JP2017520613A5 - - Google Patents
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- Publication number
- JP2017520613A5 JP2017520613A5 JP2017503504A JP2017503504A JP2017520613A5 JP 2017520613 A5 JP2017520613 A5 JP 2017520613A5 JP 2017503504 A JP2017503504 A JP 2017503504A JP 2017503504 A JP2017503504 A JP 2017503504A JP 2017520613 A5 JP2017520613 A5 JP 2017520613A5
- Authority
- JP
- Japan
- Prior art keywords
- oxy
- compound
- pharmaceutically acceptable
- acceptable salt
- tetrahydropyrrolo
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000001875 compounds Chemical class 0.000 claims 11
- 150000003839 salts Chemical class 0.000 claims 9
- 239000008194 pharmaceutical composition Substances 0.000 claims 5
- 230000004770 neurodegeneration Effects 0.000 claims 2
- 208000015122 neurodegenerative disease Diseases 0.000 claims 2
- 208000024827 Alzheimer disease Diseases 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- VYMXZQQIOZTTMU-CYBMUJFWSA-N O=C(N(C[C@@H]1N2CCC1)C2=C1)N=C1OCc(cc1F)cc(F)c1Oc1ccnc(C(F)(F)F)c1 Chemical compound O=C(N(C[C@@H]1N2CCC1)C2=C1)N=C1OCc(cc1F)cc(F)c1Oc1ccnc(C(F)(F)F)c1 VYMXZQQIOZTTMU-CYBMUJFWSA-N 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNPCT/CN2014/000695 | 2014-07-22 | ||
| CN2014000695 | 2014-07-22 | ||
| PCT/CN2015/084607 WO2016011931A1 (en) | 2014-07-22 | 2015-07-21 | Compounds |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017520613A JP2017520613A (ja) | 2017-07-27 |
| JP2017520613A5 true JP2017520613A5 (https=) | 2018-08-23 |
| JP6625603B2 JP6625603B2 (ja) | 2019-12-25 |
Family
ID=55162512
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017503504A Active JP6625603B2 (ja) | 2014-07-22 | 2015-07-21 | 化合物 |
| JP2017503553A Active JP6625604B2 (ja) | 2014-07-22 | 2015-07-21 | 化合物 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017503553A Active JP6625604B2 (ja) | 2014-07-22 | 2015-07-21 | 化合物 |
Country Status (14)
| Country | Link |
|---|---|
| US (5) | US9783546B2 (https=) |
| EP (2) | EP3172208B1 (https=) |
| JP (2) | JP6625603B2 (https=) |
| KR (2) | KR20170029516A (https=) |
| CN (2) | CN106536521B (https=) |
| AR (1) | AR101261A1 (https=) |
| AU (2) | AU2015292048B2 (https=) |
| BR (1) | BR112016030939B1 (https=) |
| CA (2) | CA2955910C (https=) |
| ES (2) | ES2744339T3 (https=) |
| RU (2) | RU2690190C2 (https=) |
| TW (1) | TW201617348A (https=) |
| UY (1) | UY36224A (https=) |
| WO (2) | WO2016011931A1 (https=) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106536521B (zh) * | 2014-07-22 | 2018-08-03 | 葛兰素史密斯克莱知识产权发展有限公司 | 化合物 |
| US11273176B2 (en) | 2016-03-02 | 2022-03-15 | The Brigham And Women's Hospital, Inc. | Use of PLA2G5-deficient suppressive macrophages in suppression of inflammation |
| EP3687980B1 (en) * | 2017-09-26 | 2022-01-19 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Radiolabeled darapladib, analogs thereof and their use as imaging compounds |
