JP2015051983A5 - - Google Patents

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Publication number
JP2015051983A5
JP2015051983A5 JP2014208930A JP2014208930A JP2015051983A5 JP 2015051983 A5 JP2015051983 A5 JP 2015051983A5 JP 2014208930 A JP2014208930 A JP 2014208930A JP 2014208930 A JP2014208930 A JP 2014208930A JP 2015051983 A5 JP2015051983 A5 JP 2015051983A5
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JP
Japan
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group
substituted
compound
alkyl group
unsubstituted
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JP2014208930A
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English (en)
Japanese (ja)
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JP2015051983A (ja
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Publication of JP2015051983A publication Critical patent/JP2015051983A/ja
Publication of JP2015051983A5 publication Critical patent/JP2015051983A5/ja
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JP2014208930A 2008-09-08 2014-10-10 アルデヒドデヒドロゲナーゼ活性のモジュレーターおよびその使用方法 Pending JP2015051983A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US9522708P 2008-09-08 2008-09-08
US61/095,227 2008-09-08

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
JP2011526202A Division JP2012502048A (ja) 2008-09-08 2009-09-03 アルデヒドデヒドロゲナーゼ活性のモジュレーターおよびその使用方法

Publications (2)

Publication Number Publication Date
JP2015051983A JP2015051983A (ja) 2015-03-19
JP2015051983A5 true JP2015051983A5 (https=) 2015-04-30

Family

ID=41797485

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2011526202A Pending JP2012502048A (ja) 2008-09-08 2009-09-03 アルデヒドデヒドロゲナーゼ活性のモジュレーターおよびその使用方法
JP2014208930A Pending JP2015051983A (ja) 2008-09-08 2014-10-10 アルデヒドデヒドロゲナーゼ活性のモジュレーターおよびその使用方法

Family Applications Before (1)

Application Number Title Priority Date Filing Date
JP2011526202A Pending JP2012502048A (ja) 2008-09-08 2009-09-03 アルデヒドデヒドロゲナーゼ活性のモジュレーターおよびその使用方法

Country Status (7)

Country Link
US (3) US8354435B2 (https=)
EP (1) EP2337563B1 (https=)
JP (2) JP2012502048A (https=)
CN (1) CN102209541B (https=)
ES (1) ES2477552T3 (https=)
TW (1) TWI464161B (https=)
WO (1) WO2010028175A1 (https=)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20090117950A (ko) * 2007-03-08 2009-11-16 더 보드 오브 트러스티스 오브 더 리랜드 스탠포드 쥬니어 유니버시티 미토콘드리아 알데히드 탈수소효소-2 조절자 및 그것의 사용 방법
EP2337563B1 (en) 2008-09-08 2014-04-09 The Board of Trustees of The Leland Stanford Junior University Modulators of aldehyde dehydrogenase activity and methods of use thereof
KR20110082180A (ko) 2008-10-28 2011-07-18 더 보드 오브 트러스티스 오브 더 리랜드 스탠포드 쥬니어 유니버시티 알데히드 탈수소효소의 조절자 및 그것의 사용방법
WO2012149106A1 (en) 2011-04-29 2012-11-01 The Board Of Trustees Of The Leland Stanford Junior University Compositions and methods for increasing proliferation of adult salivary stem cells
EP2723718A1 (en) 2011-06-24 2014-04-30 Amgen Inc. Trpm8 antagonists and their use in treatments
US8710043B2 (en) 2011-06-24 2014-04-29 Amgen Inc. TRPM8 antagonists and their use in treatments
TWI567061B (zh) 2011-07-01 2017-01-21 吉李德科學股份有限公司 用於治療成癮之化合物
US8952009B2 (en) 2012-08-06 2015-02-10 Amgen Inc. Chroman derivatives as TRPM8 inhibitors
JP6410790B2 (ja) 2013-03-14 2018-10-24 ザ ボード オブ トラスティーズ オブ ザ レランド スタンフォード ジュニア ユニバーシティー ミトコンドリアアルデヒドデヒドロゲナーゼ−2調節因子およびその使用方法
TWI773657B (zh) 2015-12-18 2022-08-11 美商亞德利克斯公司 作爲非全身tgr5促效劑之經取代之4-苯基吡啶化合物
US12084472B2 (en) 2015-12-18 2024-09-10 Ardelyx, Inc. Substituted 4-phenyl pyridine compounds as non-systemic TGR5 agonists
FR3054564B1 (fr) * 2016-07-28 2018-08-31 Advanced Biodesign Substrat specifique d'une isoenzyme de l'aldh
CN117105868A (zh) * 2022-05-24 2023-11-24 中国人民解放军海军军医大学 酰胺类醛脱氢酶激动剂、其合成方法及用途
CN115160285B (zh) * 2022-08-25 2022-11-29 云南大学 硫代酰胺类aldh2激动剂、制备方法及应用

