JP2012107057A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2012107057A5 JP2012107057A5 JP2012040330A JP2012040330A JP2012107057A5 JP 2012107057 A5 JP2012107057 A5 JP 2012107057A5 JP 2012040330 A JP2012040330 A JP 2012040330A JP 2012040330 A JP2012040330 A JP 2012040330A JP 2012107057 A5 JP2012107057 A5 JP 2012107057A5
- Authority
- JP
- Japan
- Prior art keywords
- pharmaceutically acceptable
- acceptable salt
- following formula
- salt
- formula
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 150000003839 salts Chemical class 0.000 claims 4
Applications Claiming Priority (8)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US68172305P | 2005-05-17 | 2005-05-17 | |
| US68177205P | 2005-05-17 | 2005-05-17 | |
| US68172205P | 2005-05-17 | 2005-05-17 | |
| US68168405P | 2005-05-17 | 2005-05-17 | |
| US60/681,723 | 2005-05-17 | ||
| US60/681,772 | 2005-05-17 | ||
| US60/681,722 | 2005-05-17 | ||
| US60/681,684 | 2005-05-17 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008512519A Division JP5794721B2 (ja) | 2005-05-17 | 2006-05-17 | 眼障害の治療のための組成物および方法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2012107057A JP2012107057A (ja) | 2012-06-07 |
| JP2012107057A5 true JP2012107057A5 (https=) | 2012-10-25 |
Family
ID=37431594
Family Applications (7)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008512519A Active JP5794721B2 (ja) | 2005-05-17 | 2006-05-17 | 眼障害の治療のための組成物および方法 |
| JP2012040330A Pending JP2012107057A (ja) | 2005-05-17 | 2012-02-27 | 眼障害の治療のための組成物および方法 |
| JP2012225028A Active JP6288907B2 (ja) | 2005-05-17 | 2012-10-10 | 眼障害の治療のための組成物および方法 |
| JP2015137500A Withdrawn JP2015187165A (ja) | 2005-05-17 | 2015-07-09 | 眼障害の治療のための組成物および方法 |
| JP2017099005A Withdrawn JP2017141297A (ja) | 2005-05-17 | 2017-05-18 | 眼障害の治療のための組成物および方法 |
| JP2019022433A Active JP6816180B2 (ja) | 2005-05-17 | 2019-02-12 | 眼障害の治療のための組成物および方法 |
| JP2020030710A Pending JP2020079312A (ja) | 2005-05-17 | 2020-02-26 | 眼障害の治療のための組成物および方法 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008512519A Active JP5794721B2 (ja) | 2005-05-17 | 2006-05-17 | 眼障害の治療のための組成物および方法 |
Family Applications After (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012225028A Active JP6288907B2 (ja) | 2005-05-17 | 2012-10-10 | 眼障害の治療のための組成物および方法 |
| JP2015137500A Withdrawn JP2015187165A (ja) | 2005-05-17 | 2015-07-09 | 眼障害の治療のための組成物および方法 |
| JP2017099005A Withdrawn JP2017141297A (ja) | 2005-05-17 | 2017-05-18 | 眼障害の治療のための組成物および方法 |
| JP2019022433A Active JP6816180B2 (ja) | 2005-05-17 | 2019-02-12 | 眼障害の治療のための組成物および方法 |
| JP2020030710A Pending JP2020079312A (ja) | 2005-05-17 | 2020-02-26 | 眼障害の治療のための組成物および方法 |
Country Status (15)
| Country | Link |
|---|---|
| US (34) | US8168655B2 (https=) |
| EP (3) | EP3195861A1 (https=) |
| JP (7) | JP5794721B2 (https=) |
| CN (2) | CN101175488B (https=) |
| AU (1) | AU2006247136C1 (https=) |
| CA (3) | CA2960117C (https=) |
| CY (1) | CY1118660T1 (https=) |
| DK (2) | DK2444079T3 (https=) |
| ES (2) | ES2614080T3 (https=) |
| HU (1) | HUE031979T2 (https=) |
| LT (1) | LT2444079T (https=) |
| PL (2) | PL1881823T3 (https=) |
| PT (2) | PT1881823E (https=) |
| SI (2) | SI2444079T1 (https=) |
| WO (1) | WO2006125119A1 (https=) |
Families Citing this family (101)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2004287875B2 (en) * | 2003-11-05 | 2011-06-02 | Bausch + Lomb Ireland Limited | Modulators of cellular adhesion |
| KR101411167B1 (ko) | 2005-04-13 | 2014-06-23 | 아스텍스 테라퓨틱스 리미티드 | 하이드록시벤즈아미드 유도체 및 hsp90 억제제로서의이의 용도 |
| DK2444079T3 (en) * | 2005-05-17 | 2017-01-30 | Sarcode Bioscience Inc | Compositions and Methods for the Treatment of Eye Diseases |
| US7202209B2 (en) * | 2005-07-13 | 2007-04-10 | Allergan, Inc. | Cyclosporin compositions |
| US7754725B2 (en) | 2006-03-01 | 2010-07-13 | Astex Therapeutics Ltd. | Dihydroxyphenyl isoindolymethanones |
| JP5528807B2 (ja) | 2006-10-12 | 2014-06-25 | アステックス、セラピューティックス、リミテッド | 複合薬剤 |
| GB0620259D0 (en) | 2006-10-12 | 2006-11-22 | Astex Therapeutics Ltd | Pharmaceutical compounds |
| JP5518478B2 (ja) | 2006-10-12 | 2014-06-11 | アステックス、セラピューティックス、リミテッド | 医薬化合物 |
| WO2008044041A1 (en) | 2006-10-12 | 2008-04-17 | Astex Therapeutics Limited | Pharmaceutical combinations |
| KR100930467B1 (ko) * | 2007-06-07 | 2009-12-08 | 동아제약주식회사 | 점액분비를 촉진시키는 3',4',5-트리메톡시 플라본 유도체화합물, 그의 제조방법 및 약학적 용도 |
| ES2630406T3 (es) * | 2007-10-19 | 2017-08-21 | Sarcode Bioscience Inc. | Composición y procedimientos para el tratamiento de la retinopatía diabética |
| EP2276508A4 (en) * | 2008-04-15 | 2011-12-28 | Sarcode Bioscience Inc | ADMINISTRATION OF LFA-1 ANTAGONISTS TO THE GASTROINTESTINAL SYSTEM |
| WO2009128934A1 (en) | 2008-04-15 | 2009-10-22 | Sarcode Corporation | Topical lfa-1 antagonists for use in localized treatment of immune related disorders |
