CN113230021A - 微滴递送设备和方法 - Google Patents
微滴递送设备和方法 Download PDFInfo
- Publication number
- CN113230021A CN113230021A CN202110516413.5A CN202110516413A CN113230021A CN 113230021 A CN113230021 A CN 113230021A CN 202110516413 A CN202110516413 A CN 202110516413A CN 113230021 A CN113230021 A CN 113230021A
- Authority
- CN
- China
- Prior art keywords
- package
- pharmaceutical package
- piezoelectric
- fluid
- actuator
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 238000000034 method Methods 0.000 title abstract description 19
- 239000012530 fluid Substances 0.000 claims description 33
- 238000006073 displacement reaction Methods 0.000 claims description 20
- 239000000203 mixture Substances 0.000 claims description 16
- 239000011148 porous material Substances 0.000 claims description 3
- 239000003814 drug Substances 0.000 abstract description 43
- 229940079593 drug Drugs 0.000 abstract description 43
- 239000003795 chemical substances by application Substances 0.000 abstract description 6
- 230000036316 preload Effects 0.000 abstract description 3
- 208000003556 Dry Eye Syndromes Diseases 0.000 description 19
- 206010013774 Dry eye Diseases 0.000 description 19
- 238000011282 treatment Methods 0.000 description 8
- 239000006196 drop Substances 0.000 description 7
- 238000007789 sealing Methods 0.000 description 6
- 230000028327 secretion Effects 0.000 description 6
- 239000000919 ceramic Substances 0.000 description 5
- 239000007788 liquid Substances 0.000 description 5
- 229920000642 polymer Polymers 0.000 description 5
- WHXSMMKQMYFTQS-UHFFFAOYSA-N Lithium Chemical compound [Li] WHXSMMKQMYFTQS-UHFFFAOYSA-N 0.000 description 4
- 239000000607 artificial tear Substances 0.000 description 4
- 230000001684 chronic effect Effects 0.000 description 4
- 238000009472 formulation Methods 0.000 description 4
- 239000011521 glass Substances 0.000 description 4
- 229910052744 lithium Inorganic materials 0.000 description 4
- 238000004377 microelectronic Methods 0.000 description 4
- 230000010355 oscillation Effects 0.000 description 4
- 238000009512 pharmaceutical packaging Methods 0.000 description 4
- 208000002193 Pain Diseases 0.000 description 3
- 239000004952 Polyamide Substances 0.000 description 3
- 239000004820 Pressure-sensitive adhesive Substances 0.000 description 3
- 238000004891 communication Methods 0.000 description 3
- 239000012528 membrane Substances 0.000 description 3
- 238000012986 modification Methods 0.000 description 3
- 230000004048 modification Effects 0.000 description 3
- 230000037361 pathway Effects 0.000 description 3
- 229920002647 polyamide Polymers 0.000 description 3
- -1 polyethylene terephthalate Polymers 0.000 description 3
- 230000008569 process Effects 0.000 description 3
- PMATZTZNYRCHOR-CGLBZJNRSA-N Cyclosporin A Chemical compound CC[C@@H]1NC(=O)[C@H]([C@H](O)[C@H](C)C\C=C\C)N(C)C(=O)[C@H](C(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)N(C)C(=O)CN(C)C1=O PMATZTZNYRCHOR-CGLBZJNRSA-N 0.000 description 2
- 108010036949 Cyclosporine Proteins 0.000 description 2
- PXHVJJICTQNCMI-UHFFFAOYSA-N Nickel Chemical compound [Ni] PXHVJJICTQNCMI-UHFFFAOYSA-N 0.000 description 2
- 239000003708 ampul Substances 0.000 description 2
- 230000005540 biological transmission Effects 0.000 description 2
- 229960001265 ciclosporin Drugs 0.000 description 2
- 239000011248 coating agent Substances 0.000 description 2
- 238000000576 coating method Methods 0.000 description 2
- 230000008878 coupling Effects 0.000 description 2
- 238000010168 coupling process Methods 0.000 description 2
- 238000005859 coupling reaction Methods 0.000 description 2
- 230000001186 cumulative effect Effects 0.000 description 2
- 238000013461 design Methods 0.000 description 2
- 238000010586 diagram Methods 0.000 description 2
- 238000001035 drying Methods 0.000 description 2
- 210000000744 eyelid Anatomy 0.000 description 2
- 230000006870 function Effects 0.000 description 2
- 230000001939 inductive effect Effects 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 230000003287 optical effect Effects 0.000 description 2
- 238000012858 packaging process Methods 0.000 description 2
- 238000012536 packaging technology Methods 0.000 description 2
- 230000036407 pain Effects 0.000 description 2
- 230000002085 persistent effect Effects 0.000 description 2
- 239000000825 pharmaceutical preparation Substances 0.000 description 2
- 229940127557 pharmaceutical product Drugs 0.000 description 2
- 230000004044 response Effects 0.000 description 2
- 210000002966 serum Anatomy 0.000 description 2
- 238000012360 testing method Methods 0.000 description 2
- 238000002560 therapeutic procedure Methods 0.000 description 2
- 229920001169 thermoplastic Polymers 0.000 description 2
- QCHFTSOMWOSFHM-WPRPVWTQSA-N (+)-Pilocarpine Chemical compound C1OC(=O)[C@@H](CC)[C@H]1CC1=CN=CN1C QCHFTSOMWOSFHM-WPRPVWTQSA-N 0.000 description 1
- LNAZSHAWQACDHT-XIYTZBAFSA-N (2r,3r,4s,5r,6s)-4,5-dimethoxy-2-(methoxymethyl)-3-[(2s,3r,4s,5r,6r)-3,4,5-trimethoxy-6-(methoxymethyl)oxan-2-yl]oxy-6-[(2r,3r,4s,5r,6r)-4,5,6-trimethoxy-2-(methoxymethyl)oxan-3-yl]oxyoxane Chemical compound CO[C@@H]1[C@@H](OC)[C@H](OC)[C@@H](COC)O[C@H]1O[C@H]1[C@H](OC)[C@@H](OC)[C@H](O[C@H]2[C@@H]([C@@H](OC)[C@H](OC)O[C@@H]2COC)OC)O[C@@H]1COC LNAZSHAWQACDHT-XIYTZBAFSA-N 0.000 description 1
- 229920002799 BoPET Polymers 0.000 description 1
- GAWIXWVDTYZWAW-UHFFFAOYSA-N C[CH]O Chemical group C[CH]O GAWIXWVDTYZWAW-UHFFFAOYSA-N 0.000 description 1
- 208000028006 Corneal injury Diseases 0.000 description 1
- 229930105110 Cyclosporin A Natural products 0.000 description 1
- RVGRUAULSDPKGF-UHFFFAOYSA-N Poloxamer Chemical compound C1CO1.CC1CO1 RVGRUAULSDPKGF-UHFFFAOYSA-N 0.000 description 1
- 239000004698 Polyethylene Substances 0.000 description 1
- 239000004743 Polypropylene Substances 0.000 description 1
- 239000004372 Polyvinyl alcohol Substances 0.000 description 1
- QCHFTSOMWOSFHM-UHFFFAOYSA-N SJ000285536 Natural products C1OC(=O)C(CC)C1CC1=CN=CN1C QCHFTSOMWOSFHM-UHFFFAOYSA-N 0.000 description 1
