JP2012502048A5 - - Google Patents

Download PDF

Info

Publication number
JP2012502048A5
JP2012502048A5 JP2011526202A JP2011526202A JP2012502048A5 JP 2012502048 A5 JP2012502048 A5 JP 2012502048A5 JP 2011526202 A JP2011526202 A JP 2011526202A JP 2011526202 A JP2011526202 A JP 2011526202A JP 2012502048 A5 JP2012502048 A5 JP 2012502048A5
Authority
JP
Japan
Prior art keywords
group
substituted
alkyl group
unsubstituted
halo
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2011526202A
Other languages
English (en)
Japanese (ja)
Other versions
JP2012502048A (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2009/055927 external-priority patent/WO2010028175A1/en
Publication of JP2012502048A publication Critical patent/JP2012502048A/ja
Publication of JP2012502048A5 publication Critical patent/JP2012502048A5/ja
Pending legal-status Critical Current

Links

JP2011526202A 2008-09-08 2009-09-03 アルデヒドデヒドロゲナーゼ活性のモジュレーターおよびその使用方法 Pending JP2012502048A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US9522708P 2008-09-08 2008-09-08
US61/095,227 2008-09-08
PCT/US2009/055927 WO2010028175A1 (en) 2008-09-08 2009-09-03 Modulators of aldehyde dehydrogenase activity and methods of use thereof

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2014208930A Division JP2015051983A (ja) 2008-09-08 2014-10-10 アルデヒドデヒドロゲナーゼ活性のモジュレーターおよびその使用方法

Publications (2)

Publication Number Publication Date
JP2012502048A JP2012502048A (ja) 2012-01-26
JP2012502048A5 true JP2012502048A5 (https=) 2012-10-18

Family

ID=41797485

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2011526202A Pending JP2012502048A (ja) 2008-09-08 2009-09-03 アルデヒドデヒドロゲナーゼ活性のモジュレーターおよびその使用方法
JP2014208930A Pending JP2015051983A (ja) 2008-09-08 2014-10-10 アルデヒドデヒドロゲナーゼ活性のモジュレーターおよびその使用方法

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2014208930A Pending JP2015051983A (ja) 2008-09-08 2014-10-10 アルデヒドデヒドロゲナーゼ活性のモジュレーターおよびその使用方法

Country Status (7)

Country Link
US (3) US8354435B2 (https=)
EP (1) EP2337563B1 (https=)
JP (2) JP2012502048A (https=)
CN (1) CN102209541B (https=)
ES (1) ES2477552T3 (https=)
TW (1) TWI464161B (https=)
WO (1) WO2010028175A1 (https=)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20110105602A2 (en) * 2007-03-08 2011-05-05 Daria Mochly-Rosen Mitochondrial Aldehyde Dehydrogenase-2 Modulators and Methods of Use Thereof
US8354435B2 (en) 2008-09-08 2013-01-15 The Board Of Trustees Of The Leland Stanford Junior University Modulators of aldehyde dehydrogenase activity and methods of use thereof
CN102202669A (zh) 2008-10-28 2011-09-28 利兰·斯坦福青年大学托管委员会 醛脱氢酶调节剂及其使用方法
US10457659B2 (en) 2011-04-29 2019-10-29 The Board Of Trustees Of The Leland Stanford Junior University Compositions and methods for increasing proliferation of adult salivary stem cells
EP2723718A1 (en) 2011-06-24 2014-04-30 Amgen Inc. Trpm8 antagonists and their use in treatments
JP2014527511A (ja) 2011-06-24 2014-10-16 アムジエン・インコーポレーテツド Trpm8拮抗剤及び治療におけるそれらの使用
TWI567061B (zh) 2011-07-01 2017-01-21 吉李德科學股份有限公司 用於治療成癮之化合物
US8952009B2 (en) 2012-08-06 2015-02-10 Amgen Inc. Chroman derivatives as TRPM8 inhibitors
WO2014160185A2 (en) 2013-03-14 2014-10-02 The Board Of Trustees Of The Leland Stanford Junior University Mitochondrial aldehyde dehydrogenase-2 modulators and methods of use thereof
US12084472B2 (en) 2015-12-18 2024-09-10 Ardelyx, Inc. Substituted 4-phenyl pyridine compounds as non-systemic TGR5 agonists
TWI773657B (zh) 2015-12-18 2022-08-11 美商亞德利克斯公司 作爲非全身tgr5促效劑之經取代之4-苯基吡啶化合物
FR3054564B1 (fr) * 2016-07-28 2018-08-31 Advanced Biodesign Substrat specifique d'une isoenzyme de l'aldh
CN117105868A (zh) * 2022-05-24 2023-11-24 中国人民解放军海军军医大学 酰胺类醛脱氢酶激动剂、其合成方法及用途
CN115160285B (zh) * 2022-08-25 2022-11-29 云南大学 硫代酰胺类aldh2激动剂、制备方法及应用