| EP2265124A4 (en) * | 2008-04-15 | 2011-12-28 | Sarcode Bioscience Inc | AEROSOLISED LFA-1 ANTAGONISTS FOR THE USE IN THE LOCAL TREATMENT OF IMMUNE DISEASES |
| CN105943534A (zh) * | 2008-04-15 | 2016-09-21 | 萨可德生物科学公司 | 用于局部治疗免疫相关疾病的局部lfa-1拮抗剂 |
| US8080562B2 (en) | 2008-04-15 | 2011-12-20 | Sarcode Bioscience Inc. | Crystalline pharmaceutical and methods of preparation and use thereof |
| CA2722923C (en) | 2008-04-29 | 2016-08-02 | Boehringer Ingelheim International Gmbh | Indazole compounds as ccr1 receptor antagonists |
| JP5411927B2 (ja) | 2008-05-06 | 2014-02-12 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | Ccr1アンタゴニストとしてのピラゾール化合物 |
| US8506944B2 (en) * | 2008-05-07 | 2013-08-13 | The Regents Of The University Of California | Replenishment and enrichment of ocular surface lubrication |
| HUE024146T2 (en) * | 2008-05-07 | 2016-02-29 | Univ California | Medical filling and enrichment of eye surface lubrication |
| EP2346868B1 (en) | 2008-09-26 | 2016-01-27 | Boehringer Ingelheim International Gmbh | Azaindazole compounds as ccr1 receptor antagonists |
| BRPI1010974A2 (pt) | 2009-05-22 | 2019-09-24 | Exelixis Inc | benzoxazepinas baseada em inibidores p13k/ m tor contra doenças proliferativas |
| US8952034B2 (en) | 2009-07-27 | 2015-02-10 | Gilead Sciences, Inc. | Fused heterocyclic compounds as ion channel modulators |
| US8378105B2 (en) | 2009-10-21 | 2013-02-19 | Sarcode Bioscience Inc. | Crystalline pharmaceutical and methods of preparation and use thereof |
| EP2491028B1 (en) | 2009-10-21 | 2013-12-11 | Boehringer Ingelheim International GmbH | Indazole and pyrazolopyridine compounds as ccr1 receptor antagonists |
| EP2493875B1 (en) | 2009-10-27 | 2014-08-06 | Boehringer Ingelheim International GmbH | Heterocyclic compounds as ccr1 receptor antagonists |
| CA2782384A1 (en) * | 2009-12-08 | 2011-06-16 | Boehringer Ingelheim International Gmbh | Process for synthesis of intermediates useful for making substituted indazole and azaindazole compounds |
| WO2011137109A1 (en) | 2010-04-30 | 2011-11-03 | Boehringer Ingelheim International Gmbh | Azaindazole amide compounds as ccr1 receptor antagonists |
| BR112012033402A2 (pt) | 2010-07-02 | 2017-01-24 | Gilead Sciences Inc | moduladores de canais de íons conforme os compostos heterocíclicos fundidos |
| EP2655371B1 (en) | 2010-12-23 | 2015-02-25 | Boehringer Ingelheim International GmbH | Pyrazolopiperidine compounds as ccr1 receptor antagonists |
| US8933119B2 (en) | 2011-01-03 | 2015-01-13 | The William M. Yarbrough Foundation | Method for treating phytophotodermatitis |
| US11279674B2 (en) | 2011-01-03 | 2022-03-22 | The William M. Yarbrough Foundation | Isothiocyanate functional surfactant and associated method of use |
| US11407713B2 (en) | 2011-01-03 | 2022-08-09 | The William M. Yarbrough Foundation | Isothiocyanate functional surfactants, formulations incorporating the same, and associated methods of use |
| US9962361B2 (en) | 2011-01-03 | 2018-05-08 | The William M. Yarbrough Foundation | Isothiocyanate functional surfactants, formulations incorporating the same, and associated methods of use |
| US10640464B2 (en) | 2011-01-03 | 2020-05-05 | The William M. Yarbrough Foundation | Use of isothiocyanate functional surfactants as Nrf2 inducers to treat epidermolysis bullosa simplex and related diseases |
| US10308599B2 (en) | 2011-01-03 | 2019-06-04 | The William M. Yarbrough Foundation | Isothiocyanate functional surfactants, formulations incorporating the same, and associated methods of use |
| US10647668B2 (en) | 2011-01-03 | 2020-05-12 | The William M. Yarbrough Foundation | Isothiocyanate functional surfactant and associated method of use |
| US10273205B2 (en) | 2011-01-03 | 2019-04-30 | The William M. Yarbrough Foundation | Isothiocyanate functional surfactants, formulations incorporating isothiocyanate functional surfactants and associated methods for treating biofilms |
| US8865765B2 (en) | 2011-01-12 | 2014-10-21 | The William M. Yarbrough Foundation | Method for treating eczema |
| US9532969B2 (en) | 2011-02-08 | 2017-01-03 | The William M. Yarbrough Foundation | Method for treating psoriasis |
| CA2834164A1 (en) | 2011-05-10 | 2012-11-15 | Gilead Sciences, Inc. | Fused benzoxazinones as ion channel modulators |
| TW201837023A (zh) | 2011-07-01 | 2018-10-16 | 美商基利科學股份有限公司 | 作為離子通道調節劑之稠合雜環化合物 |
| NO3175985T3 (https=) | 2011-07-01 | 2018-04-28 | ||
| CA2857127A1 (en) * | 2012-01-27 | 2013-08-01 | F. Hoffmann-La Roche Ag | Integrin antagonist conjugates for targeted delivery to cells expressing lfa-1 |
| US8889730B2 (en) | 2012-04-10 | 2014-11-18 | Pfizer Inc. | Indole and indazole compounds that activate AMPK |
