JP2017524013A5 - - Google Patents
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- Publication number
- JP2017524013A5 JP2017524013A5 JP2017507775A JP2017507775A JP2017524013A5 JP 2017524013 A5 JP2017524013 A5 JP 2017524013A5 JP 2017507775 A JP2017507775 A JP 2017507775A JP 2017507775 A JP2017507775 A JP 2017507775A JP 2017524013 A5 JP2017524013 A5 JP 2017524013A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- compound according
- hydrogen
- substituted
- pharmaceutically acceptable
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000001875 compounds Chemical class 0.000 claims 13
- 125000000217 alkyl group Chemical group 0.000 claims 10
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 6
- 229910052739 hydrogen Inorganic materials 0.000 claims 6
- 239000001257 hydrogen Substances 0.000 claims 6
- 150000003839 salts Chemical class 0.000 claims 6
- 239000008194 pharmaceutical composition Substances 0.000 claims 4
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 3
- 229910052736 halogen Inorganic materials 0.000 claims 2
- 150000002367 halogens Chemical class 0.000 claims 2
- 125000001072 heteroaryl group Chemical group 0.000 claims 2
- 125000002883 imidazolyl group Chemical group 0.000 claims 2
- 230000002265 prevention Effects 0.000 claims 2
- 125000003226 pyrazolyl group Chemical group 0.000 claims 2
- 125000004076 pyridyl group Chemical group 0.000 claims 2
- 125000000714 pyrimidinyl group Chemical group 0.000 claims 2
- 125000006570 (C5-C6) heteroaryl group Chemical group 0.000 claims 1
- 208000031261 Acute myeloid leukaemia Diseases 0.000 claims 1
- 208000010839 B-cell chronic lymphocytic leukemia Diseases 0.000 claims 1
- 208000003174 Brain Neoplasms Diseases 0.000 claims 1
- 206010006187 Breast cancer Diseases 0.000 claims 1
- 208000026310 Breast neoplasm Diseases 0.000 claims 1
- 206010028980 Neoplasm Diseases 0.000 claims 1
- 206010033128 Ovarian cancer Diseases 0.000 claims 1
- 206010061535 Ovarian neoplasm Diseases 0.000 claims 1
- 206010060862 Prostate cancer Diseases 0.000 claims 1
- 208000000236 Prostatic Neoplasms Diseases 0.000 claims 1
- 206010041067 Small cell lung cancer Diseases 0.000 claims 1
- 239000013543 active substance Substances 0.000 claims 1
- 210000004556 brain Anatomy 0.000 claims 1
- 201000008275 breast carcinoma Diseases 0.000 claims 1
- 201000011510 cancer Diseases 0.000 claims 1
- 239000000969 carrier Substances 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 125000000592 heterocycloalkyl group Chemical group 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 201000001441 melanoma Diseases 0.000 claims 1
- 208000002154 non-small cell lung carcinoma Diseases 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 208000000587 small cell lung carcinoma Diseases 0.000 claims 1
- 0 C*(c(cccc1)c1C=C1)C1=O Chemical compound C*(c(cccc1)c1C=C1)C1=O 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP14180554.9 | 2014-08-11 | ||
| EP14180554 | 2014-08-11 | ||
| PCT/EP2015/068349 WO2016023858A1 (en) | 2014-08-11 | 2015-08-10 | 6-alkynyl-pyridine derivatives as smac mimetics |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017524013A JP2017524013A (ja) | 2017-08-24 |
