US3842833A - Neb-u-pack - Google Patents

Neb-u-pack Download PDF

Info

Publication number
US3842833A
US3842833A US31403072A US3842833A US 3842833 A US3842833 A US 3842833A US 31403072 A US31403072 A US 31403072A US 3842833 A US3842833 A US 3842833A
Authority
US
Grant status
Grant
Patent type
Prior art keywords
vial
nebulizer
tip
plug
cylindrical member
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
Inventor
R Ogle
Original Assignee
IMS Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Grant date

Links

Images

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M11/00Sprayers or atomisers specially adapted for therapeutic purposes
    • A61M11/06Sprayers or atomisers specially adapted for therapeutic purposes of the injector type
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M11/00Sprayers or atomisers specially adapted for therapeutic purposes
    • A61M11/001Particle size control
    • A61M11/002Particle size control by flow deviation causing inertial separation of transported particles

Abstract

This patent describes a novel combination comprising a medicament injector comprising: a cylindrical vial having an open end and a closed end, a resilient plug adapted to be inserted at least partially through said open end of said vial; a plurality of outwardly extending rings upon said plug engaging the walls of said vial with a press fit; a cylindrical member having one closed end, said cylindrical member holding a needle extending inwardly into said cylindrical member and having a sharpened inner end; and said cylindrical member having a tip extending outwardly therefrom, said tip being an elongated member of generally circular cross-section and having a central fluid passage extending substantially the length of the tip, said tip having three zones, the first of which is cylindrical, the second or intermediate which is tapered, and the third or outlet zone which is cylindrical but of smaller external diameter than said first zone, interlocking means on said cylindrical member and cooperating interlocking means on said plug, whereby upon interlocking of said plug with said cylindrical member said vial is first held in an assembled but non-operating position and upon further interlocking of said plug with said cylindrical member, said plug is adapted to be pierced by said needle and said needle communicated with said vial without the application of substantial axial pressure on said plug and said plug is locked securely to said cylindrical member to permit aspiration upon withdrawal of said vial or to permit expulsion of the contents of said vial upon exertion of pressure on said vial through said tip; and a nebulizer comprising an air inlet, an air outlet adapted to lead to the patient, means for forcing air through said nebulizer, means within said nebulizer for evaporating and forming particles of liquid medicament for inhalation therapy in the air stream passing through said nebulizer, and a medication introduction port opening into the interior of said nebulizer above the liquid medication level within said nebulizer, said tip being at least partially received in said port whereby liquid medication can be introduced into said nebulizer by the exertion of pressure on said vial.

Description

llite taes @gle atent 11 1 1 1 NEB-lU-PACK [75] Inventor: Robert Walter Ogle, Newport Beach, Calif.

[73] Assignee: IMS Limited, El Monte, Calif.

[22] Filed: Dec. 11, 1972 [21] Appl. No.: 314,030

[52] US. Cl 128/194,-l28/239, 141/350 [51] Int. Cl A61m 15/00 [58] Field of Search..... 128/194, 220, 193, 349 BV,

