BR112022020948A2 - Sistema de distribuição livre de conservantes hidrodinamicamente atuado - Google Patents

Sistema de distribuição livre de conservantes hidrodinamicamente atuado

Info

Publication number
BR112022020948A2
BR112022020948A2 BR112022020948A BR112022020948A BR112022020948A2 BR 112022020948 A2 BR112022020948 A2 BR 112022020948A2 BR 112022020948 A BR112022020948 A BR 112022020948A BR 112022020948 A BR112022020948 A BR 112022020948A BR 112022020948 A2 BR112022020948 A2 BR 112022020948A2
Authority
BR
Brazil
Prior art keywords
fluid
chamber
valve
dispensing system
liquid
Prior art date
Application number
BR112022020948A
Other languages
English (en)
Inventor
Ivri Yehuda
Original Assignee
Kedallion Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kedallion Therapeutics Inc filed Critical Kedallion Therapeutics Inc
Publication of BR112022020948A2 publication Critical patent/BR112022020948A2/pt

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F9/00Methods or devices for treatment of the eyes; Devices for putting-in contact lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
    • A61F9/0008Introducing ophthalmic products into the ocular cavity or retaining products therein
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B05SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
    • B05BSPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES
    • B05B1/00Nozzles, spray heads or other outlets, with or without auxiliary devices such as valves, heating means
    • B05B1/02Nozzles, spray heads or other outlets, with or without auxiliary devices such as valves, heating means designed to produce a jet, spray, or other discharge of particular shape or nature, e.g. in single drops, or having an outlet of particular shape
    • B05B1/08Nozzles, spray heads or other outlets, with or without auxiliary devices such as valves, heating means designed to produce a jet, spray, or other discharge of particular shape or nature, e.g. in single drops, or having an outlet of particular shape of pulsating nature, e.g. delivering liquid in successive separate quantities ; Fluidic oscillators
    • B05B1/083Nozzles, spray heads or other outlets, with or without auxiliary devices such as valves, heating means designed to produce a jet, spray, or other discharge of particular shape or nature, e.g. in single drops, or having an outlet of particular shape of pulsating nature, e.g. delivering liquid in successive separate quantities ; Fluidic oscillators the pulsating mechanism comprising movable parts
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B05SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
    • B05BSPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES
    • B05B1/00Nozzles, spray heads or other outlets, with or without auxiliary devices such as valves, heating means
    • B05B1/30Nozzles, spray heads or other outlets, with or without auxiliary devices such as valves, heating means designed to control volume of flow, e.g. with adjustable passages
    • B05B1/3006Nozzles, spray heads or other outlets, with or without auxiliary devices such as valves, heating means designed to control volume of flow, e.g. with adjustable passages the controlling element being actuated by the pressure of the fluid to be sprayed
    • GPHYSICS
    • G02OPTICS
    • G02BOPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B5/00Optical elements other than lenses
    • G02B5/08Mirrors
    • G02B5/10Mirrors with curved faces

Landscapes

  • Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Veterinary Medicine (AREA)
  • Ophthalmology & Optometry (AREA)
  • General Physics & Mathematics (AREA)
  • Optics & Photonics (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
  • Apparatus For Disinfection Or Sterilisation (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Food Preservation Except Freezing, Refrigeration, And Drying (AREA)

Abstract

SISTEMA DE DISTRIBUIÇÃO LIVRE DE CONSERVANTES ATUADO DE FORMA HIDRODINÂMICA. A presente invenção refere-se a dispositivos de liberação de fluido ocular livre de múltiplas doses. O dispositivo de distribuição de fluido inclui um sistema dispensador de fluido e uma embalagem fluida para armazenar um líquido no mesmo e fornecer o referido líquido ao sistema dispensador. O sistema de distribuição compreende uma câmara alongada que inclui uma válvula de retenção que define um fecho frontal para a câmara. A válvula está normalmente fechada e veda hermeticamente a câmara.O dispensador inclui um motor de vibração que induz oscilações na câmara e no fluido no seu interior. As oscilações da câmara conferem momento ao fluido armazenado na câmara, o que por sua vez confere força que abre ciclicamente a válvula, para dispensar correntes ou gotículas líquidas. Fluido é dispensado somente quando o motor oscila enquanto o contrário é a válvula hermeticamente fechada.
BR112022020948A 2020-04-17 2021-04-16 Sistema de distribuição livre de conservantes hidrodinamicamente atuado BR112022020948A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US202063011808P 2020-04-17 2020-04-17
PCT/US2021/027773 WO2021212033A1 (en) 2020-04-17 2021-04-16 Hydrodynamically actuated preservative free dispensing system

Publications (1)

Publication Number Publication Date
BR112022020948A2 true BR112022020948A2 (pt) 2023-04-11

Family

ID=78080878

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112022020948A BR112022020948A2 (pt) 2020-04-17 2021-04-16 Sistema de distribuição livre de conservantes hidrodinamicamente atuado

Country Status (10)

