JP2008533007A5 - - Google Patents
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- Publication number
- JP2008533007A5 JP2008533007A5 JP2008500729A JP2008500729A JP2008533007A5 JP 2008533007 A5 JP2008533007 A5 JP 2008533007A5 JP 2008500729 A JP2008500729 A JP 2008500729A JP 2008500729 A JP2008500729 A JP 2008500729A JP 2008533007 A5 JP2008533007 A5 JP 2008533007A5
- Authority
- JP
- Japan
- Prior art keywords
- sdz
- rad isomer
- rad
- isomer
- organic solvent
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- HKVAMNSJSFKALM-GKUWKFKPSA-N Everolimus Chemical class C1C[C@@H](OCCO)[C@H](OC)C[C@@H]1C[C@@H](C)[C@H]1OC(=O)[C@@H]2CCCCN2C(=O)C(=O)[C@](O)(O2)[C@H](C)CC[C@H]2C[C@H](OC)/C(C)=C/C=C/C=C/[C@@H](C)C[C@@H](C)C(=O)[C@H](OC)[C@H](O)/C(C)=C/[C@@H](C)C(=O)C1 HKVAMNSJSFKALM-GKUWKFKPSA-N 0.000 claims 19
- 239000003960 organic solvent Substances 0.000 claims 7
- 239000012062 aqueous buffer Substances 0.000 claims 5
- WEVYAHXRMPXWCK-UHFFFAOYSA-N Acetonitrile Chemical compound CC#N WEVYAHXRMPXWCK-UHFFFAOYSA-N 0.000 claims 3
- RYHBNJHYFVUHQT-UHFFFAOYSA-N 1,4-Dioxane Chemical compound C1COCCO1 RYHBNJHYFVUHQT-UHFFFAOYSA-N 0.000 claims 2
- HKVAMNSJSFKALM-CPXURSODSA-N everolimus Chemical compound C1C[C@@H](OCCO)[C@H](OC)C[C@@H]1C[C@@H](C)[C@H]1OC(=O)[C@@H]2CCCCN2C(=O)C(=O)[C@](O)(O2)[C@H](C)CC[C@H]2C[C@H](OC)\C(C)=C\C=C\C=C/[C@@H](C)C[C@@H](C)C(=O)[C@H](OC)[C@H](O)/C(C)=C/[C@@H](C)C(=O)C1 HKVAMNSJSFKALM-CPXURSODSA-N 0.000 claims 2
- 239000003880 polar aprotic solvent Substances 0.000 claims 2
- 241000124008 Mammalia Species 0.000 claims 1
- 239000000010 aprotic solvent Substances 0.000 claims 1
- 239000002552 dosage form Substances 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US65937805P | 2005-03-07 | 2005-03-07 | |
| PCT/US2006/006125 WO2006096325A1 (en) | 2005-03-07 | 2006-02-22 | Oxepane isomer of 42-o-(2-hydroxy)ethyl-rapamycin |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2008533007A JP2008533007A (ja) | 2008-08-21 |
| JP2008533007A5 true JP2008533007A5 (https=) | 2009-04-09 |
Family
ID=36572419
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008500729A Withdrawn JP2008533007A (ja) | 2005-03-07 | 2006-02-22 | ４２−ｏ−（２−ヒドロキシ）エチル−ラパマイシンのオキセパン異性体 |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US7241771B2 (https=) |
| EP (1) | EP1856131A1 (https=) |
| JP (1) | JP2008533007A (https=) |
| CN (1) | CN101137659A (https=) |
| AU (1) | AU2006221024A1 (https=) |
| BR (1) | BRPI0608885A2 (https=) |
| CA (1) | CA2602010A1 (https=) |
| MX (1) | MX2007010892A (https=) |
| WO (1) | WO2006096325A1 (https=) |
Families Citing this family (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AR058282A1 (es) * | 2005-12-07 | 2008-01-30 | Wyeth Corp | Forma cristalina purificada de cci-779, un proceso para la preparacion del mismo, un metodo para monitorear la cristalizacion del cci-779, un kit y una composicion farmaceutica que lo comprenden y su uso en la fabricacion de un medicamento para el tratamiento del cancer. |
| CN101321770A (zh) * | 2005-12-07 | 2008-12-10 | 惠氏公司 | 由雷帕霉素42-酯硼酸酯制备雷帕霉素42-酯的可放大方法 |
| WO2007067566A2 (en) * | 2005-12-07 | 2007-06-14 | Wyeth | Methods for preparing crystalline rapamycin and for measuring crystallinity of rapamycin compounds using differential scanning calorimetry |
