ccccc12)C(OC(C)(C)C)=O)=O)OC)=O)OC Chemical compound CC[C@H](C)[C@H](CCC(C)C([C@H](C(C)C)NC([C@H](C(C)C)N(C)CCCC(O)=O)=O)=O)[C@@H](CC(N(CCC1)[C@@H]1[C@@H]([C@@H](C)C(N[C@@H](Cc1c[nH]c2ccccc12)C(OC(C)(C)C)=O)=O)OC)=O)OC XPTIAPCETXADHD-FYVMMZCLSA-N 0.000 description 1
- PEKYAXVRFPCUAE-LZZUFOLASA-N CC[C@H](C)[C@H](CCC(C)C([C@H](C(C)C)NC([C@H](C(C)C)N(C)CCCC(O)=O)=O)=O)[C@@H](CC(N(CCC1)[C@@H]1[C@@H]([C@@H](C)C(N[C@@H](Cc1c[nH]c2ccccc12)C(OCc1ccccc1)=O)=O)OC)=O)OC Chemical compound CC[C@H](C)[C@H](CCC(C)C([C@H](C(C)C)NC([C@H](C(C)C)N(C)CCCC(O)=O)=O)=O)[C@@H](CC(N(CCC1)[C@@H]1[C@@H]([C@@H](C)C(N[C@@H](Cc1c[nH]c2ccccc12)C(OCc1ccccc1)=O)=O)OC)=O)OC PEKYAXVRFPCUAE-LZZUFOLASA-N 0.000 description 1
- VJCBSIDPGAMHNS-HGABPJNWSA-N CC[C@H](C)[C@H](CCC(C)C([C@H](C(C)C)NC([C@H](C(C)C)N(C)CCCC(O)=O)=O)=O)[C@@H](CC(N(CCC1)[C@@H]1[C@@H]([C@@H](C)C(N[C@@H](Cc1ccccc1)C(N)=O)=O)OC)=O)OC Chemical compound CC[C@H](C)[C@H](CCC(C)C([C@H](C(C)C)NC([C@H](C(C)C)N(C)CCCC(O)=O)=O)=O)[C@@H](CC(N(CCC1)[C@@H]1[C@@H]([C@@H](C)C(N[C@@H](Cc1ccccc1)C(N)=O)=O)OC)=O)OC VJCBSIDPGAMHNS-HGABPJNWSA-N 0.000 description 1
- NXLKSAPPLRRUSX-SFXSRNHCSA-N CC[C@H](C)[C@H](CCC(C)C([C@H](C(C)C)NC([C@H](C(C)C)N(C)CCCC(O)=O)=O)=O)[C@@H](CC(N(CCC1)[C@@H]1[C@@H]([C@@H](C)C(N[C@@H](Cc1ccccc1)C(N1CCOCC1)=O)=O)OC)=O)OC Chemical compound CC[C@H](C)[C@H](CCC(C)C([C@H](C(C)C)NC([C@H](C(C)C)N(C)CCCC(O)=O)=O)=O)[C@@H](CC(N(CCC1)[C@@H]1[C@@H]([C@@H](C)C(N[C@@H](Cc1ccccc1)C(N1CCOCC1)=O)=O)OC)=O)OC NXLKSAPPLRRUSX-SFXSRNHCSA-N 0.000 description 1
- PVWMVVITMRAYBZ-BOWPEGOKSA-N CC[C@H](C)[C@H](CCC(C)C([C@H](C(C)C)NC([C@H](C(C)C)N(C)CCCC(O)=O)=O)=O)[C@@H](CC(N(CCC1)[C@@H]1[C@@H]([C@@H](C)C(N[C@@H](Cc1ccccc1)C(NCc1ccccc1)=O)=O)OC)=O)OC Chemical compound CC[C@H](C)[C@H](CCC(C)C([C@H](C(C)C)NC([C@H](C(C)C)N(C)CCCC(O)=O)=O)=O)[C@@H](CC(N(CCC1)[C@@H]1[C@@H]([C@@H](C)C(N[C@@H](Cc1ccccc1)C(NCc1ccccc1)=O)=O)OC)=O)OC PVWMVVITMRAYBZ-BOWPEGOKSA-N 0.000 description 1
- VMLIMIXBNHSQRH-WZHPYLGLSA-N CC[C@H](C)[C@H](CCC(C)C([C@H](C(C)C)NC([C@H](C(C)C)N(C)CCCC(O)=O)=O)=O)[C@@H](CC(N(CCC1)[C@@H]1[C@@H]([C@@H](C)C(N[C@@H](Cc1ccccc1)C(NNC(c1ccccc1)=O)=O)=O)OC)=O)OC Chemical compound CC[C@H](C)[C@H](CCC(C)C([C@H](C(C)C)NC([C@H](C(C)C)N(C)CCCC(O)=O)=O)=O)[C@@H](CC(N(CCC1)[C@@H]1[C@@H]([C@@H](C)C(N[C@@H](Cc1ccccc1)C(NNC(c1ccccc1)=O)=O)=O)OC)=O)OC VMLIMIXBNHSQRH-WZHPYLGLSA-N 0.000 description 1