- 229910000639 Spring steel Inorganic materials 0.000 description 1
- 239000004098 Tetracycline Substances 0.000 description 1
- 206010047571 Visual impairment Diseases 0.000 description 1
- 239000002313 adhesive film Substances 0.000 description 1
- 239000013566 allergen Substances 0.000 description 1
- 230000003110 anti-inflammatory effect Effects 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- 239000012298 atmosphere Substances 0.000 description 1
- 230000001580 bacterial effect Effects 0.000 description 1
- DMFGNRRURHSENX-UHFFFAOYSA-N beryllium copper Chemical compound [Be].[Cu] DMFGNRRURHSENX-UHFFFAOYSA-N 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 230000004397 blinking Effects 0.000 description 1
- 125000002057 carboxymethyl group Chemical group [H]OC(=O)C([H])([H])[*] 0.000 description 1
- 239000001913 cellulose Substances 0.000 description 1
- 229920002678 cellulose Polymers 0.000 description 1
- 238000011109 contamination Methods 0.000 description 1
- 239000013078 crystal Substances 0.000 description 1
- 229930182912 cyclosporin Natural products 0.000 description 1
- 230000006866 deterioration Effects 0.000 description 1
- 238000000203 droplet dispensing Methods 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 230000007613 environmental effect Effects 0.000 description 1
- 229920006332 epoxy adhesive Polymers 0.000 description 1
- 239000003889 eye drop Substances 0.000 description 1
- 229940012356 eye drops Drugs 0.000 description 1
- 238000011049 filling Methods 0.000 description 1
- 230000006698 induction Effects 0.000 description 1
- 239000004761 kevlar Substances 0.000 description 1
- 210000004561 lacrimal apparatus Anatomy 0.000 description 1
- 238000000608 laser ablation Methods 0.000 description 1
- 229920000609 methyl cellulose Polymers 0.000 description 1
- 239000001923 methylcellulose Substances 0.000 description 1
- 235000010981 methylcellulose Nutrition 0.000 description 1
- 230000003278 mimic effect Effects 0.000 description 1
- 238000010295 mobile communication Methods 0.000 description 1
- 229910052759 nickel Inorganic materials 0.000 description 1
- 238000005457 optimization Methods 0.000 description 1
- 238000004806 packaging method and process Methods 0.000 description 1
- 239000003973 paint Substances 0.000 description 1
- 230000000704 physical effect Effects 0.000 description 1
- 229960001416 pilocarpine Drugs 0.000 description 1
- 238000007747 plating Methods 0.000 description 1
- 229960000502 poloxamer Drugs 0.000 description 1
- 229920001983 poloxamer Polymers 0.000 description 1
- 229920000573 polyethylene Polymers 0.000 description 1
- 229920000139 polyethylene terephthalate Polymers 0.000 description 1
- 239000005020 polyethylene terephthalate Substances 0.000 description 1
- 229920001155 polypropylene Polymers 0.000 description 1
- 229920002451 polyvinyl alcohol Polymers 0.000 description 1
- 229920000036 polyvinylpyrrolidone Polymers 0.000 description 1
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 description 1
- 229940069328 povidone Drugs 0.000 description 1
- 230000001681 protective effect Effects 0.000 description 1
- 230000011514 reflex Effects 0.000 description 1
- 230000035807 sensation Effects 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 229910000679 solder Inorganic materials 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 230000000638 stimulation Effects 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
- 239000000758 substrate Substances 0.000 description 1
- 230000002459 sustained effect Effects 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 230000004488 tear evaporation Effects 0.000 description 1
- 238000010998 test method Methods 0.000 description 1
- 229930101283 tetracycline Natural products 0.000 description 1
- 229960002180 tetracycline Drugs 0.000 description 1
- 235000019364 tetracycline Nutrition 0.000 description 1
- 150000003522 tetracyclines Chemical class 0.000 description 1
- 239000004416 thermosoftening plastic Substances 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- 229940125379 topical corticosteroid Drugs 0.000 description 1
- 230000001052 transient effect Effects 0.000 description 1
- 210000003954 umbilical cord Anatomy 0.000 description 1
- 238000009423 ventilation Methods 0.000 description 1
- 238000013022 venting Methods 0.000 description 1
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F9/00—Methods or devices for treatment of the eyes; Devices for putting-in contact lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
- A61F9/0008—Introducing ophthalmic products into the ocular cavity or retaining products therein
- A61F9/0026—Ophthalmic product dispenser attachments to facilitate positioning near the eye
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F9/00—Methods or devices for treatment of the eyes; Devices for putting-in contact lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
- A61F9/0008—Introducing ophthalmic products into the ocular cavity or retaining products therein
-
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F04—POSITIVE - DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS FOR LIQUIDS OR ELASTIC FLUIDS
- F04B—POSITIVE-DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS
- F04B43/00—Machines, pumps, or pumping installations having flexible working members
- F04B43/02—Machines, pumps, or pumping installations having flexible working members having plate-like flexible members, e.g. diaphragms
- F04B43/04—Pumps having electric drive
- F04B43/043—Micropumps
- F04B43/046—Micropumps with piezoelectric drive
-
- G—PHYSICS
- G02—OPTICS
- G02C—SPECTACLES; SUNGLASSES OR GOGGLES INSOFAR AS THEY HAVE THE SAME FEATURES AS SPECTACLES; CONTACT LENSES
- G02C11/00—Non-optical adjuncts; Attachment thereof
- G02C11/10—Electronic devices other than hearing aids
-
- H—ELECTRICITY
- H10—SEMICONDUCTOR DEVICES; ELECTRIC SOLID-STATE DEVICES NOT OTHERWISE PROVIDED FOR
- H10N—ELECTRIC SOLID-STATE DEVICES NOT OTHERWISE PROVIDED FOR