Country Link
US (2) US11925577B2 (pt)
EP (1) EP4120974A4 (pt)
JP (1) JP2023523394A (pt)
KR (1) KR20230034940A (pt)
CN (1) CN115768384A (pt)
AU (1) AU2021257273A1 (pt)
BR (1) BR112022020948A2 (pt)
CA (1) CA3180199A1 (pt)
IL (1) IL297215A (pt)
WO (1) WO2021212033A1 (pt)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2016115050A1 (en) 2015-01-12 2016-07-21 Lagunita Llc Micro-droplet delivery device and methods
US10888454B2 (en) 2017-01-20 2021-01-12 Kedalion Therapeutics, Inc. Piezoelectric fluid dispenser
US11679028B2 (en) 2019-03-06 2023-06-20 Novartis Ag Multi-dose ocular fluid delivery system
US12090087B2 (en) 2020-04-17 2024-09-17 Bausch + Lomb Ireland Limited Hydrodynamically actuated preservative free dispensing system having a collapsible liquid reservoir
WO2021212033A1 (en) * 2020-04-17 2021-10-21 Kedallon Therapeutics, Inc. Hydrodynamically actuated preservative free dispensing system
US11938057B2 (en) 2020-04-17 2024-03-26 Bausch + Lomb Ireland Limited Hydrodynamically actuated preservative free dispensing system