| CN109988126B (zh) * | 2017-12-29 | 2023-05-16 | 南京富润凯德生物医药有限公司 | 一种3-氨基-氧杂环丁烷衍生物及其制备方法和应用 |
| CN109134523A (zh) * | 2018-09-30 | 2019-01-04 | 中昊(大连)化工研究设计院有限公司 | 一种3，6-二氢-2h-吡喃-4-硼酸频哪醇酯的合成新工艺 |
| JP2022116370A (ja) * | 2019-06-13 | 2022-08-10 | アグロカネショウ株式会社 | 新規な１－ベンジルアミン誘導体及びこれを有効成分とする農園芸用薬剤 |
| CN112574221B (zh) * | 2019-09-30 | 2022-03-04 | 上海纽思克生物科技有限公司 | 四环嘧啶酮类化合物、其制备方法、其组合物和用途 |
| CN112778331B (zh) * | 2019-11-09 | 2022-07-05 | 上海赛默罗生物科技有限公司 | 三环二氢咪唑并嘧啶酮衍生物、其制备方法、药物组合物和用途 |
| KR102842485B1 (ko) * | 2020-05-13 | 2025-08-05 | 뉴스코 바이오테크 리미티드 | 가교 환상 피리미디논류 화합물, 그의 제조방법, 그의 조성물 및 사용 |
| CN113666930B (zh) * | 2020-05-13 | 2022-10-25 | 上海纽思克生物科技有限公司 | 桥环嘧啶酮类化合物、其制备方法、其组合物和用途 |
| CN113861220B (zh) * | 2020-06-30 | 2023-06-16 | 上海纽思克生物科技有限公司 | 三环嘧啶酮类化合物、其制备方法、其组合物和用途 |
| CN113912622B (zh) * | 2020-07-10 | 2023-12-01 | 上海纽思克生物科技有限公司 | 三环嘧啶酮类化合物、其制备方法、其组合物和用途 |
| CN115304620A (zh) | 2021-05-07 | 2022-11-08 | 上海赛默罗生物科技有限公司 | 嘧啶酮衍生物、其制备方法、药物组合物和用途 |
| CN114057740B (zh) * | 2021-12-15 | 2024-04-02 | 上海赛默罗生物科技有限公司 | 螺环嘧啶酮衍生物、其制备方法、药物组合物和用途 |
| EP4565587A1 (en) * | 2022-08-04 | 2025-06-11 | 4B Technologies (Beijing) Co., Limited | Dihydroimidazo-pyrimidinone compounds as lp-pla2 inhibitors and use thereof |
| WO2024220459A2 (en) * | 2023-04-18 | 2024-10-24 | Scineuro Therapeutics Inc. | Combination therapy with lp-pla2 inhibitor and a second agent |
| TWI896037B (zh) * | 2023-07-17 | 2025-09-01 | 大陸商上海樞境生物科技有限公司 | 雙環[5,6]咪唑嘧啶酮類衍生物、其製備方法和應用 |
| WO2025217646A1 (en) * | 2024-04-12 | 2025-10-16 | Scineuro Therapeutics Inc. | Method of treating neurodegenerative and ocular neovascular diseases |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0127143D0 (en) * | 2001-11-10 | 2002-01-02 | Smithkline Beecham | Novel compounds |
| AU2003250470A1 (en) * | 2002-08-13 | 2004-02-25 | Warner-Lambert Company Llc | Pyrimidinone fused bicyclic metalloproteinase inhibitors |
| GB0320522D0 (en) | 2003-09-02 | 2003-10-01 | Glaxo Group Ltd | Formulation |
| WO2009147476A1 (en) | 2008-06-02 | 2009-12-10 | Matrix Laboratories Ltd. | Novel pde inhibitors, pharmaceutical compositions containing them and processes for their preparation |
| US8871928B2 (en) * | 2010-09-20 | 2014-10-28 | Glaxo Group Limited | Tricyclic compounds, preparation methods, and their uses |
| EP2651403B1 (en) * | 2010-12-17 | 2020-12-02 | Glaxo Group Limited | Use of lp-pla2 inhibitors in the treatment and prevention of eye diseases |
| CA2835707C (en) | 2011-05-09 | 2019-02-26 | Eip Pharma, Llc | Compositions and methods for treating alzheimer's disease |
| AR087309A1 (es) | 2011-07-27 | 2014-03-12 | Glaxo Group Ltd | Compuesto heterociclico de anillos condensados sustituido, composicion farmaceutica que lo comprende y su uso para la fabricacion de un medicamento para el tratamiento de enfermedades neurogenerativas y aterosclerosis |
