US3908654A - Dispensing package for a dry biological and a liquid diluent - Google Patents

Dispensing package for a dry biological and a liquid diluent Download PDF

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Publication number
US3908654A
US3908654A US49388074A US3908654A US 3908654 A US3908654 A US 3908654A US 49388074 A US49388074 A US 49388074A US 3908654 A US3908654 A US 3908654A
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Grant
Patent type
Prior art keywords
container
needle
skirt
plug
end
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Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
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Inventor
Willy Lhoest
Eloi Van Hoye
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Recherche et Industrie Therapeutiques
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Recherche et Industrie Therapeutiques
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61JCONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/05Containers specially adapted for medical or pharmaceutical purposes for collecting, storing or administering blood, plasma or medical fluids ; Infusion or perfusion containers
    • A61J1/14Details, e.g. provisions for hanging or shape retaining means; Accessories therefor, e.g. inlet or outlet ports, filters or caps
    • A61J1/20Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2089Containers or vials which are to be joined to each other in order to mix their contents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61JCONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/05Containers specially adapted for medical or pharmaceutical purposes for collecting, storing or administering blood, plasma or medical fluids ; Infusion or perfusion containers
    • A61J1/14Details, e.g. provisions for hanging or shape retaining means; Accessories therefor, e.g. inlet or outlet ports, filters or caps
    • A61J1/20Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2003Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
    • A61J1/2006Piercing means
    • A61J1/201Piercing means having one piercing end
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61JCONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/05Containers specially adapted for medical or pharmaceutical purposes for collecting, storing or administering blood, plasma or medical fluids ; Infusion or perfusion containers
    • A61J1/14Details, e.g. provisions for hanging or shape retaining means; Accessories therefor, e.g. inlet or outlet ports, filters or caps
    • A61J1/20Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2003Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
    • A61J1/2048Connecting means
    • A61J1/2065Connecting means having aligning and guiding means
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178Syringes
    • A61M5/28Syringe ampoules or carpules, i.e. ampoules or carpules provided with a needle
    • A61M5/281Syringe ampoules or carpules, i.e. ampoules or carpules provided with a needle using emptying means to expel or eject media, e.g. pistons, deformation of the ampoule, or telescoping of the ampoule
    • A61M5/282Syringe ampoules or carpules, i.e. ampoules or carpules provided with a needle using emptying means to expel or eject media, e.g. pistons, deformation of the ampoule, or telescoping of the ampoule by compression of deformable ampoule or carpule wall
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178Syringes
    • A61M5/28Syringe ampoules or carpules, i.e. ampoules or carpules provided with a needle
    • A61M5/284Syringe ampoules or carpules, i.e. ampoules or carpules provided with a needle comprising means for injection of two or more media, e.g. by mixing

Abstract

A dispensing package for a dry biological and a liquid diluent has a hollow resilient member for containing a liquid diluent, said member being open at one end and having a nozzle at the other end with a removable closure. A plug is secured in the open end of the hollow member and a skirt integral with the plug forms a chamber for the reception of a container. A hollow needle secured in the plug is in communication with the interior of the hollow resilient member and extends into the interior of the skirt. A container for a dry biological has a pierceable stopper and is frictionally engaged by the skirt in a position such that the end of the needle within the skirt is embedded in the pierceable stopper to block the flow of liquid through the needle. The stopper is spaced away from the plug. On the further advance of the container towards the plug, the needle passes through the stopper into the container to permit the transfer of the liquid diluent into the container and then back into the tube for administration through the nozzle on the removal of the nozzle closure. A syringe type needle may be substituted for the nozzle to provide for subcutaneous or intramuscular administration.

Description

United States Patent [191 Lhoest et al.