Family Cites Families (99)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2319808A (en) 1939-08-31 1943-05-25 Squibb & Sons Inc Sterol derivatives and process for producing same
DE2417763A1 (de) 1974-04-11 1975-10-30 Bayer Ag Carbonsaeureamide, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel
US4992417A (en) 1987-07-17 1991-02-12 Mount Sinai School Of Medicine Superactive human insulin analogues
US4992418A (en) 1987-07-17 1991-02-12 Mount Sinai School Of Medicine Superactive human insulin analogue-[10-Aspartic Acid-B]Human Insulin
JPH01203351A (ja) 1988-02-05 1989-08-16 Mitsui Petrochem Ind Ltd 1,4−ジヒドロキシナフタレン誘導体および医薬
JPH023351A (ja) 1988-06-16 1990-01-08 Oki Electric Ind Co Ltd 印刷装置
US4861891A (en) 1988-08-31 1989-08-29 Pfizer Inc. Antidepressant N-substituted nicotinamide compounds
US5514646A (en) 1989-02-09 1996-05-07 Chance; Ronald E. Insulin analogs modified at position 29 of the B chain
JPH03184973A (ja) 1989-12-14 1991-08-12 Rooman Kogyo:Kk 放射線障害防護剤
US5260323A (en) * 1990-06-28 1993-11-09 Hoechst Aktiengesellschaft 2,4- and 2,5-substituted pyridine-N-oxides, processes for their preparation and their use
TW197439B (https=) 1991-04-04 1993-01-01 Ueno Pharmaceutics Applic Res Co Ltd
US5283253A (en) 1991-09-23 1994-02-01 Florida State University Furyl or thienyl carbonyl substituted taxanes and pharmaceutical compositions containing them
DE4201047A1 (de) 1992-01-17 1993-07-22 Bayer Ag Substituierte isoxazolcarbonsaeureamide
US5272137A (en) 1992-02-14 1993-12-21 Mcneil-Pfc, Inc. Aqueous pharmaceutical suspension for pharmaceutical actives
US5200534A (en) 1992-03-13 1993-04-06 University Of Florida Process for the preparation of taxol and 10-deacetyltaxol
US5294637A (en) 1992-07-01 1994-03-15 Bristol-Myers Squibb Company Fluoro taxols
JP2994182B2 (ja) 1992-07-23 1999-12-27 石原産業株式会社 アミド系化合物又はその塩、それらの製造方法及びそれらを含有する有害動物防除剤
US5202448A (en) 1992-08-14 1993-04-13 Napro Biotherapeutics, Inc. Processes of converting taxanes into baccatin III
US5415869A (en) 1993-11-12 1995-05-16 The Research Foundation Of State University Of New York Taxol formulation
US5474978A (en) 1994-06-16 1995-12-12 Eli Lilly And Company Insulin analog formulations
US5461031A (en) 1994-06-16 1995-10-24 Eli Lilly And Company Monomeric insulin analog formulations
US5504188A (en) 1994-06-16 1996-04-02 Eli Lilly And Company Preparation of stable zinc insulin analog crystals
US5547929A (en) 1994-09-12 1996-08-20 Eli Lilly And Company Insulin analog formulations
US5693609A (en) 1994-11-17 1997-12-02 Eli Lilly And Company Acylated insulin analogs
JP3833281B2 (ja) * 1995-02-03 2006-10-11 日本曹達株式会社 2,6−ジクロロイソニコチン酸ベンジルアミド誘導体及び植物病害防除剤
YU18596A (sh) 1995-03-31 1998-07-10 Eli Lilly And Company Analogne formulacije monomernog insulina
DE69631347T2 (de) * 1995-09-15 2004-10-07 Upjohn Co Aminoaryl oxazolidinone n-oxide
US6072050A (en) 1996-06-11 2000-06-06 Pioneer Hi-Bred International, Inc. Synthetic promoters
FR2751645B1 (fr) 1996-07-29 1998-12-24 Sanofi Sa Amines pour la fabrication de medicaments destines a empecher la proliferation de cellules tumorales