Family Cites Families (239)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1575050A1 (de) 1966-01-12 1972-04-13 Misto Gen Equipment Co Ultraschall-Nebelerzeugungsgeraet
US3640274A (en) * 1966-11-04 1972-02-08 Colgate Palmolive Co Eye-spraying device having mirror
US3779245A (en) 1972-06-13 1973-12-18 R Windsor Device for applying materials to the area of the eye
US3812854A (en) 1972-10-20 1974-05-28 A Michaels Ultrasonic nebulizer
DE2445791C2 (de) 1974-09-25 1984-04-19 Siemens AG, 1000 Berlin und 8000 München Ultraschall-Flüssigkeitszerstäuber
US3976072A (en) 1975-09-03 1976-08-24 The United States Of America As Represented By The Secretary Of The Department Of Health, Education And Welfare Blink-operated extracorporeal tear duct
US4159803A (en) 1977-03-31 1979-07-03 MistO2 Gen Equipment Company Chamber for ultrasonic aerosol generation
US4338576A (en) 1978-07-26 1982-07-06 Tdk Electronics Co., Ltd. Ultrasonic atomizer unit utilizing shielded and grounded elements
DE2849493C2 (de) 1978-11-15 1982-01-14 Carl Heyer Gmbh, Inhalationstechnik, 5427 Bad Ems In der Hand zu haltender Aerosolspender
DE2902624C2 (de) * 1979-01-24 1985-10-10 Pfeiffer Zerstäuber Vertriebsgesellschaft mbH & Co KG, 7760 Radolfzell Ausgabepumpe
DE7917568U1 (de) 1979-06-19 1979-09-20 Bosch-Siemens Hausgeraete Gmbh, 7000 Stuttgart Inhalationsgeraet
US4352459A (en) 1979-11-13 1982-10-05 Sono-Tek Corporation Ultrasonic liquid atomizer having an axially-extending liquid feed passage
CA1178191A (en) 1980-10-06 1984-11-20 Naoyoshi Maehara Electric liquid atomizing apparatus
US4632311A (en) 1982-12-20 1986-12-30 Matsushita Electric Industrial Co., Ltd. Atomizing apparatus employing a capacitive piezoelectric transducer
US4655393A (en) 1983-01-05 1987-04-07 Sonotek Corporation High volume ultrasonic liquid atomizer
DE3574344D1 (en) * 1984-08-29 1989-12-28 Omron Tateisi Electronics Co Ultrasonic atomizer
GB2200211B (en) 1986-12-08 1991-01-16 Fuji Electric Co Ltd Vibration-type transducer
US4976259A (en) 1986-12-22 1990-12-11 Mountain Medical Equipment, Inc. Ultrasonic nebulizer
US4952581A (en) 1987-04-03 1990-08-28 The Trustees Of Columbia University In The City Of New York Use of a prostaglandin in combination with an adrenergic blocking agent for reduction of intraocular pressure
US4850534A (en) 1987-05-30 1989-07-25 Tdk Corporation Ultrasonic wave nebulizer
US4981625A (en) 1988-03-14 1991-01-01 California Institute Of Technology Monodisperse, polymeric microspheres produced by irradiation of slowly thawing frozen drops
US4882150A (en) 1988-06-03 1989-11-21 Kaufman Herbert E Drug delivery system
US5025957A (en) 1988-10-07 1991-06-25 Ryder International Corp. Liquid dispenser nozzle assembly
EP0563120B1 (en) 1990-12-17 1997-10-01 Minnesota Mining And Manufacturing Company Inhaler
US5171306A (en) 1991-03-13 1992-12-15 Vo Van T Eyedrop delivery system
US6629646B1 (en) 1991-04-24 2003-10-07 Aerogen, Inc. Droplet ejector with oscillating tapered aperture
US5938117A (en) 1991-04-24 1999-08-17 Aerogen, Inc. Methods and apparatus for dispensing liquids as an atomized spray
US5232363A (en) 1991-06-11 1993-08-03 Eran Meller Scaler with improved vibration characteristics
GB9114080D0 (en) * 1991-06-28 1991-08-14 Weston Terence E Atomising valve
US5549249A (en) 1991-12-13 1996-08-27 Contico International, Inc. Fluid spinner and nozzle head assembly with controlled fluid flood path
US5368582A (en) 1992-08-10 1994-11-29 The Schepens Eye Research Institute Method and apparatus for introducing fluid material into an eye
DE69311361T2 (de) 1992-10-13 1998-01-08 Alcon Lab Inc Zusammensetzungen zur behandlung von glaukoma die prostaglandine und clonidinderivate enthalten
GB2272389B (en) 1992-11-04 1996-07-24 Bespak Plc Dispensing apparatus
EP0687366B1 (en) 1993-03-03 2000-01-26 STREET, Graham Stewart Brandon Method and apparatus for image alignment
EP0622035B1 (en) 1993-04-30 1999-03-03 Henlopen Manufacturing Co., Inc. Applicator system for fluid cosmetic material
DE69427992T2 (de) 1993-12-22 2002-04-04 Merck & Co., Inc. Ophthalmologische verpackung und abgabevorrichtung
GB9405952D0 (en) 1994-03-25 1994-05-11 Zeneca Ltd Aqueous ophthalmic sprays
WO1996000050A1 (en) * 1994-06-23 1996-01-04 R.P. Scherer Corporation Ocular treatment device
US6085740A (en) 1996-02-21 2000-07-11 Aerogen, Inc. Liquid dispensing apparatus and methods
US6427682B1 (en) * 1995-04-05 2002-08-06 Aerogen, Inc. Methods and apparatus for aerosolizing a substance
