CN115768384A - 流体动力致动的不含防腐剂分配系统 - Google Patents
流体动力致动的不含防腐剂分配系统 Download PDFInfo
- Publication number
- CN115768384A CN115768384A CN202180029216.9A CN202180029216A CN115768384A CN 115768384 A CN115768384 A CN 115768384A CN 202180029216 A CN202180029216 A CN 202180029216A CN 115768384 A CN115768384 A CN 115768384A
- Authority
- CN
- China
- Prior art keywords
- liquid
- fluid
- chamber
- pin member
- check valve
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000012530 fluid Substances 0.000 title abstract description 48
- 239000007788 liquid Substances 0.000 claims abstract description 24
- 230000000845 anti-microbial effect Effects 0.000 claims description 7
- 238000000576 coating method Methods 0.000 claims description 7
- 239000011248 coating agent Substances 0.000 claims description 5
- 239000004599 antimicrobial Substances 0.000 claims description 4
- 238000004891 communication Methods 0.000 claims description 3
- 230000036316 preload Effects 0.000 claims description 2
- 230000005284 excitation Effects 0.000 claims 4
- 230000010355 oscillation Effects 0.000 abstract description 7
- 239000003814 drug Substances 0.000 description 5
- BQCADISMDOOEFD-UHFFFAOYSA-N Silver Chemical compound [Ag] BQCADISMDOOEFD-UHFFFAOYSA-N 0.000 description 4
- 229910052709 silver Inorganic materials 0.000 description 4
- 239000004332 silver Substances 0.000 description 4
- DZBUGLKDJFMEHC-UHFFFAOYSA-N acridine Chemical compound C1=CC=CC2=CC3=CC=CC=C3N=C21 DZBUGLKDJFMEHC-UHFFFAOYSA-N 0.000 description 3
- 229920001971 elastomer Polymers 0.000 description 3
- 239000000806 elastomer Substances 0.000 description 3
- 239000000463 material Substances 0.000 description 3
- 229910001316 Ag alloy Inorganic materials 0.000 description 2
- 229910021607 Silver chloride Inorganic materials 0.000 description 2
- 239000000654 additive Substances 0.000 description 2
- 230000001580 bacterial effect Effects 0.000 description 2
- 150000004283 biguanides Chemical class 0.000 description 2
- WDRFFJWBUDTUCA-UHFFFAOYSA-N chlorhexidine acetate Chemical compound CC(O)=O.CC(O)=O.C=1C=C(Cl)C=CC=1NC(N)=NC(N)=NCCCCCCN=C(N)N=C(N)NC1=CC=C(Cl)C=C1 WDRFFJWBUDTUCA-UHFFFAOYSA-N 0.000 description 2
- 229960001884 chlorhexidine diacetate Drugs 0.000 description 2
- 238000007906 compression Methods 0.000 description 2
- 230000006835 compression Effects 0.000 description 2
- 238000011109 contamination Methods 0.000 description 2
- 229920001903 high density polyethylene Polymers 0.000 description 2
- 239000004700 high-density polyethylene Substances 0.000 description 2
- 230000003993 interaction Effects 0.000 description 2
- 239000007769 metal material Substances 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- RARSHUDCJQSEFJ-UHFFFAOYSA-N p-Hydroxypropiophenone Chemical compound CCC(=O)C1=CC=C(O)C=C1 RARSHUDCJQSEFJ-UHFFFAOYSA-N 0.000 description 2
- 150000003839 salts Chemical class 0.000 description 2
- HKZLPVFGJNLROG-UHFFFAOYSA-M silver monochloride Chemical class [Cl-].[Ag+] HKZLPVFGJNLROG-UHFFFAOYSA-M 0.000 description 2
- 229960003600 silver sulfadiazine Drugs 0.000 description 2
- UEJSSZHHYBHCEL-UHFFFAOYSA-N silver(1+) sulfadiazinate Chemical class [Ag+].C1=CC(N)=CC=C1S(=O)(=O)[N-]C1=NC=CC=N1 UEJSSZHHYBHCEL-UHFFFAOYSA-N 0.000 description 2
- IYLLULUTZPKQBW-UHFFFAOYSA-N Acrinol Chemical compound CC(O)C(O)=O.C1=C(N)C=CC2=C(N)C3=CC(OCC)=CC=C3N=C21 IYLLULUTZPKQBW-UHFFFAOYSA-N 0.000 description 1
- 241000894006 Bacteria Species 0.000 description 1
- DPKHZNPWBDQZCN-UHFFFAOYSA-N acridine orange free base Chemical compound C1=CC(N(C)C)=CC2=NC3=CC(N(C)C)=CC=C3C=C21 DPKHZNPWBDQZCN-UHFFFAOYSA-N 0.000 description 1
- BGLGAKMTYHWWKW-UHFFFAOYSA-N acridine yellow Chemical compound [H+].[Cl-].CC1=C(N)C=C2N=C(C=C(C(C)=C3)N)C3=CC2=C1 BGLGAKMTYHWWKW-UHFFFAOYSA-N 0.000 description 1
- 239000003708 ampul Substances 0.000 description 1
- 230000001775 anti-pathogenic effect Effects 0.000 description 1
- ZXJXZNDDNMQXFV-UHFFFAOYSA-M crystal violet Chemical compound [Cl-].C1=CC(N(C)C)=CC=C1[C+](C=1C=CC(=CC=1)N(C)C)C1=CC=C(N(C)C)C=C1 ZXJXZNDDNMQXFV-UHFFFAOYSA-M 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 238000012377 drug delivery Methods 0.000 description 1
- 238000009509 drug development Methods 0.000 description 1
- 239000000975 dye Substances 0.000 description 1
- 230000008846 dynamic interplay Effects 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 229960004189 ethacridine lactate Drugs 0.000 description 1
- 229960001235 gentian violet Drugs 0.000 description 1
- 230000002070 germicidal effect Effects 0.000 description 1
- 210000003128 head Anatomy 0.000 description 1
- 229910052751 metal Inorganic materials 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- CXKWCBBOMKCUKX-UHFFFAOYSA-M methylene blue Chemical compound [Cl-].C1=CC(N(C)C)=CC2=[S+]C3=CC(N(C)C)=CC=C3N=C21 CXKWCBBOMKCUKX-UHFFFAOYSA-M 0.000 description 1
- 229960000907 methylthioninium chloride Drugs 0.000 description 1
- 244000005700 microbiome Species 0.000 description 1
- 229940023490 ophthalmic product Drugs 0.000 description 1
- 230000003534 oscillatory effect Effects 0.000 description 1
- 239000008194 pharmaceutical composition Substances 0.000 description 1
- 238000009512 pharmaceutical packaging Methods 0.000 description 1
- 239000000825 pharmaceutical preparation Substances 0.000 description 1
- 229940127557 pharmaceutical product Drugs 0.000 description 1
- -1 polyhexamethylene guanidine Polymers 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- 229920001296 polysiloxane Polymers 0.000 description 1
- 230000002335 preservative effect Effects 0.000 description 1
- 230000000717 retained effect Effects 0.000 description 1
- 238000000518 rheometry Methods 0.000 description 1
- 229920002379 silicone rubber Polymers 0.000 description 1
- 239000004945 silicone rubber Substances 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 229950003937 tolonium Drugs 0.000 description 1
- HNONEKILPDHFOL-UHFFFAOYSA-M tolonium chloride Chemical compound [Cl-].C1=C(C)C(N)=CC2=[S+]C3=CC(N(C)C)=CC=C3N=C21 HNONEKILPDHFOL-UHFFFAOYSA-M 0.000 description 1
- 238000009423 ventilation Methods 0.000 description 1
