JP2015508103A5 - - Google Patents
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- Publication number
- JP2015508103A5 JP2015508103A5 JP2014558843A JP2014558843A JP2015508103A5 JP 2015508103 A5 JP2015508103 A5 JP 2015508103A5 JP 2014558843 A JP2014558843 A JP 2014558843A JP 2014558843 A JP2014558843 A JP 2014558843A JP 2015508103 A5 JP2015508103 A5 JP 2015508103A5
- Authority
- JP
- Japan
- Prior art keywords
- substituted
- unsubstituted
- pharmaceutical composition
- effective amount
- kinase inhibitor
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000008194 pharmaceutical composition Substances 0.000 claims 18
- 102000013530 TOR Serine-Threonine Kinases Human genes 0.000 claims 16
- 108010065917 TOR Serine-Threonine Kinases Proteins 0.000 claims 16
- 229940043355 kinase inhibitor Drugs 0.000 claims 16
- 239000003757 phosphotransferase inhibitor Substances 0.000 claims 16
- NMUSYJAQQFHJEW-KVTDHHQDSA-N 5-azacytidine Chemical group O=C1N=C(N)N=CN1[C@H]1[C@H](O)[C@H](O)[C@@H](CO)O1 NMUSYJAQQFHJEW-KVTDHHQDSA-N 0.000 claims 9
- 125000000217 alkyl group Chemical group 0.000 claims 9
- 229960002756 azacitidine Drugs 0.000 claims 9
- UHDGCWIWMRVCDJ-ZAKLUEHWSA-N cytidine Chemical class O=C1N=C(N)C=CN1[C@H]1[C@H](O)[C@@H](O)[C@H](CO)O1 UHDGCWIWMRVCDJ-ZAKLUEHWSA-N 0.000 claims 9
- 208000002154 non-small cell lung carcinoma Diseases 0.000 claims 9
- 208000029729 tumor suppressor gene on chromosome 11 Diseases 0.000 claims 9
- 239000005551 L01XE03 - Erlotinib Substances 0.000 claims 6
- 125000000753 cycloalkyl group Chemical group 0.000 claims 6
- AAKJLRGGTJKAMG-UHFFFAOYSA-N erlotinib Chemical compound C=12C=C(OCCOC)C(OCCOC)=CC2=NC=NC=1NC1=CC=CC(C#C)=C1 AAKJLRGGTJKAMG-UHFFFAOYSA-N 0.000 claims 6
- 229960001433 erlotinib Drugs 0.000 claims 6
- 125000000623 heterocyclic group Chemical group 0.000 claims 6
- 125000004415 heterocyclylalkyl group Chemical group 0.000 claims 6
- 125000003710 aryl alkyl group Chemical group 0.000 claims 3
- 125000003118 aryl group Chemical group 0.000 claims 3
- 125000001316 cycloalkyl alkyl group Chemical group 0.000 claims 3
- 238000004519 manufacturing process Methods 0.000 claims 3
- 239000000651 prodrug Substances 0.000 claims 3
- 229940002612 prodrug Drugs 0.000 claims 3
- 150000003839 salts Chemical class 0.000 claims 3
- 239000012453 solvate Substances 0.000 claims 3
- 206010028980 Neoplasm Diseases 0.000 claims 2
- 150000001875 compounds Chemical class 0.000 claims 1
- 238000011156 evaluation Methods 0.000 claims 1
- 230000005713 exacerbation Effects 0.000 claims 1
- 208000000649 small cell carcinoma Diseases 0.000 claims 1
- 230000004083 survival effect Effects 0.000 claims 1
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261603012P | 2012-02-24 | 2012-02-24 | |
| US61/603,012 | 2012-02-24 | ||
| US201261716424P | 2012-10-19 | 2012-10-19 | |
| US61/716,424 | 2012-10-19 | ||
| US201261725805P | 2012-11-13 | 2012-11-13 | |
| US61/725,805 | 2012-11-13 | ||
| PCT/US2013/027235 WO2013126636A1 (en) | 2012-02-24 | 2013-02-22 | Methods for treating non- small cell lung cancer using tor kinase inhibitor combination therapy |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015508103A JP2015508103A (ja) | 2015-03-16 |
| JP2015508103A5 true JP2015508103A5 (https=) | 2016-03-10 |
| JP6114317B2 JP6114317B2 (ja) | 2017-04-12 |
Family
ID=47790539