Family Cites Families (99)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2319808A (en) 1939-08-31 1943-05-25 Squibb & Sons Inc Sterol derivatives and process for producing same
DE2417763A1 (de) 1974-04-11 1975-10-30 Bayer Ag Carbonsaeureamide, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel
US4992417A (en) 1987-07-17 1991-02-12 Mount Sinai School Of Medicine Superactive human insulin analogues
US4992418A (en) 1987-07-17 1991-02-12 Mount Sinai School Of Medicine Superactive human insulin analogue-[10-Aspartic Acid-B]Human Insulin
JPH01203351A (ja) 1988-02-05 1989-08-16 Mitsui Petrochem Ind Ltd 1,4−ジヒドロキシナフタレン誘導体および医薬
JPH023351A (ja) 1988-06-16 1990-01-08 Oki Electric Ind Co Ltd 印刷装置
US4861891A (en) 1988-08-31 1989-08-29 Pfizer Inc. Antidepressant N-substituted nicotinamide compounds
US5514646A (en) 1989-02-09 1996-05-07 Chance; Ronald E. Insulin analogs modified at position 29 of the B chain
JPH03184973A (ja) 1989-12-14 1991-08-12 Rooman Kogyo:Kk 放射線障害防護剤
US5260323A (en) * 1990-06-28 1993-11-09 Hoechst Aktiengesellschaft 2,4- and 2,5-substituted pyridine-N-oxides, processes for their preparation and their use
TW197439B (https=) 1991-04-04 1993-01-01 Ueno Pharmaceutics Applic Res Co Ltd
US5283253A (en) 1991-09-23 1994-02-01 Florida State University Furyl or thienyl carbonyl substituted taxanes and pharmaceutical compositions containing them
DE4201047A1 (de) 1992-01-17 1993-07-22 Bayer Ag Substituierte isoxazolcarbonsaeureamide
US5272137A (en) 1992-02-14 1993-12-21 Mcneil-Pfc, Inc. Aqueous pharmaceutical suspension for pharmaceutical actives
US5200534A (en) 1992-03-13 1993-04-06 University Of Florida Process for the preparation of taxol and 10-deacetyltaxol
US5294637A (en) 1992-07-01 1994-03-15 Bristol-Myers Squibb Company Fluoro taxols
JP2994182B2 (ja) 1992-07-23 1999-12-27 石原産業株式会社 アミド系化合物又はその塩、それらの製造方法及びそれらを含有する有害動物防除剤
US5202448A (en) 1992-08-14 1993-04-13 Napro Biotherapeutics, Inc. Processes of converting taxanes into baccatin III
US5415869A (en) 1993-11-12 1995-05-16 The Research Foundation Of State University Of New York Taxol formulation
US5504188A (en) 1994-06-16 1996-04-02 Eli Lilly And Company Preparation of stable zinc insulin analog crystals
US5461031A (en) 1994-06-16 1995-10-24 Eli Lilly And Company Monomeric insulin analog formulations
US5474978A (en) 1994-06-16 1995-12-12 Eli Lilly And Company Insulin analog formulations
US5547929A (en) 1994-09-12 1996-08-20 Eli Lilly And Company Insulin analog formulations
US5693609A (en) 1994-11-17 1997-12-02 Eli Lilly And Company Acylated insulin analogs
JP3833281B2 (ja) * 1995-02-03 2006-10-11 日本曹達株式会社 2,6−ジクロロイソニコチン酸ベンジルアミド誘導体及び植物病害防除剤
YU18596A (sh) 1995-03-31 1998-07-10 Eli Lilly And Company Analogne formulacije monomernog insulina
PT1019385E (pt) 1995-09-15 2004-06-30 Upjohn Co N-oxidos de aminoaril-oxazolidinona
US6072050A (en) 1996-06-11 2000-06-06 Pioneer Hi-Bred International, Inc. Synthetic promoters
