JP2017518959A5 - - Google Patents

Download PDF

Info

Publication number
JP2017518959A5
JP2017518959A5 JP2016557019A JP2016557019A JP2017518959A5 JP 2017518959 A5 JP2017518959 A5 JP 2017518959A5 JP 2016557019 A JP2016557019 A JP 2016557019A JP 2016557019 A JP2016557019 A JP 2016557019A JP 2017518959 A5 JP2017518959 A5 JP 2017518959A5
Authority
JP
Japan
Prior art keywords
alkyl
alkoxy
halogen
hydroxyl
group
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2016557019A
Other languages
English (en)
Japanese (ja)
Other versions
JP6602311B2 (ja
JP2017518959A (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2015/020444 external-priority patent/WO2015138895A1/en
Publication of JP2017518959A publication Critical patent/JP2017518959A/ja
Publication of JP2017518959A5 publication Critical patent/JP2017518959A5/ja
Application granted granted Critical
Publication of JP6602311B2 publication Critical patent/JP6602311B2/ja
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

JP2016557019A 2014-03-13 2015-03-13 B型肝炎コアタンパク質アロステリックモジュレーター Expired - Fee Related JP6602311B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201461952467P 2014-03-13 2014-03-13
US61/952,467 2014-03-13
US201462010025P 2014-06-10 2014-06-10
US62/010,025 2014-06-10
PCT/US2015/020444 WO2015138895A1 (en) 2014-03-13 2015-03-13 Hepatitis b core protein allosteric modulators

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2019085742A Division JP2019151650A (ja) 2014-03-13 2019-04-26 B型肝炎コアタンパク質アロステリックモジュレーター

Publications (3)

Publication Number Publication Date
JP2017518959A JP2017518959A (ja) 2017-07-13
JP2017518959A5 true JP2017518959A5 (https=) 2018-04-26
JP6602311B2 JP6602311B2 (ja) 2019-11-06

Family

ID=54072461

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2016557019A Expired - Fee Related JP6602311B2 (ja) 2014-03-13 2015-03-13 B型肝炎コアタンパク質アロステリックモジュレーター
JP2019085742A Withdrawn JP2019151650A (ja) 2014-03-13 2019-04-26 B型肝炎コアタンパク質アロステリックモジュレーター

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2019085742A Withdrawn JP2019151650A (ja) 2014-03-13 2019-04-26 B型肝炎コアタンパク質アロステリックモジュレーター

Country Status (23)

Country Link
US (3) US10183936B2 (https=)
EP (3) EP3607950A3 (https=)
JP (2) JP6602311B2 (https=)
KR (1) KR102363174B1 (https=)
CN (2) CN106413402B (https=)
AP (1) AP2016009477A0 (https=)
AU (2) AU2015229174B2 (https=)
CA (1) CA2942533C (https=)
CL (1) CL2016002269A1 (https=)
DK (1) DK3116316T3 (https=)
DO (1) DOP2016000233A (https=)
ES (1) ES2748029T3 (https=)
HR (1) HRP20191444T1 (https=)
HU (1) HUE046567T2 (https=)
IL (3) IL247575B (https=)
MX (2) MX363600B (https=)
PH (2) PH12016501762B1 (https=)
PL (1) PL3116316T3 (https=)
PT (1) PT3116316T (https=)
RS (1) RS59430B1 (https=)
SG (2) SG10202001506UA (https=)
WO (1) WO2015138895A1 (https=)
ZA (1) ZA201606209B (https=)