- H10N30/00—Piezoelectric or electrostrictive devices
- H10N30/20—Piezoelectric or electrostrictive devices with electrical input and mechanical output, e.g. functioning as actuators or vibrators
- H10N30/206—Piezoelectric or electrostrictive devices with electrical input and mechanical output, e.g. functioning as actuators or vibrators using only longitudinal or thickness displacement, e.g. d33 or d31 type devices
Abstract
Description
Claims (5)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201562125073P | 2015-01-12 | 2015-01-12 | |
US62/125,073 | 2015-01-12 | ||
CN201680005036.6A CN107106325B (zh) | 2015-01-12 | 2016-01-11 | 微滴递送设备和方法 |
Related Parent Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201680005036.6A Division CN107106325B (zh) | 2015-01-12 | 2016-01-11 | 微滴递送设备和方法 |
Publications (1)
Publication Number | Publication Date |
---|---|
CN113230021A true CN113230021A (zh) | 2021-08-10 |
Family
ID=56366701
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN202110516413.5A Pending CN113230021A (zh) | 2015-01-12 | 2016-01-11 | 微滴递送设备和方法 |
CN201680005036.6A Active CN107106325B (zh) | 2015-01-12 | 2016-01-11 | 微滴递送设备和方法 |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201680005036.6A Active CN107106325B (zh) | 2015-01-12 | 2016-01-11 | 微滴递送设备和方法 |
Country Status (8)
Country | Link |
---|---|
US (2) | US10624781B2 (zh) |
EP (1) | EP3244851A4 (zh) |
JP (1) | JP2018510668A (zh) |
KR (1) | KR101984116B1 (zh) |
CN (2) | CN113230021A (zh) |
AU (1) | AU2016207010A1 (zh) |
CA (1) | CA2973471A1 (zh) |
WO (1) | WO2016115050A1 (zh) |
Families Citing this family (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2018510668A (ja) | 2015-01-12 | 2018-04-19 | ケダリオン セラピューティックス,インコーポレイテッド | 微小液滴の繰り出し装置及び方法 |
WO2016164830A1 (en) * | 2015-04-10 | 2016-10-13 | Lagunita Llc | Piezoelectric dispenser with replaceable ampoule |
US10888454B2 (en) | 2017-01-20 | 2021-01-12 | Kedalion Therapeutics, Inc. | Piezoelectric fluid dispenser |
TW201902576A (zh) * | 2017-05-31 | 2019-01-16 | 日商坪田實驗室股份有限公司 | 保濕噴霧之噴霧裝置及噴霧方法 |
CN115300226A (zh) | 2017-06-10 | 2022-11-08 | 艾诺维亚股份有限公司 | 用于将一体积的流体输送到眼睛的设备 |
CN109674576B (zh) * | 2017-10-19 | 2024-02-27 | 深圳市启明医药科技有限公司 | 流体供应单元及微液滴喷射驱动装置、发生装置 |
CN111712219A (zh) * | 2017-12-08 | 2020-09-25 | 科达莱昂治疗公司 | 流体递送对准系统 |
AU2019297326A1 (en) * | 2018-07-03 | 2021-01-07 | Bausch + Lomb Ireland Limited | Topical ocular delivery devices and methods for using the same |
US10292998B1 (en) * | 2018-08-07 | 2019-05-21 | Ahad Mahootchi | Compositions and methods for prevention and treatment of eye infections |
US11679028B2 (en) | 2019-03-06 | 2023-06-20 | Novartis Ag | Multi-dose ocular fluid delivery system |
FI128476B (en) * | 2019-05-31 | 2020-06-15 | Icare Finland Oy | EQUIPMENT FOR THE OPHTHOMMOMETER AND ASSOCIATED SYSTEM, METHOD, AND USE |
JP7116959B2 (ja) * | 2019-07-19 | 2022-08-12 | 日本電信電話株式会社 | 情動制御装置、その方法、およびプログラム |
US11938057B2 (en) | 2020-04-17 | 2024-03-26 | Bausch + Lomb Ireland Limited | Hydrodynamically actuated preservative free dispensing system |
US11925577B2 (en) | 2020-04-17 | 2024-03-12 | Bausch + Lomb Ireland Limted | Hydrodynamically actuated preservative free dispensing system |
JP2022182282A (ja) * | 2021-05-28 | 2022-12-08 | 株式会社ジンズホールディングス | カートリッジ製品及びカバー部材 |
JP2022182280A (ja) | 2021-05-28 | 2022-12-08 | 株式会社ジンズホールディングス | アイウエア及びカートリッジ |
US11471657B1 (en) | 2022-03-22 | 2022-10-18 | Stat Capsule Inc. | Device and method for monitoring and treating advanced bradycardia |
US11647942B1 (en) | 2022-03-22 | 2023-05-16 | Stat Capsule Inc. | Device for monitoring and treating bradyarrhythmia |
DE102022116282A1 (de) | 2022-06-29 | 2024-01-04 | EyeNeb GmbH | Vorrichtung zum Benetzen des Auges und Verfahren dazu |
Family Cites Families (245)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE1575050A1 (de) | 1966-01-12 | 1972-04-13 | Misto Gen Equipment Co | Ultraschall-Nebelerzeugungsgeraet |
US3640274A (en) | 1966-11-04 | 1972-02-08 | Colgate Palmolive Co | Eye-spraying device having mirror |
US3779245A (en) | 1972-06-13 | 1973-12-18 | R Windsor | Device for applying materials to the area of the eye |
US3812854A (en) | 1972-10-20 | 1974-05-28 | A Michaels | Ultrasonic nebulizer |
DE2445791C2 (de) | 1974-09-25 | 1984-04-19 | Siemens AG, 1000 Berlin und 8000 München | Ultraschall-Flüssigkeitszerstäuber |
US3976072A (en) * | 1975-09-03 | 1976-08-24 | The United States Of America As Represented By The Secretary Of The Department Of Health, Education And Welfare | Blink-operated extracorporeal tear duct |
US4159803A (en) | 1977-03-31 | 1979-07-03 | MistO2 Gen Equipment Company | Chamber for ultrasonic aerosol generation |
US4338576A (en) | 1978-07-26 | 1982-07-06 | Tdk Electronics Co., Ltd. | Ultrasonic atomizer unit utilizing shielded and grounded elements |
DE2849493C2 (de) | 1978-11-15 | 1982-01-14 | Carl Heyer Gmbh, Inhalationstechnik, 5427 Bad Ems | In der Hand zu haltender Aerosolspender |
DE2902624C2 (de) | 1979-01-24 | 1985-10-10 | Pfeiffer Zerstäuber Vertriebsgesellschaft mbH & Co KG, 7760 Radolfzell | Ausgabepumpe |
DE7917568U1 (de) | 1979-06-19 | 1979-09-20 | Bosch-Siemens Hausgeraete Gmbh, 7000 Stuttgart | Inhalationsgeraet |
US4352459A (en) | 1979-11-13 | 1982-10-05 | Sono-Tek Corporation | Ultrasonic liquid atomizer having an axially-extending liquid feed passage |
US4465234A (en) | 1980-10-06 | 1984-08-14 | Matsushita Electric Industrial Co., Ltd. | Liquid atomizer including vibrator |
US4632311A (en) | 1982-12-20 | 1986-12-30 | Matsushita Electric Industrial Co., Ltd. | Atomizing apparatus employing a capacitive piezoelectric transducer |
US4655393A (en) | 1983-01-05 | 1987-04-07 | Sonotek Corporation | High volume ultrasonic liquid atomizer |
EP0173334B1 (en) | 1984-08-29 | 1989-11-23 | Omron Tateisi Electronics Co. | Ultrasonic atomizer |
GB2200211B (en) | 1986-12-08 | 1991-01-16 | Fuji Electric Co Ltd | Vibration-type transducer |
US4976259A (en) | 1986-12-22 | 1990-12-11 | Mountain Medical Equipment, Inc. | Ultrasonic nebulizer |