- IXSCVJCOIKSTBR-HGABPJNWSA-N CC[C@H](C)[C@H](CCC(C)C([C@H](C(C)C)NC([C@H](C(C)C)N(C)CCCC(O)=O)=O)=O)[C@@H](CC(N(CCC1)[C@@H]1[C@@H]([C@@H](C)C(N[C@@H](Cc1ccccc1)C(O)=O)=O)OC)=O)OC Chemical compound CC[C@H](C)[C@H](CCC(C)C([C@H](C(C)C)NC([C@H](C(C)C)N(C)CCCC(O)=O)=O)=O)[C@@H](CC(N(CCC1)[C@@H]1[C@@H]([C@@H](C)C(N[C@@H](Cc1ccccc1)C(O)=O)=O)OC)=O)OC IXSCVJCOIKSTBR-HGABPJNWSA-N 0.000 description 1
- LHBDTWABOBWNBO-VACRVIMNSA-N CC[C@H](C)[C@H](CCC(C)C([C@H](C(C)C)NC([C@H](C(C)C)N(C)CCCC(O)=O)=O)=O)[C@@H](CC(N(CCC1)[C@@H]1[C@@H]([C@@H](C)C(N[C@@H](Cc1ccccc1)C(OC1(CCC2)CC2=CC(C)C1)=O)=O)OC)=O)OC Chemical compound CC[C@H](C)[C@H](CCC(C)C([C@H](C(C)C)NC([C@H](C(C)C)N(C)CCCC(O)=O)=O)=O)[C@@H](CC(N(CCC1)[C@@H]1[C@@H]([C@@H](C)C(N[C@@H](Cc1ccccc1)C(OC1(CCC2)CC2=CC(C)C1)=O)=O)OC)=O)OC LHBDTWABOBWNBO-VACRVIMNSA-N 0.000 description 1
- UZYYKTFZCWQPSU-DCEZEIDPSA-N CC[C@H](C)[C@H](CCC(C)C([C@H](C(C)C)NC([C@H](C(C)C)N(C)CCCC(O)=O)=O)=O)[C@@H](CC(N(CCC1)[C@@H]1[C@@H]([C@@H](C)C(N[C@@H](Cc1ccccc1)C(OCc1cccc2c1cccc2)=O)=O)OC)=O)OC Chemical compound CC[C@H](C)[C@H](CCC(C)C([C@H](C(C)C)NC([C@H](C(C)C)N(C)CCCC(O)=O)=O)=O)[C@@H](CC(N(CCC1)[C@@H]1[C@@H]([C@@H](C)C(N[C@@H](Cc1ccccc1)C(OCc1cccc2c1cccc2)=O)=O)OC)=O)OC UZYYKTFZCWQPSU-DCEZEIDPSA-N 0.000 description 1
- JGCPYUSBHBGEKQ-BOWPEGOKSA-N CC[C@H](C)[C@H](CCC(C)C([C@H](C(C)C)NC([C@H](C(C)C)N(C)CCCC(O)=O)=O)=O)[C@@H](CC(N(CCC1)[C@@H]1[C@@H]([C@@H](C)C(N[C@@H](Cc1ccccc1)C(OCc1ccccc1)=O)=O)OC)=O)OC Chemical compound CC[C@H](C)[C@H](CCC(C)C([C@H](C(C)C)NC([C@H](C(C)C)N(C)CCCC(O)=O)=O)=O)[C@@H](CC(N(CCC1)[C@@H]1[C@@H]([C@@H](C)C(N[C@@H](Cc1ccccc1)C(OCc1ccccc1)=O)=O)OC)=O)OC JGCPYUSBHBGEKQ-BOWPEGOKSA-N 0.000 description 1
- DMURHDLINHZLAO-XYWUOCBASA-N CC[C@H](C)[C@H](CCC(C)C([C@H](C(C)C)NC([C@H](C(C)C)N(C)CCCC(O)=O)=O)=O)[C@@H](CC(N(CCC1)[C@@H]1[C@@H]([C@@H](C)C(N[C@@H](Cc1ccccc1)COCc(cc1)ccc1C(O)=O)=O)OC)=O)OC Chemical compound CC[C@H](C)[C@H](CCC(C)C([C@H](C(C)C)NC([C@H](C(C)C)N(C)CCCC(O)=O)=O)=O)[C@@H](CC(N(CCC1)[C@@H]1[C@@H]([C@@H](C)C(N[C@@H](Cc1ccccc1)COCc(cc1)ccc1C(O)=O)=O)OC)=O)OC DMURHDLINHZLAO-XYWUOCBASA-N 0.000 description 1
- STDCEMQURYXJNT-LKLYUCIJSA-N CC[C@H](C)[C@H](CCC(C)C([C@H](C(C)C)NC([C@H](C(C)C)N(C)CCCC(O)=O)=O)=O)[C@@H](CC(N(CCC1)[C@@H]1[C@@H]([C@@H](C)C(N[C@@H](Cc1ccccc1)COCc(cc1)ccc1C(OC)=O)=O)OC)=O)OC Chemical compound CC[C@H](C)[C@H](CCC(C)C([C@H](C(C)C)NC([C@H](C(C)C)N(C)CCCC(O)=O)=O)=O)[C@@H](CC(N(CCC1)[C@@H]1[C@@H]([C@@H](C)C(N[C@@H](Cc1ccccc1)COCc(cc1)ccc1C(OC)=O)=O)OC)=O)OC STDCEMQURYXJNT-LKLYUCIJSA-N 0.000 description 1