AR012894A1 (es) 1997-06-13 2000-11-22 Lilly Co Eli Formulacion de insulina en solucion estable, su uso para preparar un medicamento y proceso para la preparacion de la misma.
PT1027328E (pt) 1997-10-31 2006-11-30 Aventis Pharma Ltd Anilidas substituídas
WO1999032444A1 (en) 1997-12-22 1999-07-01 Eli Lilly And Company Catalyst and method for amide formation
DE69906059D1 (de) 1998-04-20 2003-04-24 Fujisawa Pharmaceutical Co Anthranilsäurederivate als inhibitoren der c-gmp-phosphodiesterase
AR019190A1 (es) * 1998-07-08 2001-12-26 Sod Conseils Rech Applic Derivados de 2-aminopiridinas, productos intermedios para su preparacion, medicamentos y composiciones farmaceuticas que los contienen y su uso para preparar medicamentos
US6780883B2 (en) * 1998-11-05 2004-08-24 Warner-Lambert Company Amide inhibitors of microsomal triglyceride transfer protein
ATE276241T1 (de) 1998-11-25 2004-10-15 Yissum Res Dev Co Antioxidationsmittel
GB9919558D0 (en) 1999-08-18 1999-10-20 Hoechst Schering Agrevo Gmbh Fungicidal compounds
WO2001032928A2 (en) 1999-11-05 2001-05-10 Phase-1 Molecular Toxicology Methods of determining individual hypersensitivity to an agent
US20020034783A1 (en) 2000-04-18 2002-03-21 Rachel Meyers 39228, a novel human alcohol dehydrogenase and uses therefor
WO2002020500A2 (en) 2000-09-01 2002-03-14 Icos Corporation Materials and methods to potentiate cancer treatment
HK1052011A1 (zh) * 2000-09-15 2003-08-29 Anormed Inc. 趋化因子受体结合杂环化合物
DE60137435D1 (de) * 2000-09-15 2009-03-05 Anormed Inc Chemokin rezeptor bindenden heterozyklische verbindungen
WO2002053544A1 (en) 2000-12-29 2002-07-11 Darwin Discovery Ltd. Pharmaceutical uses and synthesis of nicotinanilide-n-oxides
DOP2002000332A (es) * 2001-02-14 2002-08-30 Warner Lambert Co Inhibidores de piridina de metaloproteinasas de la matriz
US6678516B2 (en) 2001-05-21 2004-01-13 Nokia Corporation Method, system, and apparatus for providing services in a privacy enabled mobile and Ubicom environment
JP4448902B2 (ja) 2001-06-08 2010-04-14 株式会社医薬分子設計研究所 スルホンアミド誘導体
WO2003030937A1 (en) 2001-10-05 2003-04-17 Ono Pharmaceutical Co., Ltd. Remedies for stress diseases comprising mitochondrial benzodiazepine receptor antagonists
DE10149674A1 (de) * 2001-10-09 2003-04-24 Apogepha Arzneimittel Gmbh Orale Darreichungsformen für Propiverin oder seinen pharmazeutisch annehmbaren Salzen mit verlängerter Wirkstoffreisetzung
US20030100034A1 (en) * 2001-10-16 2003-05-29 Millennium Pharmaceuticals, Inc. 9136, a human aldehyde dehydrogenase family member and uses therefor
PY0300568A (es) * 2002-01-31 2004-10-01 Pfizer Prod Inc Metabolitos del acido(3-{[4-terc-butilbencil)-(piridin-3-sulfonil)amino]metil}fenoxi)acetico
ATE447971T1 (de) 2002-02-19 2009-11-15 Shionogi & Co Antipruriginosa
WO2003086377A1 (en) 2002-04-18 2003-10-23 Institute Of Medicinal Molecular Design. Inc. Amide derivatives
GB0215650D0 (en) 2002-07-05 2002-08-14 Cyclacel Ltd Bisarylsufonamide compounds
CA2497979A1 (en) 2002-09-06 2004-03-18 Elan Pharmaceuticals, Inc. 1, 3-diamino-2-hydroxypropane prodrug derivatives