US4952581A (en) | 1987-04-03 | 1990-08-28 | The Trustees Of Columbia University In The City Of New York | Use of a prostaglandin in combination with an adrenergic blocking agent for reduction of intraocular pressure |
US4850534A (en) | 1987-05-30 | 1989-07-25 | Tdk Corporation | Ultrasonic wave nebulizer |
US4981625A (en) | 1988-03-14 | 1991-01-01 | California Institute Of Technology | Monodisperse, polymeric microspheres produced by irradiation of slowly thawing frozen drops |
US4882150A (en) | 1988-06-03 | 1989-11-21 | Kaufman Herbert E | Drug delivery system |
US5025957A (en) | 1988-10-07 | 1991-06-25 | Ryder International Corp. | Liquid dispenser nozzle assembly |
WO1992011050A1 (en) | 1990-12-17 | 1992-07-09 | Minnesota Mining And Manufacturing Company | Inhaler |
US5171306A (en) | 1991-03-13 | 1992-12-15 | Vo Van T | Eyedrop delivery system |
US6629646B1 (en) | 1991-04-24 | 2003-10-07 | Aerogen, Inc. | Droplet ejector with oscillating tapered aperture |
US5938117A (en) | 1991-04-24 | 1999-08-17 | Aerogen, Inc. | Methods and apparatus for dispensing liquids as an atomized spray |
US5232363A (en) | 1991-06-11 | 1993-08-03 | Eran Meller | Scaler with improved vibration characteristics |
GB9114080D0 (en) | 1991-06-28 | 1991-08-14 | Weston Terence E | Atomising valve |
US5549249A (en) | 1991-12-13 | 1996-08-27 | Contico International, Inc. | Fluid spinner and nozzle head assembly with controlled fluid flood path |
US5368582A (en) | 1992-08-10 | 1994-11-29 | The Schepens Eye Research Institute | Method and apparatus for introducing fluid material into an eye |
ATE153855T1 (de) | 1992-10-13 | 1997-06-15 | Alcon Lab Inc | Zusammensetzungen zur behandlung von glaukoma die prostaglandine und clonidinderivate enthalten |
GB2272389B (en) | 1992-11-04 | 1996-07-24 | Bespak Plc | Dispensing apparatus |
DE69422803T2 (de) | 1993-03-03 | 2000-06-15 | Graham Stewart B Street | Bildausrichtung und Gerät |
DE69323727T2 (de) | 1993-04-30 | 1999-07-22 | Henlopen Mfg Co Inc | Vorrichtung zum Auftragen von flüssigen Kosmetikprodukten |
WO1995017338A1 (en) | 1993-12-22 | 1995-06-29 | Merck & Co., Inc. | Ophthalmic package and delivery device |
GB9405952D0 (en) | 1994-03-25 | 1994-05-11 | Zeneca Ltd | Aqueous ophthalmic sprays |
WO1996000050A1 (en) | 1994-06-23 | 1996-01-04 | R.P. Scherer Corporation | Ocular treatment device |
US6085740A (en) | 1996-02-21 | 2000-07-11 | Aerogen, Inc. | Liquid dispensing apparatus and methods |
US6427682B1 (en) | 1995-04-05 | 2002-08-06 | Aerogen, Inc. | Methods and apparatus for aerosolizing a substance |
US5657926A (en) | 1995-04-13 | 1997-08-19 | Toda; Kohji | Ultrasonic atomizing device |
US5828394A (en) | 1995-09-20 | 1998-10-27 | The Board Of Trustees Of The Leland Stanford Junior University | Fluid drop ejector and method |
US5627611A (en) * | 1995-12-29 | 1997-05-06 | Scheiner; Stanley A. | Artificial tears |
FR2746657B1 (fr) | 1996-03-29 | 1998-06-26 | Sofab | Dispositif antibacterien de pulverisation d'un produit liquide |
US5958342A (en) * | 1996-05-17 | 1999-09-28 | Incyte Pharmaceuticals, Inc. | Jet droplet device |
US5692651A (en) | 1996-06-06 | 1997-12-02 | Owens-Illinois Closure Inc. | Self-sealing dispensing closure |
US5881956A (en) | 1996-08-08 | 1999-03-16 | Ben Z. Cohen | Microdispensing ophthalmic pump |
US6024717A (en) | 1996-10-24 | 2000-02-15 | Vibrx, Inc. | Apparatus and method for sonically enhanced drug delivery |
US5960224A (en) | 1996-12-26 | 1999-09-28 | Fuji Photo Film Co., Ltd. | Image forming apparatus and fluid injecting apparatus |
US6065623A (en) | 1998-02-13 | 2000-05-23 | Crown Cork & Seal Technologies Corporation | Closure with lenticular lens insert |
DE19823719B4 (de) * | 1998-05-27 | 2011-12-15 | MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. | Verfahren zum Aufkonzentrieren von Substanzen |
JP3055480U (ja) | 1998-07-01 | 1999-01-12 | 孟 ▲じゃ−▼ 康 | 軽量型目薬液噴射器 |
US6070575A (en) * | 1998-11-16 | 2000-06-06 | Aradigm Corporation | Aerosol-forming porous membrane with certain pore structure |
US6232129B1 (en) * | 1999-02-03 | 2001-05-15 | Peter Wiktor | Piezoelectric pipetting device |
US6196218B1 (en) | 1999-02-24 | 2001-03-06 | Ponwell Enterprises Ltd | Piezo inhaler |
US6254860B1 (en) | 1999-04-13 | 2001-07-03 | Allergan Sales, Inc. | Ocular treatment using cyclosporin-A derivatives |
US6730066B1 (en) | 1999-08-03 | 2004-05-04 | Pharmacia Ab | Liquid delivery container |
US6235177B1 (en) | 1999-09-09 | 2001-05-22 | Aerogen, Inc. | Method for the construction of an aperture plate for dispensing liquid droplets |
US6302101B1 (en) | 1999-12-14 | 2001-10-16 | Daniel Py | System and method for application of medicament into the nasal passage |
US20010035184A1 (en) * | 1999-12-17 | 2001-11-01 | Carlos Schuler | Systems and methods for treating packaged powders |
WO2001046134A1 (en) | 1999-12-22 | 2001-06-28 | Alcon Universal Ltd. | 6-KETO PROSTAGLANDIN F1α AND ANALOGS FOR TREATING DRY EYE |
US7160511B2 (en) * | 2000-02-18 | 2007-01-09 | Olympus Corporation | Liquid pipetting apparatus and micro array manufacturing apparatus |
US7867186B2 (en) | 2002-04-08 | 2011-01-11 | Glaukos Corporation | Devices and methods for treatment of ocular disorders |
US7080644B2 (en) * | 2000-06-28 | 2006-07-25 | Microdose Technologies, Inc. | Packaging and delivery of pharmaceuticals and drugs |
US6273092B1 (en) | 2000-09-22 | 2001-08-14 | Gerard M. Nolan | Methods for treating various eye disorders |
DE10052819B4 (de) * | 2000-10-24 | 2004-02-19 | Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. | Pipettensystem und Pipettenarray sowie Verfahren zum Befüllen eines Pipettensystems |
US6722364B2 (en) * | 2001-01-12 | 2004-04-20 | Becton, Dickinson And Company | Medicament inhalation delivery devices and methods for using the same |
US20020124843A1 (en) * | 2001-02-01 | 2002-09-12 | Skiba Jeffry B. | Eye medication delivery system |
US6758837B2 (en) | 2001-02-08 | 2004-07-06 | Pharmacia Ab | Liquid delivery device and method of use thereof |