[451 Sept. 30, 1975 [22] Filed: Aug. 2, 1974 [21] Appl. No.: 493,880

[52] US. CL. 128/218 M; 128/218 D; l28/D1G. 28; 222/130; 222/206; 222/541; 128/231 [51] Int. Cl. A6IM 05/00 [58] Field of Search 222/80, 130, 206, 541, 222/85; 128/218 M, 218 D, DIG. 28; 206/222 [56] References Cited UNITED STATES PATENTS 2/1968 Hein 222/85 3.636.950 1/1972 Gomez et a1... 206/222 X 3.724.460 4/1973 Gomez et a1. 128/218 M FOREIGN PATENTS OR APPLICATIONS 1.545.963 10/1968 France 206/222 Irinmry E.raminer-Allcn N. Knowles Assistant Examiner-David A. Schcrbel Attorney, Agent, or Firm-Smith, Harding, Earley & Follmer 5 7 ABSTRACT A dispensing package for a dry biological and a liquid diluent has a hollow resilient member for containing a liquid diluent, said member being open at one end and having a nozzle at the other end with a removable closure. A plug is secured in the open end of the hollow member and a skirt integral with the plug forms a chamber for the reception of a container. A hollow needle secured in the plug is in communication with the interior of the hollow resilient member and extends into the interior of the skirt. A container for a dry biological has a pierceable stopper and is frictionally engaged by the skirt in a position such that the end of the needle within the skirt is embedded in the pierceable stopper to block the flow of liquid through the needle. The stopper is spaced away from the plug. On the further advance of the container towards the plug, the needle passes through the stopper into the container to permit the transfer of the liquid diluent into the container and then back into the tube for administration through the nozzle on the removal of the nozzle closure. A syringe type needle may be substituted for the nozzle to provide for subcutaneous or intramuscular administration.

3 Claims, 5 Drawing Figures Pia US. Patent Sept. 30,1975

FIG.4.

DISPENSING PACKAGE FOR A DRY BIOLOGICAL AND A LIQUID DILUENT BACKGROUND OF THE INVENTION I-Iein US. Pat. No. 3,369,708 discloses a dispensing package for a dry biological and a liquid diluent having a syringe element with a needle at one end and a nozzle at the other end and a container with a pierceable stopper containing a dry biological. A rubber stopper is provided to prevent liquid diluent from running out of the syringe element through the needle. When it is desired to administer the medicament, the rubber stopper is removed from the needle and a separately packaged container is forced up against the needle to cause the needle to pierce through the piercable stopper of the container. The I-Iein structure necessitates the separate packaging of the syringe element and the container for the dry biological. This requires an awkward manipula tion by the doctor or the patient involving the removal of the rubber stopper without spilling the liquid diluent and the interconnecting of the syringe element with the container. In accordance with this invention these problems are entirely eliminated by providing a dispensing package which incorporates both the dispensing element and the container for the dry biological into a single unit which is activated for administration by a simple telescoping action with maximum sterility being maintained.

BRIEF SUMMARY OF THE INVENTION A dispensing package for a dry biological and a liquid diluent has a hollow resilient member for containing a liquid diluent, said member being open at one end and having a nozzle at the other end with a removable closure. A plug is secured in the open end of the hollow member and a skirt integral with the plug forms a chamber for the reception of a container. A hollow needle secured in the plug is in communication with the interior of the hollow member and extends into the interior of the skirt. A container for a dry biological has a pierceable stopper and is frictionally engaged by the skirt in a position such that the end of the needle within the skirt is embedded in the pierceable stopper to block the flow of liquid through the needle. The stopper is spaced away from the plug. On the further advance of the container towards the plug, the needle passes through the stopper into the container to permit the transfer of the liquid diluent into the container and then back into the tube for administration through the nozzle on the removal of the nozzle closure. A syringe type needle may be substituted for the nozzle to provide for subcutaneous or intramuscular administration.

BRIEF DESCRIPTION OF THE DRAWING FIG. I is an exploded view of a dispensing package in accordance with the invention;

FIG. 2 is a side elevation of the dispensing package of FIG. I showing the elements in the shipping and storing configuration;

FIG. 3 is an enlarged vertical section of the device of FIG. 2 partially broken away;

FIG. 4 is a vertical section through the device of FIG. 2 illustrating the position of the parts with the liquid diluent having been released into the container for the dry biological; and

resilient plastic such as polyethylene, polypropylene or polyvinyl chloride, with an open end 6 and a nozzle 8 O at the other end. Nozzle 8 has a narrow passage 10 which is blocked by a twist off cap 12 which breaks off on a peripheral line of weakness shown at 13. Other caps such as a screw cap can be used.