Families Citing this family (64)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2013096744A1 (en) 2011-12-21 2013-06-27 Novira Therapeutics, Inc. Hepatitis b antiviral agents
EA038942B1 (ru) 2012-08-28 2021-11-12 Янссен Сайенсиз Айрлэнд Юси Сульфамоил-ариламиды и их применение в качестве лекарственных препаратов для лечения гепатита b
HUE034820T2 (en) 2013-02-28 2018-02-28 Janssen Sciences Ireland Uc Sulphamoyl arylamides and their use as medicaments for the treatment of hepatitis B
EA027068B1 (ru) 2013-04-03 2017-06-30 Янссен Сайенсиз Айрлэнд Юси Производные n-фенилкарбоксамида и их применение в качестве лекарственных препаратов для лечения гепатита b
EA035500B1 (ru) 2013-05-17 2020-06-25 Янссен Сайенсиз Айрлэнд Юси Производные сульфамоилтиофенамида и их применение в качестве медикаментов для лечения гепатита b
TWI651300B (zh) 2013-05-17 2019-02-21 健生科學愛爾蘭無限公司 胺磺醯基吡咯醯胺衍生物及其作為用於治療b型肝炎藥物的用途
DK3024819T3 (en) 2013-07-25 2018-06-06 Janssen Sciences Ireland Uc GLYOXAMIDE-SUBSTITUTED PYRROLAMIDE DERIVATIVES AND THE USE THEREOF AS MEDICINES FOR TREATING HEPATITIS B
KR102290189B1 (ko) 2013-10-23 2021-08-17 얀센 사이언시즈 아일랜드 언리미티드 컴퍼니 카르복스아미드 유도체 및 b형 간염 치료용 의약으로서의 이의 용도
US9169212B2 (en) 2014-01-16 2015-10-27 Novira Therapeutics, Inc. Azepane derivatives and methods of treating hepatitis B infections
US10392349B2 (en) 2014-01-16 2019-08-27 Novira Therapeutics, Inc. Azepane derivatives and methods of treating hepatitis B infections
JP6553059B2 (ja) 2014-02-05 2019-07-31 ノヴィラ・セラピューティクス・インコーポレイテッド Hbv感染の治療のための併用療法
WO2015118057A1 (en) 2014-02-06 2015-08-13 Janssen Sciences Ireland Uc Sulphamoylpyrrolamide derivatives and the use thereof as medicaments for the treatment of hepatitis b
PT3116316T (pt) 2014-03-13 2019-09-30 Assembly Biosciences Inc Moduladores alostéricos da proteína do núcleo da hepatite b
EP3271019A1 (en) 2015-03-19 2018-01-24 Novira Therapeutics Inc. Azocane and azonane derivatives and methods of treating hepatitis b infections
US10875876B2 (en) 2015-07-02 2020-12-29 Janssen Sciences Ireland Uc Cyclized sulfamoylarylamide derivatives and the use thereof as medicaments for the treatment of hepatitis B
JP6993318B2 (ja) * 2015-07-15 2022-02-03 エージェンシー フォー サイエンス,テクノロジー アンド リサーチ B型肝炎ウイルス複製の調節
TWI730985B (zh) * 2015-09-15 2021-06-21 美商艾森伯利生物科學公司 B型肝炎核心蛋白質調節劑
HK1259410A1 (zh) 2015-09-29 2019-11-29 诺维拉治疗公司 乙型肝炎抗病毒剂的晶体形式
SG10202011827YA (en) 2016-04-15 2021-01-28 Novira Therapeutics Inc Combinations and methods comprising a capsid assembly inhibitor
CN109790143A (zh) 2016-05-10 2019-05-21 C4医药公司 用于靶蛋白降解的胺连接的c3-戊二酰亚胺降解决定子体