WO2002072169A2 (en) | 2001-03-09 | 2002-09-19 | Antares Pharma, Inc. | Ocular drug delivery nebulizer |
AU2002336246B8 (en) | 2001-03-15 | 2006-02-02 | Creare Incorporated | Nebulizer having cooling chamber |
WO2002080223A1 (en) * | 2001-03-29 | 2002-10-10 | Wisconsin Alumni Research Foundation | Piezoelectric charged droplet source |
US7496401B2 (en) | 2001-04-06 | 2009-02-24 | Mattioli Engineering Ltd | Method and apparatus for skin absorption enhancement and transdermal drug delivery |
DE10154526B4 (de) | 2001-06-12 | 2007-02-08 | Physik Instrumente (Pi) Gmbh & Co | Piezoelektrisches Stellelement |
JP2003063576A (ja) | 2001-06-15 | 2003-03-05 | Taisei Kako Co Ltd | 分与容器 |
US6783035B2 (en) * | 2001-07-19 | 2004-08-31 | Valois S.A.S. | Fluid product dispenser |
US6723077B2 (en) * | 2001-09-28 | 2004-04-20 | Hewlett-Packard Development Company, L.P. | Cutaneous administration system |
JP4761709B2 (ja) | 2002-01-15 | 2011-08-31 | エアロジェン,インコーポレイテッド | エアロゾル発生器を作動するための方法およびシステム |
US6869275B2 (en) | 2002-02-14 | 2005-03-22 | Philip Morris Usa Inc. | Piezoelectrically driven fluids pump and piezoelectric fluid valve |
JP4100202B2 (ja) * | 2002-03-18 | 2008-06-11 | セイコーエプソン株式会社 | 圧電アクチュエータ、及び、液体噴射ヘッド |
US20040039355A1 (en) | 2002-08-26 | 2004-02-26 | Gonzalez Jose M. | Fluid dispensing devices and methods |
US20050261641A1 (en) | 2002-09-26 | 2005-11-24 | Warchol Mark P | Method for ophthalmic administration of medicament |
KR100452849B1 (ko) * | 2002-10-17 | 2004-10-14 | 삼성전자주식회사 | 마이크로 분사기를 이용한 프린터 헤드 |
WO2004038460A2 (en) | 2002-10-23 | 2004-05-06 | Abdulla Nael A | Aqueous ophthalmic spray and method for delivery |
US6814265B2 (en) | 2003-03-06 | 2004-11-09 | Alcon, Inc. | Device for dispensing fluid medicine |
US7201732B2 (en) | 2003-04-10 | 2007-04-10 | Hewlett-Packard Development Company, L.P. | Dispensing method and device for delivering material to an eye |
EP1468748A1 (en) | 2003-04-15 | 2004-10-20 | Microflow Engineering SA | Low-cost liquid droplet spray device and nozzle body |
CA2524178A1 (en) * | 2003-04-30 | 2004-11-18 | Aurora Discovery, Inc. | Method and system for precise dispensation of a liquid |
CA2526362C (en) | 2003-05-20 | 2012-10-09 | James F. Collins | Ophthalmic drug delivery system |
US8545463B2 (en) | 2003-05-20 | 2013-10-01 | Optimyst Systems Inc. | Ophthalmic fluid reservoir assembly for use with an ophthalmic fluid delivery device |
US20100222752A1 (en) | 2003-05-20 | 2010-09-02 | Collins Jr James F | Ophthalmic fluid delivery system |
US8021334B2 (en) | 2004-05-30 | 2011-09-20 | Nilimedix Ltd. | Drug delivery device and method |
US8128606B2 (en) | 2003-07-03 | 2012-03-06 | Hewlett-Packard Development Company, L.P. | Ophthalmic apparatus and method for administering agents to the eye |
DE10337484B4 (de) * | 2003-08-14 | 2005-05-25 | Zengerle, Roland, Prof. Dr. | Mikrodosiervorrichtung und Verfahren zur dosierten Abgabe von Flüssigkeiten |
US20050059583A1 (en) | 2003-09-15 | 2005-03-17 | Allergan, Inc. | Methods of providing therapeutic effects using cyclosporin components |
PT1682537E (pt) | 2003-11-05 | 2012-06-20 | Sarcode Bioscience Inc | Moduladores de adesão celular |
DE102004006452B4 (de) | 2004-02-05 | 2006-04-20 | Ing. Erich Pfeiffer Gmbh | Mikrodosiervorrichtung |
AU2005213356B2 (en) | 2004-02-06 | 2011-06-02 | Microdose Therapeutx, Inc. | A blister pack for use with an inhalation device |
WO2005079997A1 (de) | 2004-02-24 | 2005-09-01 | Boehringer Ingelheim International Gmbh | Zerstäuber |
MXPA06011426A (es) * | 2004-04-02 | 2007-04-20 | Gov Health & Human Serv | Sistemas y metodos de suministro en aerosol. |
US20050240162A1 (en) | 2004-04-21 | 2005-10-27 | Wen-Pin Chen | Eye treatment device |
JP2007534384A (ja) | 2004-04-23 | 2007-11-29 | ミスティック ファーマシューティカルズ, インコーポレイテッド | 複数の単位用量の薬物送達システム |
GB0410712D0 (en) * | 2004-05-13 | 2004-06-16 | Novartis Ag | Organic compounds |
CA2581595A1 (en) | 2004-09-27 | 2006-04-06 | Medical Instill Technologies, Inc. | Laterally-actuated dispenser with one-way valve for storing and dispensing metered amounts of substances |
US20060069358A1 (en) * | 2004-09-29 | 2006-03-30 | Gerondale Scott J | Controlled drop dispensing units |
CA3015269A1 (en) | 2004-11-22 | 2006-06-01 | Kaleo, Inc. | Devices, systems, and methods for medicament delivery |
EP1848541A4 (en) | 2005-02-07 | 2013-01-16 | Pharmalight Inc | METHOD AND DEVICE FOR OPHTHALMIC DELIVERY OF PHARMACEUTICALLY ACTIVE INGREDIENTS |
HUE031979T2 (en) | 2005-05-17 | 2017-08-28 | Sarcode Bioscience Inc | Preparations and methods for treating eye disorders |
EP2365377A3 (en) | 2005-05-18 | 2011-11-30 | Visual Physics, LLC | Image presentation and micro-optic security system |
UA94711C2 (uk) | 2005-05-25 | 2011-06-10 | Аэроджен, Инк. | Вібраційна система (варіанти) та спосіб її виготовлення (варіанти), спосіб вібрування пластини (варіанти), система виробництва аерозолю та спосіб лікування пацієнта |
US10646668B2 (en) | 2005-06-02 | 2020-05-12 | Respinova Ltd. | Pulsating inhaler and a method of treating upper respiratory disorders |
US20080200848A1 (en) | 2005-06-02 | 2008-08-21 | Ads & B Investment Fund L.P | Vibrating Device For Treating Nasal Congestion and Sinusitis Symptoms and Method Thereof |
DE102005025640A1 (de) * | 2005-06-03 | 2006-12-07 | Scienion Ag | Mikrodispenser und zugehöriges Betriebsverfahren |
DE102005043034A1 (de) * | 2005-09-09 | 2007-03-15 | Siemens Ag | Vorrichtung und Verfahren zur Bewegung einer Flüssigkeit |
EP1779933A1 (en) | 2005-10-26 | 2007-05-02 | The Procter and Gamble Company | Dispenser for a liquid |
US7874467B2 (en) | 2005-11-03 | 2011-01-25 | Reseal International Limited Partnership | Metered drop push button dispenser system |
FR2897599B1 (fr) | 2006-02-23 | 2010-08-27 | Rexam Pharma | Ensemble de conditionnement et de distribution de liquide. |
US20070195151A1 (en) * | 2006-02-23 | 2007-08-23 | Anderson Frank E | Hand-held ink jet pen |
EP2016778A4 (en) * | 2006-05-11 | 2010-07-28 | Eran Eilat | EYE MEDICINES DONOR |