US5657926A (en) 1995-04-13 1997-08-19 Toda; Kohji Ultrasonic atomizing device
US5828394A (en) * 1995-09-20 1998-10-27 The Board Of Trustees Of The Leland Stanford Junior University Fluid drop ejector and method
US5627611A (en) 1995-12-29 1997-05-06 Scheiner; Stanley A. Artificial tears
FR2746657B1 (fr) 1996-03-29 1998-06-26 Sofab Dispositif antibacterien de pulverisation d'un produit liquide
US5958342A (en) 1996-05-17 1999-09-28 Incyte Pharmaceuticals, Inc. Jet droplet device
US5692651A (en) 1996-06-06 1997-12-02 Owens-Illinois Closure Inc. Self-sealing dispensing closure
US5881956A (en) 1996-08-08 1999-03-16 Ben Z. Cohen Microdispensing ophthalmic pump
US6024717A (en) 1996-10-24 2000-02-15 Vibrx, Inc. Apparatus and method for sonically enhanced drug delivery
US5960224A (en) * 1996-12-26 1999-09-28 Fuji Photo Film Co., Ltd. Image forming apparatus and fluid injecting apparatus
US6065623A (en) 1998-02-13 2000-05-23 Crown Cork & Seal Technologies Corporation Closure with lenticular lens insert
DE19823719B4 (de) 1998-05-27 2011-12-15 MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. Verfahren zum Aufkonzentrieren von Substanzen
JP3055480U (ja) 1998-07-01 1999-01-12 孟 ▲じゃ−▼ 康 軽量型目薬液噴射器
US6070575A (en) 1998-11-16 2000-06-06 Aradigm Corporation Aerosol-forming porous membrane with certain pore structure
US6232129B1 (en) 1999-02-03 2001-05-15 Peter Wiktor Piezoelectric pipetting device
US6196218B1 (en) * 1999-02-24 2001-03-06 Ponwell Enterprises Ltd Piezo inhaler
US6254860B1 (en) 1999-04-13 2001-07-03 Allergan Sales, Inc. Ocular treatment using cyclosporin-A derivatives
US6730066B1 (en) 1999-08-03 2004-05-04 Pharmacia Ab Liquid delivery container
US6235177B1 (en) 1999-09-09 2001-05-22 Aerogen, Inc. Method for the construction of an aperture plate for dispensing liquid droplets
US6302101B1 (en) * 1999-12-14 2001-10-16 Daniel Py System and method for application of medicament into the nasal passage
US20010035184A1 (en) 1999-12-17 2001-11-01 Carlos Schuler Systems and methods for treating packaged powders
AU2603301A (en) 1999-12-22 2001-07-03 Alcon Universal Limited 6-keto prostaglandin F1alpha and analogs for treating dry eye
US7160511B2 (en) 2000-02-18 2007-01-09 Olympus Corporation Liquid pipetting apparatus and micro array manufacturing apparatus
US7867186B2 (en) 2002-04-08 2011-01-11 Glaukos Corporation Devices and methods for treatment of ocular disorders
US7080644B2 (en) 2000-06-28 2006-07-25 Microdose Technologies, Inc. Packaging and delivery of pharmaceuticals and drugs
US6273092B1 (en) 2000-09-22 2001-08-14 Gerard M. Nolan Methods for treating various eye disorders
DE10052819B4 (de) 2000-10-24 2004-02-19 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Pipettensystem und Pipettenarray sowie Verfahren zum Befüllen eines Pipettensystems
US6722364B2 (en) 2001-01-12 2004-04-20 Becton, Dickinson And Company Medicament inhalation delivery devices and methods for using the same
US20020124843A1 (en) 2001-02-01 2002-09-12 Skiba Jeffry B. Eye medication delivery system
US6758837B2 (en) 2001-02-08 2004-07-06 Pharmacia Ab Liquid delivery device and method of use thereof
WO2002072169A2 (en) 2001-03-09 2002-09-19 Antares Pharma, Inc. Ocular drug delivery nebulizer
EP1370318B1 (en) 2001-03-15 2005-07-20 The Government of the United States of America, as represented by the Secretary, Department of Health & Human Services Systems and methods for aerosol delivery of agents
EP1380045B1 (en) 2001-03-29 2010-08-04 Wisconsin Alumni Research Foundation Piezoelectric charged droplet source
US7496401B2 (en) * 2001-04-06 2009-02-24 Mattioli Engineering Ltd Method and apparatus for skin absorption enhancement and transdermal drug delivery
DE10154526B4 (de) 2001-06-12 2007-02-08 Physik Instrumente (Pi) Gmbh & Co Piezoelektrisches Stellelement
JP2003063576A (ja) * 2001-06-15 2003-03-05 Taisei Kako Co Ltd 分与容器
US6783035B2 (en) 2001-07-19 2004-08-31 Valois S.A.S. Fluid product dispenser
US6723077B2 (en) 2001-09-28 2004-04-20 Hewlett-Packard Development Company, L.P. Cutaneous administration system
AU2003203043A1 (en) 2002-01-15 2003-07-30 Aerogen, Inc. Methods and systems for operating an aerosol generator
US6869275B2 (en) * 2002-02-14 2005-03-22 Philip Morris Usa Inc. Piezoelectrically driven fluids pump and piezoelectric fluid valve
US20040039355A1 (en) 2002-08-26 2004-02-26 Gonzalez Jose M. Fluid dispensing devices and methods
US20050261641A1 (en) 2002-09-26 2005-11-24 Warchol Mark P Method for ophthalmic administration of medicament