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F9/00—Methods or devices for treatment of the eyes; Devices for putting-in contact lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
- A61F9/0008—Introducing ophthalmic products into the ocular cavity or retaining products therein
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
- B05B—SPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES
- B05B1/00—Nozzles, spray heads or other outlets, with or without auxiliary devices such as valves, heating means
- B05B1/02—Nozzles, spray heads or other outlets, with or without auxiliary devices such as valves, heating means designed to produce a jet, spray, or other discharge of particular shape or nature, e.g. in single drops, or having an outlet of particular shape
- B05B1/08—Nozzles, spray heads or other outlets, with or without auxiliary devices such as valves, heating means designed to produce a jet, spray, or other discharge of particular shape or nature, e.g. in single drops, or having an outlet of particular shape of pulsating nature, e.g. delivering liquid in successive separate quantities ; Fluidic oscillators
- B05B1/083—Nozzles, spray heads or other outlets, with or without auxiliary devices such as valves, heating means designed to produce a jet, spray, or other discharge of particular shape or nature, e.g. in single drops, or having an outlet of particular shape of pulsating nature, e.g. delivering liquid in successive separate quantities ; Fluidic oscillators the pulsating mechanism comprising movable parts
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
- B05B—SPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES
- B05B1/00—Nozzles, spray heads or other outlets, with or without auxiliary devices such as valves, heating means
- B05B1/30—Nozzles, spray heads or other outlets, with or without auxiliary devices such as valves, heating means designed to control volume of flow, e.g. with adjustable passages
- B05B1/3006—Nozzles, spray heads or other outlets, with or without auxiliary devices such as valves, heating means designed to control volume of flow, e.g. with adjustable passages the controlling element being actuated by the pressure of the fluid to be sprayed
-
- G—PHYSICS
- G02—OPTICS
- G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
- G02B5/00—Optical elements other than lenses
- G02B5/08—Mirrors
- G02B5/10—Mirrors with curved faces
Landscapes
- Health & Medical Sciences (AREA)
- Physics & Mathematics (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Veterinary Medicine (AREA)
- Ophthalmology & Optometry (AREA)
- General Physics & Mathematics (AREA)
- Optics & Photonics (AREA)
- Medical Preparation Storing Or Oral Administration Devices (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Food Preservation Except Freezing, Refrigeration, And Drying (AREA)
- Apparatus For Disinfection Or Sterilisation (AREA)
Abstract
提供了多剂量不含防腐剂眼部流体递送装置。流体递送装置包括流体分配系统和流体包，该流体包用于将液体储存在该流体包中并且向分配系统供应所述液体。分配系统包括长形腔室，该长形腔室包括止回阀，该止回阀限定该腔室的前部封闭件。阀通常是关闭的并且气密密封腔室。分配器包括振动马达，该振动马达引起腔室和该腔室内的流体的振荡。腔室的振荡向储存在腔室中的流体赋予动量，这进而又赋予循环地打开阀以分配流或液体微滴的力。仅在马达振荡时才会分配流体，而在其他情况下，阀是气密关闭的。
Description
技术领域
本发明总体上涉及用于分配流体药物的装置，更特别地涉及储存和递送眼科的不含防腐剂药物的这样的装置，这样的装置具体地被配置成提高易使用性并且增强患者对药物的给药说明的依从性。
背景技术
易于分配流体药物和依从给药说明是所有患者的主要关注点。特别地，不含防腐剂的分配瓶(比如眼科挤压式分配器)由于密封分配喷嘴以防止细菌进入和污染的阀机构而通常需要较大的致动力。这样的系统需要更高的压力来操作，因此需要更大的挤压力。另外，现有技术的分配瓶仅以上下颠倒取向进行分配，这需要不方便的头部操作，并且连同需要较高的致动力进一步增加了不便性。
所讨论的类型的分配器从现有技术中已知，例如从US 6,095,376、US 9,676,525、US 2014/0336596、US 2016/0107180、US 9,238,532、US 8,056,766、US 8,863,998和US10,105,720。US 2014/0336596中所示出的分配器包括出口通道，该出口通道将液体储器通过出口阀连接至出口开口，该出口阀布置在出口通道中并且在瓶被挤压而产生压力时打开。这样的不含防腐剂的挤压式瓶通常需要约25N-28N的挤压力(Ophthalmic SqueezeDispenser-Drug Development and Delivery[眼科挤压式分配器-药品开发与递送]2017年10月第17卷第7号第40页)。老年患者或手部缺乏足够力量和/或灵巧度的其他患者从这样的瓶分配药物经常会遇到问题。
这项工作提供了不含防腐剂的眼部分配装置，该装置可以水平保持或以任何方便的取向保持，同时通过电开关即可毫不费力地进行致动。这提供了符合标准药品包装工艺的有成本效益的解决方案。
发明内容
提供了多剂量不含防腐剂眼部流体递送装置。流体递送装置包括流体分配系统和流体包，该流体包用于将液体储存在该流体包中并且向分配系统供应所述液体。分配系统包括长形腔室，该长形腔室包括止回阀，该止回阀限定该腔室的前部封闭件。阀通常是关闭的并且气密密封腔室。在这项工作中，腔室包括振动马达，该振动马达引起腔室和该腔室内的流体的振荡。腔室的振荡向储存在腔室中的流体赋予动量，这进而又赋予循环地打开阀以分配流或液体微滴的力。仅在马达振荡时才会分配流体，而在其他情况下，阀是气密关闭的。
止回阀可以包括柔性板，该柔性板包括圆锥形孔，该圆锥形孔延伸穿过该柔性板的厚度，该阀可以进一步包括静止的球形构件，该球形构件与圆锥形孔的内壁切线地接合以形成气密密封的封闭件。该板可以由弹性模量在介于0.1GPa-1.2GPa之间的范围内的弹性体制成。该板的圆周可以通过固持环附接至腔室，该固持环以过盈配合与腔室接合而形成气密密封的封闭件。
圆锥形孔延伸穿过板的厚度，使得微滴通过孔的较小开口分配，而孔的较大侧与腔室处于流体连通。
球形构件可以包括抗菌涂层，该抗菌涂层覆盖球形构件的在切线接合线与孔的较小开口之间的区域。
振动马达使腔室和该腔室内的流体振荡。因此，产生了流体动力脉冲的循环，从而使阀循环地打开并且分配流体。在此，此现象的特征在于，阀与周围流体之间的振荡相互作用。由流体的动量产生的流体动力的力将阀打开并且允许流体流动通过孔。
仅在流体动力的力足够高以使孔变形时才分配流体，而在其他情况下，孔气密密封腔室。该系统防止微生物进入腔室中，从而允许储存不含防腐剂的药品。这项工作提供了方便且有成本效益的电操作的不含防腐剂分配系统。
附图说明
图1A是本发明的实施例的截面视图。
图1B是图1A的实施例的细节截面视图。
图1C是图1A至图1B的实施例的3D视图。
图2A是在操作中的本发明的实施例的侧视图和局部截面视图。
图2B是图2A的示例的细节截面视图。
图3展示了如在本发明的实施例中使用的振动马达的立体图。
图4A是本发明的实施例的前视图。
图4B是图4A的实施例的侧视图。
图4C是图4A的实施例的细节截面视图。
图5A是封闭在壳体中的示例性装置的前视图。
图5B是图5A的示例的侧视图。
图6A至图6B是具有包括旋转盖的壳体的装置的立体图。
具体实施方式
这项工作描述了用于递送不含防腐剂的溶液或悬浮液以用于眼科药品的眼部施用的分配装置和方法。分配装置包括微滴喷射系统，该微滴喷射系统流体地连接至包含要分配的液体的安瓿包。微滴喷射系统包括具有止回阀的腔室，该止回阀限定该腔室的前部封闭件。分配系统进一步包括振动马达，该振动马达使腔室振荡并且包括流体动力脉冲，这因此使阀循环地打开并且喷射流体微滴。阀通常是关闭的并且气密密封腔室。阀仅响应于由腔室的振荡引起的流体动力脉冲而打开。以此方式，仅在装置被致动时才会分配流体，而在其他情况下，孔气密密封装置并且防止细菌和微生物进入，由此允许储存不含防腐剂的药物配制品。使用振动马达进一步实现了方便且有成本效益的电子控制施用。
图1A和图1B分别展示了流体递送装置100的侧视图和放大局部截面图。递送装置100包括流体储器102和分配系统104，该流体储器和该分配系统通过通路106以流体传输关系彼此连接。分配系统104包括流体腔室108并且还包括止回阀，该止回阀包括向腔室108提供前部封闭件的孔板110。
参考图1B，可以看出，孔板110包括圆锥形或锥形孔116(为清楚起见，在虚线圆内示出)，该圆锥形或锥形孔延伸穿过该孔板的中心厚度并且具有较大的入口开口116a和较小的出口开口116b，该较大的入口开口与腔室108处于流体连通，流体微滴将通过该较小的出口开口分配。
孔板110可以由柔性弹性体(比如由美国堪萨斯州堪萨斯城VersaFlex股份有限公司制造的硅酮橡胶VersaFlex)制成。也可以使用杨氏弹性模量值介于0.5GPa至2GPa之间的其他弹性体。分配系统104进一步包括静止的球形构件114，该球形构件与提供了气密密封的封闭件的圆锥形孔的入口开口116a以压力传输关系切线地接合。在优选实施例中，球形构件114由硬度大于硅酮的高密度聚乙烯(HDPE)制成，由此在该球形构件与较软的孔板110接合时形成紧密的封闭件。优选地，球形构件114与圆锥形孔116a以介于0.01N与0.05N之间的预加载力以压力传输关系接合。孔板110和球形构件114的组合提供了如上文所描述的止回阀。球形构件114由销构件112支撑。因为可以使用能够与孔板110形成良好密封的任何形状，所以构件114可以具有除球形之外的形状。
孔板110可以通过固持环130固持至分配系统104，由此形成气密密封的封闭件。
分配系统100包括通气管126，该通气管被配置成在从该装置分配流体时均衡容器102内部的压力。通气管126的开口134在装置被保持所处的任何取向上都延伸至流体液位132上方。通气管126可以经由0.22微米过滤器128连接，以确保进入装置的空气是无菌的。
分配系统100进一步包括振动马达，该振动马达被配置成使腔室108和该腔室内的流体振荡。在此，此马达被示意性地示出为偏心机械负载118，该偏心机械负载在其通过马达(图1A至图1B未示出马达，但下文结合图3进行了描述)而旋转时使如所描述的组件振动。
图1C是图1A至图1B的实施例的3D视图。