| CA2879982C (en) | 2012-07-25 | 2020-09-01 | Sarcode Bioscience Inc. | Lfa-1 inhibitor and polymorph thereof |
| US10335387B2 (en) | 2012-07-26 | 2019-07-02 | The William M. Yarbrough Foundation | Method for treating infectious diseases with isothiocyanate functional compounds |
| US9839621B2 (en) | 2012-07-26 | 2017-12-12 | The William M. Yarbrough Foundation | Method for treating bladder cancer |
| US8865772B2 (en) | 2012-07-26 | 2014-10-21 | The William M. Yarbrough Foundation | Method for treating skin cancer |
| US9949943B2 (en) | 2012-07-26 | 2018-04-24 | The William M. Yarbrough Foundation | Method for treating neurodegenerative diseases |
| US10441561B2 (en) | 2012-07-26 | 2019-10-15 | The William M. Yanbrough Foundation | Method for treating benign prostatic hyperplasia (BPH), prostatitis, and prostate cancer |
| US10080734B2 (en) | 2012-07-26 | 2018-09-25 | The William M. Yarbrough Foundation | Method for treating autism and other neurodevelopmental disorders |
| US10434082B2 (en) | 2012-07-26 | 2019-10-08 | The William M. Yarbrough Foundation | Isothiocyanate functional compounds augmented with secondary antineoplastic medicaments and associated methods for treating neoplasms |
| US10434081B2 (en) | 2012-07-26 | 2019-10-08 | The William M. Yarbrough Foundation | Inhibitors of macrophage migration inhibitory factor |
| WO2014092958A1 (en) * | 2012-12-10 | 2014-06-19 | Molecular Targeting Technologies, Inc. | Compositions and methods of diagnosing ocular diseases |
| EA028008B1 (ru) * | 2012-12-19 | 2017-09-29 | Саркоуд Байосайенс Инк. | Составы ингибитора lfa-1 |
| JP6064062B2 (ja) | 2013-03-15 | 2017-01-18 | ファイザー・インク | Ampkを活性化させるインダゾール化合物 |
| CN113230021A (zh) | 2015-01-12 | 2021-08-10 | 科达莱昂治疗公司 | 微滴递送设备和方法 |
| ES2835274T3 (es) * | 2015-07-08 | 2021-06-22 | Axerovision Inc | Composiciones farmacéuticas que contienen un antagonista de la integrina alfa 4 para el tratamiento de afecciones inflamatorias oculares |
| CN106995439B (zh) * | 2016-01-26 | 2019-09-20 | 镇江圣安医药有限公司 | 氘取代3-(甲磺酰基)-l-苯丙氨酸衍生物及其药物组合物、药物制剂和用途 |
| US10799447B2 (en) | 2016-03-04 | 2020-10-13 | James M. Rynerson | Method of treating an eye disorder by inhibiting or disrupting bacterial biofilm formation |
| MX2019001633A (es) | 2016-08-12 | 2019-09-18 | Silk Tech Ltd | Proteina derivada de la seda para el tratamiento de la inflamacion. |
| US11903986B2 (en) | 2016-08-19 | 2024-02-20 | Akrivista Llc | Methods of diagnosing and treating dry eye syndrome and compositions for treating a human eye |
| US9981041B2 (en) * | 2016-08-23 | 2018-05-29 | Ira Jason Salzman | Ophthalmic lubricating spray |
| CN110072523A (zh) * | 2016-09-07 | 2019-07-30 | 格利亚有限责任公司 | 通过脑神经的药理皮肤激活来治疗与神经退行性病症相关的症状 |
| KR102412086B1 (ko) | 2017-01-20 | 2022-06-22 | 켄달리온 테라퓨틱스 인코포레이티드 | 압전 유체 분배기 |
| CN109134533B (zh) | 2017-06-27 | 2020-08-11 | 维眸生物科技(上海)有限公司 | 一种含磷化合物及其制备和应用 |
| ES2876292T3 (es) | 2017-07-24 | 2021-11-12 | Interquim Sa | Procedimiento de preparación y purificación del antagonista de LFA-1 lifitegrast |
| CN114376961A (zh) | 2017-08-18 | 2022-04-22 | 阿克里维斯塔有限责任公司 | 诊断和治疗干眼综合症的方法和用于治疗人类眼睛的组合物 |
| MX2020003242A (es) | 2017-09-22 | 2020-09-18 | Jubilant Epipad LLC | Compuestos heterociclicos como inhibidores de pad. |
| KR20200085836A (ko) | 2017-11-06 | 2020-07-15 | 주빌런트 프로델 엘엘씨 | Pd1/pd-l1 활성화 억제제로서의 피리미딘 유도체 |
| WO2019097547A1 (en) | 2017-11-15 | 2019-05-23 | Cipla Limited | An improved process for the preparation of lifitegrast or salts thereof |
| WO2019096996A1 (en) | 2017-11-17 | 2019-05-23 | Medichem, S.A. | A process to obtain a tetrahydroisoquinoline derivative |
| BR112020010322A2 (pt) | 2017-11-24 | 2020-11-17 | Jubilant Episcribe Llc | composto da fórmula i; composto da fórmula ia; composto da fórmula ib; processo de preparação de compostos da fórmula i; composição farmacêutica; método para o tratamento e/ou prevenção de várias doenças; uso dos compostos; método para o tratamento de câncer; e método para o tratamento e/ou prevenção de uma afecção mediada por prmt5 ou um distúrbio proliferativo ou câncer |
| WO2019113483A1 (en) | 2017-12-08 | 2019-06-13 | Kedalion Therapeutics, Inc. | Fluid delivery alignment system |
| SG11202008950PA (en) | 2018-03-13 | 2020-10-29 | Jubilant Prodel LLC | Bicyclic compounds as inhibitors of pd1/pd-l1 interaction/activation |
| US12350194B1 (en) | 2018-04-12 | 2025-07-08 | Bausch + Lomb Ireland Limited | Topical ocular delivery of fluids with controlled mass dosing and wireless communication |
| US20190314197A1 (en) | 2018-04-12 | 2019-10-17 | Kedalion Therapeutics, Inc. | Topical Ocular Delivery Methods and Devices for Use in the Same |
| CR20200553A (es) | 2018-04-18 | 2021-04-08 | Constellation Pharmaceuticals Inc | Moduladores de enzimas modificadoras de metilo, composiciones y usos de estos |
