JP2017504611A5 - - Google Patents
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- Publication number
- JP2017504611A5 JP2017504611A5 JP2016542139A JP2016542139A JP2017504611A5 JP 2017504611 A5 JP2017504611 A5 JP 2017504611A5 JP 2016542139 A JP2016542139 A JP 2016542139A JP 2016542139 A JP2016542139 A JP 2016542139A JP 2017504611 A5 JP2017504611 A5 JP 2017504611A5
- Authority
- JP
- Japan
- Prior art keywords
- inhibitor
- pharmaceutically acceptable
- combination
- cancer
- acceptable salt
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000003814 drug Substances 0.000 claims 29
- 150000003839 salts Chemical class 0.000 claims 18
- 206010028980 Neoplasm Diseases 0.000 claims 17
- 201000011510 cancer Diseases 0.000 claims 17
- 102100033793 ALK tyrosine kinase receptor Human genes 0.000 claims 16
- 101710168331 ALK tyrosine kinase receptor Proteins 0.000 claims 16
- 239000003112 inhibitor Substances 0.000 claims 10
- 229940118537 p53 inhibitor Drugs 0.000 claims 9
- 239000013543 active substance Substances 0.000 claims 4
- 206010029260 Neuroblastoma Diseases 0.000 claims 3
- 125000003854 p-chlorophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C([H])=C1Cl 0.000 claims 3
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- -1 5-chloro-1-methyl-2-oxo-1,2-dihydro-pyridin-3-yl Chemical group 0.000 claims 1
- 229940124297 CDK 4/6 inhibitor Drugs 0.000 claims 1
- 101150012716 CDK1 gene Proteins 0.000 claims 1
- 229940083347 Cyclin-dependent kinase 4 inhibitor Drugs 0.000 claims 1
- 206010058467 Lung neoplasm malignant Diseases 0.000 claims 1
- 239000002246 antineoplastic agent Substances 0.000 claims 1
- 239000013066 combination product Substances 0.000 claims 1
- 229940127555 combination product Drugs 0.000 claims 1
- 150000001875 compounds Chemical class 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 239000000890 drug combination Substances 0.000 claims 1
- 201000005202 lung cancer Diseases 0.000 claims 1
- 208000020816 lung neoplasm Diseases 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- AGBSXNCBIWWLHD-FQEVSTJZSA-N siremadlin Chemical compound COC1=NC(OC)=NC=C1C(N1C(C)C)=NC2=C1[C@H](C=1C=CC(Cl)=CC=1)N(C=1C(N(C)C=C(Cl)C=1)=O)C2=O AGBSXNCBIWWLHD-FQEVSTJZSA-N 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361920032P | 2013-12-23 | 2013-12-23 | |
| US61/920,032 | 2013-12-23 | ||
| US201461948323P | 2014-03-05 | 2014-03-05 | |
| US61/948,323 | 2014-03-05 | ||
| PCT/IB2014/067139 WO2015097621A2 (en) | 2013-12-23 | 2014-12-19 | Pharmaceutical combinations |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017504611A JP2017504611A (ja) | 2017-02-09 |
| JP2017504611A5 true JP2017504611A5 (https=) | 2018-02-01 |
| JP6532878B2 JP6532878B2 (ja) | 2019-06-19 |
Family
ID=52278689
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016542139A Expired - Fee Related JP6532878B2 (ja) | 2013-12-23 | 2014-12-19 | 組合せ医薬 |
Country Status (12)
| Country | Link |
|---|---|
| US (3) | US20160339023A1 (https=) |
| EP (1) | EP3086810A2 (https=) |
| JP (1) | JP6532878B2 (https=) |
| KR (1) | KR20160100975A (https=) |
| CN (1) | CN105848682A (https=) |
| AU (2) | AU2014372166B2 (https=) |
| BR (1) | BR112016012506A8 (https=) |
| CA (1) | CA2934866A1 (https=) |
| MX (1) | MX2016008362A (https=) |
| RU (1) | RU2016129953A (https=) |
| TW (1) | TW201609100A (https=) |
| WO (1) | WO2015097621A2 (https=) |