| JP2017524013A5 true JP2017524013A5 (https=) | 2017-10-05 |
| JP6250226B2 JP6250226B2 (ja) | 2017-12-20 |
Family
ID=51300621
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017507775A Active JP6250226B2 (ja) | 2014-08-11 | 2015-08-10 | Ｓｍａｃ模倣薬としての６−アルキニル−ピリジン誘導体 |
Country Status (34)
| Country | Link |
|---|---|
| US (4) | US9481673B2 (https=) |
| EP (1) | EP3180339B1 (https=) |
| JP (1) | JP6250226B2 (https=) |
| KR (1) | KR102445744B1 (https=) |
| CN (2) | CN106573930B (https=) |
| AP (1) | AP2017009718A0 (https=) |
| AR (1) | AR101479A1 (https=) |
| AU (1) | AU2015303308B2 (https=) |
| BR (1) | BR112017002498B1 (https=) |
| CA (1) | CA2956123C (https=) |
| CL (1) | CL2017000326A1 (https=) |
| CO (1) | CO2017001226A2 (https=) |
| CY (1) | CY1121273T1 (https=) |
| DK (1) | DK3180339T3 (https=) |
| EA (1) | EA031424B1 (https=) |
| ES (1) | ES2711763T3 (https=) |
| HR (1) | HRP20190336T1 (https=) |
| HU (1) | HUE043915T2 (https=) |
| IL (1) | IL249844B (https=) |
| LT (1) | LT3180339T (https=) |
| ME (1) | ME03303B (https=) |
| MX (1) | MX2017001835A (https=) |
| NZ (1) | NZ728073A (https=) |
| PE (1) | PE20170193A1 (https=) |
| PH (1) | PH12017500231A1 (https=) |
| PL (1) | PL3180339T3 (https=) |
| PT (1) | PT3180339T (https=) |
| RS (1) | RS58355B1 (https=) |
| SG (1) | SG11201700999YA (https=) |
| SI (1) | SI3180339T1 (https=) |
| TR (1) | TR201902023T4 (https=) |
| TW (1) | TWI723959B (https=) |
| UA (1) | UA118887C2 (https=) |
| WO (1) | WO2016023858A1 (https=) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AR101479A1 (es) * | 2014-08-11 | 2016-12-21 | Boehringer Ingelheim Int | Derivados de 6-alquinil-piridina |
| KR102392581B1 (ko) * | 2016-05-19 | 2022-04-28 | 베링거 인겔하임 인터내셔날 게엠베하 | 6-알키닐-피리딘 유도체의 제조 방법 |
| WO2018119142A1 (en) | 2016-12-21 | 2018-06-28 | Amgen Inc. | Anti-tnf alpha antibody formulations |
| WO2018178250A1 (en) | 2017-03-31 | 2018-10-04 | Boehringer Ingelheim International Gmbh | Anticancer combination therapy |
| CN113453678A (zh) | 2018-11-26 | 2021-09-28 | 德彪药业国际股份公司 | Hiv感染的联合治疗 |
| TWI894135B (zh) | 2019-01-25 | 2025-08-21 | 德商百靈佳殷格翰國際股份有限公司 | 編碼ccl21之重組棒狀病毒 |
| PH12022550721A1 (en) | 2019-09-25 | 2024-05-13 | Debiopharm Int Sa | Dosing regimens for treatment of patients with locally advanced squamous cell carcinoma |
| CR20220606A (es) | 2020-06-03 | 2023-01-23 | Boehringer Ingelheim Int | Rhabdovirus recombinante que codifica una proteína de fusión fc de dominio extracelular cd80 |
| WO2024175554A1 (en) | 2023-02-21 | 2024-08-29 | Institut Curie | Trail agonists for use in the treatment of cancer in patients having an activating alteration of fgfr3 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20060234360A1 (en) | 2005-04-13 | 2006-10-19 | Paola Branduardi | Ascorbic acid production from D-glucose in yeast |
| US7989441B2 (en) | 2005-06-08 | 2011-08-02 | Novartis Ag | Organic compounds |
| WO2007101347A1 (en) | 2006-03-07 | 2007-09-13 | Aegera Therapeutics Inc. | Bir domain binding compounds |