[56] References Cited UNITED STATES PATENTS 2,554,451 5/1951 Barry 128/220 2,574,028 11/1951 Fields 141/329 3,172,406 3/1965 Bird et al 128/194 3,203,455 8/1965 Horabin 141/329 3,378,008 4/1968 Ogle 1 128/220 3,486,539 12/1969 Jacuzzi 14l/329 3,516,407 6/1970 128/349 BV 3,563,240 2/1971 128/234 3,577,992 5/1971 128/349 BV 3,630,196 12/1971 128/194 3,729,031 4/1973 Baldwin 141/350 X Primary Examiner-Richard A. Gaudet Assistant Examiner-Lee S. Cohen Attorney, Agent, or Firm-loseph E. Mueth [57] ABSTRACT This patentdescribes a novel combination comprising a medicament injector comprising: a cylindrical vial having an open end and a closed end, a resilient plug adapted to be inserted at least partially through said open end of said vial; a plurality of outwardly extending rings upon said plug engaging the walls of said vial with a press fit; a cylindrical member having one closed end, said cylindrical member holding a needle extending inwardly into said cylindrical member and having a sharpened inner end; and said cylindrical member having a tip extending outwardly therefrom, said tip being an elongated member of generally circular cross-section and having a central fluid passage extending substantially the length of the tip, said tip having three zones, the first of which is cylindrical, the second or intermediate which is tapered, and the third or outlet zone which is cylindrical but of smaller external diameter than said first zone, interlocking means on said cylindrical member and cooperating interlocking means on said plug, whereby upon interlocking of said plug with said cylindrical member said vial is first held in an assembled but non-operating position and upon further interlocking of said plug with said cylindrical member, said plug is adapted to be pierced by said needle and said needle communicated with said vial without the application of substantial axial pressure on said plug and said plug is locked securely to said cylindrical member to permit aspiration upon withdrawal of said vial or to permit expulsion of the contents of said vial upon exertion of pressure on said vial through said tip; and a nebulizer comprising an air inlet, an air outlet adapted to lead to the patient, means for forcing air through said nebulizer, means within said nebulizer for evaporating and forming particles of liquid medicament for inhalation therapy in the air stream passing through said nebulizer, and a medication introduction port opening into the interior of said nebulizer above the liquid medication level within said nebulizer, said tip being at least partially received in said port whereby liquid medication can be introduced into said nebulizer by the exertion of pressure on said vial.

3 Claims, 2 Drawing Figures PAIENIE 0212mm Fle. 1

NEB-U-PACK BACKGROUND OF THE INVENTION The present invention is concerned with an apparatus which is useful in inhalation therapy. The increase in lung and respiratory diseases has resulted in greater use of nebulizers for the treatment of such diseases. Medication must be added to nebulizers continuously or at intervals. The present invention is primarily concerned with those medications which are added to a nebulizer at periodic or irregular intervals. At present, such medication is usually added with an ordinary syringe which is loosely received in the addition port of the nebulizer. This loose connection allows contaminated ambient hospital air to be drawn or sucked through the port and nebulizer into the patients respiratory system. This practice is highly undesirable and can lead to serious infections and complications of the lungs and respiratory system. At present, this contamination can be prevented only by shutting down or disconnecting the nebulizer during the addition of medication. This procedure is inconvenient, and requires supervision of nursing personnel to assure that the practice is followed. The present invention overcomes these problems by providing a connection between the source of the additive medication and the nebulizer part which does not permit contaminated air to enter the nebulizer. It is accordingly anticipated that this invention will be widely adopted in the art.

SUMMARY OF THE INVENTION Briefly, the present invention is a novel combination comprising a medicament injector comprising: a cylindrical vial having an open end and a closed end, a resilient plug adapted to be inserted at least partially through said open end of said vial; a plurality of outwardly extending rings upon said plug engaging the walls of said vialwith a press fit; a cylindrical member having one closed end, said cylindrical member holding a needle extending inwardly into said cylindrical member and having a sharpened inner end; and said cylindrical member having a tip extending outwardly therefrom, said tip being an elongated member of generally circular cross-section and having a central fluid passage extending substantially the length of the tip, said tip having three zones, the first of which is cylindrical, the second or intermediate which is tapered, and the third or outlet zone which is cylindrical but of smaller external diameter than said first zone, interlocking means on said cylindrical member and cooperating interlocking means on said plug, whereby upon interlocking of said plug with said cylindrical member said vial is first held in an assembled but non-operating position and upon further interlocking of said plug with said cylindrical member, said plug is adapted to be pierced by said needle and said needle communicated with said vial without the application of substantial axial pressure on said plug and said plug is locked securely to said cylindrical member to permit aspiration upon withdrawal of said vial or to permit expulsion of the contents of said vial upon exertion of pressure on said vial through said tip; and a nebulizer comprising an air inlet, an air outlet adapted to lead to the patient, means for forcing air through said nebulizer, means within said nebulizer for evaporating and forming particles of liquid medicament for inhalation therapy in the air stream passing through said nebulizer, and a medication introduction port opening into the interior of said nebulizer above the liquid medication level within said nebulizer, said tip being at least partially received in said port whereby liquid medication can be introduced into said nebulizer by the exertion of, pressure on, said vial.