图2A至图2B展示了分配系统104对振荡的响应。马达的振动引起分配系统104的本体的振荡，这进而由于流体与腔室108的固体结构的动力学相互作用而在腔室内产生流体动量。这种现象通常被称为固体-流体相互作用(SFI)。移动的流体的动量所施加的力使孔板110在箭头206a和箭头206b所指示的方向上向外挠曲，从而使孔板110与球形构件114脱离接合，由此打开如箭头208a和箭头208b所指示的流体流动通路并且喷射流体微滴210。
分配装置100由柔性梁122或允许该分配装置如通过运动偏移202和204示意性地示出的自由振荡的其他结构实施例支撑。优选地，梁122的弹簧常数为0.05N/mm至0.5N/mm。例如，梁122可以通过在支撑结构120中制造出槽124而形成，使得所产生的梁122的厚度适于提供如上所述的弹簧常数。
图3展示了示例性振动马达302。此示例的DC马达302具有直径为4mm并且总长度为17mm的圆柱形本体。偏心飞轮118附接至马达轴。飞轮的质量为1.7克，质心距旋转中心约0.7mm。马达接收4.5VDC-12VDC并且以6000RPM-12000RPM旋转，在8000RPM的旋转速度下产生0.3N的离心力。可以使用产生0.1N-1N的离心力并且旋转速度为1000RPM-50000RPM的其他DC马达。马达可以由定时器电路控制，该定时器电路被设定成根据需要提供接通时间以递送8微升-12微升的剂量。致动接通时间为60ms-200ms，这取决于使用中的流体的流变学。可以使用结合555定时器IC或基于微处理器的定时器与12伏电池(比如A23碱性电池)的定时器电路。
图4A至图4C展示了分配系统400的替代性优选实施例。图4A展示了分配系统400的前视图，并且图4B展示了该分配系统的侧视图。分配系统400包括凹面镜402，该凹面镜辅助将装置400和流体流210对准使用者的眼睛。在使用中，分配装置400定位在眼睛前方，使得对于使用者而言，眼睛的图像清晰地出现在镜中心。此时，装置在眼睛距喷嘴404的距离以及该装置相对于眼睛的角度取向方面适当地定位。在致动时，流210将精确地沉积在眼睛的角膜表面上。优选地，装置400包括0.22微米空气过滤器，该空气过滤器被配置成对流入装置400中的通气空气进行过滤，如先前示例中一样。
装置400包括止回阀，该止回阀具有孔板406，该孔板具有延伸穿过该孔板的厚度的圆锥形孔116。止回阀进一步包括球形构件114，该球形构件与圆锥形孔116的入口开口切线地接合。在此示例中，止回阀还包括压缩弹簧408，该压缩弹簧被配置成迫使孔板406抵靠球形构件114。以此方式，沿着接合线114a形成紧密的密封件，因此形成紧密和气密的封闭件。
球形构件114可以部分地覆盖有抗微生物涂层，具体地在球形构件114的不与腔室中的流体接触的区域中。因此，有涂层的区域在接合线114a与圆锥形孔的出口之间(即，在图4C上向114a的左侧)延伸。抗微生物涂层的示例包括金属形式的银、银合金或含有银的非金属材料(包括氯化银和磺胺嘧啶银的盐)。其他可选材料包括双胍类衍生物、二乙酸氯己定和二葡萄糖酸氯己定。
图5A至图5B分别展示了封装在壳体502中的分配装置400的前视图和侧视图。壳体502为图4A至图4C中相关地描述的分配系统400提供了方便的外壳并且在此以虚线示出。壳体502包括电路(未示出)和12伏电池(例如，型号A23)506。电路控制分配时间段，使得8微升-12微升的剂量被递送至眼睛的眼表面。瞬时开关504可以用于启用装置400，使得从如前文所描述的孔喷射出微滴的流。图5A至图5B还展示了镜402，该镜在装置的前侧可见。这样的壳体也可以用于如上文所描述的分配装置100。
图6A至图6B展示了壳体的一些优选特征，这些优选特征可以与如上文所描述的实施例(比如装置100和装置400)一起使用。在此示例中，壳体包括旋转盖602，该旋转盖在非使用的时间段期间覆盖分配喷嘴606。旋转盖602提供了用于防止每次使用后可能留下残留流体的外部区域上的细菌污染的器件。在通过喷嘴分配后续的流时，这样的残留流体可能会对该后续的流造成污染。优选地，旋转盖602包括柔性构件604，该柔性构件包括覆盖有抗微生物涂层的表面604a。当旋转盖602如图6B所展示的关闭时，表面604a与喷嘴606的出口开口接合。以此方式，实现了抗病原体作用。替代性地，也可以使用具有防腐作用的有机染料。例如，甲苯胺蓝、亚甲基蓝、龙胆紫、和吖啶及相关活性物质(比如吖啶橙和吖啶黄)以及乳酸依沙吖啶。杀菌聚合物(比如聚己缩胍)也是可能的。也可以使用包含添加剂的材料，这些添加剂包含具有电离效应的金属有机物质。这样的添加剂可从德国柏林的SteriOne有限责任公司获得。可以用在表面604a上的抗微生物涂层的示例包括金属形式的银、银合金或含有银的非金属材料(包括氯化银和磺胺嘧啶银的盐)。其他可选材料包括双胍类衍生物、二乙酸氯己定和二葡萄糖酸氯己定。
Claims (15)
1.一种用于向患者的眼睛递送液体的设备，所述设备包括：
a)储器，所述储器被配置成包含所述液体；
b)液体分配器，所述液体分配器与所述储器处于液体连通，其中，所述液体分配器包括止回阀和致动器；
c)其中，所述止回阀包括孔和销构件，所述液体能够通过所述孔分配，所述销构件与所述孔接合以提供所述止回阀的正常关闭配置；
d)其中，所述致动器被配置成向所述液体分配器提供机械激励，所述机械激励产生所述液体的对应的流体动力激励；以及
e)其中，所述液体的流体动力激励通过使所述孔弹性变形而打开所述止回阀来将所述液体通过所述孔喷射。
2.如权利要求1所述的设备，其中，所述致动器包括振动马达，所述振动马达具有相对于所述振动马达的旋转轴线的偏心机械负载。
3.如权利要求2所述的设备，其中，所述液体分配器由柔性构件支承，由此所述振动马达的操作通过使所述液体分配器振荡而产生所述液体的流体动力激励。
4.如权利要求3所述的设备，其中，所述柔性构件的弹簧常数介于0.05N/mm与0.5N/mm之间。
5.如权利要求1所述的设备，其中，所述孔形成在杨氏弹性模量介于0.5GPa与2GPa之间的孔板中。
6.如权利要求5所述的设备，其中，所述销构件的机械硬度大于所述孔板的机械硬度。
7.如权利要求1所述的设备，其中，所述孔是锥形的，所述孔的出口比所述孔的入口窄。
8.如权利要求1所述的设备，其中，所述销构件相对于所述液体分配器是静止的。
9.如权利要求1所述的设备，其中，所述销构件的端头与所述孔接合，并且其中，所述销构件的端头具有球形形状。
10.如权利要求9所述的设备，其中，所述销构件的端头部分地或完全地涂覆有抗菌涂层。
11.如权利要求10所述的设备，其中，在所述止回阀的正常关闭配置中，所述抗菌涂层覆盖所述销构件的端头的在所述液体分配器之外的至少一部分。
12.如权利要求1所述的设备，其中，在所述止回阀的正常关闭配置中将所述销构件与所述孔接合的预加载力介于0.01N与0.05N之间。
13.如权利要求1所述的设备，其中，所述储器包括通气口。
14.如权利要求13所述的设备，其中，所述通气口包括过滤器，所述过滤器被配置成确保进入所述储器的空气是无菌的。
15.如权利要求1所述的设备，进一步包括凹面镜，所述凹面镜被配置成当所述设备被适当地定位成向所述患者的眼睛递送所述液体时向所述患者提供所述患者的眼睛的对焦图像。
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202063011808P | 2020-04-17 | 2020-04-17 | |
| US63/011,808 | 2020-04-17 | ||
| PCT/US2021/027773 WO2021212033A1 (en) | 2020-04-17 | 2021-04-16 | Hydrodynamically actuated preservative free dispensing system |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN115768384A true CN115768384A (zh) | 2023-03-07 |
Family
ID=78080878
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202180029216.9A Pending CN115768384A (zh) | 2020-04-17 | 2021-04-16 | 流体动力致动的不含防腐剂分配系统 |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US11925577B2 (zh) |
| EP (1) | EP4120974A1 (zh) |
| JP (1) | JP2023523394A (zh) |
| KR (1) | KR20230034940A (zh) |
| CN (1) | CN115768384A (zh) |
| AU (1) | AU2021257273A1 (zh) |
| BR (1) | BR112022020948A2 (zh) |
| CA (1) | CA3180199A1 (zh) |
| IL (1) | IL297215A (zh) |
| WO (1) | WO2021212033A1 (zh) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2973471A1 (en) | 2015-01-12 | 2016-07-21 | Kedalion Therapeutics, Inc. | Micro-droplet delivery device and methods |
| US11679028B2 (en) | 2019-03-06 | 2023-06-20 | Novartis Ag | Multi-dose ocular fluid delivery system |
| US11938057B2 (en) | 2020-04-17 | 2024-03-26 | Bausch + Lomb Ireland Limited | Hydrodynamically actuated preservative free dispensing system |
Family Cites Families (239)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE1575050A1 (de) | 1966-01-12 | 1972-04-13 | Misto Gen Equipment Co | Ultraschall-Nebelerzeugungsgeraet |
| US3640274A (en) * | 1966-11-04 | 1972-02-08 | Colgate Palmolive Co | Eye-spraying device having mirror |
| US3779245A (en) | 1972-06-13 | 1973-12-18 | R Windsor | Device for applying materials to the area of the eye |
| US3812854A (en) | 1972-10-20 | 1974-05-28 | A Michaels | Ultrasonic nebulizer |
| DE2445791C2 (de) | 1974-09-25 | 1984-04-19 | Siemens AG, 1000 Berlin und 8000 München | Ultraschall-Flüssigkeitszerstäuber |
| US3976072A (en) | 1975-09-03 | 1976-08-24 | The United States Of America As Represented By The Secretary Of The Department Of Health, Education And Welfare | Blink-operated extracorporeal tear duct |
| US4159803A (en) | 1977-03-31 | 1979-07-03 | MistO2 Gen Equipment Company | Chamber for ultrasonic aerosol generation |
| US4338576A (en) | 1978-07-26 | 1982-07-06 | Tdk Electronics Co., Ltd. | Ultrasonic atomizer unit utilizing shielded and grounded elements |
| DE2849493C2 (de) | 1978-11-15 | 1982-01-14 | Carl Heyer Gmbh, Inhalationstechnik, 5427 Bad Ems | In der Hand zu haltender Aerosolspender |
| DE2902624C2 (de) * | 1979-01-24 | 1985-10-10 | Pfeiffer Zerstäuber Vertriebsgesellschaft mbH & Co KG, 7760 Radolfzell | Ausgabepumpe |
| DE7917568U1 (de) | 1979-06-19 | 1979-09-20 | Bosch-Siemens Hausgeraete Gmbh, 7000 Stuttgart | Inhalationsgeraet |
| US4352459A (en) | 1979-11-13 | 1982-10-05 | Sono-Tek Corporation | Ultrasonic liquid atomizer having an axially-extending liquid feed passage |
| CA1178191A (en) | 1980-10-06 | 1984-11-20 | Naoyoshi Maehara | Electric liquid atomizing apparatus |