EP4491236A3 (en) 2016-05-10 2025-04-02 C4 Therapeutics, Inc. Heterocyclic degronimers for target protein degradation
CN109641874A (zh) 2016-05-10 2019-04-16 C4医药公司 用于靶蛋白降解的c3-碳连接的戊二酰亚胺降解决定子体
EP3454862B1 (en) 2016-05-10 2024-09-11 C4 Therapeutics, Inc. Spirocyclic degronimers for target protein degradation
AU2017326356A1 (en) * 2016-09-15 2019-04-11 Assembly Biosciences, Inc. Hepatitis B core protein modulators
EP3519399A1 (en) * 2016-10-03 2019-08-07 Sigilon Therapeutics, Inc. Compounds, devices, and uses thereof
TWI794190B (zh) 2016-11-07 2023-03-01 加拿大商愛彼特生物製藥公司 含有取代的吡啶酮之三環化合物及其使用方法
CN106632177A (zh) * 2016-12-05 2017-05-10 万特制药(海南)有限公司 雷美替胺中间体的制备方法
DK3587420T3 (da) * 2017-02-23 2021-06-07 Fujian Cosunter Pharmaceutical Co Ltd Tricyklisk forbindelse og anvendelser heraf
SG11201908012SA (en) 2017-03-02 2019-09-27 Assembly Biosciences Inc Cyclic sulfamide compounds and methods of using same
EP3596070A1 (en) * 2017-03-13 2020-01-22 Assembly Biosciences, Inc. Process for making hepatitis b core protein modulators
AU2018238138A1 (en) 2017-03-21 2019-10-17 Arbutus Biopharma Corporation Substituted dihydroindene-4-carboxamides and analogs thereof, and methods using same
EP4717317A2 (en) 2017-06-20 2026-04-01 C4 Therapeutics, Inc. N/o-linked degrons and degronimers for protein degradation
CN115745910B (zh) 2017-07-21 2025-05-27 安塔比奥公司 化学化合物
MA50520A (fr) 2017-11-02 2020-09-09 Aicuris Gmbh & Co Kg Nouveaux indole-2-carboxamides à substitution pyrazolo-pipéridine hautement actifs agissant contre le virus de l'hépatite b (vhb)
JP2021501764A (ja) 2017-11-02 2021-01-21 アイクリス ゲゼルシャフト ミット ベシュレンクテル ハフツング ウント コンパニー コマンディトゲゼルシャフト B型肝炎ウイルス(hbv)に対して有効な新規高活性アミノチアゾール置換インドール−2−カルボキサミド
CA3090125A1 (en) 2018-03-14 2019-09-19 Janssen Sciences Ireland Unlimited Company Capsid assembly modulator dosing regimen
WO2019213584A1 (en) * 2018-05-03 2019-11-07 Emory University Modulators of orphan nuclear receptors for nash and other metabolic disorders
CN110627752B (zh) * 2018-06-25 2021-08-17 新发药业有限公司 一种3-氨甲基四氢呋喃的制备方法
CN108863884B (zh) * 2018-07-26 2020-07-03 南京富润凯德生物医药有限公司 一种用dast试剂作为消除试剂合成共轭硝基烯取代系列衍生物的方法
TWI869058B (zh) 2018-07-27 2025-01-01 加拿大商愛彼特生物製藥公司 經取代四氫環戊[c]吡咯、經取代二氫吡咯,其類似物及使用其之方法
TWI742419B (zh) * 2018-08-23 2021-10-11 大陸商福建廣生堂藥業股份有限公司 三并環類化合物的晶型及其應用
AR116946A1 (es) 2018-11-02 2021-06-30 Aicuris Gmbh & Co Kg Derivados de urea 6,7-dihidro-4h-pirazolo[4,3-c]piridinas activas contra el virus de la hepatitis b (vhb)
PY1991603A (es) 2018-11-02 2020-09-17 Aicuris Gmbh & Co Kg Nueva 6,7-dihidro-4h-pirazolo [1,5-a] pirazina indole -2-carboxamidas activas contra el virus de la hepatitis b (vhb)