- BRPYSSQOPCCFMK-ALOJLXAGSA-N CC[C@H](C)[C@H](CCC(C)C([C@H](C(C)C)NC([C@H](C(C)C)N(C)CCCC(O)=O)=O)=O)[C@@H](CC(N(CCC1)[C@@H]1[C@@H]([C@@H](C)C(N[C@@H](Cc1ccccc1)COCc1ccccc1)=O)OC)=O)OC Chemical compound CC[C@H](C)[C@H](CCC(C)C([C@H](C(C)C)NC([C@H](C(C)C)N(C)CCCC(O)=O)=O)=O)[C@@H](CC(N(CCC1)[C@@H]1[C@@H]([C@@H](C)C(N[C@@H](Cc1ccccc1)COCc1ccccc1)=O)OC)=O)OC BRPYSSQOPCCFMK-ALOJLXAGSA-N 0.000 description 1
- BDGSTHUQHCOKDL-QNICYEAASA-N CC[C@H](C)[C@H](CCC(C)C([C@H](C(C)C)NC([C@H](C(C)C)N(C)CCCC(O)=O)=O)=O)[C@@H](CC(N(CCC1)[C@@H]1[C@@H]([C@@H](C)C(N[C@](Cc1ccccc1)(COC)C=O)=O)OC)=O)OC Chemical compound CC[C@H](C)[C@H](CCC(C)C([C@H](C(C)C)NC([C@H](C(C)C)N(C)CCCC(O)=O)=O)=O)[C@@H](CC(N(CCC1)[C@@H]1[C@@H]([C@@H](C)C(N[C@](Cc1ccccc1)(COC)C=O)=O)OC)=O)OC BDGSTHUQHCOKDL-QNICYEAASA-N 0.000 description 1
- UFVLBFJUFHBIMH-KGIGHJOJSA-N CC[C@H](C)[C@H](CC[C@@H](C)C([C@H](C(C)C)NC([C@H](C(C)C)N(C)CCCC(O)=O)=O)=O)[C@@H](CC(N(CCC1)[C@@H]1[C@@H]([C@@H](C)C(CCC[C@@](C1)([C@H]1c1ccccc1)C(N)=O)=O)OC)=O)OC Chemical compound CC[C@H](C)[C@H](CC[C@@H](C)C([C@H](C(C)C)NC([C@H](C(C)C)N(C)CCCC(O)=O)=O)=O)[C@@H](CC(N(CCC1)[C@@H]1[C@@H]([C@@H](C)C(CCC[C@@](C1)([C@H]1c1ccccc1)C(N)=O)=O)OC)=O)OC UFVLBFJUFHBIMH-KGIGHJOJSA-N 0.000 description 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP10181966 | 2010-09-29 | ||
| EP10181966.2 | 2010-09-29 | ||
| EP11158466.0 | 2011-03-16 | ||
| EP11158466 | 2011-03-16 | ||
| PCT/EP2011/066658 WO2012041805A1 (de) | 2010-09-29 | 2011-09-26 | N-carboxyalkyl-auristatine und ihre verwendung |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013540114A JP2013540114A (ja) | 2013-10-31 |
| JP2013540114A5 true JP2013540114A5 (https=) | 2014-09-18 |
| JP5933562B2 JP5933562B2 (ja) | 2016-06-15 |
Family
ID=44674811
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013530690A Expired - Fee Related JP5933562B2 (ja) | 2010-09-29 | 2011-09-26 | Ｎ−カルボキシアルキル−アウリスタチンおよびその使用 |
Country Status (7)
| Country | Link |
|---|---|
| US (2) | US8987209B2 (https=) |
| EP (1) | EP2621508B1 (https=) |
| JP (1) | JP5933562B2 (https=) |
| CN (1) | CN103379912B (https=) |
| CA (1) | CA2813056C (https=) |