| US7622477B2 (en) * | 2006-02-28 | 2009-11-24 | Cordis Corporation | Isomers and 42-epimers of rapamycin alkyl ether analogs, methods of making and using the same |
| US8414525B2 (en) | 2006-11-20 | 2013-04-09 | Lutonix, Inc. | Drug releasing coatings for medical devices |
| US8414910B2 (en) | 2006-11-20 | 2013-04-09 | Lutonix, Inc. | Drug releasing coatings for medical devices |
| US20080276935A1 (en) | 2006-11-20 | 2008-11-13 | Lixiao Wang | Treatment of asthma and chronic obstructive pulmonary disease with anti-proliferate and anti-inflammatory drugs |
| US8414526B2 (en) | 2006-11-20 | 2013-04-09 | Lutonix, Inc. | Medical device rapid drug releasing coatings comprising oils, fatty acids, and/or lipids |
| US8430055B2 (en) | 2008-08-29 | 2013-04-30 | Lutonix, Inc. | Methods and apparatuses for coating balloon catheters |
| US8998846B2 (en) | 2006-11-20 | 2015-04-07 | Lutonix, Inc. | Drug releasing coatings for balloon catheters |
| US8414909B2 (en) | 2006-11-20 | 2013-04-09 | Lutonix, Inc. | Drug releasing coatings for medical devices |
| US9700704B2 (en) | 2006-11-20 | 2017-07-11 | Lutonix, Inc. | Drug releasing coatings for balloon catheters |
| US8425459B2 (en) | 2006-11-20 | 2013-04-23 | Lutonix, Inc. | Medical device rapid drug releasing coatings comprising a therapeutic agent and a contrast agent |
| US9737640B2 (en) | 2006-11-20 | 2017-08-22 | Lutonix, Inc. | Drug releasing coatings for medical devices |
| ES2645692T3 (es) | 2008-11-11 | 2017-12-07 | The Board Of Regents,The University Of Texas System | Microcápsulas de rapamicina y su uso para el tratamiento del cáncer |
| US9283211B1 (en) | 2009-11-11 | 2016-03-15 | Rapamycin Holdings, Llc | Oral rapamycin preparation and use for stomatitis |
| WO2012017449A1 (en) * | 2010-08-04 | 2012-02-09 | Meril Life Sciences Pvt. Ltd | Process for preparation of novel 42-0-(heteroalkoxyalkyl) rapamycin compounds with anti-proliferative properties" |
| CN102268015B (zh) * | 2011-08-30 | 2013-08-28 | 成都摩尔生物医药有限公司 | 一种依维莫司的合成方法 |
| WO2014160328A1 (en) | 2013-03-13 | 2014-10-02 | The Board Of Regents Of The University Of Texas System | Mtor inhibitors for prevention of intestinal polyp growth |
| CN103360411B (zh) * | 2013-07-17 | 2015-09-30 | 成都雅途生物技术有限公司 | 依维莫司结晶提纯方法 |
| EP3089737B1 (en) | 2013-12-31 | 2021-11-03 | Rapamycin Holdings, LLC | Oral rapamycin nanoparticle preparations and use |
| US9700544B2 (en) | 2013-12-31 | 2017-07-11 | Neal K Vail | Oral rapamycin nanoparticle preparations |
| WO2018204416A1 (en) | 2017-05-02 | 2018-11-08 | Revolution Medicines, Inc. | Rapamycin analogs as mtor inhibitors |
| US20210154372A1 (en) | 2017-05-15 | 2021-05-27 | C.R. Bard, Inc. | Medical device with drug-eluting coating and intermediate layer |
| IL312291A (en) | 2018-05-01 | 2024-06-01 | Revolution Medicines Inc | C-26-linked rapamycin analogs as MTOR inhibitors |
| MX2020011565A (es) | 2018-05-01 | 2021-01-29 | Revolution Medicines Inc | Analogos de rapamicina ligados a c40, c28 y c-32 como inhibidores de mtor. |