End 6 is closed by a plug 14 which has a passage 16 in which a hollow needle 18 is secured by a pressed fit. Needle 18 has a sharpened end 20 which extends downwardly within a skirt 24 which is integral with plug 14. Tube 4 contains a liquid diluent 26.

A container 30 typically containing a lyophilized biological tablet 32 is secured within skirt 24 by a frictional engagement with the skirt. Container 30 has a pierceable stopper 34 of for example, rubber, which is held in position by a thin metal cap 36. Cap 36 is frictionally engaged by a narrowed portion 40 of skirt 24. In the shipping and storing position shown in FIGS. 2 and 3, the cap 36 is spaced away from plug 14 and the needle 18 is lodged within stopper 34 with the end 20 completely blocked by the stopper to prevent diluent 26 from entering container 30.

When it is desired to administer the biological, container 30 is forced further into skirt 24 until hollow needle 18 pierces through stopper 24 at which time with the unit in a substantially upright position the liquid diluent 26 runs down into container 30 assisted if necessary by the squeezing of resilient tube 4. After the tablet 32 is dissolved, the device is turned upside down and the liquid permitted to run into resilient tube 4 assisted by squeezing and releasing tube 4. The device is maintained in the same position and twist off cap 12 is removed by twisting it at the line of weakness 13. The biological can then be dispensed, for example, into a nostril by squeezing resilient tube 4. Advantageously, passage 10 is of a size such that the liquid diluent will not run out under the force of gravity.

As shown in FIG. 5 where a subcutaneous or intramuscular injection is desired, the device of FIG. 2 may be modified to eliminate cap 12 and secure a syringe needle 50 in passage 10 by a pressed fit. A resilient cap 52 may be used as a stopper for needle 50 until admin istration is to be carried out.

The dispensing package of the invention is low in cost and disposable. It can be steam sterilized. It combines simplicity of operation with maximum sterility in reconstitution.

It will be understood that the above described embodiments are illustrative and not limiting.

We claim:

1. Dispensing package for a dry biological and a liquid diluent comprising:

a hollow resilient member for containing a liquid diluent open at one end and having a discharge opening at the other end,

removable means closing the discharge opening,

a plug in said one end,

a skirt integral with the plug forming a chamber for the reception of a container,

a hollow needle secured in said plug in communicatainer to permit the transfer of the liquid diluent tion with the interior of said hollow member and into the container and then back into the tube for extending into the interior of the skirt, administration through the discharge opening on a container for a dry biological having a pierceable the removal of the means closing the discharge stopper frictionally engaged by said skirt with said 5 opening. needle having its end within the skirt embedded in 2. A dispensing package in accordance with claim 1 the pierceable stopper to prevent the flow of liquid having a nozzle incorporating the discharge opening. through the needle and the stopper spaced away 3. A dispensing package in accordance with claim 1 from the plug, whereby further advancing the conhaving an injection needle secured in the discharge tainer into the skirt causes the needle to pass opening.

through the pierceable stopper and into the con-

Claims (3)

1. Dispensing package for a dry biological and a liquid diluent comprising: a hollow resilient member for containing a liquid diluent open at one end and having a discharge opEning at the other end, removable means closing the discharge opening, a plug in said one end, a skirt integral with the plug forming a chamber for the reception of a container, a hollow needle secured in said plug in communication with the interior of said hollow member and extending into the interior of the skirt, a container for a dry biological having a pierceable stopper frictionally engaged by said skirt with said needle having its end within the skirt embedded in the pierceable stopper to prevent the flow of liquid through the needle and the stopper spaced away from the plug, whereby further advancing the container into the skirt causes the needle to pass through the pierceable stopper and into the container to permit the transfer of the liquid diluent into the container and then back into the tube for administration through the discharge opening on the removal of the means closing the discharge opening.
2. A dispensing package in accordance with claim 1 having a nozzle incorporating the discharge opening.
3. A dispensing package in accordance with claim 1 having an injection needle secured in the discharge opening.
US3908654A 1974-08-02 1974-08-02 Dispensing package for a dry biological and a liquid diluent Expired - Lifetime US3908654A (en)