PY1991608A (es) 2018-11-02 2022-02-10 Aicuris Gmbh & Co Kg Nueva urea 6,7-dihidro-4h-pirazolo [1,5-a] pirazina activas contra el virus de la hepatitis b (vhb)
UY38435A (es) 2018-11-02 2020-05-29 Aicuris Gmbh & Co Kg Nuevas urea 6,7-dihidro-4h-pirazol[1,5-a] pirazinas activas contra el virus de la hepatitis b (vhb)
AR117189A1 (es) 2018-11-02 2021-07-21 Aicuris Gmbh & Co Kg Derivados de 6,7-dihidro-4h-pirazolo[1,5-a]pirazin indol-2-carboxamidas activos contra el virus de la hepatitis b (vhb)
TW202415643A (zh) 2018-12-12 2024-04-16 加拿大商愛彼特生物製藥公司 經取代之芳基甲基脲類及雜芳基甲基脲類、其類似物及其使用方法
CN120698983A (zh) 2018-12-20 2025-09-26 C4医药公司 靶向蛋白降解
MX2021010145A (es) 2019-02-22 2021-09-14 Janssen Sciences Ireland Unlimited Co Derivados de amida utiles en el tratamiento de una infeccion por vhb o de enfermedades inducidas por vhb.
PH12021552749A1 (en) 2019-04-30 2022-07-11 Aicuris Gmbh & Co Kg Novel phenyl and pyridyl ureas active against the hepatitis b virus (hbv)
SG11202111493WA (en) 2019-04-30 2021-11-29 Aicuris Gmbh & Co Kg Novel oxalyl piperazines active against the hepatitis b virus (hbv)
PH12021552733A1 (en) 2019-04-30 2023-01-16 Aicuris Gmbh & Co Kg Novel indolizine-2-carboxamides active against the hepatitis b virus (hbv)
SG11202111236UA (en) 2019-04-30 2021-11-29 Aicuris Gmbh & Co Kg Novel indole-2-carboxamides active against the hepatitis b virus (hbv)
MA55879A (fr) 2019-05-06 2022-03-16 Janssen Sciences Ireland Unlimited Co Dérivés d'amide utiles dans le traitement d'une infection par le virus de l'hépatite b ou de maladies induites par le virus de l'hépatite b
SG11202112590WA (en) * 2019-05-24 2021-12-30 Assembly Biosciences Inc Pharmaceutical compositions for the treatment of hbv
CN110526878A (zh) * 2019-09-16 2019-12-03 成都睿智化学研究有限公司 一种2-(噁唑基)乙胺的制备方法
CN111072551A (zh) * 2019-12-30 2020-04-28 上海睿瓦科技有限公司 催化氢化一步法制取哌啶胺的方法
CA3180706A1 (en) * 2020-04-22 2021-10-28 Assembly Biosciences, Inc. 5-membered heteroaryl carboxamide compounds for treatment of hbv
CN113135848A (zh) * 2021-04-26 2021-07-20 深圳市华先医药科技有限公司 一种巯基烯酯类化合物的制备方法
CN113636960A (zh) * 2021-08-24 2021-11-12 上海皓元医药股份有限公司 一种2-(氯磺酰基)环己烷-1-烯甲酸乙酯衍生物的制备方法
CN113717080A (zh) * 2021-10-09 2021-11-30 西安瑞联新材料股份有限公司 一种4-氯-2-氰基苯磺酰氯的合成方法
CN115353479A (zh) * 2022-07-27 2022-11-18 常州琦诺生物科技有限公司 一种5-溴-2-碘嘧啶的制备方法
WO2024089216A1 (en) 2022-10-27 2024-05-02 Syngenta Crop Protection Ag Novel sulfur-containing heteroaryl carboxamide compounds
WO2025069039A1 (en) * 2023-09-28 2025-04-03 Rajaram Samant An in situ process for the preparation of primary amine compounds