| CN120097995A (zh) | 2018-05-21 | 2025-06-06 | 星座制药公司 | 甲基修饰酶的调节剂、其组合物和用途 |
| WO2020010116A1 (en) | 2018-07-03 | 2020-01-09 | Kedalion Therapeutics, Inc. | Topical ocular delivery devices and methods for using the same |
| US11166910B2 (en) * | 2019-01-25 | 2021-11-09 | Nordiccan A/S | Cannabinoid chewing gum with sugar alcohols |
| US12097145B2 (en) | 2019-03-06 | 2024-09-24 | Bausch + Lomb Ireland Limited | Vented multi-dose ocular fluid delivery system |
| US11679028B2 (en) | 2019-03-06 | 2023-06-20 | Novartis Ag | Multi-dose ocular fluid delivery system |
| KR20220003555A (ko) | 2019-04-18 | 2022-01-10 | 아주라 오프탈믹스 엘티디 | 안구 장애의 치료를 위한 화합물 및 방법 |
| JP2022529823A (ja) * | 2019-04-22 | 2022-06-24 | アレグロ オフサルミックス エルエルシー | ドライアイの治療に使用可能な組成物および方法 |
| WO2021016414A1 (en) | 2019-07-24 | 2021-01-28 | Constellation Pharmaceuticals, Inc. | Crystalline forms of 7-chloro-2-(4-(3-methoxyazetidin-1-yl)cyclohexyl)-2,4-dimethyl-n-((6-methyl-4-(methylthio)-2-oxo-1,2-dihydropyridin-3-yl)methyl)benzo[d][1,3]dioxole-5-carboxamide |
| US20220267479A1 (en) * | 2019-07-25 | 2022-08-25 | North Carolina State University | Polyiodide binding compounds and methods of use thereof |
| US12496218B1 (en) | 2019-11-12 | 2025-12-16 | Bausch + Lomb Ireland Limited | Fractionated topical ocular drug delivery methods and devices for use in the same |
| EP4057941A4 (en) | 2019-11-15 | 2024-05-29 | Silk Technologies Ltd. | Stable formulations of silk-derived protein |
| CN115768384A (zh) | 2020-04-17 | 2023-03-07 | 科达隆治疗公司 | 流体动力致动的不含防腐剂分配系统 |
| US11938057B2 (en) | 2020-04-17 | 2024-03-26 | Bausch + Lomb Ireland Limited | Hydrodynamically actuated preservative free dispensing system |
| US12090087B2 (en) | 2020-04-17 | 2024-09-17 | Bausch + Lomb Ireland Limited | Hydrodynamically actuated preservative free dispensing system having a collapsible liquid reservoir |
| US12290472B2 (en) | 2020-04-17 | 2025-05-06 | Bausch + Lomb Ireland Limited | Hydrodynamically actuated preservative free dispensing system |
| US11459351B1 (en) | 2021-04-05 | 2022-10-04 | Azura Ophthalmics Ltd. | Compounds and methods for the treatment of ocular disorders |
| US11213551B1 (en) | 2021-04-05 | 2022-01-04 | Korb Research, Llc. | Ocular treatment compositions and methods of use thereof |
| CN115707698A (zh) * | 2021-08-18 | 2023-02-21 | 辽宁何氏医学院 | 5,7-二氯-1,2,3,4-四氢异喹啉-6-甲酰胺类化合物及其制备方法和应用 |
| EP4507786A4 (en) * | 2022-04-13 | 2026-04-22 | Univ California | METHODS OF PLASMA OR SERUM PRODUCTION AND THEIR USES |
| WO2024058212A1 (ja) * | 2022-09-15 | 2024-03-21 | 日油株式会社 | コンタクトレンズ用溶液 |
| WO2024215778A1 (en) * | 2023-04-10 | 2024-10-17 | Insitu Biologics, Inc. | Sustained release stable emulsion pharmaceutical formulations |
| WO2025223511A1 (zh) * | 2024-04-25 | 2025-10-30 | 上海翊石医药科技有限公司 | 一类苯甲酰基甘氨酸衍生物及其制备方法和应用 |
Family Cites Families (120)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US423439A (en) * | 1890-03-18 | Stove-pipe guard and register | ||
| US744A (en) * | 1838-05-17 | Mode of cutting off steam in steam-engines | ||
| GB138135A (en) * | 1918-08-13 | 1920-02-05 | Hugh William Gabbett Fairfax | Improvements in automatic firearms |
| US1680610A (en) * | 1926-09-16 | 1928-08-14 | Mary Y Harmon | Batik-frame support |
| US3773919A (en) * | 1969-10-23 | 1973-11-20 | Du Pont | Polylactide-drug mixtures |
| US3876444A (en) * | 1970-04-24 | 1975-04-08 | Gen Electric | Method of treating high strength carbon fibers |
| IE52535B1 (en) * | 1981-02-16 | 1987-12-09 | Ici Plc | Continuous release pharmaceutical compositions |
| US4713244A (en) | 1985-08-16 | 1987-12-15 | Bausch & Lomb Incorporated | Sustained-release formulation containing an amino acid polymer with a lower alkyl (C1 -C4) polar solvent |
| US4931279A (en) * | 1985-08-16 | 1990-06-05 | Bausch & Lomb Incorporated | Sustained release formulation containing an ion-exchange resin |
| US4668506A (en) | 1985-08-16 | 1987-05-26 | Bausch & Lomb Incorporated | Sustained-release formulation containing and amino acid polymer |
| US5023252A (en) | 1985-12-04 | 1991-06-11 | Conrex Pharmaceutical Corporation | Transdermal and trans-membrane delivery of drugs |
| US4992445A (en) * | 1987-06-12 | 1991-02-12 | American Cyanamid Co. | Transdermal delivery of pharmaceuticals |
| US5001139A (en) | 1987-06-12 | 1991-03-19 | American Cyanamid Company | Enchancers for the transdermal flux of nivadipine |
| GB2209937B (en) * | 1987-09-21 | 1991-07-03 | Depiopharm S A | Water insoluble polypeptides |
| ES2064327T3 (es) | 1987-11-02 | 1995-02-01 | Baylor College Medicine | Uso de icam-1 o de sus derivados funcionales para el tratamiento de una inflamacion no especifica. |