WO2004038460A2 (en) 2002-10-23 2004-05-06 Abdulla Nael A Aqueous ophthalmic spray and method for delivery
US6814265B2 (en) 2003-03-06 2004-11-09 Alcon, Inc. Device for dispensing fluid medicine
US7201732B2 (en) 2003-04-10 2007-04-10 Hewlett-Packard Development Company, L.P. Dispensing method and device for delivering material to an eye
EP1468748A1 (en) * 2003-04-15 2004-10-20 Microflow Engineering SA Low-cost liquid droplet spray device and nozzle body
EP1618060A4 (en) 2003-04-30 2007-03-21 Aurora Discovery Inc METHOD AND SYSTEM FOR ACCURATE DISTRIBUTION OF A LIQUID
US8012136B2 (en) 2003-05-20 2011-09-06 Optimyst Systems, Inc. Ophthalmic fluid delivery device and method of operation
US7883031B2 (en) * 2003-05-20 2011-02-08 James F. Collins, Jr. Ophthalmic drug delivery system
US8021334B2 (en) 2004-05-30 2011-09-20 Nilimedix Ltd. Drug delivery device and method
US8128606B2 (en) 2003-07-03 2012-03-06 Hewlett-Packard Development Company, L.P. Ophthalmic apparatus and method for administering agents to the eye
DE10337484B4 (de) 2003-08-14 2005-05-25 Zengerle, Roland, Prof. Dr. Mikrodosiervorrichtung und Verfahren zur dosierten Abgabe von Flüssigkeiten
US20050059583A1 (en) 2003-09-15 2005-03-17 Allergan, Inc. Methods of providing therapeutic effects using cyclosporin components
PL1682537T3 (pl) 2003-11-05 2012-09-28 Sarcode Bioscience Inc Modulatory adhezji komórkowej
DE102004006452B4 (de) * 2004-02-05 2006-04-20 Ing. Erich Pfeiffer Gmbh Mikrodosiervorrichtung
WO2005076872A2 (en) 2004-02-06 2005-08-25 Microdose Technologies, Inc. A blister pack for use with an inhalation device
US20050183718A1 (en) 2004-02-24 2005-08-25 Boehringer Ingelheim International Gmbh Nebulizer
IN2014DN01746A (pt) * 2004-04-02 2015-07-10 Government Of The Us Secretary Of The Dept Of Health And Human Services Ct S For Disease Control And
US20050240162A1 (en) * 2004-04-21 2005-10-27 Wen-Pin Chen Eye treatment device
WO2005102058A2 (en) 2004-04-23 2005-11-03 Mystic Pharmaceuticals, Inc. Multiple unit dose drug delivery system
GB0410712D0 (en) 2004-05-13 2004-06-16 Novartis Ag Organic compounds
BRPI0516150A (pt) 2004-09-27 2008-08-26 Medical Instill Tech Inc dispensador para liberar uma substáncia
US20060069358A1 (en) 2004-09-29 2006-03-30 Gerondale Scott J Controlled drop dispensing units
US7416540B2 (en) 2004-11-22 2008-08-26 Intelliject, Llc Devices systems and methods for medicament delivery
WO2006082588A2 (en) 2005-02-07 2006-08-10 Pharmalight Inc. Method and device for ophthalmic administration of active pharmaceutical ingredients
JP5794721B2 (ja) 2005-05-17 2015-10-14 サーコード バイオサイエンス インコーポレイテッド 眼障害の治療のための組成物および方法
DK1893074T3 (da) 2005-05-18 2013-11-04 Visual Physics Llc Billedvisning og mikrooptisk sikkerhedssystem
UA94711C2 (uk) 2005-05-25 2011-06-10 Аэроджен, Инк. Вібраційна система (варіанти) та спосіб її виготовлення (варіанти), спосіб вібрування пластини (варіанти), система виробництва аерозолю та спосіб лікування пацієнта
US10646668B2 (en) 2005-06-02 2020-05-12 Respinova Ltd. Pulsating inhaler and a method of treating upper respiratory disorders
WO2006129305A2 (en) * 2005-06-02 2006-12-07 Ads & B Investmentfund L.P A vibrating device for treating nasal congestion and sinusitis symptoms and method thereof
DE102005025640A1 (de) 2005-06-03 2006-12-07 Scienion Ag Mikrodispenser und zugehöriges Betriebsverfahren
DE102005043034A1 (de) 2005-09-09 2007-03-15 Siemens Ag Vorrichtung und Verfahren zur Bewegung einer Flüssigkeit
EP1779933A1 (en) 2005-10-26 2007-05-02 The Procter and Gamble Company Dispenser for a liquid
US7874467B2 (en) 2005-11-03 2011-01-25 Reseal International Limited Partnership Metered drop push button dispenser system
FR2897599B1 (fr) 2006-02-23 2010-08-27 Rexam Pharma Ensemble de conditionnement et de distribution de liquide.
US20070195151A1 (en) 2006-02-23 2007-08-23 Anderson Frank E Hand-held ink jet pen
JP2009536545A (ja) 2006-05-11 2009-10-15 エイラット、エラン 眼薬分配装置
US20070268340A1 (en) 2006-05-17 2007-11-22 Bruno Dacquay Ophthalmic Injection System and Method Using Piezoelectric Array
DE102006026786A1 (de) 2006-06-07 2007-12-13 Joachim Kern Dosierinhalator
US8048047B2 (en) 2006-06-23 2011-11-01 Novartis Ag Surgical cassette with improved air filtering
US20080039807A1 (en) 2006-08-08 2008-02-14 Jerrold Scott Pine Ophthalmic Drug Dispensing Tip
DE102006040316B4 (de) 2006-08-29 2012-07-05 Deutsches Zentrum für Luft- und Raumfahrt e.V. Piezokeramischer Flächenaktuator und Verfahren zur Herstellung eines solchen