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014558843A Active JP6114317B2 (ja) | 2012-02-24 | 2013-02-22 | Ｔｏｒキナーゼ阻害剤の組合せ療法を用いて、非小細胞肺がんを処置する方法 |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US9375443B2 (https=) |
| EP (1) | EP2817029B1 (https=) |
| JP (1) | JP6114317B2 (https=) |
| KR (1) | KR102064626B1 (https=) |
| CN (1) | CN104271159B (https=) |
| AU (1) | AU2013202305B2 (https=) |
| BR (1) | BR112014020786A2 (https=) |
| CA (1) | CA2864905A1 (https=) |
| EA (1) | EA028462B1 (https=) |
| ES (1) | ES2742398T3 (https=) |
| IL (2) | IL234169B (https=) |
| MX (1) | MX358303B (https=) |
| MY (1) | MY174308A (https=) |
| NI (1) | NI201400095A (https=) |
| NZ (1) | NZ628410A (https=) |
| PH (2) | PH12014501880A1 (https=) |
| SG (1) | SG11201405064RA (https=) |
| TW (1) | TWI615143B (https=) |
| WO (1) | WO2013126636A1 (https=) |
| ZA (1) | ZA201406052B (https=) |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2013203714B2 (en) | 2012-10-18 | 2015-12-03 | Signal Pharmaceuticals, Llc | Inhibition of phosphorylation of PRAS40, GSK3-beta or P70S6K1 as a marker for TOR kinase inhibitory activity |
| PE20151995A1 (es) | 2013-01-16 | 2016-01-13 | Signal Pharm Llc | Compuestos sustituidos de pirrolopirimidina, composiciones de los mismos, y metodos de tratamiento con los mismos |
| CA2902858A1 (en) * | 2013-02-28 | 2014-09-04 | Signal Pharmaceuticals, Llc | Treatment of cancer with tor kinase inhibitors |
| CN105377299B (zh) | 2013-04-17 | 2018-06-12 | 西格诺药品有限公司 | 用于治疗前列腺癌的包含二氢吡嗪并-吡嗪化合物和雄激素受体拮抗剂的组合疗法 |
| CA2909579A1 (en) | 2013-04-17 | 2014-10-23 | Signal Pharmaceuticals, Llc | Combination therapy comprising a tor kinase inhibitor and n-(3-(5-fluoro-2-(4-(2-methoxyethoxy)phenylamino)pyrimidin-4-ylamino)phenyl)acrylamide for treating cancer |
| CA2909629C (en) | 2013-04-17 | 2022-12-13 | Signal Pharmaceuticals, Llc | Pharmaceutical formulations, processes, solid forms and methods of use relating to 1-ethyl-7-(2-methyl-6-(1h-1,2,4-triazol-3-yl)pyridin-3-yl)-3,4-dihydropyrazino[2,3-b]pyrazin-2(1h)-one |
| CA2908742C (en) * | 2013-04-17 | 2021-06-01 | Signal Pharmaceuticals, Llc | Combination therapy comprising a tor kinase inhibitor and a cytidine analog for treating cancer |
| WO2014172436A1 (en) | 2013-04-17 | 2014-10-23 | Signal Pharmaceuticals, Llc | Combination therapy comprising a tor kinase inhibitor and a 5-substituted quinazolinone compound for treating cancer |
| US9630966B2 (en) | 2013-04-17 | 2017-04-25 | Signal Pharmaceuticals, Llc | Treatment of cancer with dihydropyrazino-pyrazines |
| US9505764B2 (en) | 2013-04-17 | 2016-11-29 | Signal Pharmaceuticals, Llc | Treatment of cancer with dihydropyrazino-pyrazines |
| NZ629486A (en) | 2013-05-29 | 2017-11-24 | Signal Pharm Llc | Pharmaceutical compositions of 7-(6-(2-hydroxypropan-2-yl)pyridin-3-yl)-1-((trans)-4-methoxycyclohexyl)-3,4-dihydropyrazino [2,3-b]pyrazin-2(1h)-one, a solid form thereof and methods of their use |
| ES2823756T3 (es) * | 2014-04-16 | 2021-05-10 | Signal Pharm Llc | Métodos para tratar el cáncer usando terapia de combinación de inhibidores de quinasa TOR |
| NZ714742A (en) | 2014-04-16 | 2017-04-28 | Signal Pharm Llc | Solid forms of 1-ethyl-7-(2-methyl-6-(1h-1,2,4-triazol-3-yl)pyridin-3-yl)-3,4-dihydropyrazino[2,3-b]pyrazin-2(1h)-one, compositions thereof and methods of their use |
| US9512129B2 (en) | 2014-04-16 | 2016-12-06 | Signal Pharmaceuticals, Llc | Solid forms comprising 1-ethyl-7-(2-methyl-6-(1H-1,2,4-triazol-3-yl)pyridin-3-yl)-3,4-dihydropyrazino[2,3-b]pyrazin-2(1H)-one and a coformer |