It is an object of the present invention to provide a novel system for use in inhalation therapy.

More particularly, it is an object of the present invention to provide for the safer introduction of additive medication to nebulizers.

Still another object of the present invention is to provide a system in which contaminated hospital air cannot enter the nebulizer during the addition of additive medication.

These and other objects and advantages of the invention will be apparent from the more detailed description which follows taken in conjunction with the accompanying drawings.

DESCRIPTION OF THE PREFERRED EMBODIMENTS Turning to the drawings:

FIG. 1 shows a perspective view of one embodiment of the device of the present invention.

FIG. 2 is an enlarged sectional view of the device of FIG. 1.

Turning to the drawings in greater detail, the holder comprises a generally cylindrical hollow tubular holder 10 having an open end 12 and a closed end 14. The cylindrical vial 16 has a resilient stopper 18 in its open end sealing on the inside walls of the via] 16. The stopper 18 generally, although not necessarily, has a thin imperforate central diaphragm portion. The stopper 18 is provided with an externally threaded projection 20 thereon. The tubular holder 10 has a needle 22 therein and a tip 24 on its exterior which tip is provided with a fluid passage 26 terminates in opening 28. The tip 24 has a first cylindrical zone 30, a second zone 32 which is tapered and a third cylindrical zone 34 having a smaller external diameter than zone 30.

Within the tubular holder 10, there is provided a thrust portion 36. The lower end of needle 22 communicates with the hole 38 in the closed end of the tubular holder 10. The upper end of needle 22 has a sharp terminal portion 40 having a hole 42 therein. The thrust portion 36 may also have internal threads 44 in proximity to its upper end, the threads on the projection 20 and the threads 44 being adapted when made up to cause said sharp terminal portion 40 of the needle to puncture said stopper 18. When the projection 20 is made up with threads 44, the stopper 18 functions as a piston to expel the contents of the vial 16 through needle 22 and passage 26 as said vial 16 is advanced into said tubular holder 10.

In operation, for intravenous use, the vial 16 containing liquid medication is partially made up with the holder 10 simply by turning the vial and the threads on projection into the threads 44. The tip 24 is theninserted in the part of a nebulizer 46 as is more fully hereinafter described. The threads are then further made up until the thread 20 on the stopper 18 are fully made up with threads 44. At this point, the sharp terminal portion 40 has punctured the stopper 18. By applying a slight further force on the vial, the vial can be advanced into the holder causing the stopper to expel the contents of the vial through the tip into the nebulizer 46.

The nebulizer, generally 46, has an air inlet 48, and an air outlet 50. The outlet 50 is connected to an airflow apparatus 52 having a regulatory flow valve 54. The air leaving at 56 is ducted to the patient. The airflow apparatus 52 is familiar to those skilled in the art, and need not be described in more elaborate detail.

The nebulizer 46 is provided with an air jet 58, a liquid capillary 60, and a dispersing ball 62. The liquid medication 64 enters the capillary 60 at opening 66. The high velocity air in jet 58 draws the liquid up the capillary to point 68 where a miniscus or drop starts to form. When the liquid particle has become sufficiently large, it is carried away by the jet stream and impacts ball 62 which breaks up the particle into finer particles. The finer particles are carried to the patient. The heavier particles collect on the ball 62 and the inside surfaces 70 of the nebulizer, and eventually return to the liquid pool 64. Additional air may be introduced at opening 72. This opening may, however, be closed off. Medication is introduced via port 74. The exterior of tapered zone 32 engages the interior of port 74 which prevents contaminated air from being drawn into and through the nebulizer. The zone 34 is smaller in external diameter than the internal diameter of port 74, and hence is receivable therein. The zone 30 is larger in external diameter than the internal diameter of port 74. Hence, a seal is formed on the tapered zone 32.