FR2908329B1 (fr) 2006-11-14 2011-01-07 Telemaq Dispositif et methode de distribution de fluide par ultrasons
US8196576B2 (en) 2007-02-28 2012-06-12 Microdose Therapeutx, Inc. Inhaler
US20080214940A1 (en) 2007-03-02 2008-09-04 Benaron David A Medical imaging lens system, and method with high-efficiency light collection and collinear illumination
US20090008413A1 (en) * 2007-04-17 2009-01-08 Choi Hee Jin Airless dispensing pump container with an airtight push down type nozzle head
ITRM20070275A1 (it) 2007-05-17 2008-11-18 Federighi Federigo Flacone erogatore multidose per preparati liquidi senza conservanti.
JP5137710B2 (ja) 2007-07-26 2013-02-06 キヤノン株式会社 液体カートリッジ
EP2197461B1 (en) 2007-10-08 2018-02-21 Aurinia Pharmaceuticals Inc. Ophthalmic compositions comprising calcineurin inhibitors or mtor inhibitors
US20090114737A1 (en) 2007-11-07 2009-05-07 Health & Life Co., Ltd. Aerosolization device
US20090212127A1 (en) 2007-12-14 2009-08-27 Weidlinger Associates, Inc. Fuel injector with single crystal piezoelectric actuator stack
US20090212133A1 (en) * 2008-01-25 2009-08-27 Collins Jr James F Ophthalmic fluid delivery device and method of operation
US8734408B2 (en) 2008-02-05 2014-05-27 Alvin J. Marx Automated eyedrop delivery system with eyelid retracting legs
EP2271337B1 (en) 2008-04-04 2014-09-03 Mimetogen Pharmaceuticals Inc. Beta-turn peptidomimetic cyclic compounds for treating dry eye
WO2009139817A2 (en) 2008-04-15 2009-11-19 Sarcode Corporation Crystalline pharmaceutical and methods of preparation and use thereof
DE102008022987A1 (de) * 2008-05-09 2009-11-12 Pari Pharma Gmbh Vernebler für Beatmungsmaschinen und Beatmungsmaschine mit einem solchen Vernebler
US20100001090A1 (en) * 2008-07-03 2010-01-07 Arthur Hampton Neergaard Liquid Particle Emitting Device
US7656076B1 (en) 2008-07-15 2010-02-02 Iptrade, Inc. Unimorph/bimorph piezoelectric package
BRPI0917384A2 (pt) 2008-08-28 2015-11-17 Deka Products Lp sistema de dispensar produto
US20100072302A1 (en) 2008-09-19 2010-03-25 Miro Cater Discharge device
US20100076388A1 (en) 2008-09-19 2010-03-25 Miro Cater Discharge device for pharmaceutical media
US20100072301A1 (en) 2008-09-19 2010-03-25 Miro Cater Discharge device
US20090192443A1 (en) * 2008-10-06 2009-07-30 Collins Jr James F Ophthalmic fluid delivery device and method of operation
CN102238949A (zh) 2008-10-09 2011-11-09 拉姆斯科股份有限公司 治疗干眼综合征的组合物和方法
WO2010078428A1 (en) 2008-12-30 2010-07-08 Optimyst Systems, Inc. Ophthalmic fluid delivery system
EP3053913B1 (en) 2009-05-01 2018-03-07 Aerie Pharmaceuticals, Inc. Dual mechanism inhibitors for the treatment of disease
JP2012533392A (ja) 2009-07-22 2012-12-27 アドバンスト オフサルミック ファーマ リミテッド 眼科薬剤のミストを投与するための装置
FR2950036B1 (fr) 2009-09-11 2011-12-16 Rexam Pharma La Verpilliere Dispositif de distribution de liquide
EP2302712A1 (en) 2009-09-28 2011-03-30 Stichting IMEC Nederland Method for resonance frequency tuning of micromachined structures
US8596781B2 (en) 2009-10-15 2013-12-03 Adlens Beacon, Inc. Fluid filled lens reservoir system and manufacturing method of the reservoir system
US9801757B2 (en) 2011-08-31 2017-10-31 Johnson & Johnson Vision Care, Inc. Liquid dispensing reservoir
US9039666B2 (en) 2009-10-21 2015-05-26 Johnson & Johnson Vision Care, Inc. Method and apparatus for liquid dispensing
US20110106025A1 (en) 2009-10-29 2011-05-05 Hall Gary S Ophthalmic fluid pump
WO2011050175A1 (en) 2009-10-21 2011-04-28 Sarcode Corporation Crystalline pharmaceutical and methods of preparation and use thereof
KR20120105002A (ko) * 2009-11-18 2012-09-24 레키드 벤카이저 엘엘씨 표면 처리 장치 및 방법
DE102010011047A1 (de) 2010-03-11 2011-09-15 Johnson Matthey Catalysts (Germany) Gmbh Biegewandler
EP2555994A4 (en) 2010-04-06 2014-02-19 Reseal Internat Ltd Partnership DISTRIBUTION SYSTEM FOR DISTRIBUTION OF MEASURED VOLUMES OF PURE OR STERILE FLUID SUBSTANCES
DE102010003810A1 (de) 2010-04-09 2011-10-13 Henkel Ag & Co. Kgaa Abgabevorrichtung mit piezo-elektrischem Element
JP5171879B2 (ja) 2010-05-06 2013-03-27 株式会社エヌ・ティ・ティ・ドコモ 移動通信端末及び再接続方法
KR101153613B1 (ko) 2010-05-25 2012-06-18 삼성전기주식회사 마이크로 이젝터 및 그 제조방법
DE102010017216A1 (de) 2010-06-02 2011-12-08 Technische Universität Berlin Ventilvorrichtung zum Steuern eines Flusses eines Fluides durch einen Fluidkanal, Anordnung sowie Mehrwegventilvorrichtung
JP2013531548A (ja) 2010-07-15 2013-08-08 コリンシアン オフサルミック,インコーポレイティド 遠隔治療及び遠隔モニタリングを実施する方法及びシステム