| US4632311A (en) | 1982-12-20 | 1986-12-30 | Matsushita Electric Industrial Co., Ltd. | Atomizing apparatus employing a capacitive piezoelectric transducer |
| US4655393A (en) | 1983-01-05 | 1987-04-07 | Sonotek Corporation | High volume ultrasonic liquid atomizer |
| DE3574344D1 (en) * | 1984-08-29 | 1989-12-28 | Omron Tateisi Electronics Co | Ultrasonic atomizer |
| GB2200211B (en) | 1986-12-08 | 1991-01-16 | Fuji Electric Co Ltd | Vibration-type transducer |
| US4976259A (en) | 1986-12-22 | 1990-12-11 | Mountain Medical Equipment, Inc. | Ultrasonic nebulizer |
| US4952581A (en) | 1987-04-03 | 1990-08-28 | The Trustees Of Columbia University In The City Of New York | Use of a prostaglandin in combination with an adrenergic blocking agent for reduction of intraocular pressure |
| US4850534A (en) | 1987-05-30 | 1989-07-25 | Tdk Corporation | Ultrasonic wave nebulizer |
| US4981625A (en) | 1988-03-14 | 1991-01-01 | California Institute Of Technology | Monodisperse, polymeric microspheres produced by irradiation of slowly thawing frozen drops |
| US4882150A (en) | 1988-06-03 | 1989-11-21 | Kaufman Herbert E | Drug delivery system |
| US5025957A (en) | 1988-10-07 | 1991-06-25 | Ryder International Corp. | Liquid dispenser nozzle assembly |
| DE69127826T2 (de) | 1990-12-17 | 1998-04-09 | Minnesota Mining & Mfg | Inhalationsgerät |
| US5171306A (en) | 1991-03-13 | 1992-12-15 | Vo Van T | Eyedrop delivery system |
| US6629646B1 (en) | 1991-04-24 | 2003-10-07 | Aerogen, Inc. | Droplet ejector with oscillating tapered aperture |
| US5938117A (en) | 1991-04-24 | 1999-08-17 | Aerogen, Inc. | Methods and apparatus for dispensing liquids as an atomized spray |
| US5232363A (en) | 1991-06-11 | 1993-08-03 | Eran Meller | Scaler with improved vibration characteristics |
| GB9114080D0 (en) * | 1991-06-28 | 1991-08-14 | Weston Terence E | Atomising valve |
| US5549249A (en) | 1991-12-13 | 1996-08-27 | Contico International, Inc. | Fluid spinner and nozzle head assembly with controlled fluid flood path |
| US5368582A (en) | 1992-08-10 | 1994-11-29 | The Schepens Eye Research Institute | Method and apparatus for introducing fluid material into an eye |
| DE69311361T2 (de) | 1992-10-13 | 1998-01-08 | Alcon Lab Inc | Zusammensetzungen zur behandlung von glaukoma die prostaglandine und clonidinderivate enthalten |
| GB2272389B (en) | 1992-11-04 | 1996-07-24 | Bespak Plc | Dispensing apparatus |
| US5712732A (en) | 1993-03-03 | 1998-01-27 | Street; Graham Stewart Brandon | Autostereoscopic image display adjustable for observer location and distance |
| EP0622035B1 (en) | 1993-04-30 | 1999-03-03 | Henlopen Manufacturing Co., Inc. | Applicator system for fluid cosmetic material |
| EP0735975B1 (en) | 1993-12-22 | 2001-08-16 | Merck & Co. Inc. | Ophthalmic package and delivery device |
| GB9405952D0 (en) | 1994-03-25 | 1994-05-11 | Zeneca Ltd | Aqueous ophthalmic sprays |
| WO1996000050A1 (en) | 1994-06-23 | 1996-01-04 | R.P. Scherer Corporation | Ocular treatment device |
| US6085740A (en) | 1996-02-21 | 2000-07-11 | Aerogen, Inc. | Liquid dispensing apparatus and methods |
| US6427682B1 (en) * | 1995-04-05 | 2002-08-06 | Aerogen, Inc. | Methods and apparatus for aerosolizing a substance |
| US5657926A (en) | 1995-04-13 | 1997-08-19 | Toda; Kohji | Ultrasonic atomizing device |
| US5828394A (en) * | 1995-09-20 | 1998-10-27 | The Board Of Trustees Of The Leland Stanford Junior University | Fluid drop ejector and method |
| US5627611A (en) | 1995-12-29 | 1997-05-06 | Scheiner; Stanley A. | Artificial tears |
| FR2746657B1 (fr) | 1996-03-29 | 1998-06-26 | Sofab | Dispositif antibacterien de pulverisation d'un produit liquide |
| US5958342A (en) | 1996-05-17 | 1999-09-28 | Incyte Pharmaceuticals, Inc. | Jet droplet device |
| US5692651A (en) | 1996-06-06 | 1997-12-02 | Owens-Illinois Closure Inc. | Self-sealing dispensing closure |
| US5881956A (en) | 1996-08-08 | 1999-03-16 | Ben Z. Cohen | Microdispensing ophthalmic pump |
| US6024717A (en) | 1996-10-24 | 2000-02-15 | Vibrx, Inc. | Apparatus and method for sonically enhanced drug delivery |
| US5960224A (en) * | 1996-12-26 | 1999-09-28 | Fuji Photo Film Co., Ltd. | Image forming apparatus and fluid injecting apparatus |
| US6065623A (en) | 1998-02-13 | 2000-05-23 | Crown Cork & Seal Technologies Corporation | Closure with lenticular lens insert |
| DE19823719B4 (de) | 1998-05-27 | 2011-12-15 | MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. | Verfahren zum Aufkonzentrieren von Substanzen |
| JP3055480U (ja) | 1998-07-01 | 1999-01-12 | 孟 ▲じゃ−▼ 康 | 軽量型目薬液噴射器 |
| US6070575A (en) | 1998-11-16 | 2000-06-06 | Aradigm Corporation | Aerosol-forming porous membrane with certain pore structure |
| US6232129B1 (en) | 1999-02-03 | 2001-05-15 | Peter Wiktor | Piezoelectric pipetting device |
| US6196218B1 (en) * | 1999-02-24 | 2001-03-06 | Ponwell Enterprises Ltd | Piezo inhaler |
| US6254860B1 (en) | 1999-04-13 | 2001-07-03 | Allergan Sales, Inc. | Ocular treatment using cyclosporin-A derivatives |
| US6730066B1 (en) | 1999-08-03 | 2004-05-04 | Pharmacia Ab | Liquid delivery container |
| US6235177B1 (en) | 1999-09-09 | 2001-05-22 | Aerogen, Inc. | Method for the construction of an aperture plate for dispensing liquid droplets |
| US6302101B1 (en) * | 1999-12-14 | 2001-10-16 | Daniel Py | System and method for application of medicament into the nasal passage |
| US20010035184A1 (en) | 1999-12-17 | 2001-11-01 | Carlos Schuler | Systems and methods for treating packaged powders |
| WO2001046134A1 (en) | 1999-12-22 | 2001-06-28 | Alcon Universal Ltd. | 6-KETO PROSTAGLANDIN F1α AND ANALOGS FOR TREATING DRY EYE |
| US7160511B2 (en) | 2000-02-18 | 2007-01-09 | Olympus Corporation | Liquid pipetting apparatus and micro array manufacturing apparatus |
| US7867186B2 (en) | 2002-04-08 | 2011-01-11 | Glaukos Corporation | Devices and methods for treatment of ocular disorders |
| US7080644B2 (en) | 2000-06-28 | 2006-07-25 | Microdose Technologies, Inc. | Packaging and delivery of pharmaceuticals and drugs |
| US6273092B1 (en) | 2000-09-22 | 2001-08-14 | Gerard M. Nolan | Methods for treating various eye disorders |