| EP2739627A4 (en) * | 2011-07-27 | 2015-01-21 | Glaxo Group Ltd | 2,3-DIHYDROIMIDAZO [1,2-C] PYRIMIDIN-5 (1H) -ONE COMPOUNDS AND USE AS INHIBITORS OF LP-PLA2 |
| CN103827118B (zh) * | 2011-07-27 | 2016-03-09 | 葛兰素集团有限公司 | 双环嘧啶酮化合物 |
| JP2014534206A (ja) | 2011-10-17 | 2014-12-18 | エナンタ ファーマシューティカルズ インコーポレイテッド | Ｃ型肝炎ウイルス阻害剤 |
| JP6065786B2 (ja) | 2012-09-14 | 2017-01-25 | 信越化学工業株式会社 | 化学増幅レジスト材料及びパターン形成方法 |
| AU2014210260B2 (en) * | 2013-01-25 | 2016-08-04 | Glaxosmithkline Intellectual Property Development Limited | Bicyclic pyrimidone compounds as inhibitors of Lp-PLA2 |
| EP2948452B1 (en) * | 2013-01-25 | 2017-08-09 | GlaxoSmithKline Intellectual Property Development Limited | 2,3-dihydroimidazol[1,2-c]pyrimidin-5(1h)-one based lipoprotein-associated phospholipase a2 (lp-pla2) inhibitors |
| CN103927116A (zh) * | 2014-03-18 | 2014-07-16 | 兴唐通信科技有限公司 | 基于触屏设备的手势输入汉字的键盘和方法 |
| CN106536521B (zh) | 2014-07-22 | 2018-08-03 | 葛兰素史密斯克莱知识产权发展有限公司 | 化合物 |
-
2015
- 2015-07-21 CN CN201580039345.0A patent/CN106536521B/zh active Active
- 2015-07-21 KR KR1020177001425A patent/KR20170029516A/ko not_active Withdrawn
- 2015-07-21 RU RU2017105353A patent/RU2690190C2/ru not_active IP Right Cessation
- 2015-07-21 ES ES15824385T patent/ES2744339T3/es active Active
- 2015-07-21 KR KR1020177001423A patent/KR20170034889A/ko not_active Withdrawn
- 2015-07-21 EP EP15824385.7A patent/EP3172208B1/en active Active
- 2015-07-21 AU AU2015292048A patent/AU2015292048B2/en not_active Ceased
- 2015-07-21 WO PCT/CN2015/084607 patent/WO2016011931A1/en not_active Ceased
- 2015-07-21 CA CA2955910A patent/CA2955910C/en active Active
- 2015-07-21 JP JP2017503504A patent/JP6625603B2/ja active Active
- 2015-07-21 RU RU2017105476A patent/RU2017105476A/ru not_active Application Discontinuation
- 2015-07-21 AR ARP150102300A patent/AR101261A1/es unknown
- 2015-07-21 BR BR112016030939-1A patent/BR112016030939B1/pt active IP Right Grant
- 2015-07-21 CN CN201580040421.XA patent/CN106536525B/zh active Active
- 2015-07-21 UY UY0001036224A patent/UY36224A/es unknown
- 2015-07-21 CA CA2970537A patent/CA2970537C/en active Active
- 2015-07-21 US US15/327,685 patent/US9783546B2/en active Active
- 2015-07-21 ES ES15825267T patent/ES2747636T3/es active Active
- 2015-07-21 US US15/327,706 patent/US10125141B2/en active Active
- 2015-07-21 EP EP15825267.6A patent/EP3172211B1/en active Active
- 2015-07-21 TW TW104123494A patent/TW201617348A/zh unknown
- 2015-07-21 AU AU2015292049A patent/AU2015292049B2/en not_active Ceased
- 2015-07-21 JP JP2017503553A patent/JP6625604B2/ja active Active
- 2015-07-21 WO PCT/CN2015/084606 patent/WO2016011930A1/en not_active Ceased
-
2018
- 2018-09-27 US US16/143,788 patent/US10428078B2/en active Active
-
2019
- 2019-07-29 US US16/524,238 patent/US11999746B2/en active Active
-
2024
- 2024-04-25 US US18/646,178 patent/US20240300965A1/en active Pending
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