JP2020097577A5 - - Google Patents
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- JP2020097577A5 JP2020097577A5 JP2019233099A JP2019233099A JP2020097577A5 JP 2020097577 A5 JP2020097577 A5 JP 2020097577A5 JP 2019233099 A JP2019233099 A JP 2019233099A JP 2019233099 A JP2019233099 A JP 2019233099A JP 2020097577 A5 JP2020097577 A5 JP 2020097577A5
- Authority
- JP
- Japan
- Prior art keywords
- pharmaceutical composition
- compound
- pharmaceutically acceptable
- chemical formula
- acceptable carrier
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 239000008194 pharmaceutical composition Substances 0.000 claims 7
- 150000001875 compounds Chemical class 0.000 claims 5
- 239000003937 drug carrier Substances 0.000 claims 2
- 239000000126 substance Substances 0.000 claims 2
- 206010028980 Neoplasm Diseases 0.000 claims 1
- 239000002246 antineoplastic agent Substances 0.000 claims 1
- 201000011510 cancer Diseases 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- 0 CCC1=C(CCPCC2=CC=CCC2)*2=CC*=C2*(Cc2c(C)cccc2)C1=O Chemical compound CCC1=C(CCPCC2=CC=CCC2)*2=CC*=C2*(Cc2c(C)cccc2)C1=O 0.000 description 2
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2022076459A JP2022105170A (ja) | 2013-11-15 | 2022-05-06 | ７－ベンジル－４－（２－メチルベンジル）－２，４，６，７，８，９－ヘキサヒドロイミダゾ［１，２－ａ］ピリド［３，４－ｅ］ピリミジン－５（１ｈ）－オン、その塩及びその使用方法 |
| JP2024027134A JP2024059840A (ja) | 2013-11-15 | 2024-02-27 | ７－ベンジル－４－（２－メチルベンジル）－２，４，６，７，８，９－ヘキサヒドロイミダゾ［１，２－ａ］ピリド［３，４－ｅ］ピリミジン－５（１ｈ）－オン、その塩及びその使用方法 |
Applications Claiming Priority (8)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361904718P | 2013-11-15 | 2013-11-15 | |
| US61/904,718 | 2013-11-15 | ||
| US14/208,657 US9265765B2 (en) | 2013-03-13 | 2014-03-13 | 7-benzyl-10-(2-methylbenzyl)-2,6,7,8,9,10-hexahydroimidazo[1,2-A]pyrido[4,3-D]pyrimidin-5(3H)-one, salts thereof and methods of using the same in combination therapy |
| US14/208,657 | 2014-03-13 | ||
| US14/341,392 US9376437B2 (en) | 2013-03-13 | 2014-07-25 | 7-benzyl-4-(2-methylbenzyl)-2,4,6,7,8,9-hexahydroimidazo[1,2-a]pyrido[3,4-e]pyrimidin-5(1H)-one, salts thereof and methods of using the same in combination therapy |
| PCT/US2014/048241 WO2015073072A1 (en) | 2013-11-15 | 2014-07-25 | 7-benzyl-4-(2-methylbenzyl)-2,4,6,7,8,9-hexahydroimidazo[1,2-a]pyrido[3,4-e]pyrimidin-5(1h)-one |
| US14/341,392 | 2014-07-25 | ||
| USPCT/US2014/048241 | 2014-07-25 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016554306A Division JP6670751B2 (ja) | 2013-11-15 | 2014-09-12 | ７−ベンジル−４−（２−メチルベンジル）−２，４，６，７，８，９−ヘキサヒドロイミダゾ［１，２−ａ］ピリド［３，４−ｅ］ピリミジン−５（１ｈ）−オン、その塩及びその使用方法 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022076459A Division JP2022105170A (ja) | 2013-11-15 | 2022-05-06 | ７－ベンジル－４－（２－メチルベンジル）－２，４，６，７，８，９－ヘキサヒドロイミダゾ［１，２－ａ］ピリド［３，４－ｅ］ピリミジン－５（１ｈ）－オン、その塩及びその使用方法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2020097577A JP2020097577A (ja) | 2020-06-25 |