| DE10052819B4 (de) | 2000-10-24 | 2004-02-19 | Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. | Pipettensystem und Pipettenarray sowie Verfahren zum Befüllen eines Pipettensystems |
| US6722364B2 (en) | 2001-01-12 | 2004-04-20 | Becton, Dickinson And Company | Medicament inhalation delivery devices and methods for using the same |
| US20020124843A1 (en) | 2001-02-01 | 2002-09-12 | Skiba Jeffry B. | Eye medication delivery system |
| US6758837B2 (en) | 2001-02-08 | 2004-07-06 | Pharmacia Ab | Liquid delivery device and method of use thereof |
| AU2002247280A1 (en) | 2001-03-09 | 2002-09-24 | Antares Pharma, Inc. | Ocular drug delivery nebulizer |
| US7225807B2 (en) | 2001-03-15 | 2007-06-05 | Creare Incorporated | Systems and methods for aerosol delivery of agents |
| WO2002080223A1 (en) | 2001-03-29 | 2002-10-10 | Wisconsin Alumni Research Foundation | Piezoelectric charged droplet source |
| US7496401B2 (en) * | 2001-04-06 | 2009-02-24 | Mattioli Engineering Ltd | Method and apparatus for skin absorption enhancement and transdermal drug delivery |
| DE10154526B4 (de) | 2001-06-12 | 2007-02-08 | Physik Instrumente (Pi) Gmbh & Co | Piezoelektrisches Stellelement |
| JP2003063576A (ja) * | 2001-06-15 | 2003-03-05 | Taisei Kako Co Ltd | 分与容器 |
| US6783035B2 (en) | 2001-07-19 | 2004-08-31 | Valois S.A.S. | Fluid product dispenser |
| US6723077B2 (en) | 2001-09-28 | 2004-04-20 | Hewlett-Packard Development Company, L.P. | Cutaneous administration system |
| WO2003059424A1 (en) | 2002-01-15 | 2003-07-24 | Aerogen, Inc. | Methods and systems for operating an aerosol generator |
| US6869275B2 (en) * | 2002-02-14 | 2005-03-22 | Philip Morris Usa Inc. | Piezoelectrically driven fluids pump and piezoelectric fluid valve |
| US20040039355A1 (en) | 2002-08-26 | 2004-02-26 | Gonzalez Jose M. | Fluid dispensing devices and methods |
| US20050261641A1 (en) | 2002-09-26 | 2005-11-24 | Warchol Mark P | Method for ophthalmic administration of medicament |
| US8133210B2 (en) | 2002-10-23 | 2012-03-13 | Al-Abdulla Nael A | Aqueous ophthalmic spray and method for delivery of artificial tears to the ocular surface |
| US6814265B2 (en) | 2003-03-06 | 2004-11-09 | Alcon, Inc. | Device for dispensing fluid medicine |
| US7201732B2 (en) | 2003-04-10 | 2007-04-10 | Hewlett-Packard Development Company, L.P. | Dispensing method and device for delivering material to an eye |
| EP1468748A1 (en) * | 2003-04-15 | 2004-10-20 | Microflow Engineering SA | Low-cost liquid droplet spray device and nozzle body |
| EP1618060A4 (en) | 2003-04-30 | 2007-03-21 | Aurora Discovery Inc | METHOD AND SYSTEM FOR ACCURATE DISTRIBUTION OF A LIQUID |
| US8545463B2 (en) * | 2003-05-20 | 2013-10-01 | Optimyst Systems Inc. | Ophthalmic fluid reservoir assembly for use with an ophthalmic fluid delivery device |
| US7883031B2 (en) * | 2003-05-20 | 2011-02-08 | James F. Collins, Jr. | Ophthalmic drug delivery system |
| US8021334B2 (en) | 2004-05-30 | 2011-09-20 | Nilimedix Ltd. | Drug delivery device and method |
| US8128606B2 (en) | 2003-07-03 | 2012-03-06 | Hewlett-Packard Development Company, L.P. | Ophthalmic apparatus and method for administering agents to the eye |
| DE10337484B4 (de) | 2003-08-14 | 2005-05-25 | Zengerle, Roland, Prof. Dr. | Mikrodosiervorrichtung und Verfahren zur dosierten Abgabe von Flüssigkeiten |
| US20050059583A1 (en) | 2003-09-15 | 2005-03-17 | Allergan, Inc. | Methods of providing therapeutic effects using cyclosporin components |
| EP1682537B1 (en) | 2003-11-05 | 2012-03-28 | SARcode Bioscience Inc. | Modulators of cellular adhesion |
| DE102004006452B4 (de) * | 2004-02-05 | 2006-04-20 | Ing. Erich Pfeiffer Gmbh | Mikrodosiervorrichtung |
| CA2554068A1 (en) | 2004-02-06 | 2005-08-25 | Microdose Technologies, Inc. | A blister pack for use with an inhalation device |
| WO2005079997A1 (de) | 2004-02-24 | 2005-09-01 | Boehringer Ingelheim International Gmbh | Zerstäuber |
| IN2014DN01746A (zh) * | 2004-04-02 | 2015-07-10 | Government Of The Us Secretary Of The Dept Of Health And Human Services Ct S For Disease Control And | |
| US20050240162A1 (en) * | 2004-04-21 | 2005-10-27 | Wen-Pin Chen | Eye treatment device |
| CA2563365A1 (en) | 2004-04-23 | 2005-11-03 | Mystic Pharmaceuticals, Inc. | Multiple unit dose drug delivery system |
| GB0410712D0 (en) | 2004-05-13 | 2004-06-16 | Novartis Ag | Organic compounds |
| EP1814420A4 (en) | 2004-09-27 | 2008-07-16 | Medical Instill Tech Inc | SIDE-OPERATING DISTRIBUTOR PROVIDED WITH A NON-RETURN VALVE FOR STORING AND DISPENSING QUANTITIES OF SUBSTANCES |
| US20060069358A1 (en) | 2004-09-29 | 2006-03-30 | Gerondale Scott J | Controlled drop dispensing units |
| CA2586525C (en) | 2004-11-22 | 2013-01-15 | Intelliject, Llc | Devices, systems, and methods for medicament delivery |
| WO2006082588A2 (en) | 2005-02-07 | 2006-08-10 | Pharmalight Inc. | Method and device for ophthalmic administration of active pharmaceutical ingredients |
| PL2444079T3 (pl) | 2005-05-17 | 2017-07-31 | Sarcode Bioscience Inc. | Kompozycje i sposoby leczenia chorób oczu |
| ES2563755T3 (es) | 2005-05-18 | 2016-03-16 | Visual Physics, Llc | Presentación de imágenes y sistema de seguridad micro-óptico |
| EA012656B1 (ru) | 2005-05-25 | 2009-12-30 | Аэроджен, Инк. | Вибрационные системы и их применение |
| ATE537864T1 (de) * | 2005-06-02 | 2012-01-15 | Ads & B Invest Fund L P | Vibriervorrichtung zur behandlung von nasaler kongestion und sinusitis-symptomen |
| US10646668B2 (en) | 2005-06-02 | 2020-05-12 | Respinova Ltd. | Pulsating inhaler and a method of treating upper respiratory disorders |
| DE102005025640A1 (de) | 2005-06-03 | 2006-12-07 | Scienion Ag | Mikrodispenser und zugehöriges Betriebsverfahren |
| DE102005043034A1 (de) | 2005-09-09 | 2007-03-15 | Siemens Ag | Vorrichtung und Verfahren zur Bewegung einer Flüssigkeit |
| EP1779933A1 (en) | 2005-10-26 | 2007-05-02 | The Procter and Gamble Company | Dispenser for a liquid |
| US7874467B2 (en) | 2005-11-03 | 2011-01-25 | Reseal International Limited Partnership | Metered drop push button dispenser system |
| FR2897599B1 (fr) | 2006-02-23 | 2010-08-27 | Rexam Pharma | Ensemble de conditionnement et de distribution de liquide. |