EA201390122A1 (ru) 2010-07-15 2014-05-30 Коринтиан Офтэлмик, Инк. Устройство для генерирования капель
US10154923B2 (en) 2010-07-15 2018-12-18 Eyenovia, Inc. Drop generating device
JP2013531044A (ja) 2010-07-15 2013-08-01 コリンシアン オフサルミック,インコーポレイティド 点眼薬送達
US9132243B2 (en) 2010-07-23 2015-09-15 Tannermedico A/S Method of administering a substance to the throat
FR2963326B1 (fr) 2010-07-30 2012-09-07 Rexam Healthcare La Verpillier Embout et recipient de distribution de liquide
IE20110394A1 (en) 2010-09-07 2013-01-02 Univ Limerick A liquid droplet dispenser
US20130206857A1 (en) 2011-01-21 2013-08-15 Biodot, Inc. Piezoelectric dispenser with a longitudinal transducer and replaceable capillary tube
US9068566B2 (en) 2011-01-21 2015-06-30 Biodot, Inc. Piezoelectric dispenser with a longitudinal transducer and replaceable capillary tube
US9186690B2 (en) 2011-02-01 2015-11-17 Bausch & Lomb Incorporated Ergonomic hand-operable fluid-dispensing device
WO2013012760A1 (en) 2011-07-15 2013-01-24 Numeta Sciences, Inc. Compositions and methods for modulating metabolic pathways
WO2013011473A2 (en) 2011-07-19 2013-01-24 Koninklijke Philips Electronics N.V. Domestic appliance comprising an actuator
US9346075B2 (en) 2011-08-26 2016-05-24 Nordson Corporation Modular jetting devices
JP2014528793A (ja) 2011-09-19 2014-10-30 クラフト,ダニエル,エル. 点眼剤ディスペンサー
TR201903465T4 (tr) 2011-09-20 2019-04-22 Allergan Inc Presbiyopi, hafif hiperopi ve düzensiz astigmatizmin tedavi edilmesine yönelik bileşimler ve yöntemler.
DE102011114584B3 (de) 2011-09-30 2012-05-31 Carl Zeiss Meditec Ag Ophthalmochirurgische Steuerungsvorrichtung und ophthalmochirurgisches System mit einer solchen Steuerungsvorrichtung
US8957048B2 (en) 2011-10-06 2015-02-17 Allergan, Inc. Compositions for the treatment of dry eye
WO2013070658A2 (en) 2011-11-08 2013-05-16 Fairchild Semiconductor Corporation Modulation scheme for driving a piezo element
DE102011086755A1 (de) 2011-11-21 2013-05-23 Aptar Radolfzell Gmbh Spender zum Austrag von pharmazeutischen Flüssigkeiten
CH705799A1 (it) 2011-11-24 2013-05-31 Luso Pharma Sagl Testa di erogazione multi-dose con otturatore a membrana elastica. originale: Testa di erogazione multi-dose perfezionata.
WO2013090468A1 (en) 2011-12-12 2013-06-20 Corinthian Ophthalmic, Inc. High modulus polymeric ejector mechanism, ejector device, and methods of use
US8591635B2 (en) 2011-12-19 2013-11-26 Chrysler Group Llc Fluid aeration-reduction system
US20130164436A1 (en) * 2011-12-27 2013-06-27 Ricoh Company Thin film manufacturing apparatus, thin film manufacturing method, liquid droplet ejecting head, and inkjet recording apparatus
US9254642B2 (en) 2012-01-19 2016-02-09 AdvanJet Control method and apparatus for dispensing high-quality drops of high-viscosity material
JP6329130B2 (ja) 2012-04-10 2018-05-30 アイノビア,インコーポレイティド 噴霧エジェクタ機構、電荷分離及び制御可能な液滴電荷を提供する装置、並びに低投与量の点眼
CN109011046B (zh) 2012-04-20 2021-10-01 艾诺维亚股份有限公司 用于向目标输送流体的装置
WO2013160883A1 (en) 2012-04-26 2013-10-31 Koninklijke Philips N.V. A nebulizer and a method of manufacturing a nebulizer
EP2664329A1 (de) 2012-05-15 2013-11-20 F. Holzer GmbH Ophthalmologisches Vehikelsystem
MX2014013962A (es) 2012-05-15 2015-06-17 Eyenovia Inc Dispositivos eyectores, métodos, accionadores y circuitos para los mismos.
US9132238B2 (en) 2012-06-26 2015-09-15 Becton, Dickinson And Company Blow fill seal luer syringe
AU2013295706A1 (en) 2012-07-25 2015-02-19 Sarcode Bioscience Inc. LFA-1 inhibitor and polymorph thereof
WO2014037420A1 (en) 2012-09-07 2014-03-13 Glaxo Group Limited Liquid droplet dispenser
JP6433294B2 (ja) 2012-09-27 2018-12-05 テルモ株式会社 輸液ポンプ
US8927921B1 (en) 2012-10-02 2015-01-06 Sun Nuclear Corporation Systems and methods for composite dose quality assurance with three dimensional arrays
CN105191050B (zh) 2013-02-12 2018-03-13 Sis资源有限公司 用于电子香烟的感应充电
US9962288B2 (en) 2013-03-07 2018-05-08 Novartis Ag Active acoustic streaming in hand piece for occlusion surge mitigation
US20140276054A1 (en) 2013-03-15 2014-09-18 Volcano Corporation Piezoelectric-Actuated Fluid-Delivery Devices and Associated Systems and Methods
US20150018781A1 (en) * 2013-04-10 2015-01-15 California Institute Of Technology Systems, devices, and methods for topical drug delivery to the eye
US8976451B2 (en) 2013-08-02 2015-03-10 Forward Optics Co., Ltd Lens array module
US20150035180A1 (en) 2013-08-02 2015-02-05 Forward Optics Co., Ltd. Method for fabricating an arrayed optical element