Having fully described the invention it is intended that it be limited only by the lawful scope of the appended claims.

I claim:

1. A novel combination comprising a medicament injector comprising: a cylindrical vial having an open end and a closed end, a resilient plug adapted to be inserted at least partially through said open end of said vial; a plurality of outwardly extending rings upon said plug engaging the walls of said vial with a press fit; a cylindrical member having one closed end, said cylindrical member holding a needle extending inwardly into said cylindrical member and having a sharpened inner end; and said cylindrical member having a tip extending outwardly therefrom, said tip being an elongated member of generally circular cross-section and having a central fluid passage extending substantially the length of the tip, said central fluid passage being in fluid communication with said needle, said tip having three zones, the first of which is cylindrical, the second or intermediate which is tapered, and the third or outlet zone which is cylindrical but of smaller external diameter than said first zone, interlocking means on said cylindrical member and cooperating interlocking means on said plug, whereby upon interlocking of said plug with said cylindrical member said vial is first held in an assembled but non-operating position and upon further interlocking of said plug with said cylindrical member, said plug is adapted to be pierced by said sharpened inner end of said needle and said needle communicated with said vial without the application of substantial axial pressure on said plug and said plug is locked securely to said cylindrical member to permit aspiration upon withdrawal of said vial or to permit expulsion of the contents of said vial upon exertion of pressure on said vial through said tip; and a nebulizer comprising an air inlet, an air outlet adapted to lead to the patient, means for forcing air'through said nebulizer, means within nebulizer for evaporating and forming particles of liquid medicament for inhalation therapy in the air stream passing through said nebulizer and a medication introduction port opening into the interior of said nebulizer above the liquid medication level within said nebulizer, said tip being at least partially received in said port and contacting said port to form a seal therewith whereby liquid medication can be introduced into said nebulizer by the exertion of pressure on said vial.

2. The combination of claim 1 wherein the inside diameter of said port is slightly larger than the outside diameter of said third or outlet zone of said tip.

3. The combination of claim 2 wherein said first zone of said tip is larger in outside diameter than the inside diameter of said port whereby the tapered exterior of said second or intermediate zone of said tip acts as a stop which limits the axial advancement of said tip into said port and serves to close said port during expulsion of the contents of said vial into said nebulizer.

Claims (3)

1. A novel combination comprising a medicament injector comprising: a cylindrical vial having an open end and a closed end, a resilient plug adapted to be inserted at least partially through said open end of said vial; a plurality of outwardly extending rings upon said plug engaging the walls of said vial with a press fit; a cylindrical member having one closed end, said cylindrical member holding a needle extending inwardly into said cylindrical member and having a sharpened inner end; and said cylindrical member having a tip extending outwardly therefrom, said tip being an elongated member of generally circular cross-section and having a central fluid passage extending substantially the length of the tip, said central fluid passage beiNg in fluid communication with said needle, said tip having three zones, the first of which is cylindrical, the second or intermediate which is tapered, and the third or outlet zone which is cylindrical but of smaller external diameter than said first zone, interlocking means on said cylindrical member and cooperating interlocking means on said plug, whereby upon interlocking of said plug with said cylindrical member said vial is first held in an assembled but non-operating position and upon further interlocking of said plug with said cylindrical member, said plug is adapted to be pierced by said sharpened inner end of said needle and said needle communicated with said vial without the application of substantial axial pressure on said plug and said plug is locked securely to said cylindrical member to permit aspiration upon withdrawal of said vial or to permit expulsion of the contents of said vial upon exertion of pressure on said vial through said tip; and a nebulizer comprising an air inlet, an air outlet adapted to lead to the patient, means for forcing air through said nebulizer, means within nebulizer for evaporating and forming particles of liquid medicament for inhalation therapy in the air stream passing through said nebulizer and a medication introduction port opening into the interior of said nebulizer above the liquid medication level within said nebulizer, said tip being at least partially received in said port and contacting said port to form a seal therewith whereby liquid medication can be introduced into said nebulizer by the exertion of pressure on said vial.
2. The combination of claim 1 wherein the inside diameter of said port is slightly larger than the outside diameter of said third or outlet zone of said tip.
3. The combination of claim 2 wherein said first zone of said tip is larger in outside diameter than the inside diameter of said port whereby the tapered exterior of said second or intermediate zone of said tip acts as a stop which limits the axial advancement of said tip into said port and serves to close said port during expulsion of the contents of said vial into said nebulizer.
US3842833A 1972-12-11 1972-12-11 Neb-u-pack Expired - Lifetime US3842833A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
US3842833A US3842833A (en) 1972-12-11 1972-12-11 Neb-u-pack