| US20070195151A1 (en) | 2006-02-23 | 2007-08-23 | Anderson Frank E | Hand-held ink jet pen |
| JP2009536545A (ja) | 2006-05-11 | 2009-10-15 | エイラット、エラン | 眼薬分配装置 |
| US20070268340A1 (en) | 2006-05-17 | 2007-11-22 | Bruno Dacquay | Ophthalmic Injection System and Method Using Piezoelectric Array |
| DE102006026786A1 (de) | 2006-06-07 | 2007-12-13 | Joachim Kern | Dosierinhalator |
| US8048047B2 (en) | 2006-06-23 | 2011-11-01 | Novartis Ag | Surgical cassette with improved air filtering |
| US20080039807A1 (en) | 2006-08-08 | 2008-02-14 | Jerrold Scott Pine | Ophthalmic Drug Dispensing Tip |
| DE102006040316B4 (de) | 2006-08-29 | 2012-07-05 | Deutsches Zentrum für Luft- und Raumfahrt e.V. | Piezokeramischer Flächenaktuator und Verfahren zur Herstellung eines solchen |
| FR2908329B1 (fr) | 2006-11-14 | 2011-01-07 | Telemaq | Dispositif et methode de distribution de fluide par ultrasons |
| US8196576B2 (en) | 2007-02-28 | 2012-06-12 | Microdose Therapeutx, Inc. | Inhaler |
| US20080214940A1 (en) | 2007-03-02 | 2008-09-04 | Benaron David A | Medical imaging lens system, and method with high-efficiency light collection and collinear illumination |
| US20090008413A1 (en) * | 2007-04-17 | 2009-01-08 | Choi Hee Jin | Airless dispensing pump container with an airtight push down type nozzle head |
| ITRM20070275A1 (it) | 2007-05-17 | 2008-11-18 | Federighi Federigo | Flacone erogatore multidose per preparati liquidi senza conservanti. |
| JP5137710B2 (ja) | 2007-07-26 | 2013-02-06 | キヤノン株式会社 | 液体カートリッジ |
| MX2010003364A (es) | 2007-10-08 | 2010-07-06 | Lux Biosciences Inc | Composiciones oftalmicas que comprenden inhibidores de calcineurina o inhibidores de mtor. |
| US20090114737A1 (en) | 2007-11-07 | 2009-05-07 | Health & Life Co., Ltd. | Aerosolization device |
| US20090212127A1 (en) | 2007-12-14 | 2009-08-27 | Weidlinger Associates, Inc. | Fuel injector with single crystal piezoelectric actuator stack |
| US20090212133A1 (en) * | 2008-01-25 | 2009-08-27 | Collins Jr James F | Ophthalmic fluid delivery device and method of operation |
| US8734408B2 (en) | 2008-02-05 | 2014-05-27 | Alvin J. Marx | Automated eyedrop delivery system with eyelid retracting legs |
| CA2720141C (en) | 2008-04-04 | 2014-01-28 | Mimetogen Pharmaceuticals Inc. | Beta-turn peptidomimetic cyclic compounds for treating dry eye |
| WO2009139817A2 (en) | 2008-04-15 | 2009-11-19 | Sarcode Corporation | Crystalline pharmaceutical and methods of preparation and use thereof |
| DE102008022987A1 (de) * | 2008-05-09 | 2009-11-12 | Pari Pharma Gmbh | Vernebler für Beatmungsmaschinen und Beatmungsmaschine mit einem solchen Vernebler |
| US20100001090A1 (en) * | 2008-07-03 | 2010-01-07 | Arthur Hampton Neergaard | Liquid Particle Emitting Device |
| US7656076B1 (en) | 2008-07-15 | 2010-02-02 | Iptrade, Inc. | Unimorph/bimorph piezoelectric package |
| WO2010025382A2 (en) | 2008-08-28 | 2010-03-04 | Deka Products Limited Partnership | Product dispensing system |
| US20100072302A1 (en) | 2008-09-19 | 2010-03-25 | Miro Cater | Discharge device |
| US20100072301A1 (en) | 2008-09-19 | 2010-03-25 | Miro Cater | Discharge device |
| US20100076388A1 (en) | 2008-09-19 | 2010-03-25 | Miro Cater | Discharge device for pharmaceutical media |
| US20090192443A1 (en) * | 2008-10-06 | 2009-07-30 | Collins Jr James F | Ophthalmic fluid delivery device and method of operation |
| AU2009302167B9 (en) | 2008-10-09 | 2014-05-29 | Ramscor, Inc. | Composition and method for treating dry eye syndrome |
| WO2010078428A1 (en) | 2008-12-30 | 2010-07-08 | Optimyst Systems, Inc. | Ophthalmic fluid delivery system |
| CA2929545C (en) | 2009-05-01 | 2019-04-09 | Aerie Pharmaceuticals, Inc. | Dual mechanism inhibitors for the treatment of disease |
| EP2456509A1 (en) | 2009-07-22 | 2012-05-30 | Advanced Ophthalmic Pharma Ltd. | Device for applying an ophthalmic medicament mist |
| FR2950036B1 (fr) | 2009-09-11 | 2011-12-16 | Rexam Pharma La Verpilliere | Dispositif de distribution de liquide |
| EP2302712A1 (en) | 2009-09-28 | 2011-03-30 | Stichting IMEC Nederland | Method for resonance frequency tuning of micromachined structures |
| US8596781B2 (en) | 2009-10-15 | 2013-12-03 | Adlens Beacon, Inc. | Fluid filled lens reservoir system and manufacturing method of the reservoir system |
| US9801757B2 (en) | 2011-08-31 | 2017-10-31 | Johnson & Johnson Vision Care, Inc. | Liquid dispensing reservoir |
| US9039666B2 (en) | 2009-10-21 | 2015-05-26 | Johnson & Johnson Vision Care, Inc. | Method and apparatus for liquid dispensing |
| US20110106025A1 (en) | 2009-10-29 | 2011-05-05 | Hall Gary S | Ophthalmic fluid pump |
| WO2011050175A1 (en) | 2009-10-21 | 2011-04-28 | Sarcode Corporation | Crystalline pharmaceutical and methods of preparation and use thereof |
| EP2501492B1 (en) * | 2009-11-18 | 2019-12-25 | Reckitt Benckiser LLC | Ultrasonic surface treatment device and method |
| DE102010011047A1 (de) | 2010-03-11 | 2011-09-15 | Johnson Matthey Catalysts (Germany) Gmbh | Biegewandler |
| KR20130092959A (ko) | 2010-04-06 | 2013-08-21 | 리실 인터내셔널 리미티드 파트너쉽 | 계량된 볼륨들의 순수 또는 무균성 유동가능 물질들을 분배하기 위한 전달 시스템 |
| DE102010003810A1 (de) | 2010-04-09 | 2011-10-13 | Henkel Ag & Co. Kgaa | Abgabevorrichtung mit piezo-elektrischem Element |
| JP5171879B2 (ja) | 2010-05-06 | 2013-03-27 | 株式会社エヌ・ティ・ティ・ドコモ | 移動通信端末及び再接続方法 |
| KR101153613B1 (ko) | 2010-05-25 | 2012-06-18 | 삼성전기주식회사 | 마이크로 이젝터 및 그 제조방법 |
| DE102010017216A1 (de) | 2010-06-02 | 2011-12-08 | Technische Universität Berlin | Ventilvorrichtung zum Steuern eines Flusses eines Fluides durch einen Fluidkanal, Anordnung sowie Mehrwegventilvorrichtung |
| EA201390121A8 (ru) | 2010-07-15 | 2014-02-28 | Коринтиан Офтэлмик, Инк. | Способ и система для выполнения дистанционного лечения и контроля |
| US10154923B2 (en) | 2010-07-15 | 2018-12-18 | Eyenovia, Inc. | Drop generating device |
| KR101545413B1 (ko) | 2010-07-15 | 2015-08-18 | 아이노비아 인코포레이티드 | 점적 발생 디바이스 |
| AU2011278924B2 (en) | 2010-07-15 | 2015-06-18 | Eyenovia, Inc. | Ophthalmic drug delivery |
| US9132243B2 (en) | 2010-07-23 | 2015-09-15 | Tannermedico A/S | Method of administering a substance to the throat |