FR2751645B1 (fr) 1996-07-29 1998-12-24 Sanofi Sa Amines pour la fabrication de medicaments destines a empecher la proliferation de cellules tumorales
ZA984697B (en) 1997-06-13 1999-12-01 Lilly Co Eli Stable insulin formulations.
BR9813331A (pt) * 1997-10-31 2000-08-22 Aventis Pharma Ltd Composto, uso do mesmo, composição farmacêutica, processo para o tratamento de um paciente humano ou animal não humano que sofra ou esteja sujeito a condições que possam ser melhoradas pela administração de um inibidor da adesão celular mediada pela a4b1, e, resina
AU1832099A (en) 1997-12-22 1999-07-12 Eli Lilly And Company Catalyst and method for amide formation
US6384080B1 (en) 1998-04-20 2002-05-07 Fujisawa Pharmaceutical Co., Ltd. Anthranilic acid derivatives as inhibitors of the cGMP-phosphodiesterase
AR019190A1 (es) 1998-07-08 2001-12-26 Sod Conseils Rech Applic Derivados de 2-aminopiridinas, productos intermedios para su preparacion, medicamentos y composiciones farmaceuticas que los contienen y su uso para preparar medicamentos
US6780883B2 (en) 1998-11-05 2004-08-24 Warner-Lambert Company Amide inhibitors of microsomal triglyceride transfer protein
ATE276241T1 (de) 1998-11-25 2004-10-15 Yissum Res Dev Co Antioxidationsmittel
GB9919558D0 (en) * 1999-08-18 1999-10-20 Hoechst Schering Agrevo Gmbh Fungicidal compounds
WO2001032928A2 (en) 1999-11-05 2001-05-10 Phase-1 Molecular Toxicology Methods of determining individual hypersensitivity to an agent
EP1402026A2 (en) 2000-04-18 2004-03-31 Millennium Pharmaceuticals, Inc. 39228, a human alcohol dehydrogenase and uses therefor
WO2002020500A2 (en) 2000-09-01 2002-03-14 Icos Corporation Materials and methods to potentiate cancer treatment
CA2419224A1 (en) * 2000-09-15 2002-03-21 Anormed Inc. Chemokine receptor binding heterocyclic compounds
US6835731B2 (en) * 2000-09-15 2004-12-28 Anormed, Inc. Chemokine receptor binding heterocyclic compounds
US7141590B2 (en) * 2000-12-29 2006-11-28 Ucb Sa Pharmaceutical uses and synthesis of nicotinanilide-N-oxides
DOP2002000332A (es) * 2001-02-14 2002-08-30 Warner Lambert Co Inhibidores de piridina de metaloproteinasas de la matriz
US6678516B2 (en) 2001-05-21 2004-01-13 Nokia Corporation Method, system, and apparatus for providing services in a privacy enabled mobile and Ubicom environment
JP4448902B2 (ja) 2001-06-08 2010-04-14 株式会社医薬分子設計研究所 スルホンアミド誘導体
JPWO2003030937A1 (ja) 2001-10-05 2005-01-20 小野薬品工業株式会社 ミトコンドリアルベンゾジアゼピン受容体アンタゴニストからなるストレス疾患の治療剤
DE10149674A1 (de) * 2001-10-09 2003-04-24 Apogepha Arzneimittel Gmbh Orale Darreichungsformen für Propiverin oder seinen pharmazeutisch annehmbaren Salzen mit verlängerter Wirkstoffreisetzung
US20030100034A1 (en) * 2001-10-16 2003-05-29 Millennium Pharmaceuticals, Inc. 9136, a human aldehyde dehydrogenase family member and uses therefor
PY0300568A (es) 2002-01-31 2004-10-01 Pfizer Prod Inc Metabolitos del acido(3-{[4-terc-butilbencil)-(piridin-3-sulfonil)amino]metil}fenoxi)acetico