Applications Claiming Priority (11)

Application Number Priority Date Filing Date Title
US3842833A US3842833A (en) 1972-12-11 1972-12-11 Neb-u-pack
CA 184209 CA1009109A (en) 1972-12-11 1973-10-25 Medicament injector
JP12298773A JPS529958B2 (en) 1972-12-11 1973-11-02
DE19732356173 DE2356173A1 (en) 1972-12-11 1973-11-09 Means for inputting a liquid medicament into the sputtering chamber of an inhaler
DE19737340215 DE7340215U (en) 1972-12-11 1973-11-09 Inhaler liquid medicine with a sputtering chamber and for this particular fuellphiole
ES198281U ES198281Y (en) 1972-12-11 1973-12-03 Madicamento injector.
FR7343438A FR2209542B3 (en) 1972-12-11 1973-12-05
GB5638773A GB1453605A (en) 1972-12-11 1973-12-05 Apparatus for use in inhalation therapy
IT5418373A IT1000256B (en) 1972-12-11 1973-12-07 of medicine injector
HK31177A HK31177A (en) 1972-12-11 1977-06-16 Apparatus for use in inhalation therapy
MY7700272A MY7700272A (en) 1972-12-11 1977-12-30 Apparatus for use in inhalation therapy

Publications (1)

Publication Number Publication Date
US3842833A true US3842833A (en) 1974-10-22

Family

ID=23218250

Family Applications (1)

Application Number Title Priority Date Filing Date
US3842833A Expired - Lifetime US3842833A (en) 1972-12-11 1972-12-11 Neb-u-pack

Country Status (7)

Country Link
US (1) US3842833A (en)
JP (1) JPS529958B2 (en)
CA (1) CA1009109A (en)
DE (2) DE2356173A1 (en)
ES (1) ES198281Y (en)
FR (1) FR2209542B3 (en)
GB (1) GB1453605A (en)

