|
US8993808B2
(en)
|
2009-01-21 |
2015-03-31 |
Oryzon Genomics, S.A. |
Phenylcyclopropylamine derivatives and their medical use
|
|
US8859555B2
(en)
|
2009-09-25 |
2014-10-14 |
Oryzon Genomics S.A. |
Lysine Specific Demethylase-1 inhibitors and their use
|
|
EP2486002B1
(en)
|
2009-10-09 |
2019-03-27 |
Oryzon Genomics, S.A. |
Substituted heteroaryl- and aryl- cyclopropylamine acetamides and their use
|
|
WO2011106106A2
(en)
|
2010-02-24 |
2011-09-01 |
Oryzon Genomics, S.A. |
Lysine demethylase inhibitors for diseases and disorders associated with hepadnaviridae
|
|
WO2011106574A2
(en)
|
2010-02-24 |
2011-09-01 |
Oryzon Genomics, S.A. |
Inhibitors for antiviral use
|
|
CA2796726C
(en)
|
2010-04-19 |
2021-02-16 |
Oryzon Genomics S.A. |
Lysine specific demethylase-1 inhibitors and their use
|
|
US9006449B2
(en)
|
2010-07-29 |
2015-04-14 |
Oryzon Genomics, S.A. |
Cyclopropylamine derivatives useful as LSD1 inhibitors
|
|
BR112013002164B1
(pt)
|
2010-07-29 |
2021-11-09 |
Oryzon Genomics S.A. |
Inibidores de desmetilase à base de arilciclopropilamina de lsd1, seus usos, e composição farmacêutica
|
|
US9061966B2
(en)
|
2010-10-08 |
2015-06-23 |
Oryzon Genomics S.A. |
Cyclopropylamine inhibitors of oxidases
|
|
WO2012072713A2
(en)
|
2010-11-30 |
2012-06-07 |
Oryzon Genomics, S.A. |
Lysine demethylase inhibitors for diseases and disorders associated with flaviviridae
|
|
EP2712315B1
(en)
|
2011-02-08 |
2021-11-24 |
Oryzon Genomics, S.A. |
Lysine demethylase inhibitors for myeloproliferative disorders
|
|
PE20141202A1
(es)
*
|
2011-08-09 |
2014-10-03 |
Takeda Pharmaceutical |
Compuesto de ciclopropanoamina
|
|
EP2768805B1
(en)
|
2011-10-20 |
2020-03-25 |
Oryzon Genomics, S.A. |
(hetero)aryl cyclopropylamine compounds as lsd1 inhibitors
|
|
JP6046154B2
(ja)
|
2011-10-20 |
2016-12-14 |
オリソン ヘノミクス エセ. アー. |
Lsd1阻害剤としての(ヘテロ)アリールシクロプロピルアミン化合物
|
|
DK2903968T3
(en)
|
2012-10-02 |
2017-01-30 |
Gilead Sciences Inc |
INHIBITORS OF HISTON DEMETHYLASES
|
|
CA2887598A1
(en)
|
2012-10-12 |
2014-04-17 |
Takeda Pharmaceutical Company Limited |
Cyclopropanamine compound and use thereof
|
|
EP2740474A1
(en)
*
|
2012-12-05 |
2014-06-11 |
Instituto Europeo di Oncologia S.r.l. |
Cyclopropylamine derivatives useful as inhibitors of histone demethylases kdm1a
|
|
PE20151667A1
(es)
|
2013-02-27 |
2015-11-27 |
Epitherapeutics Aps |
Inhibidores de histona desmetilasas
|
|
WO2014194280A2
(en)
*
|
2013-05-30 |
2014-12-04 |
The Board of Regents of the Nevada System of Higher Education on behalf of the University of |
Novel suicidal lsd1 inhibitors targeting sox2-expressing cancer cells
|
|
ES2897946T3
(es)
*
|
2013-07-25 |
2022-03-03 |
Dong A St Co Ltd |
Método para preparar un derivado de benzamida, intermedio novedoso utilizado en la preparación de la benzamida y método para preparar un intermedio novedoso