PT1477186E (pt) 2002-02-19 2010-02-11 Shionogi & Co Antipruriginosos
JP4595059B2 (ja) 2002-04-18 2010-12-08 株式会社医薬分子設計研究所 アミド誘導体
GB0215650D0 (en) 2002-07-05 2002-08-14 Cyclacel Ltd Bisarylsufonamide compounds
CN1732161A (zh) 2002-09-06 2006-02-08 艾伦药物公司 1,3-二氨基-2-羟基丙烷前体药物衍生物
EP1402888A1 (en) 2002-09-18 2004-03-31 Jerini AG The use of substituted carbocyclic compounds as rotamases inhibitors
EP1402887A1 (en) 2002-09-18 2004-03-31 Jerini AG New compounds for the inhibition of undesired cell proliferation and use thereof
US7135575B2 (en) 2003-03-03 2006-11-14 Array Biopharma, Inc. P38 inhibitors and methods of use thereof
US7022850B2 (en) 2003-05-22 2006-04-04 Bristol-Myers Squibb Co. Bicyclicpyrimidones and their use to treat diseases
JP4359754B2 (ja) * 2003-07-03 2009-11-04 三菱瓦斯化学株式会社 基板の洗浄剤
WO2005007889A1 (en) 2003-07-21 2005-01-27 Oncotherapy Science, Inc. Method for diagnosing colorectal cancers
WO2005011561A2 (en) 2003-08-04 2005-02-10 Labcoat, Ltd. Stent coating apparatus and method
GB0318814D0 (en) * 2003-08-11 2003-09-10 Smithkline Beecham Corp Novel compounds
JPWO2005016351A1 (ja) 2003-08-18 2006-10-12 塩野義製薬株式会社 カンナビノイド受容体アゴニストの新規用途
FR2861074B1 (fr) 2003-10-17 2006-04-07 Sanofi Synthelabo Derives de n-[phenyl(piperidin-2-yl)methyl]benzamide, leur preparation et leur application en therapeutique
FR2861071B1 (fr) 2003-10-17 2006-01-06 Sanofi Synthelabo Derives de n-[phenyl(alkylpiperidin-2-yl) methyl]benzamide, leur prepartation et leur application en therapeutique
WO2005057213A1 (en) 2003-12-09 2005-06-23 The Board Of Trustees Of The Leland Stanford Junior University Methods and compositions for modulating mitochondrial aldehyde dehydrogenase-2
GT200500013A (es) * 2004-01-23 2005-08-10 Amidas herbicidas
WO2005084392A2 (en) 2004-03-03 2005-09-15 Convivia 4-methylpyrazole formulations for inhibiting ethanol intolerance
WO2005110422A2 (en) 2004-05-19 2005-11-24 Boehringer Ingelheim International Gmbh Treatment of diseases associated with altered level of amyloid beta peptides
CN1749415A (zh) 2004-09-15 2006-03-22 上海人类基因组研究中心 硝酸甘油治疗急性心绞痛疗效检测方法和试剂盒
US7456194B2 (en) * 2004-11-12 2008-11-25 Bristol-Myers Squibb Company Imidazo-fused oxazolo [4,5-b]pyridine and imidazo-fused thiazolo[4,5-b]pyridine based tricyclic compounds and pharmaceutical compositions comprising same
US7888374B2 (en) * 2005-01-28 2011-02-15 Abbott Laboratories Inhibitors of c-jun N-terminal kinases
DOP2006000051A (es) 2005-02-24 2006-08-31 Lilly Co Eli Inhibidores de vegf-r2 y métodos
NZ566136A (en) 2005-09-23 2010-04-30 Pfizer Prod Inc Pyridinaminosulfonyl substituted benzamides as inhibitors of cytochrome p450 3a4 (cyp3a4)
WO2007075783A2 (en) 2005-12-22 2007-07-05 Wyeth Substituted isoquinoline-1,3(2h,4h)-diones, 1-thioxo-1,4-dihydro-2h-isoquinoline-3-ones and 1,4-dihydro-3(2h)-isoquinolones and use thereof as kinase inhibitor