| ES (1) | ES2553874T3 (https=) |
| WO (1) | WO2012041805A1 (https=) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8987209B2 (en) | 2010-09-29 | 2015-03-24 | Seattle Genetics, Inc. | N-carboxyalkyl-auristatin and the use thereof |
| US9029406B2 (en) | 2011-03-16 | 2015-05-12 | Seattle Genetics, Inc | N-carboxyalkylauristatins and use thereof |
| KR102023496B1 (ko) * | 2011-04-21 | 2019-09-20 | 시애틀 지네틱스, 인크. | 신규 결합제-약물 콘주게이트 (adc) 및 그의 용도 |
| US9981046B2 (en) | 2012-05-15 | 2018-05-29 | Concortis Biosystems, Corp., a wholly owned Subsidiary of Sorrento Therapeutics, Inc. | Drug-conjugates, conjugation methods, and uses thereof |
| FR3005051A1 (fr) * | 2013-04-25 | 2014-10-31 | Pf Medicament | Derives de la dolastatine 10 et d'auristatines |
| US10208125B2 (en) | 2013-07-15 | 2019-02-19 | University of Pittsburgh—of the Commonwealth System of Higher Education | Anti-mucin 1 binding agents and uses thereof |
| WO2015057876A1 (en) | 2013-10-15 | 2015-04-23 | Sorrento Therapeutics Inc. | Drug-conjugates with a targeting molecule and two different drugs |
| BR112016012538A2 (pt) | 2013-12-17 | 2017-09-26 | Novartis Ag | peptídeos citotóxicos e conjugados dos mesmos |
| RU2692563C2 (ru) | 2014-04-25 | 2019-06-25 | Пьер Фабр Медикамент | Конъюгат антитела против igf-1r с лекарственным средством и его применение для лечения рака |
| BR112016024363A2 (pt) | 2014-04-25 | 2017-10-10 | Pf Medicament | conjugado de anticorpo-fármaco e seu uso para tratamento de câncer |
| CN106573956A (zh) | 2014-06-13 | 2017-04-19 | 诺华股份有限公司 | 澳瑞他汀衍生物及其缀合物 |
| EP3160513B1 (en) | 2014-06-30 | 2020-02-12 | Glykos Finland Oy | Saccharide derivative of a toxic payload and antibody conjugates thereof |
| EP3250238B1 (en) | 2015-01-28 | 2022-06-01 | Sorrento Therapeutics, Inc. | Antibody drug conjugates |
| CN106279352B (zh) | 2015-05-29 | 2020-05-22 | 上海新理念生物医药科技有限公司 | 海兔毒素10的衍生物及其应用 |
| EP3554544A4 (en) | 2016-12-16 | 2020-07-29 | Bluefin Biomedicine, Inc. | ANTI-PROTEIN 1 ANTIBODY CONTAINING AN ANTI-CUB DOMAIN (CDCP1), ANTIBODY-DRUG CONJUGATES AND THEIR METHODS OF USE |
| EP3725798B1 (en) * | 2017-12-15 | 2026-03-04 | Sichuan Kelun-Biotech Biopharmaceutical Co., Ltd. | Bioactive conjugate, preparation method therefor and use thereof |