|
|
ES2734209T3
(es)
*
|
2013-08-06 |
2019-12-04 |
Imago Biosciences Inc |
Inhibidores de KDM1A para el tratamiento de enfermedades
|
|
JP6602779B2
(ja)
|
2014-02-13 |
2019-11-06 |
インサイト・コーポレイション |
Lsd1阻害剤としてのシクロプロピルアミン類
|
|
US9527835B2
(en)
|
2014-02-13 |
2016-12-27 |
Incyte Corporation |
Cyclopropylamines as LSD1 inhibitors
|
|
EP3105219B9
(en)
|
2014-02-13 |
2018-10-03 |
Incyte Corporation |
Cyclopropylamines as lsd1 inhibitors
|
|
EP3105218B1
(en)
*
|
2014-02-13 |
2019-09-25 |
Incyte Corporation |
Cyclopropylamines as lsd1 inhibitors
|
|
CN104042616B
(zh)
*
|
2014-02-20 |
2016-08-24 |
复旦大学附属眼耳鼻喉科医院 |
赖氨酸特异性去甲基化酶1抑制剂的应用
|
|
MY180575A
(en)
|
2014-04-11 |
2020-12-02 |
Takeda Pharmaceuticals Co |
Cyclopropanamine compound and use thereof
|
|
KR102400920B1
(ko)
|
2014-05-01 |
2022-05-20 |
셀젠 콴티셀 리서치, 인크. |
리신 특이적 데메틸라제-1의 억제제
|
|
US9695180B2
(en)
|
2014-07-10 |
2017-07-04 |
Incyte Corporation |
Substituted imidazo[1,2-a]pyrazines as LSD1 inhibitors
|
|
US9695167B2
(en)
|
2014-07-10 |
2017-07-04 |
Incyte Corporation |
Substituted triazolo[1,5-a]pyridines and triazolo[1,5-a]pyrazines as LSD1 inhibitors
|
|
US9758523B2
(en)
|
2014-07-10 |
2017-09-12 |
Incyte Corporation |
Triazolopyridines and triazolopyrazines as LSD1 inhibitors
|
|
WO2016007731A1
(en)
|
2014-07-10 |
2016-01-14 |
Incyte Corporation |
Imidazopyridines and imidazopyrazines as lsd1 inhibitors
|
|
SG11201701182VA
(en)
|
2014-08-27 |
2017-03-30 |
Gilead Sciences Inc |
Compounds and methods for inhibiting histone demethylases
|
|
WO2016055935A1
(en)
*
|
2014-10-06 |
2016-04-14 |
Glaxosmithkline Intellectual Property (No.2) Limited |
Combination of lysine-specific demethylase 1 inhibitor and thrombopoietin agonist
|
|
EA039196B1
(ru)
*
|
2014-10-08 |
2021-12-16 |
Инсайт Корпорейшн |
Циклопропиламины в качестве ингибиторов lsd1
|
|
WO2016123387A1
(en)
*
|
2015-01-30 |
2016-08-04 |
Genentech, Inc. |
Therapeutic compounds and uses thereof
|
|
CA2976350C
(en)
|
2015-02-12 |
2023-09-19 |
Hugh Young Rienhoff, Jr. |
Kdm1a inhibitors for the treatment of disease
|
|
EP3277689B1
(en)
|
2015-04-03 |
2019-09-04 |
Incyte Corporation |
Heterocyclic compounds as lsd1 inhibitors
|
|
US10526287B2
(en)
|
2015-04-23 |
2020-01-07 |
Constellation Pharmaceuticals, Inc. |
LSD1 inhibitors and uses thereof
|
|
EP3090998A1
(en)
|
2015-05-06 |
2016-11-09 |
F. Hoffmann-La Roche AG |
Solid forms
|
|
AU2016275702A1
(en)
|
2015-06-12 |
2017-12-21 |
Oryzon Genomics, S.A. |
Biomarkers associated with LSD1 inhibitors and uses thereof
|
|
WO2017013061A1
(en)
|
2015-07-17 |
2017-01-26 |
Oryzon Genomics, S.A. |
Biomarkers associated with lsd1 inhibitors and uses thereof
|
|
MY189367A
(en)
*
|
2015-08-12 |
2022-02-08 |
Incyte Corp |
Salts of an lsd1 inhibitor
|
|