| JP2020097577A5 true JP2020097577A5 (https=) | 2020-10-08 |
Family
ID=53057842
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016554306A Active JP6670751B2 (ja) | 2013-11-15 | 2014-09-12 | ７−ベンジル−４−（２−メチルベンジル）−２，４，６，７，８，９−ヘキサヒドロイミダゾ［１，２−ａ］ピリド［３，４−ｅ］ピリミジン−５（１ｈ）−オン、その塩及びその使用方法 |
| JP2019233099A Pending JP2020097577A (ja) | 2013-11-15 | 2019-12-24 | ７−ベンジル−４−（２−メチルベンジル）−２，４，６，７，８，９−ヘキサヒドロイミダゾ［１，２−ａ］ピリド［３，４−ｅ］ピリミジン−５（１ｈ）−オン、その塩及びその使用方法 |
| JP2022076459A Pending JP2022105170A (ja) | 2013-11-15 | 2022-05-06 | ７－ベンジル－４－（２－メチルベンジル）－２，４，６，７，８，９－ヘキサヒドロイミダゾ［１，２－ａ］ピリド［３，４－ｅ］ピリミジン－５（１ｈ）－オン、その塩及びその使用方法 |
| JP2024027134A Pending JP2024059840A (ja) | 2013-11-15 | 2024-02-27 | ７－ベンジル－４－（２－メチルベンジル）－２，４，６，７，８，９－ヘキサヒドロイミダゾ［１，２－ａ］ピリド［３，４－ｅ］ピリミジン－５（１ｈ）－オン、その塩及びその使用方法 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016554306A Active JP6670751B2 (ja) | 2013-11-15 | 2014-09-12 | ７−ベンジル−４−（２−メチルベンジル）−２，４，６，７，８，９−ヘキサヒドロイミダゾ［１，２−ａ］ピリド［３，４−ｅ］ピリミジン−５（１ｈ）−オン、その塩及びその使用方法 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022076459A Pending JP2022105170A (ja) | 2013-11-15 | 2022-05-06 | ７－ベンジル－４－（２－メチルベンジル）－２，４，６，７，８，９－ヘキサヒドロイミダゾ［１，２－ａ］ピリド［３，４－ｅ］ピリミジン－５（１ｈ）－オン、その塩及びその使用方法 |
| JP2024027134A Pending JP2024059840A (ja) | 2013-11-15 | 2024-02-27 | ７－ベンジル－４－（２－メチルベンジル）－２，４，６，７，８，９－ヘキサヒドロイミダゾ［１，２－ａ］ピリド［３，４－ｅ］ピリミジン－５（１ｈ）－オン、その塩及びその使用方法 |
Country Status (25)
| Country | Link |
|---|---|
| EP (3) | EP3068401B1 (https=) |
| JP (4) | JP6670751B2 (https=) |
| KR (5) | KR102318238B1 (https=) |
| CN (2) | CN106163524B (https=) |
| AU (4) | AU2014349150B2 (https=) |
| BR (1) | BR112016011072B1 (https=) |
| CA (2) | CA2930535C (https=) |
| CY (2) | CY1121628T1 (https=) |
| DK (2) | DK3546461T3 (https=) |
| EA (1) | EA033744B1 (https=) |
| ES (2) | ES2895600T3 (https=) |
| HR (2) | HRP20190814T1 (https=) |
| HU (2) | HUE043291T2 (https=) |
| IL (6) | IL296386B2 (https=) |
| LT (2) | LT3546461T (https=) |
| ME (1) | ME03387B (https=) |
| MX (3) | MX2016006318A (https=) |
| PL (2) | PL3068401T3 (https=) |
| PT (2) | PT3068401T (https=) |
| RS (2) | RS62572B1 (https=) |
| SG (1) | SG10201809189UA (https=) |
| SI (2) | SI3546461T1 (https=) |
| SM (2) | SMT202100607T1 (https=) |
| TR (1) | TR201906711T4 (https=) |
| WO (1) | WO2015073109A1 (https=) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR102318238B1 (ko) | 2013-11-15 | 2021-10-26 | 온코슈틱스 인코포레이티드 | 7-벤질-4-(2-메틸벤질)-2,4,6,7,8,9-헥사하이드로이미다조[1,2-a]피리도[3,4-e]피리미딘-5(1H)-온, 이의 염 및 이의 용도 |