| ATE90570T1 (de) | 1988-01-29 | 1993-07-15 | Sumitomo Pharma | Verbesserte formulierungen mit kontrollierter abgabe. |
| DE3802996A1 (de) * | 1988-02-02 | 1989-08-10 | Cassella Ag | Verwendung von 2-oxo-pyrrolidin-1-acetamid zur bestimmung der glomerulaeren filtrationsrate beim menschen |
| US5424399A (en) * | 1988-06-28 | 1995-06-13 | The Children's Medical Center Corporation | Human CR3α/β heterodimers |
| DE68923048T2 (de) | 1988-08-23 | 1995-11-16 | Dana Farber Cancer Inst Inc | Alpha-Subeinheit des LFA-1-Leukocyt-Adhäsions-Rezeptors. |
| DE68929096T2 (de) | 1988-09-01 | 2000-05-11 | Bayer Corp., Pittsburgh | Menschliches Rhinovirusrezeptorprotein, das die Virusinfektionsanfälligkeit hemmt |
| AU4412889A (en) | 1988-09-28 | 1990-04-18 | Dana-Farber Cancer Institute | Intercellular adhesion molecules, and their binding ligands |
| US5149780A (en) * | 1988-10-03 | 1992-09-22 | The Scripps Research Institute | Peptides and antibodies that inhibit integrin-ligand binding |
| JPH04505009A (ja) | 1989-03-09 | 1992-09-03 | ダナ・ファーバー・キャンサー・インスティチュート | クローニングlfa―1 |
| AU5553290A (en) | 1989-04-28 | 1990-11-29 | Baylor College Of Medicine | Dissemination of hiv-1 infected cells |
| CH679207A5 (https=) | 1989-07-28 | 1992-01-15 | Debiopharm Sa | |
| WO1991019511A1 (en) | 1990-06-18 | 1991-12-26 | The General Hospital Corporation | CONTROLLING CELLULAR IMMUNE/INFLAMMATORY RESPONSES WITH β2 INTEGRINS |
| CA2046830C (en) | 1990-07-19 | 1999-12-14 | Patrick P. Deluca | Drug delivery system involving inter-action between protein or polypeptide and hydrophobic biodegradable polymer |
| US5318965A (en) | 1990-08-24 | 1994-06-07 | Abbott Laboratories | Quinobenzoxazine, antineoplastic agents |
| JPH06500555A (ja) | 1990-08-27 | 1994-01-20 | カイロン コーポレイション | 病気の処置のためのペプチドの薬物 |
| JP2995860B2 (ja) | 1990-11-27 | 1999-12-27 | 味の素株式会社 | 新規ペプチド |
| US5288854A (en) * | 1990-11-28 | 1994-02-22 | Center For Blood Research, Inc. | Functional derivatives of ICAM-1 which are substantially capable of binding to LFA-1 but are substantially incapable of binding to MAC-1 |
| CH683149A5 (fr) * | 1991-07-22 | 1994-01-31 | Debio Rech Pharma Sa | Procédé pour la préparation de microsphères en matériau polymère biodégradable. |
| JP3679112B2 (ja) * | 1991-10-04 | 2005-08-03 | アメリカ合衆国 | 細胞接着分子の遮断による眼の炎症の治療 |
| GB9211268D0 (en) | 1992-05-28 | 1992-07-15 | Ici Plc | Salts of basic peptides with carboxyterminated polyesters |
| US5298492A (en) | 1992-08-04 | 1994-03-29 | Schering Corporation | Diamino acid derivatives as antihypertensives |
| WO1994004188A1 (en) | 1992-08-21 | 1994-03-03 | Genentech, Inc. | Method for treating an lfa-1-mediated disorder |
| AU5466794A (en) | 1992-11-18 | 1994-06-08 | Helsinki University Licensing Ltd Oy | Peptides from human icam-2 and from human icam-1 and their analogs for use in therapy and diagnosis |
| NZ261250A (en) | 1993-01-06 | 1997-08-22 | Kinerton Ltd | Ionic conjugates of polypeptides |
| US5672659A (en) * | 1993-01-06 | 1997-09-30 | Kinerton Limited | Ionic molecular conjugates of biodegradable polyesters and bioactive polypeptides |
| US5424289A (en) * | 1993-07-30 | 1995-06-13 | Alza Corporation | Solid formulations of therapeutic proteins for gastrointestinal delivery |
| US5397791A (en) | 1993-08-09 | 1995-03-14 | Merck & Co., Inc. | Fibrinogen receptor antagonists |
| ES2147210T3 (es) * | 1993-12-03 | 2000-09-01 | Hoffmann La Roche | Derivados de acido acetico como medicamentos. |
| US5470953A (en) * | 1993-12-23 | 1995-11-28 | Icos Corporation | Human β2 integrin α subunit |
| CA2188287A1 (en) | 1994-04-19 | 1995-10-26 | Stephen Benedict | Icam-1/lfa-1 short-chain peptides and method of using same |
| US5849327A (en) | 1994-07-29 | 1998-12-15 | Advanced Polymer Systems, Inc. | Delivery of drugs to the lower gastrointestinal tract |
| US5585359A (en) * | 1994-09-29 | 1996-12-17 | Merck & Co., Inc. | Inhibitors of farnesyl-protein transferase |
| EP0710657B1 (de) * | 1994-11-02 | 1998-08-26 | MERCK PATENT GmbH | Adhäsionsrezeptor-Antagonisten |
| US5612052A (en) | 1995-04-13 | 1997-03-18 | Poly-Med, Inc. | Hydrogel-forming, self-solvating absorbable polyester copolymers, and methods for use thereof |
| US5747035A (en) | 1995-04-14 | 1998-05-05 | Genentech, Inc. | Polypeptides with increased half-life for use in treating disorders involving the LFA-1 receptor |
| ATE288444T1 (de) * | 1995-05-29 | 2005-02-15 | Pfizer | Dipeptide, die die ausschüttung von wachstumshormonen stimulieren |
| US5877224A (en) | 1995-07-28 | 1999-03-02 | Rutgers, The State University Of New Jersey | Polymeric drug formulations |
| US5980945A (en) | 1996-01-16 | 1999-11-09 | Societe De Conseils De Recherches Et D'applications Scientifique S.A. | Sustained release drug formulations |