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US3908654A US3908654A (en) 1974-08-02 1974-08-02 Dispensing package for a dry biological and a liquid diluent

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US3908654A US3908654A (en) 1974-08-02 1974-08-02 Dispensing package for a dry biological and a liquid diluent
FR7522377A FR2281037A7 (en) 1974-08-02 1975-07-17 Packaging for the preparation and administration of a composition based on a dry organic product and a liquid diluent
DE19757524200 DE7524200U (en) 1974-08-02 1975-07-30 Dispensing package for a dry serum and means a liquid verduennungsmittel

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Cited By (48)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4408699A (en) * 1980-02-07 1983-10-11 Pacer Technology And Resources, Inc. Dispensing tip for cyanoacrylate adhesives
US4410321A (en) * 1982-04-06 1983-10-18 Baxter Travenol Laboratories, Inc. Closed drug delivery system
US4411662A (en) * 1982-04-06 1983-10-25 Baxter Travenol Laboratories, Inc. Sterile coupling
WO1983003539A1 (en) * 1982-04-06 1983-10-27 Baxter Travenol Lab Container for mixing a liquid and a solid
WO1983003587A1 (en) * 1982-04-06 1983-10-27 Baxter Travenol Lab Separated packaging and sterile processing for liquid-powder mixing
US4413753A (en) * 1980-05-15 1983-11-08 Pacer Technology And Resources, Inc. Dispenser for cyanoacrylate adhesives
US4415393A (en) * 1981-10-22 1983-11-15 Baxter Travenol Laboratories, Inc. Method of making a frangible port protector
US4445895A (en) * 1981-07-16 1984-05-01 Sterling Drug Inc. Prepackaged, disposable hypodermic syringes
FR2552404A1 (en) * 1983-09-26 1985-03-29 Merck Sharp & Dohme Whole preparation and issuance of a solution, plug shutter for this set and this stopper METHOD
JPS61501129A (en) * 1984-02-10 1986-06-12
US4624667A (en) * 1984-06-11 1986-11-25 Abbott Laboratories Additive transfer device
US4666063A (en) * 1985-08-23 1987-05-19 Wheeling Stamping Company Container with twist-off tamper evident feature
EP0225861A1 (en) * 1985-12-12 1987-06-16 Mediplast AB Transfer device
JPS63135642U (en) * 1986-09-05 1988-09-06
US4787536A (en) * 1985-03-29 1988-11-29 Aktiebolaget Draco Dosage package
WO1995031232A1 (en) * 1994-05-11 1995-11-23 Plas-Pak Industries, Inc. Dual barrel syringe and method of use
US5830193A (en) * 1993-12-28 1998-11-03 Higashikawa; Tetsuro Syringe
US20050028813A1 (en) * 2001-10-05 2005-02-10 Ian Harrison Apparatus for the nasal or oral delivery of a medicament
US6948491B2 (en) * 2001-03-20 2005-09-27 Aerogen, Inc. Convertible fluid feed system with comformable reservoir and methods
US6978941B2 (en) 2001-05-02 2005-12-27 Aerogen, Inc. Base isolated nebulizing device and methods
US7032590B2 (en) 2001-03-20 2006-04-25 Aerogen, Inc. Fluid filled ampoules and methods for their use in aerosolizers
US7040549B2 (en) 1991-04-24 2006-05-09 Aerogen, Inc. Systems and methods for controlling fluid feed to an aerosol generator
US7066398B2 (en) 1999-09-09 2006-06-27 Aerogen, Inc. Aperture plate and methods for its construction and use
US20060257199A1 (en) * 2005-05-10 2006-11-16 Sogaro Alberto C Disposable dispensing device