| HUE052821T2 (hu) * | 2015-01-30 | 2021-05-28 | Oncoceutics Inc | 7-benzil-4-(4-trifluormetil)benzil-1,2,6,7,8,9-hexahidroimidazo[1,2-a]pirido[3,4-e]pirimidin-5(4H)-on és sói és azok terápiában történõ alkalmazása |
| RS66519B1 (sr) * | 2016-01-29 | 2025-03-31 | Oncoceutics Inc | Modulacija g protein-spregnutog receptora (gpcr) pomoću imipridona |
| PE20231050A1 (es) | 2016-03-02 | 2023-07-11 | Eisai Randd Man Co Ltd | Conjugados de anticuerpo y farmaco basados en eribulina y metodos para su uso |
| CA3033667A1 (en) * | 2016-08-12 | 2018-02-15 | Nanjing Gator Meditech Company, Ltd. | Protein kinase regulators |
| ES2928773T3 (es) | 2017-01-17 | 2022-11-22 | Heparegenix Gmbh | Inhibidores de proteína cinasas para fomentar la regeneración hepática o reducir o prevenir la muerte de hepatocitos |
| US10172862B2 (en) * | 2017-01-30 | 2019-01-08 | Oncoceutics, Inc. | Imipridones for gliomas |
| EP3849559A4 (en) * | 2018-09-12 | 2022-06-01 | Denovo Biopharma LLC | COMBINATION OF ENZASTAURIN AND INHIBITORS OF BTK AND USES THEREOF |
| KR102536315B1 (ko) | 2020-09-11 | 2023-05-25 | 아주대학교산학협력단 | 네라티닙을 유효성분으로 포함하는 퇴행성 관절염 예방 또는 치료용 조성물 |
| CN117599041B (zh) * | 2024-01-22 | 2024-05-03 | 中国人民解放军军事科学院军事医学研究院 | 去氢雌马酚及其衍生物作为新型辐射防护剂和细胞保护剂的医药用途 |
| EP4684834A1 (de) | 2024-07-26 | 2026-01-28 | BRIU GmbH | Kristallformen onkologisch wirksamer imipridone und verfahren zu deren herstellung |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2150062A1 (de) * | 1971-10-07 | 1973-04-12 | Boehringer Sohn Ingelheim | Imidazo- eckige klammer auf 1,2-a eckige klammer zu -pyrido- eckige klammer auf 4,3-d eckige klammer zu -pyrimidine, deren saeureadditionssalze und verfahren zu deren herstellung |
| US4783450A (en) | 1987-04-13 | 1988-11-08 | Warner-Lambert Company | Use of commercial lecithin as skin penetration enhancer |
| US7635690B2 (en) * | 1999-01-22 | 2009-12-22 | Emory University | HIV-1 mutations selected for by β-2′,3′-didehydro-2′,3′-dideoxy-5-fluorocytidine |
| WO2003075917A1 (en) * | 2002-03-08 | 2003-09-18 | Signal Pharmaceuticals, Inc. | Combination therapy for treating, preventing or managing proliferative disorders and cancers |
| KR20070114753A (ko) * | 2005-02-18 | 2007-12-04 | 아브락시스 바이오사이언스 인크. | 치료제의 조합 및 투여 방식, 및 조합 요법 |
| US20080221135A1 (en) * | 2005-05-13 | 2008-09-11 | Bristol-Myers Squibb Company | Combination therapy |
| CA2746129A1 (en) * | 2008-12-11 | 2010-06-17 | Abraxis Bioscience, Llc | Combination chemotherapy of nanoparticulate taxanes and inhibitors of pro-survival and/or inflammatory signals |
| US9724337B2 (en) * | 2009-04-21 | 2017-08-08 | University Of Kentucky Research Foundation | AG-205 for the treatment of breast cancer |