| US5840332A (en) | 1996-01-18 | 1998-11-24 | Perio Products Ltd. | Gastrointestinal drug delivery system |
| US6111033A (en) | 1996-04-23 | 2000-08-29 | Kinerton, Limited | Acidic polylactic polymers |
| HRP970493A2 (en) | 1996-09-23 | 1998-08-31 | Wienman E. Phlips | Oral delayed immediate release medical formulation and method for preparing the same |
| CA2217134A1 (en) | 1996-10-09 | 1998-04-09 | Sumitomo Pharmaceuticals Co., Ltd. | Sustained release formulation |
| WO1998023608A1 (en) * | 1996-11-27 | 1998-06-04 | Dupont Pharmaceuticals Company | Novel integrin receptor antagonists |
| US5968895A (en) | 1996-12-11 | 1999-10-19 | Praecis Pharmaceuticals, Inc. | Pharmaceutical formulations for sustained drug delivery |
| US5893985A (en) | 1997-03-14 | 1999-04-13 | The Lincoln Electric Company | Plasma arc torch |
| AR012443A1 (es) | 1997-04-16 | 2000-10-18 | Uriach & Cia Sa J | Nuevas carboxamidas como inhibidores de la agregacion plaquetaria, procedimiento para su preparacion, composiciones farmaceuticas que loscontienen y uso de los mismos en la manufactura de medicamentos |
| ES2306482T3 (es) | 1997-08-28 | 2008-11-01 | Novartis Ag | Antagonistas de antigeno-1 funcion con funcion de linfocito. |
| HUP0101587A3 (en) | 1998-03-27 | 2003-03-28 | Genentech Inc | Antagonists for treatment of cd11/cd18 adhesion receptor mediated disorders |
| WO2000003705A1 (en) * | 1998-07-14 | 2000-01-27 | Alcon Laboratories, Inc. | Use of 11-(3-dimethylaminopropylidene)-6,11-dihydrodibenz[b,e]oxepin-2-acetic acid for the manufacture of a medicament for treating non-allergic ophthalmic inflammatory disorders and for the prevention of ocular neovascularization |
| US6331640B1 (en) * | 1998-10-13 | 2001-12-18 | Hoffmann-La Roche Inc. | Diaminopropionic acid derivatives |
| DE69921353T2 (de) | 1998-11-27 | 2005-11-10 | Kanji Takada | Oral anzuwendendes arzneimittel zur wirkstoffverabreichung im magendarmtrakt |
| IT1304152B1 (it) * | 1998-12-10 | 2001-03-08 | Mediolanum Farmaceutici Srl | Composizioni comprendenti un peptide ed acido polilattico-glicolicoatte alla preparazione di impianti sottocutanei aventi un prolungato |
| US6670321B1 (en) * | 1998-12-30 | 2003-12-30 | The Children's Medical Center Corporation | Prevention and treatment for retinal ischemia and edema |
| US6773916B1 (en) * | 1999-01-05 | 2004-08-10 | The Flinders University Of South Australia | Agents and methods for treatment and diagnosis of ocular disorders |
| AU2847200A (en) | 1999-01-27 | 2000-08-18 | G.D. Searle & Co. | Novel hydroxyamidino carboxylate derivatives useful as nitric oxide synthase inhibitors |
| EP1028114A1 (en) * | 1999-02-13 | 2000-08-16 | Aventis Pharma Deutschland GmbH | Novel guanidine derivatives as inhibitors of cell adhesion |
| ES2255490T3 (es) * | 1999-03-31 | 2006-07-01 | Janssen Pharmaceutica N.V. | Almidon pregelatinizado en una formulacion de liberacion controlada. |
| US6645525B1 (en) | 1999-06-23 | 2003-11-11 | Sedum Laboratories, Inc. | Ionically formulated biomolecule microcarriers |
| CN1164334C (zh) | 1999-08-18 | 2004-09-01 | 研究及应用科学协会股份有限公司 | 肽的缓释制剂 |
| ECSP003707A (es) | 1999-10-13 | 2002-05-23 | Novartis Ag | Diazepanes |
| NZ518483A (en) * | 1999-10-22 | 2004-03-26 | Biogen Inc | Use of CD40:CD154 binding interruptor to treat immunological complications of the eye |
| US6605597B1 (en) * | 1999-12-03 | 2003-08-12 | Cv Therapeutics, Inc. | Partial or full A1agonists-N-6 heterocyclic 5′-thio substituted adenosine derivatives |
| US6294522B1 (en) * | 1999-12-03 | 2001-09-25 | Cv Therapeutics, Inc. | N6 heterocyclic 8-modified adenosine derivatives |
| DE60039783D1 (de) * | 1999-12-14 | 2008-09-18 | Genentech Inc | Lfa-1 antagonisten und tnf-alpha antagonisten zur |
| EP1263453A4 (en) | 1999-12-31 | 2008-02-20 | Univ Rutgers | PHARMACEUTICAL FORMULATION CONSISTING OF A POLYMERMATRIX, FOR REGULATING THE TIME-CONTROLLED RELEASE OF BIOLOGICALLY ACTIVE SUBSTANCES |
| US7521061B2 (en) | 1999-12-31 | 2009-04-21 | Rutgers, The State University Of New Jersey | Pharmaceutical formulation for regulating the timed release of biologically active compounds based on a polymer matrix |
| US7326425B2 (en) | 1999-12-31 | 2008-02-05 | Rutgers, The State University | Pharmaceutical formulation composed of a polymer blend and an active compound for time-controlled release |
| AU777721B2 (en) | 2000-01-14 | 2004-10-28 | Larson, Richard | Peptide inhibitors of LFA-1/ICAM-1 interaction |
| US20030064105A1 (en) | 2000-08-25 | 2003-04-03 | Myung-Jin Kim | Lipophilic-coated microparticle containing a protein drug and formulation comprising same |
| US6515124B2 (en) | 2000-02-09 | 2003-02-04 | Hoffman-La Roche Inc. | Dehydroamino acids |
