JP4761709B2 - エアロゾル発生器を作動するための方法およびシステム - Google Patents
エアロゾル発生器を作動するための方法およびシステム Download PDFInfo
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Description
本願は、係属中の米国特許出願番号09/876,542(2001年6月7日出願)、09/876,402(2001年6月7日出願)および09/812,987(2001年3月20日出願)(これらの完全な開示は、本明細書中で参考として援用される)に関する。
本発明は、一般に、液体エアロゾル発生器に関する。特に、本発明は、患者へのエアロゾル化液体の送達を改善するための噴霧器(nebule)の中身を識別するための、方法およびデバイスに関する。
本発明は、患者に対する安全性のレベルを改善し、そして患者へのエアロゾル送達の有効性の増大を提供するためのデバイスおよび方法を提供する。
本発明のエアロゾル発生器システムは、1つの局面において、少なくとも1つのセンサと連絡するコントローラーに接続されたエアロゾル発生器を備え、その結果、エアロゾルの患者への送達順序は、少なくとも部分的に、センサにより得られた情報に基づき得る。幾つかの例示的な実施形態において、このシステムは、噴霧器識別センサを備えて、噴霧器上の識別マーカーを読み取り、噴霧器内に配置された液体の型を識別する。他の例示的な実施形態において、このシステムは、呼吸特性センサを備え、このセンサは、患者の呼吸特性をモニタリングおよび記録して、コントローラーが、患者の呼吸パターンに一致するようなエアロゾルの送達を指示する。なお他の例示的な実施形態において、エアロゾル発生器システムは、噴霧器識別センサおよび呼吸特性センサの両方を備える。
工程200において、選択は以下の特定のレジームに対してなされる。この場合、レジームIは、エアロゾルが連続的に発生されるレジームである(工程202)。レジームIIは、吸入期のみの間にエアロゾル発生を提供する(工程204)。この場合、工程206において、エアロゾル発生が、吸入期の開始で始まるようにセットされ、そして工程208において、エアロゾル発生は、吸入期が止まる場合に止まるようセットされる。工程210において、エアロゾル発生は、吸入期の開始で始まる。工程212において、吸入期が終わる時、エアロゾル発生が止まる(工程214)。
あるいは、このように所定の割合は、送風機における連続した別々の時点の間の時間間隔(例えば、送風機による連続吸入生成の連続開始)に基づき得る。あるいは、このような割合は、送風機回路における空気圧に基づき得るか、または他のパラメーターに基づき得る。レジームIIIに関して、この場合、工程218において、第1の所定の時点は、吸入の第1の所定の割合の完了と対応するようにセットされる。工程220において、第2の所定の時点は、完了した吸入割合の第2の所定の割合に対応するようにセットされる。例えば、上記のように、第1の所定の時点は、完了した吸入期の20%と対応し得、そして第2の所定の時点は、同じ吸入が生じた時点の70%での時点と一致し得る。工程222において、エアロゾル発生は、吸入期における、第1の所定の時点で始まる。工程224において、第2の所定の時点に達した場合、コントローラーは工程214を実行し、そしてエアロゾル発生を止める。
Claims (10)
- システムであって、
送風機を備えた、送風機回路;
振動可能な有孔プレートを備えるエアロゾル発生器であって、エアロゾルを該送風機回路へと放出するように構成されている、エアロゾル発生器;
液体を保持し、かつ該エアロゾル発生器と接続するように構成された噴霧器本体を備える、噴霧器;および
振動要素に接続されたコントローラー、を備え、ここで、該噴霧器が、該エアロゾル発生器の作動を制御するために使用可能な情報を有する識別子を、該有孔プレートが該噴霧器上の識別子から読まれた情報に基づき作動プログラムに従って振動されるように含み、該識別子が識別マーカーであり、ここで、該システムが、患者の1つ以上の呼吸特性を測定し、そして該コントローラーが、測定された該1つ以上の呼吸特性に基づいて該振動要素を振動し、そして、該コントローラーが、該エアロゾル発生器に、呼吸サイクルの第1の所定の時間においてエアロゾル生成を開始させ、そして該呼吸サイクルの第2の所定の時間においてエアロゾル生成を停止させるように構成されており、該呼吸サイクルにおける第1の所定の時間が吸気の第1の部分の後に存在し、そして該呼吸サイクルにおける第2の所定の時間が当該吸気の第2の部分の後に存在する、呼吸サイクルシステム。 - ハウジングをさらに備え、そして前記エアロゾル発生器と連絡している貯蔵器をさらに備え、ここで前記噴霧器本体が打鍵要素を備え、該噴霧器が該ハウジング中に挿入される場合、該打鍵要素が、該ハウジングと鍵合わせされる場合に該貯蔵器への接近を提供し、これによって液体が該噴霧器から該貯蔵器に移され、該打鍵要素がねじ山、タブおよびスロットからなる群から選択される、請求項1に記載のシステム。
- 前記振動可能な有孔プレートが、第1の面、第2の面およびそれらを通る複数の孔を有するエアロゾル化要素、ならびに振動要素を備え;そしてここで、前記貯蔵器が、前記エアロゾル発生器のエアロゾル化要素の第1の面と液体連絡している、
請求項2に記載のシステム。 - 前記コントローラーが、複数の記憶された作動プログラムを備える、請求項3に記載のシステム。
- 該コントローラーが、呼吸パターンに基づいてエアロゾル生成の時間間隔を調整するように構成されている、請求項3に記載のシステム。
- 測定された前記呼吸特性が、患者の吸入パターン、最大吸気流速、呼吸数、呼気パラメーター、または吸入の調節である、請求項3に記載のシステム。
- 前記貯蔵器上に配置されたスリットシール膜をさらに備え、ここで前記噴霧器が、前記打鍵要素が前記ハウジングと鍵合わせされて前記液体が該噴霧器から該貯蔵器に移されることを可能にする場合に、該スリットシール膜を通じて突出するように構成されている、請求項2に記載のシステム。
- 請求項3に記載のシステムであって、該システムが呼吸サイクルの第1の所定の時間を感知するセンサをさらに備え、ここで、該センサが、前記コントローラーと連絡している、システム。
- 前記コントローラーが、ある間隔の間エアロゾルを提供するように構成されており、該間隔は、呼気期の一部分および連続する吸気期の一部分を含み、該呼気期の開始後に始まり、そして該連続する吸気期の間に終わる、請求項3に記載のシステム。
- 前記液体をさらに含み、ここで該液体が抗生物質を含有する、請求項1に記載のシステム。
Applications Claiming Priority (15)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US34980502P | 2002-01-15 | 2002-01-15 | |
US34976302P | 2002-01-15 | 2002-01-15 | |
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- 2003-01-15 ES ES03702161.5T patent/ES2603067T3/es not_active Expired - Lifetime
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- 2003-01-15 WO PCT/US2003/001516 patent/WO2003059424A1/en active Application Filing
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JPH0838604A (ja) * | 1994-05-06 | 1996-02-13 | Siemens Elema Ab | 麻酔装置用の安全装置 |
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JP2005514991A (ja) | 2005-05-26 |
US6968840B2 (en) | 2005-11-29 |
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JP2006150093A (ja) | 2006-06-15 |
US7331339B2 (en) | 2008-02-19 |
US20030140921A1 (en) | 2003-07-31 |
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