| JP2013525308A (ja) * | 2010-04-16 | 2013-06-20 | キュリス，インコーポレイテッド | Ｋ−ｒａｓ変異を有する癌の治療 |
| WO2011144622A1 (en) * | 2010-05-17 | 2011-11-24 | Boehringer Ingelheim International Gmbh | 1h - imidazo [4, 5 - c] quinolines |
| US8735386B2 (en) * | 2010-07-23 | 2014-05-27 | Boehringer Ingelheim International Gmbh | Aminopyrazoloquinazolines |
| EP2694678A2 (en) * | 2011-04-04 | 2014-02-12 | Netherland Cancer Institute | Methods and compositions for predicting resistance to anticancer treatment |
| EP3679934B1 (en) * | 2011-04-29 | 2024-06-05 | The Penn State Research Foundation | Small molecule trail gene induction by normal and tumor cells as an anticancer therapy |
| US8377946B1 (en) * | 2011-12-30 | 2013-02-19 | Pharmacyclics, Inc. | Pyrazolo[3,4-d]pyrimidine and pyrrolo[2,3-d]pyrimidine compounds as kinase inhibitors |
| SI2968294T1 (sl) * | 2013-03-13 | 2019-08-30 | Oncoceutics, Inc. | 7-benzil-10-(2-metilbenzil)-2,6,7,8,9,10-heksahidroimidazo(1,2-A)pirido (4,3-D)pirimidin-5(3H)-on za uporabo pri zdravljenju raka |
| KR102318238B1 (ko) | 2013-11-15 | 2021-10-26 | 온코슈틱스 인코포레이티드 | 7-벤질-4-(2-메틸벤질)-2,4,6,7,8,9-헥사하이드로이미다조[1,2-a]피리도[3,4-e]피리미딘-5(1H)-온, 이의 염 및 이의 용도 |
| JP6756435B2 (ja) * | 2014-03-31 | 2020-09-16 | ザ スクリプス リサーチ インスティテュート | Ｔｒａｉｌ誘導のためのファーマコフォア |
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2014
- 2014-09-12 KR KR1020167015829A patent/KR102318238B1/ko active Active
- 2014-09-12 EP EP14861931.5A patent/EP3068401B1/en active Active
- 2014-09-12 DK DK19158371.5T patent/DK3546461T3/da active
- 2014-09-12 IL IL296386A patent/IL296386B2/en unknown
- 2014-09-12 IL IL311202A patent/IL311202A/en unknown
- 2014-09-12 SG SG10201809189UA patent/SG10201809189UA/en unknown
- 2014-09-12 SI SI201431890T patent/SI3546461T1/sl unknown
- 2014-09-12 MX MX2016006318A patent/MX2016006318A/es active IP Right Grant
- 2014-09-12 LT LTEP19158371.5T patent/LT3546461T/lt unknown
- 2014-09-12 PT PT14861931T patent/PT3068401T/pt unknown
- 2014-09-12 BR BR112016011072-2A patent/BR112016011072B1/pt active IP Right Grant
- 2014-09-12 HR HRP20190814TT patent/HRP20190814T1/hr unknown
- 2014-09-12 KR KR1020237045471A patent/KR102742700B1/ko active Active
- 2014-09-12 CN CN201480070502.XA patent/CN106163524B/zh active Active
- 2014-09-12 EA EA201691008A patent/EA033744B1/ru unknown
- 2014-09-12 HU HUE14861931A patent/HUE043291T2/hu unknown
- 2014-09-12 SM SM20210607T patent/SMT202100607T1/it unknown
- 2014-09-12 TR TR2019/06711T patent/TR201906711T4/tr unknown
- 2014-09-12 HR HRP20211653TT patent/HRP20211653T8/hr unknown
- 2014-09-12 ME MEP-2019-129A patent/ME03387B/me unknown
- 2014-09-12 CN CN201910972122.XA patent/CN110669047A/zh active Pending