Family Cites Families (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1480553A (en) * 1976-06-03 1977-07-20 Pfizer Ltd Tricyclic sulphonamides
JPS58225074A (ja) * 1982-06-25 1983-12-27 Chugai Pharmaceut Co Ltd ジベンゾオキサゼピン誘導体
GB9109557D0 (en) * 1991-05-02 1991-06-26 Wellcome Found Chemical compounds
US5512563A (en) * 1993-07-29 1996-04-30 American Cyanamid Company Tricyclic benzazepine vasopressin antagonists
EP1678121A4 (en) * 2003-10-24 2007-07-25 Exelixis Inc MODULATORS OF TAO KINASES AND METHODS OF USE
DE102004004928A1 (de) * 2004-01-31 2005-08-18 Bayer Healthcare Ag Dibenzoxazepine II
CA2625423A1 (en) * 2005-10-17 2007-04-26 Acadia Pharmaceuticals Inc. Cb-1 modulating compounds and their use
US20070105835A1 (en) 2005-11-07 2007-05-10 Kazantsev Aleksey G Compositions and methods for modulating poly(ADP-ribose) polymerase activity
WO2008036139A2 (en) 2006-06-07 2008-03-27 The Regents Of The University Of California Inhibitors of mshc and homologs thereof, and methods of identifying same
WO2008118141A2 (en) 2006-10-17 2008-10-02 Acadia Pharmaceuticals Inc. Use of cannabinoid modulating compounds in combination with other therapeutic compounds for adjunctive therapy
CN102164605A (zh) 2008-07-23 2011-08-24 美国卫生和人力服务部 用作抗疟药的疟原虫表面阴离子通道抑制剂
CN104530079B (zh) * 2009-12-18 2017-10-20 北京凯因科技股份有限公司 C型肝炎病毒复制的新型抑制剂
WO2012045194A1 (en) 2010-10-09 2012-04-12 Abbott Laboratories Benzodiazepinones as fak inhibitors for treatment of cancer
EP3085368A1 (en) 2011-07-01 2016-10-26 Baruch S. Blumberg Institute Sulfamoylbenzamide derivatives as antiviral agents against hbv infection
WO2013010069A1 (en) 2011-07-13 2013-01-17 Indiana University Research And Technology Corporation Modified viral structural protein with antiviral activity
EA026977B1 (ru) 2012-01-06 2017-06-30 Янссен Сайенсиз Айрлэнд Юси 4,4-дизамещенные 1,4-дигидропиримидины и их применение в качестве лекарственных препаратов для лечения гепатита b
EA026957B1 (ru) 2012-08-28 2017-06-30 Янссен Сайенсиз Айрлэнд Юси Конденсированные бициклические производные сульфамоила и их применение в качестве лекарственных препаратов для лечения гепатита b
EA038942B1 (ru) 2012-08-28 2021-11-12 Янссен Сайенсиз Айрлэнд Юси Сульфамоил-ариламиды и их применение в качестве лекарственных препаратов для лечения гепатита b
MX2015002954A (es) 2012-09-10 2015-06-05 Hoffmann La Roche Nuevas 6-aminoacido-heteroarilhidropirimidinas para el tratamiento y profilaxis de la infeccion del virus de la hepatitis b.
CA2889892A1 (en) 2012-11-09 2014-05-15 Indiana University Research And Technology Corporation Alternative uses for hbv assembly effectors
CA2892606A1 (en) 2012-12-06 2014-06-12 Baruch S. Blumberg Institute Functionalized benzamide derivatives as antiviral agents against hbv infection
CN105209031A (zh) 2012-12-27 2015-12-30 德雷克塞尔大学 针对hbv感染的新型抗病毒剂
RU2519546C1 (ru) 2013-01-16 2014-06-10 Общество С Ограниченной Ответственностью "Биоинтегратор" (Ооо "Биоинтегратор") КОНЪЮГАТЫ И МАЛЫЕ МОЛЕКУЛЫ, ВЗАИМОДЕЙСТВУЮЩИЕ С РЕЦЕПТОРОМ CD16а
HUE034820T2 (en) 2013-02-28 2018-02-28 Janssen Sciences Ireland Uc Sulphamoyl arylamides and their use as medicaments for the treatment of hepatitis B
AR095426A1 (es) 2013-03-14 2015-10-14 Onyx Therapeutics Inc Inhibidores tripeptídicos de la epoxicetona proteasa
MY181020A (en) 2013-03-15 2020-12-16 Sanofi Sa Heteroaryl compounds and uses thereof
EA027068B1 (ru) 2013-04-03 2017-06-30 Янссен Сайенсиз Айрлэнд Юси Производные n-фенилкарбоксамида и их применение в качестве лекарственных препаратов для лечения гепатита b
CN105209470B (zh) 2013-05-17 2018-02-06 豪夫迈·罗氏有限公司 用于治疗和预防乙型肝炎病毒感染的6‑桥连的杂芳基二氢嘧啶
TWI651300B (zh) 2013-05-17 2019-02-21 健生科學愛爾蘭無限公司 胺磺醯基吡咯醯胺衍生物及其作為用於治療b型肝炎藥物的用途
EA035500B1 (ru) 2013-05-17 2020-06-25 Янссен Сайенсиз Айрлэнд Юси Производные сульфамоилтиофенамида и их применение в качестве медикаментов для лечения гепатита b
EA031077B1 (ru) 2013-06-19 2018-11-30 Серагон Фармасьютикалз, Инк. Модулятор рецептора эстрогена и его применения
WO2015017412A1 (en) * 2013-07-29 2015-02-05 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services 11-oxo-10,11-dihydrodibenzo[b,f][1,4]thiazepine s-oxide derivatives and their use as dopamine d2 receptor antagonists
PT3116316T (pt) 2014-03-13 2019-09-30 Assembly Biosciences Inc Moduladores alostéricos da proteína do núcleo da hepatite b
WO2015189035A1 (en) 2014-06-10 2015-12-17 Basf Se Substituted [1,2,4]triazole and imidazole compounds as fungicides
TWI730985B (zh) 2015-09-15 2021-06-21 美商艾森伯利生物科學公司 B型肝炎核心蛋白質調節劑
US10811219B2 (en) 2018-08-07 2020-10-20 Applied Materials Israel Ltd. Method for evaluating a region of an object