US20070268340A1 (en) * | 2006-05-17 | 2007-11-22 | Bruno Dacquay | Ophthalmic Injection System and Method Using Piezoelectric Array |
DE102006026786A1 (de) | 2006-06-07 | 2007-12-13 | Joachim Kern | Dosierinhalator |
US8048047B2 (en) | 2006-06-23 | 2011-11-01 | Novartis Ag | Surgical cassette with improved air filtering |
US20080039807A1 (en) | 2006-08-08 | 2008-02-14 | Jerrold Scott Pine | Ophthalmic Drug Dispensing Tip |
DE102006040316B4 (de) | 2006-08-29 | 2012-07-05 | Deutsches Zentrum für Luft- und Raumfahrt e.V. | Piezokeramischer Flächenaktuator und Verfahren zur Herstellung eines solchen |
FR2908329B1 (fr) | 2006-11-14 | 2011-01-07 | Telemaq | Dispositif et methode de distribution de fluide par ultrasons |
US8196576B2 (en) * | 2007-02-28 | 2012-06-12 | Microdose Therapeutx, Inc. | Inhaler |
US20080214940A1 (en) | 2007-03-02 | 2008-09-04 | Benaron David A | Medical imaging lens system, and method with high-efficiency light collection and collinear illumination |
US20090008413A1 (en) | 2007-04-17 | 2009-01-08 | Choi Hee Jin | Airless dispensing pump container with an airtight push down type nozzle head |
ITRM20070275A1 (it) | 2007-05-17 | 2008-11-18 | Federighi Federigo | Flacone erogatore multidose per preparati liquidi senza conservanti. |
US8272576B2 (en) * | 2007-06-22 | 2012-09-25 | Arizona Board of Regents, a body corporate acting for and on behalf of Arizona State University | Gas dynamic virtual nozzle for generation of microscopic droplet streams |
JP5137710B2 (ja) * | 2007-07-26 | 2013-02-06 | キヤノン株式会社 | 液体カートリッジ |
CA2701482C (en) | 2007-10-08 | 2018-10-23 | Lux Biosciences, Inc. | Ophthalmic compositions comprising calcineurin inhibitors or mtor inhibitors |
US20090114737A1 (en) | 2007-11-07 | 2009-05-07 | Health & Life Co., Ltd. | Aerosolization device |
US20090212127A1 (en) * | 2007-12-14 | 2009-08-27 | Weidlinger Associates, Inc. | Fuel injector with single crystal piezoelectric actuator stack |
US20090212133A1 (en) | 2008-01-25 | 2009-08-27 | Collins Jr James F | Ophthalmic fluid delivery device and method of operation |
US8734408B2 (en) | 2008-02-05 | 2014-05-27 | Alvin J. Marx | Automated eyedrop delivery system with eyelid retracting legs |
EP2271337B1 (en) | 2008-04-04 | 2014-09-03 | Mimetogen Pharmaceuticals Inc. | Beta-turn peptidomimetic cyclic compounds for treating dry eye |
US8080562B2 (en) | 2008-04-15 | 2011-12-20 | Sarcode Bioscience Inc. | Crystalline pharmaceutical and methods of preparation and use thereof |
DE102008022987A1 (de) | 2008-05-09 | 2009-11-12 | Pari Pharma Gmbh | Vernebler für Beatmungsmaschinen und Beatmungsmaschine mit einem solchen Vernebler |
EP2296896B1 (en) * | 2008-05-23 | 2022-05-18 | FUJIFILM Corporation | Fluid droplet ejecting |
US20100001090A1 (en) | 2008-07-03 | 2010-01-07 | Arthur Hampton Neergaard | Liquid Particle Emitting Device |
US8944344B2 (en) * | 2008-07-08 | 2015-02-03 | Sonics & Materials Inc. | Multi-element ultrasonic atomizer |
US7656076B1 (en) | 2008-07-15 | 2010-02-02 | Iptrade, Inc. | Unimorph/bimorph piezoelectric package |
MX2011002154A (es) * | 2008-08-28 | 2011-05-25 | Deka Products Lp | Sistema de suministro de producto. |
US20100076388A1 (en) | 2008-09-19 | 2010-03-25 | Miro Cater | Discharge device for pharmaceutical media |
US20100072301A1 (en) | 2008-09-19 | 2010-03-25 | Miro Cater | Discharge device |
US20100072302A1 (en) | 2008-09-19 | 2010-03-25 | Miro Cater | Discharge device |
US20090192443A1 (en) | 2008-10-06 | 2009-07-30 | Collins Jr James F | Ophthalmic fluid delivery device and method of operation |
JP5731980B2 (ja) | 2008-10-09 | 2015-06-10 | ラムズコア, インコーポレイテッド | ドライアイ症候群の処置のための組成物および方法 |
EP3354643B1 (en) | 2009-05-01 | 2020-10-28 | Aerie Pharmaceuticals, Inc. | Dual mechanism inhibitors for the treatment of disease |
EP2456509A1 (en) * | 2009-07-22 | 2012-05-30 | Advanced Ophthalmic Pharma Ltd. | Device for applying an ophthalmic medicament mist |
FR2950036B1 (fr) | 2009-09-11 | 2011-12-16 | Rexam Pharma La Verpilliere | Dispositif de distribution de liquide |
EP2302712A1 (en) | 2009-09-28 | 2011-03-30 | Stichting IMEC Nederland | Method for resonance frequency tuning of micromachined structures |
US8596781B2 (en) * | 2009-10-15 | 2013-12-03 | Adlens Beacon, Inc. | Fluid filled lens reservoir system and manufacturing method of the reservoir system |
US8378105B2 (en) | 2009-10-21 | 2013-02-19 | Sarcode Bioscience Inc. | Crystalline pharmaceutical and methods of preparation and use thereof |
US20110106025A1 (en) | 2009-10-29 | 2011-05-05 | Hall Gary S | Ophthalmic fluid pump |
US9801757B2 (en) | 2011-08-31 | 2017-10-31 | Johnson & Johnson Vision Care, Inc. | Liquid dispensing reservoir |
US9039666B2 (en) | 2009-10-21 | 2015-05-26 | Johnson & Johnson Vision Care, Inc. | Method and apparatus for liquid dispensing |
EP2501494A1 (en) | 2009-11-18 | 2012-09-26 | Reckitt Benckiser LLC | Surface treatment device and method |
DK2546656T3 (da) * | 2010-02-09 | 2019-07-22 | Cytena Gmbh | Udtømningsindretning til væskemateriale, der indeholder partikler |
DE102010011047A1 (de) | 2010-03-11 | 2011-09-15 | Johnson Matthey Catalysts (Germany) Gmbh | Biegewandler |
AU2011238914A1 (en) | 2010-04-06 | 2012-11-29 | Reseal International Limited Partnership | Delivery system for dispensing metered volumes of pure or sterile flowable substances |
DE102010003810A1 (de) | 2010-04-09 | 2011-10-13 | Henkel Ag & Co. Kgaa | Abgabevorrichtung mit piezo-elektrischem Element |
JP5171879B2 (ja) | 2010-05-06 | 2013-03-27 | 株式会社エヌ・ティ・ティ・ドコモ | 移動通信端末及び再接続方法 |
KR101153613B1 (ko) * | 2010-05-25 | 2012-06-18 | 삼성전기주식회사 | 마이크로 이젝터 및 그 제조방법 |
DE102010017216A1 (de) | 2010-06-02 | 2011-12-08 | Technische Universität Berlin | Ventilvorrichtung zum Steuern eines Flusses eines Fluides durch einen Fluidkanal, Anordnung sowie Mehrwegventilvorrichtung |
AU2011278924B2 (en) | 2010-07-15 | 2015-06-18 | Eyenovia, Inc. | Ophthalmic drug delivery |
EA201390121A8 (ru) | 2010-07-15 | 2014-02-28 | Коринтиан Офтэлмик, Инк. | Способ и система для выполнения дистанционного лечения и контроля |