EP1402888A1 (en) 2002-09-18 2004-03-31 Jerini AG The use of substituted carbocyclic compounds as rotamases inhibitors
EP1402887A1 (en) 2002-09-18 2004-03-31 Jerini AG New compounds for the inhibition of undesired cell proliferation and use thereof
US7135575B2 (en) 2003-03-03 2006-11-14 Array Biopharma, Inc. P38 inhibitors and methods of use thereof
US7022850B2 (en) 2003-05-22 2006-04-04 Bristol-Myers Squibb Co. Bicyclicpyrimidones and their use to treat diseases
JP4359754B2 (ja) * 2003-07-03 2009-11-04 三菱瓦斯化学株式会社 基板の洗浄剤
EP1649054A1 (en) 2003-07-21 2006-04-26 Oncotherapy Science, Inc. Method for diagnosing colorectal cancers
WO2005011561A2 (en) 2003-08-04 2005-02-10 Labcoat, Ltd. Stent coating apparatus and method
GB0318814D0 (en) * 2003-08-11 2003-09-10 Smithkline Beecham Corp Novel compounds
EP1661572A1 (en) 2003-08-18 2006-05-31 Shionogi & Co., Ltd. Novel use of cannabinoid receptor agonist
FR2861071B1 (fr) 2003-10-17 2006-01-06 Sanofi Synthelabo Derives de n-[phenyl(alkylpiperidin-2-yl) methyl]benzamide, leur prepartation et leur application en therapeutique
FR2861074B1 (fr) 2003-10-17 2006-04-07 Sanofi Synthelabo Derives de n-[phenyl(piperidin-2-yl)methyl]benzamide, leur preparation et leur application en therapeutique
AU2004298048A1 (en) 2003-12-09 2005-06-23 The Board Of Trustees Of The Leland Stanford Junior University Methods and compositions for modulating mitochondrial aldehyde dehydrogenase-2
GT200500013A (es) * 2004-01-23 2005-08-10 Amidas herbicidas
WO2005084392A2 (en) 2004-03-03 2005-09-15 Convivia 4-methylpyrazole formulations for inhibiting ethanol intolerance
WO2005110422A2 (en) 2004-05-19 2005-11-24 Boehringer Ingelheim International Gmbh Treatment of diseases associated with altered level of amyloid beta peptides
CN1749415A (zh) 2004-09-15 2006-03-22 上海人类基因组研究中心 硝酸甘油治疗急性心绞痛疗效检测方法和试剂盒
ES2377758T3 (es) * 2004-11-12 2012-03-30 Bristol-Myers Squibb Company Compuestos tricíclicos basados en tiazolo[4,5-b]piridina imidazo-fusionada y composiciones farmacéuticas que los comprenden
US7888374B2 (en) * 2005-01-28 2011-02-15 Abbott Laboratories Inhibitors of c-jun N-terminal kinases
DOP2006000051A (es) 2005-02-24 2006-08-31 Lilly Co Eli Inhibidores de vegf-r2 y métodos
HRP20100272T2 (hr) 2005-09-23 2010-07-31 Pfizer Products Incorporated Piridinaminosulfonil supstituirani benzamidi kao inhibitori citokroma p450 3a4 (cyp3a4)
AU2006331765A1 (en) 2005-12-22 2007-07-05 Wyeth Substituted isoquinoline-1,3(2H,4H)-diones, 1-thioxo-1,4-dihydro-2H-isoquinoline-3-ones and 1,4-dihydro-3(2H)-isoquinolones and use thereof as kinase inhibitor
MX2008012404A (es) * 2006-03-28 2008-10-09 Novartis Ag Derivados de amida y su aplicacion para el tratamiento de enfermedades relacionadas con proteina-g.
EP2727585A1 (en) 2006-05-16 2014-05-07 Takeda Pharmaceutical Company Limited In-vivo screening method
WO2007136707A2 (en) 2006-05-17 2007-11-29 University Of Utah Research Foundation Methods and compositions related to eosinophil regulation