Similar Documents

Publication Publication Date Title
JP2017518959A5 (https=)
CN104918612B (zh) 作为抗hbv感染的抗病毒剂的官能化苯甲酰胺衍生物
CN111848615B (zh) 吡啶酮衍生物及包含其的抗流感病毒药物组合物
JP6466348B2 (ja) スルファモイル−アリールアミドおよびb型肝炎を処置するための医薬品としてのその使用
KR101942151B1 (ko) Hbv 감염에 대한 항바이러스 물질
JP2021534124A5 (https=)
JP2016121196A5 (https=)
JP2018536648A5 (https=)
JP2018515495A5 (https=)
RU2015107803A (ru) Производные дигидроксипиримидинкарбоновой кислоты и их применение в лечении, облегчении или предотвращении вирусного заболевания
JP2020533288A5 (https=)
PH12015500758B1 (en) Pyrrolo[3,2-d]pyrimidine derivatives for the treatment of viral infections and other diseases
JP5822840B2 (ja) 眼疾患処置薬
JP2016534148A5 (https=)
JP2018535963A5 (https=)
JP2016536316A5 (https=)
US9988390B2 (en) Pyrimidone derivatives and their use in the treatment, amelioration or prevention of a viral disease
JP2016512823A5 (https=)
CN108727378A (zh) 新型异喹啉类化合物及其医药用途
RU2014143250A (ru) Производные 7-оксо-тиазолопиридин карбоновой кислоты и их применение при лечении, облегчении или профилактике вирусного заболевания
JP2020507589A5 (https=)
WO2013138753A1 (en) Prodrugs of riluzole and their method of use
JP6628252B2 (ja) 虚血性眼疾患の処置用の医薬組成物
JP2011506588A5 (https=)
JP7159440B2 (ja) ジカチオン化合物及びその製造方法と使用