Cited By (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4094317A (en) * 1976-06-11 1978-06-13 Wasnich Richard D Nebulization system
US4344574A (en) * 1979-10-24 1982-08-17 Sherritt Gordon Mines Limited Cross-flow nebulizer
WO2003057291A1 (en) * 2002-01-07 2003-07-17 Aerogen, Inc. Devices and methods for nebulizing fluids for inhalation
EP1510231A3 (en) * 2002-09-30 2005-05-11 Baby's Breath Ltd. Aerosol inhalation device and nebulizer
US6978941B2 (en) 2001-05-02 2005-12-27 Aerogen, Inc. Base isolated nebulizing device and methods
US7032590B2 (en) 2001-03-20 2006-04-25 Aerogen, Inc. Fluid filled ampoules and methods for their use in aerosolizers
US7040549B2 (en) 1991-04-24 2006-05-09 Aerogen, Inc. Systems and methods for controlling fluid feed to an aerosol generator
US7066398B2 (en) 1999-09-09 2006-06-27 Aerogen, Inc. Aperture plate and methods for its construction and use
US7174888B2 (en) 1995-04-05 2007-02-13 Aerogen, Inc. Liquid dispensing apparatus and methods
US7195011B2 (en) 2001-03-20 2007-03-27 Aerogen, Inc. Convertible fluid feed system with comformable reservoir and methods
US7201167B2 (en) 2004-04-20 2007-04-10 Aerogen, Inc. Method and composition for the treatment of lung surfactant deficiency or dysfunction
US20070163575A1 (en) * 2005-12-30 2007-07-19 Rojas Antonio M Jr Nebulizer
US20070209659A1 (en) * 1995-04-05 2007-09-13 Aerogen, Inc. Liquid dispensing apparatus and methods
US7290541B2 (en) 2004-04-20 2007-11-06 Aerogen, Inc. Aerosol delivery apparatus and method for pressure-assisted breathing systems
US7322349B2 (en) 2000-05-05 2008-01-29 Aerogen, Inc. Apparatus and methods for the delivery of medicaments to the respiratory system
US7331339B2 (en) 2000-05-05 2008-02-19 Aerogen, Inc. Methods and systems for operating an aerosol generator
US20090071470A1 (en) * 2007-09-18 2009-03-19 Robert Abrams Emergency medication dose nebulizer
US20090071473A1 (en) * 2007-09-18 2009-03-19 Robert Abrams Semi-automatic emergency medication dose nebulizer
US20090151716A1 (en) * 2007-09-18 2009-06-18 Robert Abrams Semi-automatic emergency medication dose nebulizer
US7600511B2 (en) 2001-11-01 2009-10-13 Novartis Pharma Ag Apparatus and methods for delivery of medicament to a respiratory system
US7628339B2 (en) 1991-04-24 2009-12-08 Novartis Pharma Ag Systems and methods for controlling fluid feed to an aerosol generator
US7677467B2 (en) 2002-01-07 2010-03-16 Novartis Pharma Ag Methods and devices for aerosolizing medicament
US7771642B2 (en) 2002-05-20 2010-08-10 Novartis Ag Methods of making an apparatus for providing aerosol for medical treatment
US20100269818A1 (en) * 2007-09-18 2010-10-28 Robert Abrams Semi-automatic emergency medication dose nebulizer
US7946291B2 (en) 2004-04-20 2011-05-24 Novartis Ag Ventilation systems and methods employing aerosol generators
US7971588B2 (en) 2000-05-05 2011-07-05 Novartis Ag Methods and systems for operating an aerosol generator
US8042536B1 (en) * 2006-10-18 2011-10-25 Care 2 Medical Nebulizer apparatus
US8267081B2 (en) 2009-02-20 2012-09-18 Baxter International Inc. Inhaled anesthetic agent therapy and delivery system
US8291902B2 (en) 2007-09-18 2012-10-23 Robert Abrams Enhanced semi-automatic emergency medication dose nebulizer
US8336545B2 (en) 2000-05-05 2012-12-25 Novartis Pharma Ag Methods and systems for operating an aerosol generator
US8616195B2 (en) 2003-07-18 2013-12-31 Novartis Ag Nebuliser for the production of aerosolized medication
US9108211B2 (en) 2005-05-25 2015-08-18 Nektar Therapeutics Vibration systems and methods

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4228795A (en) * 1977-03-08 1980-10-21 Babington Robert S Apparatus for producing finely divided liquid spray
US6000394A (en) * 1994-10-26 1999-12-14 Paul Rizau Pari-Werk Gmbh Generation of an aerosol of an exact dose
DE4438292C2 (en) * 1994-10-26 1999-07-22 Pari Gmbh Exact dose aerosol generation for inhalation therapy