| BRPI0720049A2 (pt) * | 2006-12-07 | 2014-01-07 | Novartis Ag | Derivados de piridina utilizados como inibidores de xiap |
| US8859541B2 (en) * | 2012-02-27 | 2014-10-14 | Boehringer Ingelheim International Gmbh | 6-alkynylpyridines |
| US9278978B2 (en) | 2013-08-23 | 2016-03-08 | Boehringer Ingelheim International Gmbh | 6-Alkynyl Pyridine |
| US9249151B2 (en) | 2013-08-23 | 2016-02-02 | Boehringer Ingelheim International Gmbh | Bis-amido pyridines |
| AR101479A1 (es) | 2014-08-11 | 2016-12-21 | Boehringer Ingelheim Int | Derivados de 6-alquinil-piridina |
-
2015
- 2015-08-07 AR ARP150102551A patent/AR101479A1/es active IP Right Grant
- 2015-08-10 TW TW104125989A patent/TWI723959B/zh active
- 2015-08-10 SG SG11201700999YA patent/SG11201700999YA/en unknown
- 2015-08-10 ME MEP-2019-29A patent/ME03303B/me unknown
- 2015-08-10 NZ NZ728073A patent/NZ728073A/en unknown
- 2015-08-10 AP AP2017009718A patent/AP2017009718A0/en unknown
- 2015-08-10 KR KR1020177005822A patent/KR102445744B1/ko active Active
- 2015-08-10 EP EP15747820.7A patent/EP3180339B1/en active Active
- 2015-08-10 HU HUE15747820A patent/HUE043915T2/hu unknown
- 2015-08-10 ES ES15747820T patent/ES2711763T3/es active Active
- 2015-08-10 RS RS20190219A patent/RS58355B1/sr unknown
- 2015-08-10 WO PCT/EP2015/068349 patent/WO2016023858A1/en not_active Ceased
- 2015-08-10 EA EA201790349A patent/EA031424B1/ru not_active IP Right Cessation
- 2015-08-10 TR TR2019/02023T patent/TR201902023T4/tr unknown
- 2015-08-10 MX MX2017001835A patent/MX2017001835A/es active IP Right Grant
- 2015-08-10 JP JP2017507775A patent/JP6250226B2/ja active Active
- 2015-08-10 US US14/821,870 patent/US9481673B2/en active Active
- 2015-08-10 PT PT15747820T patent/PT3180339T/pt unknown
- 2015-08-10 CN CN201580039248.1A patent/CN106573930B/zh active Active
- 2015-08-10 AU AU2015303308A patent/AU2015303308B2/en active Active
- 2015-08-10 BR BR112017002498-5A patent/BR112017002498B1/pt active IP Right Grant
- 2015-08-10 HR HRP20190336TT patent/HRP20190336T1/hr unknown
- 2015-08-10 SI SI201530611T patent/SI3180339T1/sl unknown
- 2015-08-10 PE PE2017000209A patent/PE20170193A1/es unknown
- 2015-08-10 PL PL15747820T patent/PL3180339T3/pl unknown
- 2015-08-10 DK DK15747820.7T patent/DK3180339T3/en active
- 2015-08-10 CN CN201911357061.2A patent/CN111440164B/zh active Active
- 2015-08-10 CA CA2956123A patent/CA2956123C/en active Active
- 2015-08-10 LT LTEP15747820.7T patent/LT3180339T/lt unknown
- 2015-10-08 UA UAA201702213A patent/UA118887C2/uk unknown
-
2016
- 2016-10-03 US US15/283,494 patent/US9801871B2/en active Active
- 2016-12-29 IL IL249844A patent/IL249844B/en active IP Right Grant
-
2017
- 2017-02-08 CL CL2017000326A patent/CL2017000326A1/es unknown
- 2017-02-08 PH PH12017500231A patent/PH12017500231A1/en unknown
- 2017-02-08 CO CONC2017/0001226A patent/CO2017001226A2/es unknown
- 2017-09-26 US US15/715,351 patent/US10413536B2/en active Active
-
2019
- 2019-02-19 CY CY20191100213T patent/CY1121273T1/el unknown
- 2019-08-02 US US16/530,084 patent/US20190358218A1/en not_active Abandoned
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