US7174888B2 (en) 1995-04-05 2007-02-13 Aerogen, Inc. Liquid dispensing apparatus and methods
US7201167B2 (en) 2004-04-20 2007-04-10 Aerogen, Inc. Method and composition for the treatment of lung surfactant deficiency or dysfunction
US20070209659A1 (en) * 1995-04-05 2007-09-13 Aerogen, Inc. Liquid dispensing apparatus and methods
US7290541B2 (en) 2004-04-20 2007-11-06 Aerogen, Inc. Aerosol delivery apparatus and method for pressure-assisted breathing systems
US7322349B2 (en) 2000-05-05 2008-01-29 Aerogen, Inc. Apparatus and methods for the delivery of medicaments to the respiratory system
US7331339B2 (en) 2000-05-05 2008-02-19 Aerogen, Inc. Methods and systems for operating an aerosol generator
US7360536B2 (en) 2002-01-07 2008-04-22 Aerogen, Inc. Devices and methods for nebulizing fluids for inhalation
US7600511B2 (en) 2001-11-01 2009-10-13 Novartis Pharma Ag Apparatus and methods for delivery of medicament to a respiratory system
US7628339B2 (en) 1991-04-24 2009-12-08 Novartis Pharma Ag Systems and methods for controlling fluid feed to an aerosol generator
US20090318860A1 (en) * 2006-07-04 2009-12-24 Yoshio Oyama End Portion Of Hermetically Sealed Container Having Fine Opening Surface Obtained Easily by Cleavage
US20100010434A1 (en) * 2006-11-07 2010-01-14 Yoshio Oyama Mechanism capable of providing neat cleaved opening surface and ampule with movable gasket
US7677467B2 (en) 2002-01-07 2010-03-16 Novartis Pharma Ag Methods and devices for aerosolizing medicament
US7771642B2 (en) 2002-05-20 2010-08-10 Novartis Ag Methods of making an apparatus for providing aerosol for medical treatment
WO2010139670A1 (en) * 2009-06-02 2010-12-09 Sanofi-Aventis Deutschland Gmbh Medicated module for a drug delivery device
WO2010139669A1 (en) * 2009-06-02 2010-12-09 Sanofi-Aventis Deutschland Gmbh Medicated module with premix medicament
US7946291B2 (en) 2004-04-20 2011-05-24 Novartis Ag Ventilation systems and methods employing aerosol generators
US7971588B2 (en) 2000-05-05 2011-07-05 Novartis Ag Methods and systems for operating an aerosol generator
US8336545B2 (en) 2000-05-05 2012-12-25 Novartis Pharma Ag Methods and systems for operating an aerosol generator
US8616195B2 (en) 2003-07-18 2013-12-31 Novartis Ag Nebuliser for the production of aerosolized medication
US9108211B2 (en) 2005-05-25 2015-08-18 Nektar Therapeutics Vibration systems and methods
US20160113377A1 (en) * 2012-11-27 2016-04-28 Socoplan Device for Containing, Dispensing and Applying to a Substrate Content in Liquid, Gel, Cream or Paste Form
US9550036B2 (en) 2011-03-03 2017-01-24 Impel Neuropharma Inc. Nasal drug delivery device
US9919117B2 (en) 2011-05-09 2018-03-20 Impel Neuropharma Inc. Nozzles for nasal drug delivery
US10016582B2 (en) 2008-02-07 2018-07-10 University Of Washington Through Its Center For Commercialization Circumferential aerosol device

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US3636950A (en) * 1968-11-14 1972-01-25 American Home Prod Disposable cartridge for admixing two components of injectable medicament
US3724460A (en) * 1968-11-14 1973-04-03 American Home Prod Disposable cartridge for admixing two components of injectable medicament