Cited By (43)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4094317A (en) * 1976-06-11 1978-06-13 Wasnich Richard D Nebulization system
US4344574A (en) * 1979-10-24 1982-08-17 Sherritt Gordon Mines Limited Cross-flow nebulizer
US7040549B2 (en) 1991-04-24 2006-05-09 Aerogen, Inc. Systems and methods for controlling fluid feed to an aerosol generator
US7628339B2 (en) 1991-04-24 2009-12-08 Novartis Pharma Ag Systems and methods for controlling fluid feed to an aerosol generator
US8561604B2 (en) 1995-04-05 2013-10-22 Novartis Ag Liquid dispensing apparatus and methods
US7174888B2 (en) 1995-04-05 2007-02-13 Aerogen, Inc. Liquid dispensing apparatus and methods
US20070209659A1 (en) * 1995-04-05 2007-09-13 Aerogen, Inc. Liquid dispensing apparatus and methods
US7066398B2 (en) 1999-09-09 2006-06-27 Aerogen, Inc. Aperture plate and methods for its construction and use
US8398001B2 (en) 1999-09-09 2013-03-19 Novartis Ag Aperture plate and methods for its construction and use
US20070023547A1 (en) * 1999-09-09 2007-02-01 Aerogen, Inc. Aperture plate and methods for its construction and use
US8336545B2 (en) 2000-05-05 2012-12-25 Novartis Pharma Ag Methods and systems for operating an aerosol generator
US7331339B2 (en) 2000-05-05 2008-02-19 Aerogen, Inc. Methods and systems for operating an aerosol generator
US7322349B2 (en) 2000-05-05 2008-01-29 Aerogen, Inc. Apparatus and methods for the delivery of medicaments to the respiratory system
US7748377B2 (en) 2000-05-05 2010-07-06 Novartis Ag Methods and systems for operating an aerosol generator
US7971588B2 (en) 2000-05-05 2011-07-05 Novartis Ag Methods and systems for operating an aerosol generator
US8196573B2 (en) 2001-03-20 2012-06-12 Novartis Ag Methods and systems for operating an aerosol generator
US7195011B2 (en) 2001-03-20 2007-03-27 Aerogen, Inc. Convertible fluid feed system with comformable reservoir and methods
US7032590B2 (en) 2001-03-20 2006-04-25 Aerogen, Inc. Fluid filled ampoules and methods for their use in aerosolizers
US7104463B2 (en) 2001-05-02 2006-09-12 Aerogen, Inc. Base isolated nebulizing device and methods
US6978941B2 (en) 2001-05-02 2005-12-27 Aerogen, Inc. Base isolated nebulizing device and methods
US7600511B2 (en) 2001-11-01 2009-10-13 Novartis Pharma Ag Apparatus and methods for delivery of medicament to a respiratory system
WO2003057291A1 (en) * 2002-01-07 2003-07-17 Aerogen, Inc. Devices and methods for nebulizing fluids for inhalation
US8539944B2 (en) 2002-01-07 2013-09-24 Novartis Ag Devices and methods for nebulizing fluids for inhalation
US20080184993A1 (en) * 2002-01-07 2008-08-07 Aerogen, Inc. Devices and methods for nebulizing fluids for inhalation
US7677467B2 (en) 2002-01-07 2010-03-16 Novartis Pharma Ag Methods and devices for aerosolizing medicament
US7771642B2 (en) 2002-05-20 2010-08-10 Novartis Ag Methods of making an apparatus for providing aerosol for medical treatment
EP1510231A3 (en) * 2002-09-30 2005-05-11 Baby's Breath Ltd. Aerosol inhalation device and nebulizer
US8616195B2 (en) 2003-07-18 2013-12-31 Novartis Ag Nebuliser for the production of aerosolized medication
US7267121B2 (en) 2004-04-20 2007-09-11 Aerogen, Inc. Aerosol delivery apparatus and method for pressure-assisted breathing systems
US7201167B2 (en) 2004-04-20 2007-04-10 Aerogen, Inc. Method and composition for the treatment of lung surfactant deficiency or dysfunction
US7946291B2 (en) 2004-04-20 2011-05-24 Novartis Ag Ventilation systems and methods employing aerosol generators
US7290541B2 (en) 2004-04-20 2007-11-06 Aerogen, Inc. Aerosol delivery apparatus and method for pressure-assisted breathing systems
US9108211B2 (en) 2005-05-25 2015-08-18 Nektar Therapeutics Vibration systems and methods
US20070163575A1 (en) * 2005-12-30 2007-07-19 Rojas Antonio M Jr Nebulizer
US8042536B1 (en) * 2006-10-18 2011-10-25 Care 2 Medical Nebulizer apparatus
US8015969B2 (en) * 2007-09-18 2011-09-13 Robert Abrams Semi-automatic emergency medication dose nebulizer
US7836885B2 (en) * 2007-09-18 2010-11-23 Robert Abrams Semi-automatic emergency medication dose nebulizer
US20100269818A1 (en) * 2007-09-18 2010-10-28 Robert Abrams Semi-automatic emergency medication dose nebulizer
US20090071473A1 (en) * 2007-09-18 2009-03-19 Robert Abrams Semi-automatic emergency medication dose nebulizer
US20090151716A1 (en) * 2007-09-18 2009-06-18 Robert Abrams Semi-automatic emergency medication dose nebulizer
US20090071470A1 (en) * 2007-09-18 2009-03-19 Robert Abrams Emergency medication dose nebulizer
US8291902B2 (en) 2007-09-18 2012-10-23 Robert Abrams Enhanced semi-automatic emergency medication dose nebulizer
US8267081B2 (en) 2009-02-20 2012-09-18 Baxter International Inc. Inhaled anesthetic agent therapy and delivery system