US10335322B2 (en) * 2013-08-26 2019-07-02 Lightside Md, Llc Adhesive support devices and methods of making and using them
US20150086397A1 (en) 2013-09-25 2015-03-26 Hsiao-Kang Ma Micropump with separate chamber
US9282803B2 (en) 2013-10-03 2016-03-15 Donald John Ciervo Ultrasonic cosmetic applicator
US9676525B2 (en) 2013-12-17 2017-06-13 Aptar Radolfzell Gmbh Protective cap for a dispenser, and discharge device for discharging pharmaceutical and/or cosmetical liquids
CN106102570A (zh) 2014-01-10 2016-11-09 马尔西奥·马克·阿布雷乌 在abreu脑热通道处监视并提供处理的装置
US20150256730A1 (en) 2014-03-05 2015-09-10 Forward Optics Co., Ltd. Image-capturing device configured for a handheld electronic device
US20150276994A1 (en) 2014-03-28 2015-10-01 Forward Optics Co., Ltd. Method of making a lens array plate with an aperture mask layer
DE102014208064B4 (de) * 2014-04-29 2015-12-03 Heraeus Medical Gmbh Lavage-System mit einem Druckgasmotor sowie Verfahren zum Erzeugen eines Sprühstoßes
US10610651B2 (en) 2014-06-09 2020-04-07 Aerami Therapeutics, Inc. Self-puncturing liquid drug cartridges and associated dispenser
GB2542527B (en) * 2014-07-16 2020-08-26 Murata Manufacturing Co Fluid control device
CN104146816B (zh) 2014-09-02 2016-04-13 镇江万新光学眼镜有限公司 一种眼部雾化送药装置
TWI658828B (zh) 2014-10-31 2019-05-11 中國醫藥大學 用於舒緩及減輕近視之醫藥組合物及其製備方法與用途
WO2016115050A1 (en) 2015-01-12 2016-07-21 Lagunita Llc Micro-droplet delivery device and methods
US20160213866A1 (en) 2015-01-23 2016-07-28 William Tan Ultrasonic vaporizing element
CA2981070A1 (en) 2015-04-10 2016-10-13 Kedalion Therapeutics, Inc. Piezoelectric dispenser with replaceable ampoule
GB201507687D0 (en) * 2015-04-30 2015-06-17 Leafgreen Ltd Pulsed spray nozzle arrangement
US9700686B2 (en) 2015-06-03 2017-07-11 Novopyxis, Inc. Fluid delivery devices and methods
CN204813955U (zh) 2015-07-22 2015-12-02 吉林大学 可调压力腔室体积的次声实验系统
US20170028626A1 (en) 2015-07-29 2017-02-02 Ecole Polytechnique Federale De Lausanne (Epfl) Compact Drop-on-Demand Apparatus Using Light Actuation Through Optical Fibers
US20180229247A1 (en) 2015-08-14 2018-08-16 Leafgreen Limited Pulsed spray nozzle arrangements
GB201518337D0 (en) 2015-10-16 2015-12-02 The Technology Partnership Plc Linear device
DE102015224617B4 (de) 2015-12-08 2017-07-20 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Freistrahldosiersystem für das Auge
JP2017120975A (ja) 2015-12-28 2017-07-06 ルネサスエレクトロニクス株式会社 撮像素子
EP3432769A4 (en) 2016-03-24 2020-07-22 Brien Holden Vision Institute DEVICES AND METHOD FOR GENERATING AN IRRITATION FOR EVALUATING SENSITIVITY
US10672298B2 (en) 2016-10-17 2020-06-02 Sanmina Corporation System and method for a blood flow simulator
US10888454B2 (en) * 2017-01-20 2021-01-12 Kedalion Therapeutics, Inc. Piezoelectric fluid dispenser
IT201700038005A1 (it) * 2017-04-06 2018-10-06 Zodiak S R L Dispositivo per la somministrazione di sostanze
EP3634550A4 (en) 2017-06-10 2021-03-03 Eyenovia, Inc. METHODS AND DEVICES FOR HANDLING A FLUID AND DELIVERING THE FLUID TO THE EYE
CN109674576B (zh) 2017-10-19 2024-02-27 深圳市启明医药科技有限公司 流体供应单元及微液滴喷射驱动装置、发生装置
US11278448B2 (en) 2017-12-08 2022-03-22 Kedalion Therapeutics, Inc. Fluid delivery alignment system
US20190314197A1 (en) 2018-04-12 2019-10-17 Kedalion Therapeutics, Inc. Topical Ocular Delivery Methods and Devices for Use in the Same
JP2021529598A (ja) 2018-07-03 2021-11-04 ケダリオン セラピューティックス,インコーポレイテッド 局所眼内送達装置及びこれを使用した方法
WO2020023547A1 (en) 2018-07-23 2020-01-30 Wellness Insight Technologies, Inc. System for analyzing and controlling consumable media dosing information
EP3934643A4 (en) 2019-03-04 2022-11-30 Eyenovia, Inc. METHODS AND DEVICES FOR DELIVERING ATROPINE INTO THE EYE AS A MICRODOSED FLOW OF DROPLETS
US11679028B2 (en) 2019-03-06 2023-06-20 Novartis Ag Multi-dose ocular fluid delivery system
US20220192874A1 (en) 2020-04-17 2022-06-23 Kedaliion Therapeutics, Inc. Hydrodynamically Actuated Preservative Free Dispensing System
US11938057B2 (en) 2020-04-17 2024-03-26 Bausch + Lomb Ireland Limited Hydrodynamically actuated preservative free dispensing system
US12090087B2 (en) 2020-04-17 2024-09-17 Bausch + Lomb Ireland Limited Hydrodynamically actuated preservative free dispensing system having a collapsible liquid reservoir
WO2021212033A1 (en) * 2020-04-17 2021-10-21 Kedallon Therapeutics, Inc. Hydrodynamically actuated preservative free dispensing system

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US11925577B2 (en) 2024-03-12
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