Families Citing this family (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK2118123T3 (en) | 2007-01-31 | 2016-01-25 | Dana Farber Cancer Inst Inc | Stabilized p53 peptides and uses thereof |
| US8592377B2 (en) | 2007-03-28 | 2013-11-26 | President And Fellows Of Harvard College | Stitched polypeptides |
| ES2711526T3 (es) | 2010-08-13 | 2019-05-06 | Aileron Therapeutics Inc | Macrociclos peptidomiméticos |
| TW201806968A (zh) | 2011-10-18 | 2018-03-01 | 艾利倫治療公司 | 擬肽巨環化合物 |
| BR112014020103A2 (pt) | 2012-02-15 | 2018-10-09 | Aileron Therapeutics, Inc. | macrociclos peptidomiméticos |
| EP2819688A4 (en) | 2012-02-15 | 2015-10-28 | Aileron Therapeutics Inc | TRIAZOL AND THIOETHER-COUPLED PEPTIDOMIMETIC MACROCYCLES |
| WO2014071241A1 (en) | 2012-11-01 | 2014-05-08 | Aileron Therapeutics, Inc. | Disubstituted amino acids and methods of preparation and use thereof |
| WO2014138429A2 (en) | 2013-03-06 | 2014-09-12 | Aileron Therapeutics, Inc. | Peptidomimetic macrocycles and use thereof in regulating hif1alpha |
| AU2015320545C1 (en) | 2014-09-24 | 2020-05-14 | Aileron Therapeutics, Inc. | Peptidomimetic macrocycles and formulations thereof |
| EP3197478A4 (en) | 2014-09-24 | 2018-05-30 | Aileron Therapeutics, Inc. | Peptidomimetic macrocycles and uses thereof |
| WO2016154058A1 (en) | 2015-03-20 | 2016-09-29 | Aileron Therapeutics, Inc. | Peptidomimetic macrocycles and uses thereof |
| EP3319944A4 (en) | 2015-07-10 | 2019-04-24 | Arvinas, Inc. | MDM2-BASED MODULATORS OF PROTEOLYSIS AND RELATED USE METHODS |
| RU2018108804A (ru) * | 2015-08-14 | 2019-09-16 | Новартис Аг | Фармацевтические комбинации и их применение |
| WO2017037579A1 (en) | 2015-08-28 | 2017-03-09 | Novartis Ag | Mdm2 inhibitors and combinations thereof |
| US10813933B2 (en) | 2016-05-17 | 2020-10-27 | Japanese Foundation For Cancer Research | Therapeutic agent for lung cancer that has acquired EGFR-TKI resistance |
| US20200268728A1 (en) * | 2016-12-20 | 2020-08-27 | Sumitomo Dainippon Pharma Co., Ltd. | Drug targeting cancer stem cell |
| US11173211B2 (en) | 2016-12-23 | 2021-11-16 | Arvinas Operations, Inc. | Compounds and methods for the targeted degradation of rapidly accelerated Fibrosarcoma polypeptides |
| CA3048340A1 (en) * | 2017-01-10 | 2018-07-19 | Novartis Ag | Pharmaceutical combination comprising an alk inhibitor and a shp2 inhibitor |
| ES2928773T3 (es) | 2017-01-17 | 2022-11-22 | Heparegenix Gmbh | Inhibidores de proteína cinasas para fomentar la regeneración hepática o reducir o prevenir la muerte de hepatocitos |
| JP6617208B2 (ja) * | 2017-03-31 | 2019-12-11 | ノバルティス アーゲー | 血液腫瘍におけるｈｄｍ２−ｐ５３相互作用阻害剤の用量およびレジメン |
| EP3766883B1 (en) | 2018-03-12 | 2022-09-28 | Luoxin Pharmaceutical (Shanghai) Co., Ltd. | Imidaxopyrolone compound and application thereof |
| WO2019182936A1 (en) | 2018-03-19 | 2019-09-26 | Ariad Pharmaceuticals, Inc. | Methods of treating cancer in pediatric patients |
| WO2019195609A2 (en) | 2018-04-04 | 2019-10-10 | Arvinas Operations, Inc. | Modulators of proteolysis and associated methods of use |
| US11091522B2 (en) | 2018-07-23 | 2021-08-17 | Aileron Therapeutics, Inc. | Peptidomimetic macrocycles and uses thereof |
| JP7297053B2 (ja) | 2018-08-20 | 2023-06-23 | アルビナス・オペレーションズ・インコーポレイテッド | 神経変性疾患を治療するためのｅ３ユビキチンリガーゼ結合活性を有するキメラ（ｐｒｏｔａｃ）化合物を標的とし、アルファ－シヌクレインタンパク質を標的とするタンパク質分解 |
| WO2022047145A1 (en) | 2020-08-28 | 2022-03-03 | Arvinas Operations, Inc. | Rapidly accelerating fibrosarcoma protein degrading compounds and associated methods of use |