EP2001851A2 (en) * 2006-03-28 2008-12-17 Novartis AG Amide derivatives and their application for the treament of g protein related diseases
EP2742936A1 (en) 2006-05-16 2014-06-18 Takeda Pharmaceutical Company Limited Fused heterocyclic compound and use thereof
WO2007136707A2 (en) 2006-05-17 2007-11-29 University Of Utah Research Foundation Methods and compositions related to eosinophil regulation
US20080003585A1 (en) 2006-06-29 2008-01-03 Bio-Rad Laboratories, Inc., A Corporation Of The State Of Delaware Purification and amplification of nucleic acids in a microfluidic device
EP2046769A2 (en) 2006-07-27 2009-04-15 Cv Therapeutics, Inc. Aldh-2 inhibitors in the treatment of addiction
PE20080906A1 (es) 2006-08-17 2008-07-05 Kemia Inc Derivados heteroarilo como inhibidores de citocina
US8927715B2 (en) 2006-08-25 2015-01-06 Vitae Pharmaceuticals, Inc. Inhibitors of 11β-hydroxysteroid dehydrogenase type 1
DE602006021591D1 (de) * 2006-12-11 2011-06-09 Genetics Co Inc Aromatische 1,4-DI-Carboxylamide und deren Verwendung
US20100298314A1 (en) 2006-12-20 2010-11-25 Schering Corporation Novel jnk inhibitors
CN101611007A (zh) * 2006-12-20 2009-12-23 先灵公司 新颖的jnk抑制剂
WO2008103354A2 (en) 2007-02-20 2008-08-28 Cropsolution, Inc. Modulators of acetyl-coenzyme a carboxylase and methods of use thereof
KR20090117950A (ko) 2007-03-08 2009-11-16 더 보드 오브 트러스티스 오브 더 리랜드 스탠포드 쥬니어 유니버시티 미토콘드리아 알데히드 탈수소효소-2 조절자 및 그것의 사용 방법
CA2709784A1 (en) 2007-12-21 2009-07-09 University Of Rochester Method for altering the lifespan of eukaryotic organisms
WO2009137045A2 (en) 2008-05-07 2009-11-12 The Board Of Trustees Of The Leland Stanford Junior University Crystal structure of aldehyde dehydrogenase and methods of use thereof
AU2009253812A1 (en) 2008-06-04 2009-12-10 Ambrilia Biopharma Inc. HIV integrase inhibitors from pyridoxine
EP2307379A2 (en) 2008-06-27 2011-04-13 Novartis AG Organic compounds
EP2337563B1 (en) 2008-09-08 2014-04-09 The Board of Trustees of The Leland Stanford Junior University Modulators of aldehyde dehydrogenase activity and methods of use thereof
KR20110082180A (ko) 2008-10-28 2011-07-18 더 보드 오브 트러스티스 오브 더 리랜드 스탠포드 쥬니어 유니버시티 알데히드 탈수소효소의 조절자 및 그것의 사용방법
EP2435407B1 (en) 2009-05-29 2019-12-25 RaQualia Pharma Inc. Aryl substituted carboxamide derivatives as calcium or sodium channel blockers
PE20140199A1 (es) 2010-10-20 2014-02-16 Gruenenthal Chemie 6-amino-nicotinamidas sustituidas como moduladores de kcnq2/3
EP2651412A4 (en) 2010-12-14 2014-08-13 Beth Israel Hospital ANDROGEN RECEPTOR AND HER APPLICATION PROCEDURES
WO2012106534A2 (en) 2011-02-02 2012-08-09 The Regents Of The University Of California Hiv integrase inhibitors
WO2012149106A1 (en) 2011-04-29 2012-11-01 The Board Of Trustees Of The Leland Stanford Junior University Compositions and methods for increasing proliferation of adult salivary stem cells
KR20140075693A (ko) 2011-08-29 2014-06-19 인피니티 파마슈티칼스, 인코포레이티드 헤테로사이클릭 화합물 및 그의 용도

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