| WO2015160882A1 (en) | 2014-04-16 | 2015-10-22 | Signal Pharmaceuticals, Llc | SOLID FORMS COMPRISING 7-(6-(2-HYDROXYPROPAN-2YL) PYRIDIN-3-YL)-1-(TRANS)-4-METHOXYCYCLOHEXYL)-3, 4-DIHYDROPYRAZINO[2,3-b] PYRAZIN-2(1H)-ONE, AND A COFORMER, COMPOSITIONS AND METHODS OF USE THEREOF |
| WO2016010886A1 (en) | 2014-07-14 | 2016-01-21 | Signal Pharmaceuticals, Llc | Methods of treating a cancer using substituted pyrrolopyrimidine compounds, compositions thereof |
| NZ629796A (en) | 2014-07-14 | 2015-12-24 | Signal Pharm Llc | Amorphous form of 4-((4-(cyclopentyloxy)-5-(2-methylbenzo[d]oxazol-6-yl)-7h-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-3-methoxy-n-methylbenzamide, compositions thereof and methods of their use |
| JP6871919B2 (ja) | 2015-06-16 | 2021-05-19 | ナノファギックス エルエルシー | 薬物送達及びイメージング化学コンジュゲート、製剤及びその使用方法 |
| CN108473495B (zh) | 2015-11-20 | 2022-04-12 | 福马治疗有限公司 | 作为泛素-特异性蛋白酶1抑制剂的嘌呤酮 |
| WO2018144791A1 (en) * | 2017-02-03 | 2018-08-09 | Millennium Pharmaceuticals, Inc. | Combination of vps34 inhibitors and mtor inhibitors |
| TWI787284B (zh) | 2017-06-22 | 2022-12-21 | 美商西建公司 | 以b型肝炎病毒感染表徵之肝細胞癌之治療 |
| EP3704229B1 (en) * | 2017-11-01 | 2023-12-20 | Juno Therapeutics, Inc. | Process for producing a t cell composition |
| EP3749298B1 (en) * | 2018-02-07 | 2023-04-05 | Lovelace Biomedical Research Institute | Inhalable dry powder cytidine analogue composition and method of use as a treatment for cancer |
| MX2022001019A (es) * | 2019-07-31 | 2022-02-22 | Ribon Therapeutics Inc | Amidas heterobiciclicas como inhibidoras del cumulo de diferenciacion 38 (cd38). |
| CN119841827A (zh) * | 2023-10-17 | 2025-04-18 | 中国科学院上海药物研究所 | 一类嘌呤类化合物及其应用 |
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-
2013
- 2013-02-22 EP EP13707520.6A patent/EP2817029B1/en active Active
- 2013-02-22 BR BR112014020786-0A patent/BR112014020786A2/pt not_active IP Right Cessation
- 2013-02-22 US US13/773,686 patent/US9375443B2/en active Active
- 2013-02-22 AU AU2013202305A patent/AU2013202305B2/en not_active Ceased
- 2013-02-22 NZ NZ628410A patent/NZ628410A/en not_active IP Right Cessation
- 2013-02-22 MY MYPI2014702320A patent/MY174308A/en unknown
- 2013-02-22 ES ES13707520T patent/ES2742398T3/es active Active
- 2013-02-22 CA CA2864905A patent/CA2864905A1/en not_active Abandoned
- 2013-02-22 MX MX2014010198A patent/MX358303B/es active IP Right Grant
- 2013-02-22 KR KR1020147026551A patent/KR102064626B1/ko active Active
- 2013-02-22 JP JP2014558843A patent/JP6114317B2/ja active Active
- 2013-02-22 EA EA201491584A patent/EA028462B1/ru not_active IP Right Cessation
- 2013-02-22 SG SG11201405064RA patent/SG11201405064RA/en unknown
- 2013-02-22 CN CN201380021414.6A patent/CN104271159B/zh active Active
- 2013-02-22 TW TW102106348A patent/TWI615143B/zh active
- 2013-02-22 WO PCT/US2013/027235 patent/WO2013126636A1/en not_active Ceased
-
2014
- 2014-08-18 ZA ZA2014/06052A patent/ZA201406052B/en unknown
- 2014-08-18 IL IL234169A patent/IL234169B/en active IP Right Grant
- 2014-08-20 PH PH12014501880A patent/PH12014501880A1/en unknown
- 2014-08-22 NI NI201400095A patent/NI201400095A/es unknown
-
2017
- 2017-08-17 PH PH12017501500A patent/PH12017501500A1/en unknown
-
2020
- 2020-05-13 IL IL274647A patent/IL274647A/en unknown
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