Family Cites Families (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5663149A (en) | 1994-12-13 | 1997-09-02 | Arizona Board Of Regents Acting On Behalf Of Arizona State University | Human cancer inhibitory pentapeptide heterocyclic and halophenyl amides |
| WO1999035164A1 (en) | 1998-01-09 | 1999-07-15 | Arizona Board Of Regents, A Body Corporate, Acting On Behalf Of Arizona State University | Anti-cryptococcal peptides |
| CA2370245A1 (en) | 1999-05-14 | 2000-11-23 | Boehringer Ingelheim Pharmaceuticals, Inc. | Enzyme-activated anti-tumor prodrug compounds |
| US6323315B1 (en) | 1999-09-10 | 2001-11-27 | Basf Aktiengesellschaft | Dolastatin peptides |
| US6884869B2 (en) | 2001-04-30 | 2005-04-26 | Seattle Genetics, Inc. | Pentapeptide compounds and uses related thereto |
| US6737409B2 (en) | 2001-07-19 | 2004-05-18 | Hoffmann-La Roche Inc. | Dolastatin 10 derivatives |
| WO2003026577A2 (en) | 2001-09-24 | 2003-04-03 | Seattle Genetics, Inc. | P-amidobenzylethers in drug delivery agents |
| US7091186B2 (en) | 2001-09-24 | 2006-08-15 | Seattle Genetics, Inc. | p-Amidobenzylethers in drug delivery agents |
| SI1545613T1 (sl) | 2002-07-31 | 2011-11-30 | Seattle Genetics Inc | Avristatinski konjugati in njihova uporaba za zdravljenje raka avtoimunske bolezni ali infekcijskebolezni |
| US7498298B2 (en) | 2003-11-06 | 2009-03-03 | Seattle Genetics, Inc. | Monomethylvaline compounds capable of conjugation to ligands |
| WO2006132670A2 (en) | 2004-11-12 | 2006-12-14 | Seattle Genetics, Inc. | Auristatins having an aminobenzoic acid unit at the n terminus |
| JP5171621B2 (ja) | 2005-07-07 | 2013-03-27 | シアトル ジェネティックス， インコーポレイテッド | フェニルアラニン側鎖修飾をｃ末端に有するモノメチルバリン化合物 |
| US8871720B2 (en) | 2005-07-07 | 2014-10-28 | Seattle Genetics, Inc. | Monomethylvaline compounds having phenylalanine carboxy modifications at the C-terminus |
| CN101573384B (zh) * | 2006-10-27 | 2013-02-20 | 健泰科生物技术公司 | 抗体和免疫偶联物及其用途 |
| KR20140116546A (ko) * | 2006-10-27 | 2014-10-02 | 제넨테크, 인크. | 항체 및 면역접합체 및 이들의 용도 |
| JP5394246B2 (ja) * | 2007-03-30 | 2014-01-22 | ジェネンテック， インコーポレイテッド | 抗体及びイムノコンジュゲートとこれらの使用方法 |
| EP2265283B1 (en) | 2008-03-18 | 2014-09-03 | Seattle Genetics, Inc. | Auristatin drug linker conjugates |
| CN103200950B (zh) | 2010-06-10 | 2016-03-16 | 西雅图基因公司 | 新颖的耳他汀衍生物及其用途 |
| US8987209B2 (en) | 2010-09-29 | 2015-03-24 | Seattle Genetics, Inc. | N-carboxyalkyl-auristatin and the use thereof |