| EP1296943A1 (fr) * | 2000-05-05 | 2003-04-02 | Societe De Conseils De Recherches Et D'applications Scientifiques S.A. (S.C.R.A.S.) | Derives d'aminoacides et leur application a titre de medicaments |
| GB0011817D0 (en) | 2000-05-16 | 2000-07-05 | Pharmacia & Upjohn Spa | Antagonists of integrin receptors |
| NZ523445A (en) * | 2000-06-29 | 2004-10-29 | Abbott Lab | Aryl phenylheterocyclyl sulfide derivatives and their use as cell adhesion-inhibiting anti-inflammatory and immune-suppressive agents |
| AR030817A1 (es) | 2000-10-02 | 2003-09-03 | Novartis Ag | Derivados de diazacicloalcanodiona |
| GB0025208D0 (en) | 2000-10-13 | 2000-11-29 | Euro Celtique Sa | Delayed release pharmaceutical formulations |
| US6653478B2 (en) * | 2000-10-27 | 2003-11-25 | Ortho-Mcneil Pharmaceutical, Inc. | Substituted benzimidazol-2-ones as vasopressin receptor antagonists and neuropeptide Y modulators |
| DE10055857A1 (de) | 2000-11-10 | 2002-08-22 | Creative Peptides Sweden Ab Dj | Neue pharmazeutische Depotformulierung |
| GB0028367D0 (en) * | 2000-11-21 | 2001-01-03 | Celltech Chiroscience Ltd | Chemical compounds |
| AU2002248142B2 (en) * | 2000-11-28 | 2007-11-01 | Genentech, Inc. | LFA-1 antagonist compounds |
| US20030008848A1 (en) | 2000-12-19 | 2003-01-09 | Fleck Roman Wolfgang | Small molecules useful in the treatment of inflammatory disease |
| WO2002058672A2 (en) | 2001-01-26 | 2002-08-01 | Debio Recherche Pharmaceutique S.A. | Microparticles of biodegradable polymer encapsulating a biologically active substance |
| DE60216830T2 (de) * | 2001-02-06 | 2007-06-14 | Pfizer Products Inc., Groton | Pharmazeutische Zusammensetzungen zur Behandlung von Störungen des ZNS oder anderen Erkrankungen |
| WO2002098370A2 (en) * | 2001-03-02 | 2002-12-12 | Medimmune, Inc. | Methods of administering/dosing cd2 antagonists for the prevention and treatment of autoimmune disorders or inflammatory disorders |
| WO2002074247A2 (en) | 2001-03-19 | 2002-09-26 | Praecis Pharmaceuticals Incorporated | Pharmaceutical formulations for sustained release |
| US6872382B1 (en) * | 2001-05-21 | 2005-03-29 | Alcon, Inc. | Use of selective PDE IV inhibitors to treat dry eye disorders |
| JP4583751B2 (ja) | 2001-06-06 | 2010-11-17 | アベンティス・フアーマ・リミテッド | 炎症性疾患の治療に使用するための置換されたテトラヒドロイソキノリン |
| EP1465592A2 (en) | 2001-12-19 | 2004-10-13 | Alza Corporation | Formulation and dosage form for increasing oral bioavailability of hydrophilic macromolecules |
| ATE432689T1 (de) | 2002-03-04 | 2009-06-15 | Ipsen Pharma | Arzneimittelformulierungen mit verzögerter freisetzung mit einem trägerpeptid |
| AU2003250482A1 (en) * | 2002-08-13 | 2004-02-25 | Warner-Lambert Company Llc | Phthalimide derivatives as matrix metalloproteinase inhibitors |
| CA2497977A1 (en) | 2002-09-20 | 2004-04-01 | Alcon, Inc. | Use of cytokine synthesis inhibitors for the treatment of dry eye disorders |
| US7785578B2 (en) * | 2002-10-11 | 2010-08-31 | Aciont, Inc. | Non-invasive ocular drug delivery |
| US7501538B2 (en) | 2003-08-08 | 2009-03-10 | Transtech Pharma, Inc. | Aryl and heteroaryl compounds, compositions and methods of use |
| WO2005014533A2 (en) | 2003-08-08 | 2005-02-17 | Transtech Pharma, Inc. | Aryl and heteroaryl compounds, compositions, and methods of use |
| WO2005042710A1 (en) | 2003-10-28 | 2005-05-12 | The Government Of The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Use of statin to kill ebv-transformed b cells |
| AU2004287875B2 (en) * | 2003-11-05 | 2011-06-02 | Bausch + Lomb Ireland Limited | Modulators of cellular adhesion |
| GT200500139A (es) | 2004-06-08 | 2005-07-25 | Metodo para la preparacion de acidos hidroxamicos | |
| DK2444079T3 (en) * | 2005-05-17 | 2017-01-30 | Sarcode Bioscience Inc | Compositions and Methods for the Treatment of Eye Diseases |
| US7541420B2 (en) * | 2006-06-30 | 2009-06-02 | Sabic Innovative Plastics Ip B.V. | Method for making molded polycarbonate articles with improved color |
| JP4193895B2 (ja) | 2006-10-12 | 2008-12-10 | 横河電機株式会社 | 欠陥検査装置 |
| ES2630406T3 (es) * | 2007-10-19 | 2017-08-21 | Sarcode Bioscience Inc. | Composición y procedimientos para el tratamiento de la retinopatía diabética |
| WO2009128934A1 (en) * | 2008-04-15 | 2009-10-22 | Sarcode Corporation | Topical lfa-1 antagonists for use in localized treatment of immune related disorders |
| US8080562B2 (en) | 2008-04-15 | 2011-12-20 | Sarcode Bioscience Inc. | Crystalline pharmaceutical and methods of preparation and use thereof |
| EP2276508A4 (en) * | 2008-04-15 | 2011-12-28 | Sarcode Bioscience Inc | ADMINISTRATION OF LFA-1 ANTAGONISTS TO THE GASTROINTESTINAL SYSTEM |
| US8337942B2 (en) * | 2009-08-28 | 2012-12-25 | Minsek David W | Light induced plating of metals on silicon photovoltaic cells |