EP3341353A1
(en)
|
2015-08-27 |
2018-07-04 |
Genentech, Inc. |
Therapeutic compounds and methods of use thereof
|
|
US10059668B2
(en)
*
|
2015-11-05 |
2018-08-28 |
Mirati Therapeutics, Inc. |
LSD1 inhibitors
|
|
US10899732B2
(en)
|
2015-11-25 |
2021-01-26 |
Genentech, Inc. |
Substituted benzamides useful as sodium channel blockers
|
|
WO2017097865A1
(en)
*
|
2015-12-07 |
2017-06-15 |
Istituto Europeo Di Oncologia |
Combination of caloric restriction (cr) or igf1/insulin receptor inhibitor with lsd1 inhibitor
|
|
US9809541B2
(en)
|
2015-12-29 |
2017-11-07 |
Mirati Therapeutics, Inc. |
LSD1 inhibitors
|
|
RU2018127657A
(ru)
|
2015-12-30 |
2020-01-31 |
Новартис Аг |
Виды терапии на основе иммуноэффекторных клеток с улучшенной эффективностью
|
|
CA3017408C
(en)
|
2016-03-15 |
2025-08-19 |
Oryzon Genomics, S.A. |
LSD1 INHIBITOR COMBINATIONS FOR THE TREATMENT OF HEMATOLOGICAL MALIGNITIS
|
|
ES3057783T3
(en)
|
2016-03-15 |
2026-03-04 |
Oryzon Genomics Sa |
Combinations of lsd1 inhibitors for use in the treatment of neoplastic diseases
|
|
WO2017158136A1
(en)
|
2016-03-16 |
2017-09-21 |
Oryzon Genomics, S.A. |
Methods to determine kdm1a target engagement and chemoprobes useful therefor
|
|
CN107200706A
(zh)
*
|
2016-03-16 |
2017-09-26 |
中国科学院上海药物研究所 |
一类氟取代的环丙胺类化合物及其制备方法、药物组合物和用途
|
|
EP3854782A1
(en)
|
2016-03-30 |
2021-07-28 |
Genentech, Inc. |
Substituted benzamides and methods of use thereof
|
|
TWI833686B
(zh)
|
2016-04-22 |
2024-03-01 |
美商英塞特公司 |
Lsd1 抑制劑之調配物
|
|
CN107459476B
(zh)
*
|
2016-06-03 |
2022-06-24 |
中国科学院上海药物研究所 |
反吲哚啉环丙胺类化合物及其制备方法、药物组合物和用途
|
|
RS58951B1
(sr)
|
2016-06-10 |
2019-08-30 |
Oryzon Genomics Sa |
Lečenje multiple skleroze
|
|
WO2018020366A1
(en)
|
2016-07-26 |
2018-02-01 |
Glaxosmithkline Intellectual Property (No.2) Limited |
Crystalline (r)-mandelate salt of (1r,2s)-2-phenylcyclopropylamine
|
|
SG10201610038SA
(en)
*
|
2016-07-29 |
2017-12-28 |
Apple Inc |
Systems and methods for management of asymmetrical multi-tapped battery packs
|
|
CN111194306B
(zh)
|
2016-08-16 |
2023-05-16 |
伊美格生物科学公司 |
用于制备kdm1a抑制剂的方法和过程
|
|
AU2017347549A1
(en)
|
2016-10-17 |
2019-05-02 |
Genentech, Inc. |
Therapeutic compounds and methods of use thereof
|
|
EP3535414A1
(en)
|
2016-11-03 |
2019-09-11 |
Oryzon Genomics, S.A. |
Pharmacodynamic biomarkers for personalized cancer care using epigenetic modifying agents
|
|
WO2018083189A1
(en)
|
2016-11-03 |
2018-05-11 |
Oryzon Genomics, S.A. |
Biomarkers for determining responsiveness to lsd1 inhibitors
|
|
MA51507A
(fr)
|
2016-12-09 |
2020-11-11 |
Constellation Pharmaceuticals Inc |
Marqueurs pour un traitement personnalisé du cancer avec des inhibiteurs de lsd1
|
|
US11433053B2
(en)
|
2017-01-24 |
2022-09-06 |
Medshine Discovery Inc. |
LSD1 inhibitor and preparation method and application thereof