| US9029406B2 (en) | 2011-03-16 | 2015-05-12 | Seattle Genetics, Inc | N-carboxyalkylauristatins and use thereof |
| KR102023496B1 (ko) | 2011-04-21 | 2019-09-20 | 시애틀 지네틱스, 인크. | 신규 결합제-약물 콘주게이트 (adc) 및 그의 용도 |
| AU2012351685A1 (en) | 2011-12-14 | 2014-07-03 | Seattle Genetics, Inc. | FGFR antibody drug conjugates (ADCs) and the use thereof |
-
2011
- 2011-09-26 US US13/876,777 patent/US8987209B2/en active Active
- 2011-09-26 CA CA2813056A patent/CA2813056C/en not_active Expired - Fee Related
- 2011-09-26 JP JP2013530690A patent/JP5933562B2/ja not_active Expired - Fee Related
- 2011-09-26 EP EP11760500.6A patent/EP2621508B1/de not_active Not-in-force
- 2011-09-26 ES ES11760500.6T patent/ES2553874T3/es active Active
- 2011-09-26 CN CN201180057131.8A patent/CN103379912B/zh not_active Expired - Fee Related
- 2011-09-26 WO PCT/EP2011/066658 patent/WO2012041805A1/de not_active Ceased
-
2015
- 2015-02-05 US US14/615,005 patent/US20150148298A1/en not_active Abandoned
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2013540114A5 (https=) | ||
| ES2651162T3 (es) | Antagonistas fluorados de integrina | |
| JP2013533228A5 (https=) | ||
| TW201740979A (zh) | 熱休克蛋白（ｈｓｐ）９０抑制劑藥物共軛物 | |
| JP2015532295A5 (https=) | ||
| JP2013231086A (ja) | 化学療法の強化方法 | |
| CN1396830A (zh) | 含有双膦酸盐的肠胃外药物组合物 | |
| JP2013537195A5 (ja) | 疾患を治療するための医薬品及び同医薬品を含むキット | |
| JP2020507589A5 (https=) | ||
| JP2005506352A5 (https=) | ||
| EA200300424A1 (ru) | Соли изотиазол-4-карбоксамида и их применение в качестве антигиперпролиферативных агентов | |
| JP2010511701A5 (https=) | ||
| JP2005508337A5 (https=) | ||
| JP2010527985A5 (https=) | ||
| JP2010505865A5 (https=) | ||
| JP2018529648A5 (https=) | ||
| JOP20240217A1 (ar) | مشتقات الكوينولين كمُعدِّلات للعضو x2 لمستقبل بروتين g مرتبط بـ mas ومنتجات ذات صلة | |
| US11883423B2 (en) | Nucleobase analogue derivatives and their applications | |
| CN105246483A (zh) | 用于γ-谷氨酰循环调节的方法和组合物 | |
| AU2008236994A1 (en) | Method of treating melanoma | |
| WO2023244639A1 (en) | Methods of predicting cns cancer response to treatment with egfr inhibitors | |
| JP2018512390A (ja) | Ｐｓｍａリガンド−チューブリシン化合物を用いた癌の処置方法 | |
| JP2010535203A5 (https=) | ||
| WO2021086426A1 (en) | D-amphetamine compounds, compositions, and processes for making and using the same | |
| CN103827100B (zh) | 用于降低血清尿酸的[1,2,4]噻二嗪1,1-二氧化物化合物 |