- 2014-09-12 KR KR1020247040934A patent/KR20250006309A/ko active Pending
- 2014-09-12 DK DK14861931.5T patent/DK3068401T3/da active
- 2014-09-12 RS RS20211310A patent/RS62572B1/sr unknown
- 2014-09-12 KR KR1020217034110A patent/KR102453679B1/ko active Active
- 2014-09-12 SI SI201431203T patent/SI3068401T1/sl unknown
- 2014-09-12 JP JP2016554306A patent/JP6670751B2/ja active Active
- 2014-09-12 EP EP21183202.7A patent/EP3939594A1/en active Pending
- 2014-09-12 AU AU2014349150A patent/AU2014349150B2/en active Active
- 2014-09-12 EP EP19158371.5A patent/EP3546461B1/en active Active
- 2014-09-12 LT LTEP14861931.5T patent/LT3068401T/lt unknown
- 2014-09-12 PL PL14861931T patent/PL3068401T3/pl unknown
- 2014-09-12 RS RS20190518A patent/RS58745B1/sr unknown
- 2014-09-12 SM SM20190291T patent/SMT201900291T1/it unknown
- 2014-09-12 HU HUE19158371A patent/HUE056389T2/hu unknown
- 2014-09-12 CA CA2930535A patent/CA2930535C/en active Active
- 2014-09-12 WO PCT/US2014/055373 patent/WO2015073109A1/en not_active Ceased
- 2014-09-12 MX MX2020002814A patent/MX390132B/es unknown
- 2014-09-12 PT PT191583715T patent/PT3546461T/pt unknown
- 2014-09-12 ES ES19158371T patent/ES2895600T3/es active Active
- 2014-09-12 KR KR1020227034791A patent/KR20220140042A/ko not_active Ceased
- 2014-09-12 CA CA3204925A patent/CA3204925A1/en active Pending
- 2014-09-12 ES ES14861931T patent/ES2724331T3/es active Active
- 2014-09-12 PL PL19158371T patent/PL3546461T3/pl unknown
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2016
- 2016-05-11 IL IL245603A patent/IL245603B/en active IP Right Grant
- 2016-05-13 MX MX2022001966A patent/MX2022001966A/es unknown
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2019
- 2019-05-14 CY CY20191100520T patent/CY1121628T1/el unknown
- 2019-07-24 IL IL268248A patent/IL268248B/en active IP Right Grant
- 2019-12-24 JP JP2019233099A patent/JP2020097577A/ja active Pending
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2020
- 2020-02-06 AU AU2020200875A patent/AU2020200875B2/en active Active
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2021
- 2021-03-24 IL IL281785A patent/IL281785B/en unknown
- 2021-11-02 CY CY20211100939T patent/CY1124832T1/el unknown
- 2021-12-05 IL IL288674A patent/IL288674B2/en unknown
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2022
- 2022-05-06 AU AU2022203043A patent/AU2022203043B2/en active Active
- 2022-05-06 JP JP2022076459A patent/JP2022105170A/ja active Pending
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2024
- 2024-02-27 JP JP2024027134A patent/JP2024059840A/ja active Pending
- 2024-12-12 AU AU2024278350A patent/AU2024278350A1/en active Pending