| FR2963326B1 (fr) | 2010-07-30 | 2012-09-07 | Rexam Healthcare La Verpillier | Embout et recipient de distribution de liquide |
| IE20110394A1 (en) | 2010-09-07 | 2013-01-02 | Univ Limerick | A liquid droplet dispenser |
| US20130206857A1 (en) | 2011-01-21 | 2013-08-15 | Biodot, Inc. | Piezoelectric dispenser with a longitudinal transducer and replaceable capillary tube |
| CN103429348B (zh) | 2011-01-21 | 2016-03-09 | 拜奥－多特公司 | 具有纵向变换器和可替换毛细管的压电分配器 |
| US9186690B2 (en) | 2011-02-01 | 2015-11-17 | Bausch & Lomb Incorporated | Ergonomic hand-operable fluid-dispensing device |
| MX2014000419A (es) | 2011-07-15 | 2014-09-22 | Nusirt Sciences Inc | Composicones y metodos para modular trayectorias metabolicas. |
| JP6357416B2 (ja) | 2011-07-19 | 2018-07-11 | コーニンクレッカ フィリップス エヌ ヴェＫｏｎｉｎｋｌｉｊｋｅ Ｐｈｉｌｉｐｓ Ｎ．Ｖ． | アクチュエーターを有する家庭用電気器具 |
| US9346075B2 (en) | 2011-08-26 | 2016-05-24 | Nordson Corporation | Modular jetting devices |
| JP2014528793A (ja) | 2011-09-19 | 2014-10-30 | クラフト，ダニエル，エル． | 点眼剤ディスペンサー |
| CA2849366C (en) | 2011-09-20 | 2019-09-10 | Juan Carlos Abad | Compositions and methods for treating presbyopia, mild hyperopia, and irregular astigmatism |
| DE102011114584B3 (de) | 2011-09-30 | 2012-05-31 | Carl Zeiss Meditec Ag | Ophthalmochirurgische Steuerungsvorrichtung und ophthalmochirurgisches System mit einer solchen Steuerungsvorrichtung |
| US8957048B2 (en) | 2011-10-06 | 2015-02-17 | Allergan, Inc. | Compositions for the treatment of dry eye |
| WO2013070658A2 (en) | 2011-11-08 | 2013-05-16 | Fairchild Semiconductor Corporation | Modulation scheme for driving a piezo element |
| DE102011086755A1 (de) | 2011-11-21 | 2013-05-23 | Aptar Radolfzell Gmbh | Spender zum Austrag von pharmazeutischen Flüssigkeiten |
| CH705799A1 (it) | 2011-11-24 | 2013-05-31 | Luso Pharma Sagl | Testa di erogazione multi-dose con otturatore a membrana elastica. originale: Testa di erogazione multi-dose perfezionata. |
| WO2013090459A1 (en) | 2011-12-12 | 2013-06-20 | Corinthian Ophthalmic, Inc. | Ejector mechanism, ejector device, and methods of use |
| US8591635B2 (en) | 2011-12-19 | 2013-11-26 | Chrysler Group Llc | Fluid aeration-reduction system |
| US20130164436A1 (en) * | 2011-12-27 | 2013-06-27 | Ricoh Company | Thin film manufacturing apparatus, thin film manufacturing method, liquid droplet ejecting head, and inkjet recording apparatus |
| US9254642B2 (en) | 2012-01-19 | 2016-02-09 | AdvanJet | Control method and apparatus for dispensing high-quality drops of high-viscosity material |
| AU2013245946A1 (en) | 2012-04-10 | 2014-11-27 | Eyenovia, Inc. | Spray ejector mechanisms and devices providing charge isolation and controllable droplet charge, and low dosage volume opthalmic administration |
| EA201491906A1 (ru) | 2012-04-20 | 2015-03-31 | Айновиа, Инк. | Распылительное эжекторное устройство и способы его использования |
| RU2627380C2 (ru) | 2012-04-26 | 2017-08-08 | Конинклейке Филипс Н.В. | Ингалятор и способ изготовления ингалятора |
| SG10201602609XA (en) | 2012-05-15 | 2016-05-30 | Eyenovia Inc | Ejector devices, methods, drivers, and circuits therefor |
| EP2664329A1 (de) | 2012-05-15 | 2013-11-20 | F. Holzer GmbH | Ophthalmologisches Vehikelsystem |
| US9132238B2 (en) | 2012-06-26 | 2015-09-15 | Becton, Dickinson And Company | Blow fill seal luer syringe |
| EP3715345B1 (en) | 2012-07-25 | 2024-04-10 | Novartis AG | Preparation of lfa-1 inhibitor |
| JP6378681B2 (ja) | 2012-09-07 | 2018-08-22 | グラクソ グループ リミテッドＧｌａｘｏ Ｇｒｏｕｐ Ｌｉｍｉｔｅｄ | 液滴ディスペンサ |
| WO2014049661A1 (ja) | 2012-09-27 | 2014-04-03 | テルモ株式会社 | 輸液ポンプ |
| US8927921B1 (en) | 2012-10-02 | 2015-01-06 | Sun Nuclear Corporation | Systems and methods for composite dose quality assurance with three dimensional arrays |
| MY178764A (en) | 2013-02-12 | 2020-10-20 | Sis Resources Ltd | Inductive charging for an electronic cigarette |
| US9962288B2 (en) | 2013-03-07 | 2018-05-08 | Novartis Ag | Active acoustic streaming in hand piece for occlusion surge mitigation |
| US20140276054A1 (en) | 2013-03-15 | 2014-09-18 | Volcano Corporation | Piezoelectric-Actuated Fluid-Delivery Devices and Associated Systems and Methods |
| US20150018781A1 (en) * | 2013-04-10 | 2015-01-15 | California Institute Of Technology | Systems, devices, and methods for topical drug delivery to the eye |
| US20150035180A1 (en) | 2013-08-02 | 2015-02-05 | Forward Optics Co., Ltd. | Method for fabricating an arrayed optical element |
| US8976451B2 (en) | 2013-08-02 | 2015-03-10 | Forward Optics Co., Ltd | Lens array module |
| US10335322B2 (en) * | 2013-08-26 | 2019-07-02 | Lightside Md, Llc | Adhesive support devices and methods of making and using them |
| US20150086397A1 (en) | 2013-09-25 | 2015-03-26 | Hsiao-Kang Ma | Micropump with separate chamber |
| US9282803B2 (en) | 2013-10-03 | 2016-03-15 | Donald John Ciervo | Ultrasonic cosmetic applicator |
| US9676525B2 (en) | 2013-12-17 | 2017-06-13 | Aptar Radolfzell Gmbh | Protective cap for a dispenser, and discharge device for discharging pharmaceutical and/or cosmetical liquids |
| CA2936235A1 (en) | 2014-01-10 | 2015-07-16 | Marcio Marc Abreu | Devices to monitor and provide treatment at an abreu brain tunnel |
| US20150256730A1 (en) | 2014-03-05 | 2015-09-10 | Forward Optics Co., Ltd. | Image-capturing device configured for a handheld electronic device |
| US20150276994A1 (en) | 2014-03-28 | 2015-10-01 | Forward Optics Co., Ltd. | Method of making a lens array plate with an aperture mask layer |
| DE102014208064B4 (de) | 2014-04-29 | 2015-12-03 | Heraeus Medical Gmbh | Lavage-System mit einem Druckgasmotor sowie Verfahren zum Erzeugen eines Sprühstoßes |
| US10610651B2 (en) | 2014-06-09 | 2020-04-07 | Aerami Therapeutics, Inc. | Self-puncturing liquid drug cartridges and associated dispenser |
| JP6052475B2 (ja) * | 2014-07-16 | 2016-12-27 | 株式会社村田製作所 | 流体制御装置 |
| CN104146816B (zh) | 2014-09-02 | 2016-04-13 | 镇江万新光学眼镜有限公司 | 一种眼部雾化送药装置 |
| TWI658828B (zh) | 2014-10-31 | 2019-05-11 | 中國醫藥大學 | 用於舒緩及減輕近視之醫藥組合物及其製備方法與用途 |
| CA2973471A1 (en) | 2015-01-12 | 2016-07-21 | Kedalion Therapeutics, Inc. | Micro-droplet delivery device and methods |
| CA2973880A1 (en) | 2015-01-23 | 2016-07-28 | William Tan | Ultrasonic vaporizing element |