Also Published As

Publication number Publication date Type
CA1009109A (en) 1977-04-26 grant
FR2209542B3 (en) 1976-10-15 grant
DE2356173A1 (en) 1974-06-27 application
JPS4989399A (en) 1974-08-27 application
JPS529958B2 (en) 1977-03-19 grant
DE7340215U (en) 1976-12-30 grant
CA1009109A1 (en) grant
ES198281U (en) 1975-05-16 application
ES198281Y (en) 1975-10-16 grant
FR2209542A1 (en) 1974-07-05 application
GB1453605A (en) 1976-10-27 application

Similar Documents

Publication Publication Date Title
US3580249A (en) Aerosol nebulizers
US3342180A (en) Disposable liquid-powder package and hypodermic syringe
US3416567A (en) Syringe valve
US3578037A (en) Method for filling a syringe
US3502097A (en) Catheter-infuser connector
US3527215A (en) Syringe construction having internal bladder
US3089490A (en) Disposable cartridge type hypodermic syringes
US5429614A (en) Drug delivery system
US4133314A (en) Extension transfer set
US4804366A (en) Cartridge and adapter for introducing a beneficial agent into an intravenous delivery system
US4620847A (en) Device for administering powdered substances
US4998921A (en) Intermittent I.V. therapy needle sheath
US5527306A (en) Vial adapter
US4753638A (en) Medical syringe
US4998926A (en) Parenteral fluid administration set
US4316462A (en) Filtering device for an injection device
US3908654A (en) Dispensing package for a dry biological and a liquid diluent
US3885607A (en) Device for providing fluid communication between two sealed vessels
US4768568A (en) Hazardous material vial apparatus providing expansible sealed and filter vented chambers
US3872867A (en) Wet-dry additive assembly
US5716346A (en) Method and apparatus for loading syringes without the need for hypodermic needles
US2812117A (en) Venoclysis apparatus
US5080654A (en) Fluid injection device for intravenous delivery system
US4623343A (en) Parenteral fluid administration apparatus and method
US3664337A (en) Respiration assembly and methods