| US8378105B2 (en) | 2009-10-21 | 2013-02-19 | Sarcode Bioscience Inc. | Crystalline pharmaceutical and methods of preparation and use thereof |
| CA2879982C (en) * | 2012-07-25 | 2020-09-01 | Sarcode Bioscience Inc. | Lfa-1 inhibitor and polymorph thereof |
-
2006
- 2006-05-17 DK DK11181066.9T patent/DK2444079T3/en active
- 2006-05-17 CA CA2960117A patent/CA2960117C/en active Active
- 2006-05-17 CN CN2006800171884A patent/CN101175488B/zh not_active Ceased
- 2006-05-17 ES ES11181066.9T patent/ES2614080T3/es active Active
- 2006-05-17 ES ES06770607T patent/ES2530780T3/es active Active
- 2006-05-17 AU AU2006247136A patent/AU2006247136C1/en active Active
- 2006-05-17 HU HUE11181066A patent/HUE031979T2/en unknown
- 2006-05-17 WO PCT/US2006/019327 patent/WO2006125119A1/en not_active Ceased
- 2006-05-17 EP EP16201157.1A patent/EP3195861A1/en not_active Withdrawn
- 2006-05-17 PT PT06770607T patent/PT1881823E/pt unknown
- 2006-05-17 CA CA2609053A patent/CA2609053C/en active Active
- 2006-05-17 PL PL06770607T patent/PL1881823T3/pl unknown
- 2006-05-17 PT PT111810669T patent/PT2444079T/pt unknown
- 2006-05-17 DK DK06770607.7T patent/DK1881823T3/en active
- 2006-05-17 CA CA2985444A patent/CA2985444C/en active Active
- 2006-05-17 US US11/436,906 patent/US8168655B2/en active Active
- 2006-05-17 SI SI200632151A patent/SI2444079T1/sl unknown
- 2006-05-17 LT LTEP11181066.9T patent/LT2444079T/lt unknown
- 2006-05-17 EP EP11181066.9A patent/EP2444079B1/en active Active
- 2006-05-17 PL PL11181066T patent/PL2444079T3/pl unknown
- 2006-05-17 CN CN2012100314315A patent/CN102617557A/zh active Pending
- 2006-05-17 SI SI200631898T patent/SI1881823T1/sl unknown
- 2006-05-17 EP EP06770607.7A patent/EP1881823B1/en active Active
- 2006-05-17 JP JP2008512519A patent/JP5794721B2/ja active Active
-
2009
- 2009-07-23 US US12/508,311 patent/US20100092541A1/en not_active Abandoned
- 2009-07-23 US US12/508,367 patent/US8084047B2/en active Active
-
2011
- 2011-01-21 US US13/011,760 patent/US8771715B2/en active Active
- 2011-01-21 US US13/011,775 patent/US8758776B2/en active Active
-
2012
- 2012-02-16 US US13/398,542 patent/US8592450B2/en active Active
- 2012-02-27 JP JP2012040330A patent/JP2012107057A/ja active Pending
- 2012-10-10 JP JP2012225028A patent/JP6288907B2/ja active Active
-
2013
- 2013-08-08 US US13/962,369 patent/US20140073666A1/en not_active Abandoned
- 2013-08-08 US US13/962,440 patent/US20140099387A1/en not_active Abandoned
- 2013-10-03 US US14/045,131 patent/US9045457B2/en active Active
- 2013-10-03 US US14/045,159 patent/US10188641B2/en active Active
-
2014
- 2014-05-12 US US14/275,159 patent/US9045458B2/en active Active
- 2014-05-12 US US14/275,241 patent/US9051297B2/en active Active
-
2015
- 2015-01-30 US US14/609,743 patent/US20150140075A1/en not_active Abandoned
- 2015-01-30 US US14/610,291 patent/US20150140080A1/en not_active Abandoned
- 2015-01-30 US US14/610,043 patent/US20150140078A1/en not_active Abandoned
- 2015-01-30 US US14/610,465 patent/US20150175581A1/en not_active Abandoned
- 2015-01-30 US US14/610,370 patent/US20150175579A1/en not_active Abandoned
- 2015-01-30 US US14/610,414 patent/US20150175580A1/en not_active Abandoned
- 2015-01-30 US US14/609,795 patent/US20150216857A1/en not_active Abandoned
- 2015-01-30 US US14/610,346 patent/US20150175578A1/en not_active Abandoned
- 2015-01-30 US US14/610,464 patent/US20150174119A1/en not_active Abandoned
- 2015-01-30 US US14/610,401 patent/US20150140082A1/en not_active Abandoned
- 2015-01-30 US US14/610,182 patent/US20150140079A1/en not_active Abandoned
- 2015-01-30 US US14/610,251 patent/US20150152090A1/en not_active Abandoned
- 2015-01-30 US US14/610,338 patent/US20150140081A1/en not_active Abandoned
- 2015-01-30 US US14/609,998 patent/US20150140077A1/en not_active Abandoned
- 2015-01-30 US US14/609,967 patent/US20150182520A1/en not_active Abandoned
- 2015-01-30 US US14/610,318 patent/US20150175577A1/en not_active Abandoned
- 2015-01-30 US US14/609,770 patent/US20150140076A1/en not_active Abandoned
- 2015-07-09 JP JP2015137500A patent/JP2015187165A/ja not_active Withdrawn
-
2016
- 2016-11-21 US US15/357,237 patent/US20170143690A1/en not_active Abandoned
- 2016-11-30 US US15/364,935 patent/US20170143691A1/en not_active Abandoned
- 2016-12-08 US US15/372,863 patent/US20170143692A1/en not_active Abandoned
- 2016-12-09 US US15/373,604 patent/US20170143693A1/en not_active Abandoned
-
2017
- 2017-02-24 CY CY20171100257T patent/CY1118660T1/el unknown
- 2017-05-18 JP JP2017099005A patent/JP2017141297A/ja not_active Withdrawn
-
2019
- 2019-02-12 JP JP2019022433A patent/JP6816180B2/ja active Active
-
2020
- 2020-02-26 JP JP2020030710A patent/JP2020079312A/ja active Pending
-
2022
- 2022-07-27 US US17/815,256 patent/US12558350B2/en active Active