JP2018524304A5 - - Google Patents
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- JP2018524304A5 JP2018524304A5 JP2017564668A JP2017564668A JP2018524304A5 JP 2018524304 A5 JP2018524304 A5 JP 2018524304A5 JP 2017564668 A JP2017564668 A JP 2017564668A JP 2017564668 A JP2017564668 A JP 2017564668A JP 2018524304 A5 JP2018524304 A5 JP 2018524304A5
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- JP
- Japan
- Prior art keywords
- independently
- hydrogen
- case
- cycloalkyl
- compound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 150000001875 compounds Chemical class 0.000 claims 26
- 229910052739 hydrogen Inorganic materials 0.000 claims 16
- 239000001257 hydrogen Substances 0.000 claims 16
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 8
- 150000002431 hydrogen Chemical class 0.000 claims 8
- 150000003839 salts Chemical class 0.000 claims 7
- 239000012453 solvate Substances 0.000 claims 6
- 239000000203 mixture Substances 0.000 claims 5
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 claims 4
- -1 -alkylaryl Chemical group 0.000 claims 4
- 125000000623 heterocyclic group Chemical group 0.000 claims 4
- 150000004677 hydrates Chemical class 0.000 claims 4
- 125000004429 atom Chemical group 0.000 claims 3
- 229910052799 carbon Inorganic materials 0.000 claims 3
- 125000001072 heteroaryl group Chemical group 0.000 claims 3
- 239000008194 pharmaceutical composition Substances 0.000 claims 3
- PAJMKGZZBBTTOY-ZFORQUDYSA-N treprostinil Chemical compound C1=CC=C(OCC(O)=O)C2=C1C[C@@H]1[C@@H](CC[C@@H](O)CCCCC)[C@H](O)C[C@@H]1C2 PAJMKGZZBBTTOY-ZFORQUDYSA-N 0.000 claims 3
- 229960005032 treprostinil Drugs 0.000 claims 3
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical group [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims 2
- 125000000217 alkyl group Chemical group 0.000 claims 2
- 125000003118 aryl group Chemical group 0.000 claims 2
- 125000000753 cycloalkyl group Chemical group 0.000 claims 2
- 150000002148 esters Chemical class 0.000 claims 2
- 229910052757 nitrogen Inorganic materials 0.000 claims 2
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 2
- 125000004070 6 membered heterocyclic group Chemical group 0.000 claims 1
- 201000001320 Atherosclerosis Diseases 0.000 claims 1
- 206010007559 Cardiac failure congestive Diseases 0.000 claims 1
- 208000003790 Foot Ulcer Diseases 0.000 claims 1
- 206010019280 Heart failures Diseases 0.000 claims 1
- 206010062016 Immunosuppression Diseases 0.000 claims 1
- 206010022562 Intermittent claudication Diseases 0.000 claims 1
- 208000029523 Interstitial Lung disease Diseases 0.000 claims 1
- 208000002193 Pain Diseases 0.000 claims 1
- 208000018262 Peripheral vascular disease Diseases 0.000 claims 1
- 206010064911 Pulmonary arterial hypertension Diseases 0.000 claims 1
- 208000001647 Renal Insufficiency Diseases 0.000 claims 1
- 150000001413 amino acids Chemical class 0.000 claims 1
- 208000006673 asthma Diseases 0.000 claims 1
- 230000036523 atherogenesis Effects 0.000 claims 1
- 150000001721 carbon Chemical group 0.000 claims 1
- 125000001559 cyclopropyl group Chemical group [H]C1([H])C([H])([H])C1([H])* 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 208000035475 disorder Diseases 0.000 claims 1
- 125000001188 haloalkyl group Chemical group 0.000 claims 1
- 229920000140 heteropolymer Polymers 0.000 claims 1
- 229920001519 homopolymer Polymers 0.000 claims 1
- 230000001506 immunosuppresive effect Effects 0.000 claims 1
- 208000021156 intermittent vascular claudication Diseases 0.000 claims 1
- 230000000302 ischemic effect Effects 0.000 claims 1
- 230000007654 ischemic lesion Effects 0.000 claims 1
- 201000006370 kidney failure Diseases 0.000 claims 1
- 230000002981 neuropathic effect Effects 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 102000004196 processed proteins & peptides Human genes 0.000 claims 1
- 108090000765 processed proteins & peptides Proteins 0.000 claims 1
- 230000002062 proliferating effect Effects 0.000 claims 1
- 102000004169 proteins and genes Human genes 0.000 claims 1
- 108090000623 proteins and genes Proteins 0.000 claims 1
- 208000005069 pulmonary fibrosis Diseases 0.000 claims 1
- 208000002815 pulmonary hypertension Diseases 0.000 claims 1
- 230000008085 renal dysfunction Effects 0.000 claims 1
- 230000037317 transdermal delivery Effects 0.000 claims 1
Priority Applications (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2021151659A JP7850537B2 (ja) | 2015-06-17 | 2021-09-17 | トレプロスチニル誘導体ならびにその組成物および使用 |
| JP2023209782A JP2024019523A (ja) | 2015-06-17 | 2023-12-13 | トレプロスチニル誘導体ならびにその組成物および使用 |