|
|
JP2020511511A
(ja)
|
2017-03-24 |
2020-04-16 |
ジェネンテック, インコーポレイテッド |
ナトリウムチャネル阻害剤としての4−ピペリジン−n−(ピリミジン−4−イル)クロマン−7−スルホンアミド誘導体
|
|
WO2018197583A1
(en)
|
2017-04-26 |
2018-11-01 |
Istituto Europeo Di Oncologia |
Use of a combinational therapy of lsd1 inhibitors with p21 activators in the treatment of cancer
|
|
TWI770925B
(zh)
|
2017-05-26 |
2022-07-11 |
日商大鵬藥品工業股份有限公司 |
使用有新穎聯苯化合物之抗腫瘤效果增強劑
|
|
KR102361918B1
(ko)
|
2017-05-26 |
2022-02-14 |
다이호야쿠힌고교 가부시키가이샤 |
신규 비페닐 화합물 또는 그의 염
|
|
AU2018276611B2
(en)
|
2017-05-31 |
2022-01-06 |
Taiho Pharmaceutical Co., Ltd. |
Method for predicting therapeutic effect of LSD1 inhibitor based on expression of INSM1
|
|
KR20180134675A
(ko)
*
|
2017-06-09 |
2018-12-19 |
한미약품 주식회사 |
시클로프로필아민 유도체 화합물 및 이의 용도
|
|
JP2020152641A
(ja)
*
|
2017-07-07 |
2020-09-24 |
国立研究開発法人理化学研究所 |
リジン特異的脱メチル化酵素1阻害活性を有する新規化合物、その製造方法及びその用途
|
|
FI3661510T3
(fi)
|
2017-08-03 |
2024-12-18 |
Oryzon Genomics Sa |
Menetelmiä käyttäytymismuutosten hoitamiseksi
|
|
AR112900A1
(es)
|
2017-09-13 |
2019-12-26 |
Hanmi Pharm Ind Co Ltd |
Compuesto derivado de pirazol y uso de este
|
|
WO2019068326A1
(en)
|
2017-10-05 |
2019-04-11 |
Université D'aix-Marseille |
INHIBITORS OF LSD1 FOR THE TREATMENT AND PREVENTION OF CARDIOMYOPATHIES
|
|
KR20190040763A
(ko)
|
2017-10-11 |
2019-04-19 |
한미약품 주식회사 |
피라졸로피리딘 유도체 화합물 및 이의 용도
|
|
KR20190040783A
(ko)
|
2017-10-11 |
2019-04-19 |
한미약품 주식회사 |
라이신 특이적 데메틸라제-1 억제제로서의 피라졸 유도체
|
|
WO2019083971A1
(en)
|
2017-10-23 |
2019-05-02 |
Children's Medical Center Corporation |
METHODS OF TREATING CANCER USING LSD1 INHIBITORS IN COMBINATION WITH IMMUNOTHERAPY
|
|
WO2019109095A1
(en)
*
|
2017-12-01 |
2019-06-06 |
Beth Israel Deaconess Medical Center, Inc. |
Arsenic trioxide and retinoic acid compounds for treatment of idh2-associated disorders
|
|
CN108107199B
(zh)
*
|
2017-12-21 |
2019-02-12 |
广州市进德生物科技有限公司 |
一种酶化学发光法测定尿酸的检测试剂盒
|
|
AR114263A1
(es)
|
2018-02-26 |
2020-08-12 |
Genentech Inc |
Compuestos terapéuticos y métodos para utilizarlos
|
|
WO2019191702A1
(en)
|
2018-03-30 |
2019-10-03 |
F. Hoffmann-La Roche Ag |
Substituted hydro-pyrido-azines as sodium channel inhibitors
|
|
EP3790867B1
(en)
|
2018-05-11 |
2024-03-27 |
Imago Biosciences Inc. |
Kdm1a inhibitors for the treatment of disease
|
|
TW202003490A
(zh)
|
2018-05-22 |
2020-01-16 |
瑞士商赫孚孟拉羅股份公司 |
治療性化合物及其使用方法
|
|
CA3106484C
(en)
*
|
2018-07-20 |
2024-06-25 |
Cspc Zhongqi Pharmaceutical Technology (Shijiazhuang) Co., Ltd. |
A salt of an lsd1 inhibitor and its crystal form
|
|
US10968200B2
(en)
|
2018-08-31 |
2021-04-06 |
Incyte Corporation |
Salts of an LSD1 inhibitor and processes for preparing the same
|
|
WO2020052647A1
(zh)
*
|
2018-09-13 |
2020-03-19 |
南京明德新药研发有限公司 |
作为lsd1抑制剂的杂螺环类化合物及其应用
|
|
CN112689638B
(zh)
*
|
2018-09-13 |
2022-11-08 |