US20080003585A1 (en) 2006-06-29 2008-01-03 Bio-Rad Laboratories, Inc., A Corporation Of The State Of Delaware Purification and amplification of nucleic acids in a microfluidic device
KR20090033417A (ko) 2006-07-27 2009-04-03 씨브이 쎄러퓨틱스, 인코포레이티드 중독의 치료에서의 aldh-2 저해제
PE20080906A1 (es) 2006-08-17 2008-07-05 Kemia Inc Derivados heteroarilo como inhibidores de citocina
US8927715B2 (en) 2006-08-25 2015-01-06 Vitae Pharmaceuticals, Inc. Inhibitors of 11β-hydroxysteroid dehydrogenase type 1
ATE507205T1 (de) * 2006-12-11 2011-05-15 Genetics Co Inc Aromatische 1,4-di-carboxylamide und deren verwendung
CN101631786A (zh) 2006-12-20 2010-01-20 先灵公司 新颖的jnk抑制剂
CN101611007A (zh) * 2006-12-20 2009-12-23 先灵公司 新颖的jnk抑制剂
WO2008103354A2 (en) 2007-02-20 2008-08-28 Cropsolution, Inc. Modulators of acetyl-coenzyme a carboxylase and methods of use thereof
US20110105602A2 (en) 2007-03-08 2011-05-05 Daria Mochly-Rosen Mitochondrial Aldehyde Dehydrogenase-2 Modulators and Methods of Use Thereof
WO2009086303A2 (en) 2007-12-21 2009-07-09 University Of Rochester Method for altering the lifespan of eukaryotic organisms
WO2009137045A2 (en) 2008-05-07 2009-11-12 The Board Of Trustees Of The Leland Stanford Junior University Crystal structure of aldehyde dehydrogenase and methods of use thereof
RU2010153656A (ru) 2008-06-04 2012-07-20 Амбрилиа Байофарма Инк. (Ca) Ингибиторы интегразы вич из пиридоксина
US9187426B2 (en) * 2008-06-27 2015-11-17 Novartis Ag Organic compounds
US8354435B2 (en) 2008-09-08 2013-01-15 The Board Of Trustees Of The Leland Stanford Junior University Modulators of aldehyde dehydrogenase activity and methods of use thereof
CN102202669A (zh) 2008-10-28 2011-09-28 利兰·斯坦福青年大学托管委员会 醛脱氢酶调节剂及其使用方法
CN105254557A (zh) 2009-05-29 2016-01-20 拉夸里亚创药株式会社 作为钙或钠通道阻滞剂的芳基取代羧酰胺衍生物
JP5947307B2 (ja) 2010-10-20 2016-07-06 グリュネンタール・ゲゼルシャフト・ミト・ベシュレンクテル・ハフツング Kcnq2/3調節因子としての置換6−アミノ−ニコチンアミド
US20140088187A1 (en) 2010-12-14 2014-03-27 Beth Israel Deaconess Medical Center Androgen receptor inhibitors and methods of use thereof
WO2012106534A2 (en) 2011-02-02 2012-08-09 The Regents Of The University Of California Hiv integrase inhibitors
US10457659B2 (en) 2011-04-29 2019-10-29 The Board Of Trustees Of The Leland Stanford Junior University Compositions and methods for increasing proliferation of adult salivary stem cells
MX2014002542A (es) 2011-08-29 2014-07-09 Infinity Pharmaceuticals Inc Compuestos heterociclicos y usos de los mismos.

Similar Documents

Publication Publication Date Title
JP2012502048A5 (https=)
JP2015051983A5 (https=)
JP2010514786A5 (https=)
JP2013508279A5 (https=)
JP2010529147A5 (https=)
JP2018524304A5 (https=)
JP2008195730A5 (https=)
JP2013510120A5 (https=)
JP2017518959A5 (https=)
JP2009263394A5 (https=)
JP2016503797A5 (https=)
JP2016505595A5 (https=)
JP2009143956A5 (https=)
JP2011516511A5 (https=)
JP2018135343A5 (https=)
JP2009543795A5 (https=)
JP2009532417A5 (https=)
JP2010090149A5 (https=)
JP2007526257A5 (https=)
JP2013518036A5 (https=)
JP2014530838A5 (https=)
JP2010522710A5 (https=)
JP2010510232A5 (https=)
JP2013515037A5 (https=)
JP2012522841A5 (https=)