AU2011278934B2 (en) | 2010-07-15 | 2015-02-26 | Eyenovia, Inc. | Drop generating device |
US10154923B2 (en) | 2010-07-15 | 2018-12-18 | Eyenovia, Inc. | Drop generating device |
US9132243B2 (en) | 2010-07-23 | 2015-09-15 | Tannermedico A/S | Method of administering a substance to the throat |
FR2963326B1 (fr) | 2010-07-30 | 2012-09-07 | Rexam Healthcare La Verpillier | Embout et recipient de distribution de liquide |
WO2012032503A1 (en) * | 2010-09-07 | 2012-03-15 | University Of Limerick | A liquid droplet dispenser |
US20130206857A1 (en) | 2011-01-21 | 2013-08-15 | Biodot, Inc. | Piezoelectric dispenser with a longitudinal transducer and replaceable capillary tube |
EP2665557B1 (en) * | 2011-01-21 | 2020-01-01 | Biodot, Inc. | Piezoelectric dispenser with a longitudinal transducer and replaceable capillary tube |
US9186690B2 (en) | 2011-02-01 | 2015-11-17 | Bausch & Lomb Incorporated | Ergonomic hand-operable fluid-dispensing device |
AU2012284267B2 (en) | 2011-07-15 | 2017-06-29 | Nusirt Sciences, Inc. | Compositions and methods for modulating metabolic pathways |
RU2594968C2 (ru) | 2011-07-19 | 2016-08-20 | Конинклейке Филипс Н.В. | Бытовое электрическое устройство, содержащее исполнительный механизм |
US9346075B2 (en) | 2011-08-26 | 2016-05-24 | Nordson Corporation | Modular jetting devices |
EP2758014A4 (en) | 2011-09-19 | 2015-09-02 | Daniel L Kraft | DISPENSER OF EYE DROPS |
WO2013041967A2 (en) | 2011-09-20 | 2013-03-28 | Altavista Instituto De Investigation Medica S.A.S | Compositions and methods for treating presbyopia, mild hyperopia, and irregular astigmatism |
DE102011114584B3 (de) | 2011-09-30 | 2012-05-31 | Carl Zeiss Meditec Ag | Ophthalmochirurgische Steuerungsvorrichtung und ophthalmochirurgisches System mit einer solchen Steuerungsvorrichtung |
US8957048B2 (en) | 2011-10-06 | 2015-02-17 | Allergan, Inc. | Compositions for the treatment of dry eye |
US20140285121A1 (en) | 2011-11-08 | 2014-09-25 | Fairchild Semiconductor Corporation | Modulation scheme for driving a piezo element |
DE102011086755A1 (de) | 2011-11-21 | 2013-05-23 | Aptar Radolfzell Gmbh | Spender zum Austrag von pharmazeutischen Flüssigkeiten |
CH705799A1 (it) | 2011-11-24 | 2013-05-31 | Luso Pharma Sagl | Testa di erogazione multi-dose con otturatore a membrana elastica. originale: Testa di erogazione multi-dose perfezionata. |
JP6105621B2 (ja) | 2011-12-12 | 2017-03-29 | アイノビア,インコーポレイティド | 高弾性高分子エジェクタ機構、エジェクタ装置及びそれらの使用方法 |
US8591635B2 (en) | 2011-12-19 | 2013-11-26 | Chrysler Group Llc | Fluid aeration-reduction system |
US20130164436A1 (en) | 2011-12-27 | 2013-06-27 | Ricoh Company | Thin film manufacturing apparatus, thin film manufacturing method, liquid droplet ejecting head, and inkjet recording apparatus |
US9254642B2 (en) | 2012-01-19 | 2016-02-09 | AdvanJet | Control method and apparatus for dispensing high-quality drops of high-viscosity material |
AU2013245946A1 (en) | 2012-04-10 | 2014-11-27 | Eyenovia, Inc. | Spray ejector mechanisms and devices providing charge isolation and controllable droplet charge, and low dosage volume opthalmic administration |
KR102108588B1 (ko) | 2012-04-20 | 2020-05-07 | 아이노비아 인코포레이티드 | 분사 토출기 디바이스 및 이용 방법들 |
US9821125B2 (en) * | 2012-04-26 | 2017-11-21 | Koninklijke Philips N.V. | Nebulizer and a method of manufacturing a nebulizer |
CA2873508A1 (en) | 2012-05-15 | 2013-11-21 | Eyenovia, Inc. | Ejector devices, methods, drivers, and circuits therefor |
EP2664329A1 (de) | 2012-05-15 | 2013-11-20 | F. Holzer GmbH | Ophthalmologisches Vehikelsystem |
US9132238B2 (en) | 2012-06-26 | 2015-09-15 | Becton, Dickinson And Company | Blow fill seal luer syringe |
KR102157608B1 (ko) | 2012-07-25 | 2020-09-18 | 에스에이알코드 바이오사이언스 인코포레이티드 | Lfa-1 저해제 및 그의 다형체 |
WO2014037420A1 (en) | 2012-09-07 | 2014-03-13 | Glaxo Group Limited | Liquid droplet dispenser |
WO2014049661A1 (ja) | 2012-09-27 | 2014-04-03 | テルモ株式会社 | 輸液ポンプ |
US8927921B1 (en) | 2012-10-02 | 2015-01-06 | Sun Nuclear Corporation | Systems and methods for composite dose quality assurance with three dimensional arrays |
CN105191050B (zh) | 2013-02-12 | 2018-03-13 | Sis资源有限公司 | 用于电子香烟的感应充电 |
US9962288B2 (en) | 2013-03-07 | 2018-05-08 | Novartis Ag | Active acoustic streaming in hand piece for occlusion surge mitigation |
US20140276054A1 (en) | 2013-03-15 | 2014-09-18 | Volcano Corporation | Piezoelectric-Actuated Fluid-Delivery Devices and Associated Systems and Methods |
US20150018781A1 (en) | 2013-04-10 | 2015-01-15 | California Institute Of Technology | Systems, devices, and methods for topical drug delivery to the eye |
US20150035180A1 (en) | 2013-08-02 | 2015-02-05 | Forward Optics Co., Ltd. | Method for fabricating an arrayed optical element |
US8976451B2 (en) | 2013-08-02 | 2015-03-10 | Forward Optics Co., Ltd | Lens array module |
WO2015031389A2 (en) | 2013-08-26 | 2015-03-05 | Lightside Md, Llc | Adhesive support devices and methods of making and using them |
US20150086397A1 (en) * | 2013-09-25 | 2015-03-26 | Hsiao-Kang Ma | Micropump with separate chamber |
US9282803B2 (en) | 2013-10-03 | 2016-03-15 | Donald John Ciervo | Ultrasonic cosmetic applicator |
US9676525B2 (en) | 2013-12-17 | 2017-06-13 | Aptar Radolfzell Gmbh | Protective cap for a dispenser, and discharge device for discharging pharmaceutical and/or cosmetical liquids |
CA2936235A1 (en) * | 2014-01-10 | 2015-07-16 | Marcio Marc Abreu | Devices to monitor and provide treatment at an abreu brain tunnel |
US20150256730A1 (en) | 2014-03-05 | 2015-09-10 | Forward Optics Co., Ltd. | Image-capturing device configured for a handheld electronic device |
US20150276994A1 (en) | 2014-03-28 | 2015-10-01 | Forward Optics Co., Ltd. | Method of making a lens array plate with an aperture mask layer |
DE102014208064B4 (de) | 2014-04-29 | 2015-12-03 | Heraeus Medical Gmbh | Lavage-System mit einem Druckgasmotor sowie Verfahren zum Erzeugen eines Sprühstoßes |
US10307550B2 (en) | 2014-06-09 | 2019-06-04 | Dance Biopharm Inc. | Liquid drug cartridges and associated dispenser |