| WO2024054591A1 (en) | 2022-09-07 | 2024-03-14 | Arvinas Operations, Inc. | Rapidly accelerated fibrosarcoma (raf) degrading compounds and associated methods of use |
| US12448399B2 (en) | 2023-01-26 | 2025-10-21 | Arvinas Operations, Inc. | Cereblon-based KRAS degrading PROTACs and uses related thereto |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2007105058A2 (en) | 2006-03-16 | 2007-09-20 | Pfizer Products Inc. | Pyrazole compounds |
| NZ577197A (en) * | 2006-12-08 | 2011-02-25 | Irm Llc | Pyrimidine compounds especially 4-phenylamino-2-arylamino-pyrimidine derivatives and compositions as protein kinase inhibitors |
| EA017405B9 (ru) * | 2006-12-08 | 2014-05-30 | АйАрЭм ЭлЭлСи | Соединения и композиции в качестве ингибиторов протеинкиназы |
| MX2010010968A (es) * | 2008-04-07 | 2010-10-26 | Irm Llc | Compuestos y composiciones como inhibidores de cinasa de proteina. |
| ES2554513T3 (es) | 2008-05-23 | 2015-12-21 | Novartis Ag | Derivados de quinolinas y quinoxalinas como inhibidores de la proteína tirosina quinasa |
| ES2522346T3 (es) * | 2008-08-22 | 2014-11-14 | Novartis Ag | Compuestos de pirrolopirimidina como inhibidores de CDK |
| AR077975A1 (es) * | 2009-08-28 | 2011-10-05 | Irm Llc | Derivados de pirazol pirimidina y composiciones como inhibidores de cinasa de proteina |
| US8440693B2 (en) | 2009-12-22 | 2013-05-14 | Novartis Ag | Substituted isoquinolinones and quinazolinones |
| CU24130B1 (es) * | 2009-12-22 | 2015-09-29 | Novartis Ag | Isoquinolinonas y quinazolinonas sustituidas |
| UA108746C2 (xx) * | 2009-12-22 | 2015-06-10 | Заміщені ізохінолінони та хіназолінони | |
| RS54189B1 (sr) * | 2011-02-02 | 2015-12-31 | Novartis Ag | Postupci za korišćenje inibitora alk |
| US20140296248A1 (en) * | 2011-04-04 | 2014-10-02 | Stichting het Nederlands Kanker Instiuut-Antoni van Leeuwenhoek ziekenhuis | Methods and compositions for predicting resistance to anticancer treatment |
| UY34591A (es) * | 2012-01-26 | 2013-09-02 | Novartis Ag | Compuestos de imidazopirrolidinona |
| EP2916841A1 (en) * | 2012-11-07 | 2015-09-16 | Novartis AG | Combination therapy |
-
2014
- 2014-12-19 KR KR1020167016376A patent/KR20160100975A/ko not_active Withdrawn
- 2014-12-19 MX MX2016008362A patent/MX2016008362A/es unknown
- 2014-12-19 BR BR112016012506A patent/BR112016012506A8/pt not_active IP Right Cessation
- 2014-12-19 WO PCT/IB2014/067139 patent/WO2015097621A2/en not_active Ceased
- 2014-12-19 EP EP14821861.3A patent/EP3086810A2/en not_active Withdrawn
- 2014-12-19 CN CN201480070695.9A patent/CN105848682A/zh active Pending
- 2014-12-19 AU AU2014372166A patent/AU2014372166B2/en not_active Ceased
- 2014-12-19 CA CA2934866A patent/CA2934866A1/en not_active Abandoned
- 2014-12-19 US US15/107,232 patent/US20160339023A1/en not_active Abandoned
- 2014-12-19 JP JP2016542139A patent/JP6532878B2/ja not_active Expired - Fee Related
- 2014-12-19 RU RU2016129953A patent/RU2016129953A/ru not_active Application Discontinuation
- 2014-12-23 TW TW103145083A patent/TW201609100A/zh unknown
-
2017
- 2017-10-09 AU AU2017245295A patent/AU2017245295A1/en not_active Withdrawn
-
2018
- 2018-01-25 US US15/879,942 patent/US20180185365A1/en not_active Abandoned
- 2018-11-05 US US16/180,078 patent/US20190134033A1/en not_active Abandoned
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