| EP3880266B1 (en) | 2018-11-14 | 2025-05-07 | Lutonix, Inc. | Medical device with drug-eluting coating on modified device surface |
| EP3952937A1 (en) | 2019-04-08 | 2022-02-16 | Bard Peripheral Vascular, Inc. | Medical device with drug-eluting coating on modified device surface |
| CA3256390A1 (en) | 2022-05-25 | 2023-11-30 | Revolution Medicines, Inc. | CANCER TREATMENT METHODS USING AN MTOR INHIBITOR |
| CN116813642B (zh) * | 2023-06-29 | 2024-04-19 | 浙江康润制药有限公司 | 一种依维莫司纯化方法 |
| GB202415232D0 (en) | 2024-10-16 | 2024-11-27 | Nacamed As | Composition |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PT98990A (pt) | 1990-09-19 | 1992-08-31 | American Home Prod | Processo para a preparacao de esteres de acidos carboxilicos de rapamicina |
| NO921449L (no) | 1991-04-17 | 1992-10-19 | American Home Prod | Karbamater av rapamycin |
| CA2102116A1 (en) | 1991-05-31 | 1992-12-01 | Gary R. Schulte | Use of rapamycin prodrugs as immunosuppressant agents |
| US5221740A (en) | 1992-01-16 | 1993-06-22 | American Home Products Corporation | Oxepane isomers of rapamycin useful as immunosuppressive agents |
| GB9221220D0 (en) | 1992-10-09 | 1992-11-25 | Sandoz Ag | Organic componds |
| US5516770A (en) | 1993-09-30 | 1996-05-14 | American Home Products Corporation | Rapamycin formulation for IV injection |
| US5780462A (en) | 1995-12-27 | 1998-07-14 | American Home Products Corporation | Water soluble rapamycin esters |
| CA2319131A1 (en) * | 1998-01-26 | 1999-07-29 | Walter H. Moos | Mitochondria protecting agents for treating mitochondria associated diseases |
| US6331547B1 (en) | 1999-08-18 | 2001-12-18 | American Home Products Corporation | Water soluble SDZ RAD esters |
| US6277983B1 (en) | 2000-09-27 | 2001-08-21 | American Home Products Corporation | Regioselective synthesis of rapamycin derivatives |
| US6670355B2 (en) | 2000-06-16 | 2003-12-30 | Wyeth | Method of treating cardiovascular disease |
| JP2004507465A (ja) | 2000-08-11 | 2004-03-11 | ワイス | エストロゲン受容体陽性癌腫の治療方法 |
| ATE411321T1 (de) | 2000-09-19 | 2008-10-15 | Wyeth Corp | Wasserlösliche rapamycin-ester |
| US6399625B1 (en) | 2000-09-27 | 2002-06-04 | Wyeth | 1-oxorapamycins |
| US6440991B1 (en) | 2000-10-02 | 2002-08-27 | Wyeth | Ethers of 7-desmethlrapamycin |
| EP1419153A1 (en) | 2001-08-22 | 2004-05-19 | Wyeth | Rapamycin dialdehydes |
| DK1419154T3 (da) | 2001-08-22 | 2006-01-09 | Wyeth Corp | Rapamycin-29-enoler |
| EP1646635A1 (en) | 2003-07-16 | 2006-04-19 | Wyeth | Cci-779 isomer c |
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2006
- 2006-02-22 CA CA002602010A patent/CA2602010A1/en not_active Abandoned
- 2006-02-22 JP JP2008500729A patent/JP2008533007A/ja not_active Withdrawn
- 2006-02-22 WO PCT/US2006/006125 patent/WO2006096325A1/en not_active Ceased
- 2006-02-22 AU AU2006221024A patent/AU2006221024A1/en not_active Abandoned
- 2006-02-22 MX MX2007010892A patent/MX2007010892A/es active IP Right Grant
- 2006-02-22 EP EP06735687A patent/EP1856131A1/en not_active Withdrawn
- 2006-02-22 CN CNA2006800074672A patent/CN101137659A/zh not_active Withdrawn
- 2006-02-22 BR BRPI0608885A patent/BRPI0608885A2/pt not_active IP Right Cessation
- 2006-02-22 US US11/359,166 patent/US7241771B2/en not_active Expired - Fee Related