| CA2981070A1 (en) | 2015-04-10 | 2016-10-13 | Kedalion Therapeutics, Inc. | Piezoelectric dispenser with replaceable ampoule |
| GB201507687D0 (en) * | 2015-04-30 | 2015-06-17 | Leafgreen Ltd | Pulsed spray nozzle arrangement |
| US9700686B2 (en) | 2015-06-03 | 2017-07-11 | Novopyxis, Inc. | Fluid delivery devices and methods |
| CN204813955U (zh) | 2015-07-22 | 2015-12-02 | 吉林大学 | 可调压力腔室体积的次声实验系统 |
| US20170028626A1 (en) | 2015-07-29 | 2017-02-02 | Ecole Polytechnique Federale De Lausanne (Epfl) | Compact Drop-on-Demand Apparatus Using Light Actuation Through Optical Fibers |
| EP3334536B1 (en) | 2015-08-14 | 2019-10-09 | Leafgreen Limited | Pulsed spray nozzle arrangements |
| GB201518337D0 (en) | 2015-10-16 | 2015-12-02 | The Technology Partnership Plc | Linear device |
| DE102015224617B4 (de) | 2015-12-08 | 2017-07-20 | Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. | Freistrahldosiersystem für das Auge |
| JP2017120975A (ja) | 2015-12-28 | 2017-07-06 | ルネサスエレクトロニクス株式会社 | 撮像素子 |
| EP3432769A4 (en) | 2016-03-24 | 2020-07-22 | Brien Holden Vision Institute | DEVICES AND METHOD FOR GENERATING AN IRRITATION FOR EVALUATING SENSITIVITY |
| US10672298B2 (en) | 2016-10-17 | 2020-06-02 | Sanmina Corporation | System and method for a blood flow simulator |
| WO2018136618A2 (en) | 2017-01-20 | 2018-07-26 | Kedalion Therapeutics, Inc. | Piezoelectric fluid dispenser |
| IT201700038005A1 (it) * | 2017-04-06 | 2018-10-06 | Zodiak S R L | Dispositivo per la somministrazione di sostanze |
| JP7227163B2 (ja) | 2017-06-10 | 2023-02-21 | アイノビア，インコーポレイティド | 流体を取扱い、目に流体を送出するための方法および装置 |
| CN109674576B (zh) | 2017-10-19 | 2024-02-27 | 深圳市启明医药科技有限公司 | 流体供应单元及微液滴喷射驱动装置、发生装置 |
| JP7436363B2 (ja) | 2017-12-08 | 2024-02-21 | ノバルティス アーゲー | 流体送達アライメントシステム |
| US20190314196A1 (en) | 2018-04-12 | 2019-10-17 | Kedalion Therapeutics, Inc. | Topical Ocular Delivery Methods and Devices for Use in the Same |
| KR20210028233A (ko) | 2018-07-03 | 2021-03-11 | 켄달리온 테라퓨틱스 인코포레이티드 | 국소 안구 전달 디바이스들 및 이를 사용하기 위한 방법들 |
| EP3826497A4 (en) | 2018-07-23 | 2022-05-04 | Wellness Insight Technologies, Inc. | SYSTEM FOR ANALYSIS AND CONTROL OF DOSING INFORMATION FOR CONSUMABLES |
| CN113660935B (zh) | 2019-03-04 | 2023-12-08 | 艾诺维亚股份有限公司 | 用于以微剂量液滴流向眼睛递送毛果芸香碱的方法和装置 |
| US11679028B2 (en) | 2019-03-06 | 2023-06-20 | Novartis Ag | Multi-dose ocular fluid delivery system |
| US20210137732A1 (en) | 2019-03-06 | 2021-05-13 | Kedalion Therapeutics, Inc. | Vented Multi-dose Ocular Fluid Delivery System |
| US20220192874A1 (en) | 2020-04-17 | 2022-06-23 | Kedaliion Therapeutics, Inc. | Hydrodynamically Actuated Preservative Free Dispensing System |
| WO2021212038A1 (en) | 2020-04-17 | 2021-10-21 | Kedalion Therapeutics, Inc. | Hydrodynamically actuated preservative free dispensing system having a collapsible liquid reservoir |
| US11938057B2 (en) | 2020-04-17 | 2024-03-26 | Bausch + Lomb Ireland Limited | Hydrodynamically actuated preservative free dispensing system |
-
2021
- 2021-04-16 JP JP2022562678A patent/JP2023523394A/ja active Pending
- 2021-04-16 US US17/233,105 patent/US11925577B2/en active Active
- 2021-04-16 KR KR1020227040058A patent/KR20230034940A/ko active Search and Examination
- 2021-04-16 IL IL297215A patent/IL297215A/en unknown
- 2021-04-16 AU AU2021257273A patent/AU2021257273A1/en active Pending
- 2021-04-16 CA CA3180199A patent/CA3180199A1/en active Pending
- 2021-04-16 WO PCT/US2021/027773 patent/WO2021212033A1/en unknown
- 2021-04-16 CN CN202180029216.9A patent/CN115768384A/zh active Pending
- 2021-04-16 BR BR112022020948A patent/BR112022020948A2/pt unknown
- 2021-04-16 EP EP21788931.0A patent/EP4120974A1/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| AU2021257273A1 (en) | 2022-11-17 |
| KR20230034940A (ko) | 2023-03-10 |
| CA3180199A1 (en) | 2021-10-21 |
| EP4120974A1 (en) | 2023-01-25 |
| US20210322209A1 (en) | 2021-10-21 |
| IL297215A (en) | 2022-12-01 |
| WO2021212033A1 (en) | 2021-10-21 |
| JP2023523394A (ja) | 2023-06-05 |
| WO2021212033A8 (en) | 2022-11-24 |
| US11925577B2 (en) | 2024-03-12 |
| BR112022020948A2 (pt) | 2023-04-11 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN115768384A (zh) | 流体动力致动的不含防腐剂分配系统 | |
| US20210322210A1 (en) | Hydrodynamically Actuated Preservative Free Dispensing System having a Collapsible Liquid Reservoir | |
| US11938057B2 (en) | Hydrodynamically actuated preservative free dispensing system | |
| US20220192874A1 (en) | Hydrodynamically Actuated Preservative Free Dispensing System | |
| US20220355329A1 (en) | Spray ejector device and methods of use | |
| US20210137732A1 (en) | Vented Multi-dose Ocular Fluid Delivery System | |
| US20100222752A1 (en) | Ophthalmic fluid delivery system | |
| JP2009536545A (ja) | 眼薬分配装置 | |
| US20230089768A1 (en) | Non-Gravitational Fluid Delivery Device For Ophthalmic Applications | |
| EP0765276B1 (en) | Non-streaming ophthalmic tip and delivery device | |
| ES2811762T3 (es) | Dispensador de medicamento | |
| AU8044898A (en) | Eye fluid applicator | |
| AU2020407652A1 (en) | Vented multi-dose ocular fluid delivery system | |
| JP2019069087A (ja) | 眼科用薬液投与器及び薬液投与部材 | |
| JP2022547244A (ja) | 眼科用の非重力流体送達装置 | |
| US20200337896A1 (en) | Methods and devices for delivering atropine to the eye as a micro-dose stream of droplets | |
| WO2023215705A2 (en) | Vented multi-dose ocular fluid delivery system | |
| JP2023123200A (ja) | 点眼補助具 |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| TA01 | Transfer of patent application right | ||
| TA01 | Transfer of patent application right |
Effective date of registration: 20230512 Address after: Basel, SUI Applicant after: NOVARTIS AG Address before: new jersey Applicant before: Kodaron Treatment Co. |
|
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| TA01 | Transfer of patent application right | ||
| TA01 | Transfer of patent application right |
Effective date of registration: 20240226 Address after: Ai Erlandubailin Applicant after: Bausch & Lomb Ireland Ltd. Country or region after: Ireland Address before: Basel, SUI Applicant before: NOVARTIS AG Country or region before: Switzerland |