南昌弘益药业有限公司 |
作为lsd1抑制剂的环丙胺类化合物及其应用
|
|
US20220024891A1
(en)
*
|
2018-12-04 |
2022-01-27 |
The Board Of Regents Of The University Of Texas System |
Therapeutics targeting mutant adenomatous polyposis coli (apc) for the treatment of cancer
|
|
WO2020138398A1
(ja)
*
|
2018-12-28 |
2020-07-02 |
国立研究開発法人理化学研究所 |
リジン特異的脱メチル化酵素1を阻害する新規化合物、その製造方法及びその用途
|
|
CN113365996B
(zh)
*
|
2019-02-01 |
2024-09-03 |
韩美药品株式会社 |
咪唑吡啶衍生化合物以及药物组成物
|
|
US12479845B2
(en)
|
2019-02-01 |
2025-11-25 |
Hanmi Pharm. Co., Ltd. |
Imidazopyridine derivative compounds and use of same
|
|
US20220151999A1
(en)
|
2019-03-20 |
2022-05-19 |
Oryzon Genomics, S.A. |
Methods of treating attention deficit hyperactivity disorder using kdm1a inhibitors such as the compound vafidemstat
|
|
LT3941466T
(lt)
|
2019-03-20 |
2026-02-25 |
Oryzon Genomics, S.A. |
Vafidemstatas ribinio asmenybės sutrikimo simptomų, nesusijusių su agresija, gydymui
|
|
CN114341366A
(zh)
|
2019-07-05 |
2022-04-12 |
奥莱松基因组股份有限公司 |
用于使用kdm1a抑制剂个体化治疗小细胞肺癌的生物标志物和方法
|
|
WO2021058024A1
(zh)
*
|
2019-09-29 |
2021-04-01 |
南京明德新药研发有限公司 |
Lsd1抑制剂
|
|
CN115915992A
(zh)
*
|
2020-05-28 |
2023-04-04 |
耐克创新有限合伙公司 |
包括流体移动控制器和可调节足部支撑压力的足部支撑系统
|
|
EP3964204A1
(en)
|
2020-09-08 |
2022-03-09 |
Université d'Aix-Marseille |
Lsd1 inhibitors for use in the treatment and prevention of fibrosis of tissues
|
|
WO2022171044A1
(zh)
*
|
2021-02-09 |
2022-08-18 |
南昌弘益药业有限公司 |
一种氧氮杂螺环化合物、其盐型及其晶型
|
|
US20250073232A1
(en)
|
2021-04-08 |
2025-03-06 |
Oryzon Genomics, S.A. |
Combinations of lsd1 inhibitors for treating myeloid cancers
|
|
CN116888122A
(zh)
*
|
2021-06-22 |
2023-10-13 |
南昌弘益药业有限公司 |
含氮氧杂螺环类化合物及其应用
|
|
CN113512031B
(zh)
*
|
2021-07-01 |
2024-01-30 |
都创(上海)医药开发有限公司 |
一种lsd1酶抑制剂tak-418中间体化合物制备方法
|
|
EP4419093A1
(en)
|
2021-10-20 |
2024-08-28 |
Queen Mary University of London |
Sequential treatments and biomarkers to reverse resistance to kinase inhibitors
|
|
GB202115017D0
(en)
|
2021-10-20 |
2021-12-01 |
Univ London Queen Mary |
Sequential treatments and biomarkers to reverse resistance to kinase inhibitors
|
|
US20250295660A1
(en)
|
2022-05-09 |
2025-09-25 |
Oryzon Genomics, S.A. |
Methods of treating nf1-mutant tumors using lsd1 inhibitors
|
|
EP4522136A1
(en)
|
2022-05-09 |
2025-03-19 |
Oryzon Genomics, S.A. |
Methods of treating malignant peripheral nerve sheath tumor (mpnst) using lsd1 inhibitors
|
|
CN120529900A
(zh)
|
2022-11-24 |
2025-08-22 |
奥莱松基因组股份有限公司 |
用于治疗癌症的LSD1抑制剂和Menin抑制剂的组合
|
|
TW202508595A
(zh)
|
2023-05-04 |
2025-03-01 |
美商銳新醫藥公司 |
用於ras相關疾病或病症之組合療法
|
|
US20250049810A1
(en)
|
2023-08-07 |
2025-02-13 |
Revolution Medicines, Inc. |
Methods of treating a ras protein-related disease or disorder
|
|
CN117164465B
(zh)
*
|
2023-09-04 |
2025-07-01 |
郑州大学 |
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