JP6052475B2 (ja) | 2014-07-16 | 2016-12-27 | 株式会社村田製作所 | 流体制御装置 |
CN104146816B (zh) | 2014-09-02 | 2016-04-13 | 镇江万新光学眼镜有限公司 | 一种眼部雾化送药装置 |
TWI658828B (zh) | 2014-10-31 | 2019-05-11 | 中國醫藥大學 | 用於舒緩及減輕近視之醫藥組合物及其製備方法與用途 |
JP2018510668A (ja) | 2015-01-12 | 2018-04-19 | ケダリオン セラピューティックス,インコーポレイテッド | 微小液滴の繰り出し装置及び方法 |
KR20170108057A (ko) | 2015-01-23 | 2017-09-26 | 윌리엄 탄 | 초음파 증발 요소 |
WO2016164830A1 (en) | 2015-04-10 | 2016-10-13 | Lagunita Llc | Piezoelectric dispenser with replaceable ampoule |
GB201507687D0 (en) | 2015-04-30 | 2015-06-17 | Leafgreen Ltd | Pulsed spray nozzle arrangement |
ES2907828T3 (es) | 2015-06-03 | 2022-04-26 | Novopyxis Inc | Método para general una nebulización en aerosol |
CN204813955U (zh) | 2015-07-22 | 2015-12-02 | 吉林大学 | 可调压力腔室体积的次声实验系统 |
US20170028626A1 (en) | 2015-07-29 | 2017-02-02 | Ecole Polytechnique Federale De Lausanne (Epfl) | Compact Drop-on-Demand Apparatus Using Light Actuation Through Optical Fibers |
WO2017029467A1 (en) | 2015-08-14 | 2017-02-23 | Leafgreen Limited | Pulsed spray nozzle arrangements |
GB201518337D0 (en) | 2015-10-16 | 2015-12-02 | The Technology Partnership Plc | Linear device |
DE102015224617B4 (de) * | 2015-12-08 | 2017-07-20 | Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. | Freistrahldosiersystem für das Auge |
JP2017120975A (ja) | 2015-12-28 | 2017-07-06 | ルネサスエレクトロニクス株式会社 | 撮像素子 |
US20190099071A1 (en) | 2016-03-24 | 2019-04-04 | Brien Holden Vision Institute | Devices and Method for Generating A Stimulus to Evaluate Ocular Sensitivity |
US10672298B2 (en) | 2016-10-17 | 2020-06-02 | Sanmina Corporation | System and method for a blood flow simulator |
US10888454B2 (en) | 2017-01-20 | 2021-01-12 | Kedalion Therapeutics, Inc. | Piezoelectric fluid dispenser |
CN115300226A (zh) | 2017-06-10 | 2022-11-08 | 艾诺维亚股份有限公司 | 用于将一体积的流体输送到眼睛的设备 |
CN109674576B (zh) | 2017-10-19 | 2024-02-27 | 深圳市启明医药科技有限公司 | 流体供应单元及微液滴喷射驱动装置、发生装置 |
CN111712219A (zh) | 2017-12-08 | 2020-09-25 | 科达莱昂治疗公司 | 流体递送对准系统 |
US20190314198A1 (en) | 2018-04-12 | 2019-10-17 | Kedalion Therapeutics, Inc. | Topical Ocular Delivery Methods and Devices for Use in the Same |
AU2019297326A1 (en) | 2018-07-03 | 2021-01-07 | Bausch + Lomb Ireland Limited | Topical ocular delivery devices and methods for using the same |
EP3826497A4 (en) | 2018-07-23 | 2022-05-04 | Wellness Insight Technologies, Inc. | SYSTEM FOR ANALYSIS AND CONTROL OF DOSING INFORMATION FOR CONSUMABLES |
CA3131264A1 (en) | 2019-03-04 | 2020-09-10 | Eyenovia, Inc. | Methods and devices for delivering pilocarpine to the eye as a micro-dose stream of droplets |
US11679028B2 (en) | 2019-03-06 | 2023-06-20 | Novartis Ag | Multi-dose ocular fluid delivery system |
US20210137732A1 (en) | 2019-03-06 | 2021-05-13 | Kedalion Therapeutics, Inc. | Vented Multi-dose Ocular Fluid Delivery System |
US11925577B2 (en) | 2020-04-17 | 2024-03-12 | Bausch + Lomb Ireland Limted | Hydrodynamically actuated preservative free dispensing system |
US11938057B2 (en) | 2020-04-17 | 2024-03-26 | Bausch + Lomb Ireland Limited | Hydrodynamically actuated preservative free dispensing system |
EP4120973A4 (en) | 2020-04-17 | 2024-04-17 | Bausch Lomb Ireland Ltd | HYDRODYNAMIC ACTUATED PRESERVATIVE-FREE DISPENSING SYSTEM WITH COLLAPSIBLE LIQUID CONTAINER |
US20220192874A1 (en) | 2020-04-17 | 2022-06-23 | Kedaliion Therapeutics, Inc. | Hydrodynamically Actuated Preservative Free Dispensing System |
-
2016
- 2016-01-11 JP JP2017532607A patent/JP2018510668A/ja active Pending
- 2016-01-11 US US14/992,975 patent/US10624781B2/en active Active
- 2016-01-11 CA CA2973471A patent/CA2973471A1/en not_active Abandoned
- 2016-01-11 WO PCT/US2016/012903 patent/WO2016115050A1/en active Application Filing
- 2016-01-11 KR KR1020177022269A patent/KR101984116B1/ko active IP Right Grant
- 2016-01-11 EP EP16737682.1A patent/EP3244851A4/en active Pending
- 2016-01-11 CN CN202110516413.5A patent/CN113230021A/zh active Pending
- 2016-01-11 CN CN201680005036.6A patent/CN107106325B/zh active Active
- 2016-01-11 AU AU2016207010A patent/AU2016207010A1/en not_active Abandoned
-
2020
- 2020-04-17 US US16/852,123 patent/US11819453B2/en active Active
Also Published As
Publication number | Publication date |
---|---|
JP2018510668A (ja) | 2018-04-19 |
AU2016207010A1 (en) | 2017-08-03 |
US20200246182A1 (en) | 2020-08-06 |
CN107106325A (zh) | 2017-08-29 |
US11819453B2 (en) | 2023-11-21 |
KR20170104555A (ko) | 2017-09-15 |
EP3244851A4 (en) | 2018-08-22 |
CA2973471A1 (en) | 2016-07-21 |
US10624781B2 (en) | 2020-04-21 |
US20160199225A1 (en) | 2016-07-14 |
EP3244851A1 (en) | 2017-11-22 |
WO2016115050A1 (en) | 2016-07-21 |
CN107106325B (zh) | 2021-05-25 |
KR101984116B1 (ko) | 2019-05-31 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CN107106325B (zh) | 微滴递送设备和方法 | |
US20200197220A1 (en) | Ophthalmic Dispenser With Replaceable Ampoule | |
US10646373B2 (en) | Ejector mechanism, ejector device, and methods of use | |
KR102412086B1 (ko) | 압전 유체 분배기 | |
KR101545413B1 (ko) | 점적 발생 디바이스 | |
US20160015564A1 (en) | Drug-delivery pumps and methods of manufacture | |
US20150018781A1 (en) | Systems, devices, and methods for topical drug delivery to the eye |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
PB01 | Publication | ||
PB01 | Publication | ||
SE01 | Entry into force of request for substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
TA01 | Transfer of patent application right | ||
TA01 | Transfer of patent application right |
Effective date of registration: 20221227 Address after: Basel, SUI Applicant after: NOVARTIS AG Address before: California, USA Applicant before: LAGUNITA LLC |
|
TA01 | Transfer of patent application right | ||
TA01 | Transfer of patent application right |
Effective date of registration: 20240227 Address after: Ai Erlandubailin Applicant after: Bausch & Lomb Ireland Ltd. Country or region after: Ireland Address before: Basel, SUI Applicant before: NOVARTIS AG Country or region before: Switzerland |