| JP2025194875A JP2026021603A (ja) | 2015-06-17 | 2025-11-14 | トレプロスチニル誘導体ならびにその組成物および使用 |
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201514742579A | 2015-06-17 | 2015-06-17 | |
| US14/742,579 | 2015-06-17 | ||
| US14/742,544 | 2015-06-17 | ||
| US14/742,544 US9394227B1 (en) | 2015-06-17 | 2015-06-17 | Treprostinil derivatives and compositions and uses thereof |
| US14/829,180 | 2015-08-18 | ||
| US14/829,180 US9643911B2 (en) | 2015-06-17 | 2015-08-18 | Treprostinil derivatives and compositions and uses thereof |
| PCT/US2016/037383 WO2016205202A1 (en) | 2015-06-17 | 2016-06-14 | Treprostinil derivatives and compositions and uses thereof |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021151659A Division JP7850537B2 (ja) | 2015-06-17 | 2021-09-17 | トレプロスチニル誘導体ならびにその組成物および使用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018524304A JP2018524304A (ja) | 2018-08-30 |
| JP2018524304A5 true JP2018524304A5 (https=) | 2019-07-11 |
| JP7013245B2 JP7013245B2 (ja) | 2022-01-31 |
Family
ID=56204034
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017564668A Active JP7013245B2 (ja) | 2015-06-17 | 2016-06-14 | トレプロスチニル誘導体ならびにその組成物および使用 |
| JP2021151659A Active JP7850537B2 (ja) | 2015-06-17 | 2021-09-17 | トレプロスチニル誘導体ならびにその組成物および使用 |
| JP2023209782A Pending JP2024019523A (ja) | 2015-06-17 | 2023-12-13 | トレプロスチニル誘導体ならびにその組成物および使用 |
| JP2025194875A Pending JP2026021603A (ja) | 2015-06-17 | 2025-11-14 | トレプロスチニル誘導体ならびにその組成物および使用 |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021151659A Active JP7850537B2 (ja) | 2015-06-17 | 2021-09-17 | トレプロスチニル誘導体ならびにその組成物および使用 |
| JP2023209782A Pending JP2024019523A (ja) | 2015-06-17 | 2023-12-13 | トレプロスチニル誘導体ならびにその組成物および使用 |
| JP2025194875A Pending JP2026021603A (ja) | 2015-06-17 | 2025-11-14 | トレプロスチニル誘導体ならびにその組成物および使用 |
Country Status (10)
| Country | Link |
|---|---|
| US (11) | US9643911B2 (https=) |
| EP (3) | EP3835291A1 (https=) |
| JP (4) | JP7013245B2 (https=) |
| KR (2) | KR102711773B1 (https=) |
| CN (1) | CN108349926A (https=) |
| CA (1) | CA2989317A1 (https=) |
| ES (2) | ES2897721T3 (https=) |
| HK (1) | HK1258913A1 (https=) |
| IL (4) | IL305157B2 (https=) |
| WO (1) | WO2016205202A1 (https=) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3712142B1 (en) | 2013-01-11 | 2022-07-06 | Corsair Pharma, Inc. | Prodrugs of treprostinil |
| US9505737B2 (en) | 2013-01-11 | 2016-11-29 | Corsair Pharma, Inc. | Treprostinil derivative compounds and methods of using same |
| US9643911B2 (en) * | 2015-06-17 | 2017-05-09 | Corsair Pharma, Inc. | Treprostinil derivatives and compositions and uses thereof |
| US9394227B1 (en) | 2015-06-17 | 2016-07-19 | Corsair Pharma, Inc. | Treprostinil derivatives and compositions and uses thereof |
| US10898494B2 (en) | 2016-05-05 | 2021-01-26 | Liquidia Technologies, Inc. | Dry powder treprostinil for the treatment of pulmonary hypertension |
| JP7220650B2 (ja) | 2016-09-26 | 2023-02-10 | ユナイテッド セラピューティクス コーポレイション | トレプロスチニルプロドラッグ |
| US20190099383A1 (en) * | 2017-09-30 | 2019-04-04 | Samos Pharmaceuticals, Inc. | Transdermal Delivery of Selexipag Metabolite |
| EP3498283A1 (en) * | 2017-12-14 | 2019-06-19 | Ipsol AG | Glycosidic derivatives of treprostinil |
| JP2022546314A (ja) * | 2019-08-23 | 2022-11-04 | ユナイテッド セラピューティクス コーポレイション | トレプロスチニルプロドラッグ |
| AU2021255621A1 (en) | 2020-04-17 | 2022-10-20 | United Therapeutics Corporation | Treprostinil for use in the treatment of intersitial lung disease |
| WO2022132655A1 (en) | 2020-12-14 | 2022-06-23 | United Therapeutics Corporation | Methods of treating disease with treprostinil prodrugs |
| AU2022229367A1 (en) | 2021-03-03 | 2023-09-14 | United Therapeutics Corporation | A dry powder composition of trestinil and its prodrug thereof and further comprising comprising (e)-3,6-bis[4-(n-carbonyl-2-propenyl)amidobutyl]-2,5-diketopiperazine (fdkp) |
| WO2022194195A1 (zh) * | 2021-03-16 | 2022-09-22 | 江苏恒瑞医药股份有限公司 | 一种曲前列环素衍生物及其用途 |
| US20230263807A1 (en) | 2022-02-08 | 2023-08-24 | United Therapeutics Corporation | Treprostinil iloprost combination therapy |
| CN115448839B (zh) * | 2022-10-14 | 2025-02-14 | 广州楷石医药有限公司 | 一种曲前列尼尔的前体药物 |
| CN115894240B9 (zh) * | 2022-10-14 | 2026-03-13 | 广州楷石医药有限公司 | 曲前列尼尔的前体药物及其应用 |
| AU2024208919A1 (en) * | 2023-01-19 | 2025-07-17 | United Therapeutics Corporation | Treprostinil analogs |
| CN117800845B (zh) * | 2023-03-28 | 2026-04-14 | 广州楷石医药有限公司 | 一种羟基取代曲前列尼尔衍生物、合成方法及其应用 |
| AU2024289343A1 (en) * | 2023-07-03 | 2026-01-22 | Cf Pharmtech Guangzhou Limited | Treprostinil derivative, and preparation method therefor and use thereof |
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