Cited By (74)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4408699A (en) * 1980-02-07 1983-10-11 Pacer Technology And Resources, Inc. Dispensing tip for cyanoacrylate adhesives
US4413753A (en) * 1980-05-15 1983-11-08 Pacer Technology And Resources, Inc. Dispenser for cyanoacrylate adhesives
US4445895A (en) * 1981-07-16 1984-05-01 Sterling Drug Inc. Prepackaged, disposable hypodermic syringes
US4415393A (en) * 1981-10-22 1983-11-15 Baxter Travenol Laboratories, Inc. Method of making a frangible port protector
US4410321A (en) * 1982-04-06 1983-10-18 Baxter Travenol Laboratories, Inc. Closed drug delivery system
WO1983003587A1 (en) * 1982-04-06 1983-10-27 Baxter Travenol Lab Separated packaging and sterile processing for liquid-powder mixing
US4484920A (en) * 1982-04-06 1984-11-27 Baxter Travenol Laboratories, Inc. Container for mixing a liquid and a solid
US4432755A (en) * 1982-04-06 1984-02-21 Baxter Travenol Laboratories, Inc. Sterile coupling
US4411662A (en) * 1982-04-06 1983-10-25 Baxter Travenol Laboratories, Inc. Sterile coupling
WO1983003539A1 (en) * 1982-04-06 1983-10-27 Baxter Travenol Lab Container for mixing a liquid and a solid
US4458733A (en) * 1982-04-06 1984-07-10 Baxter Travenol Laboratories, Inc. Mixing apparatus
US4467588A (en) * 1982-04-06 1984-08-28 Baxter Travenol Laboratories, Inc. Separated packaging and sterile processing for liquid-powder mixing
FR2552404A1 (en) * 1983-09-26 1985-03-29 Merck Sharp & Dohme Whole preparation and issuance of a solution, plug shutter for this set and this stopper METHOD
EP0138681A2 (en) * 1983-09-26 1985-04-24 LABORATOIRES MERCK, SHARP & DOHME-CHIBRET Assembly for preparing and dispensing a solution
EP0138681A3 (en) * 1983-09-26 1985-05-22 Laboratoires Merck, Sharp & Dohme-Chibret Assembly for preparing and dispensing a solution, a stopper for this assembly and process for making this stopper
US4573506A (en) * 1983-09-26 1986-03-04 Laboratories Merck Sharp & Dohme - Chibret Two-bottle assembly for preparing and dispensing a solution
JPS61501129A (en) * 1984-02-10 1986-06-12
JPH0349262B2 (en) * 1984-02-10 1991-07-29 Baxter Int
US4624667A (en) * 1984-06-11 1986-11-25 Abbott Laboratories Additive transfer device
US4787536A (en) * 1985-03-29 1988-11-29 Aktiebolaget Draco Dosage package
US4666063A (en) * 1985-08-23 1987-05-19 Wheeling Stamping Company Container with twist-off tamper evident feature
EP0225861A1 (en) * 1985-12-12 1987-06-16 Mediplast AB Transfer device
JPS63135642U (en) * 1986-09-05 1988-09-06
JPH0422745Y2 (en) * 1986-09-05 1992-05-26
US7628339B2 (en) 1991-04-24 2009-12-08 Novartis Pharma Ag Systems and methods for controlling fluid feed to an aerosol generator
US7040549B2 (en) 1991-04-24 2006-05-09 Aerogen, Inc. Systems and methods for controlling fluid feed to an aerosol generator
US5830193A (en) * 1993-12-28 1998-11-03 Higashikawa; Tetsuro Syringe
WO1995031232A1 (en) * 1994-05-11 1995-11-23 Plas-Pak Industries, Inc. Dual barrel syringe and method of use
US5725499A (en) * 1994-05-11 1998-03-10 Plas-Pak Industries, Inc. Dual barreled syringe and methods of assembly and use
US7174888B2 (en) 1995-04-05 2007-02-13 Aerogen, Inc. Liquid dispensing apparatus and methods
US20070209659A1 (en) * 1995-04-05 2007-09-13 Aerogen, Inc. Liquid dispensing apparatus and methods
US8561604B2 (en) 1995-04-05 2013-10-22 Novartis Ag Liquid dispensing apparatus and methods
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Also Published As

Publication number Publication date Type
FR2281037A7 (en) 1976-02-27 application
DE7524200U (en) 1975-12-11 grant

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