JP2007302689A5 - - Google Patents
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- Publication number
- JP2007302689A5 JP2007302689A5 JP2007185746A JP2007185746A JP2007302689A5 JP 2007302689 A5 JP2007302689 A5 JP 2007302689A5 JP 2007185746 A JP2007185746 A JP 2007185746A JP 2007185746 A JP2007185746 A JP 2007185746A JP 2007302689 A5 JP2007302689 A5 JP 2007302689A5
- Authority
- JP
- Japan
- Prior art keywords
- formula
- pharmaceutical composition
- hexanoyl
- hexyl
- alkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- -1 n-propoxy, n-pentoxy Chemical group 0.000 claims 3
- 239000008194 pharmaceutical composition Substances 0.000 claims 3
- 125000000217 alkyl group Chemical group 0.000 claims 2
- 125000001280 n-hexyl group Chemical group C(CCCCC)* 0.000 claims 2
- 206010014561 Emphysema Diseases 0.000 claims 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 1
- 125000003342 alkenyl group Chemical group 0.000 claims 1
- 125000001589 carboacyl group Chemical group 0.000 claims 1
- 150000001875 compounds Chemical class 0.000 claims 1
- 229910052739 hydrogen Inorganic materials 0.000 claims 1
- 239000001257 hydrogen Substances 0.000 claims 1
- 125000000740 n-pentyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US16041599P | 1999-10-19 | 1999-10-19 | |
| US60/160,415 | 1999-10-19 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2001532746A Division JP4074458B2 (ja) | 1999-10-19 | 2000-10-13 | Ｒａｒ選択的レチノイド拮抗薬を用いた気腫の治療 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2007302689A JP2007302689A (ja) | 2007-11-22 |
| JP2007302689A5 true JP2007302689A5 (https=) | 2008-01-10 |
| JP4850791B2 JP4850791B2 (ja) | 2012-01-11 |
Family
ID=22576814
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2001532746A Expired - Fee Related JP4074458B2 (ja) | 1999-10-19 | 2000-10-13 | Ｒａｒ選択的レチノイド拮抗薬を用いた気腫の治療 |
| JP2007185746A Expired - Fee Related JP4850791B2 (ja) | 1999-10-19 | 2007-07-17 | Ｒａｒ選択的レチノイド拮抗薬を用いた気腫の治療 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2001532746A Expired - Fee Related JP4074458B2 (ja) | 1999-10-19 | 2000-10-13 | Ｒａｒ選択的レチノイド拮抗薬を用いた気腫の治療 |
Country Status (33)
| Country | Link |
|---|---|
| US (1) | US6300350B1 (https=) |
| EP (1) | EP1225878B1 (https=) |
| JP (2) | JP4074458B2 (https=) |
| KR (1) | KR100485581B1 (https=) |
| CN (1) | CN1201730C (https=) |
| AR (1) | AR029648A1 (https=) |
| AT (1) | ATE344661T1 (https=) |
| AU (1) | AU777325B2 (https=) |
| BR (1) | BR0015225A (https=) |
| CA (1) | CA2387844C (https=) |
| CY (1) | CY1105941T1 (https=) |
| CZ (1) | CZ20021657A3 (https=) |
| DE (1) | DE60031790T2 (https=) |
| DK (1) | DK1225878T3 (https=) |
| ES (1) | ES2274810T3 (https=) |
| HR (1) | HRP20020329A2 (https=) |
| HU (1) | HUP0203295A3 (https=) |
| IL (1) | IL149151A0 (https=) |
| JO (1) | JO2178B1 (https=) |
| MA (1) | MA26835A1 (https=) |
| MX (1) | MXPA02003843A (https=) |
| MY (1) | MY129001A (https=) |
| NO (1) | NO328738B1 (https=) |
| NZ (1) | NZ518118A (https=) |
| PE (1) | PE20010678A1 (https=) |
| PL (1) | PL357499A1 (https=) |
| PT (1) | PT1225878E (https=) |
| RS (1) | RS50165B (https=) |
| RU (1) | RU2257383C2 (https=) |
| TR (1) | TR200201071T2 (https=) |
| TW (1) | TWI288639B (https=) |
| WO (1) | WO2001030326A1 (https=) |
| ZA (1) | ZA200202576B (https=) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU4228000A (en) * | 1999-04-14 | 2000-11-14 | Allergan Sales, Inc. | Methods and compositions for the treatment and prevention of lung disease |
| BR0212583A (pt) * | 2001-09-18 | 2004-10-13 | Hoffmann La Roche | Agonistas i para retinóides de alquil uréia |
| EP1430023B1 (en) | 2001-09-18 | 2009-04-08 | F. Hoffmann-La Roche Ag | Substituied urea retinoid agonists ii |
| US6858615B2 (en) | 2002-02-19 | 2005-02-22 | Parion Sciences, Inc. | Phenyl guanidine sodium channel blockers |
| US7745442B2 (en) | 2003-08-20 | 2010-06-29 | Parion Sciences, Inc. | Methods of reducing risk of infection from pathogens |
| GB2388581A (en) | 2003-08-22 | 2003-11-19 | Danisco | Coated aqueous beads |
| ES2481167T3 (es) | 2003-08-22 | 2014-07-29 | Dupont Nutrition Biosciences Aps | Composición que comprende una bacteriocina y un extracto de una planta de la familia Labiatae |
| US20100076037A1 (en) * | 2006-11-02 | 2010-03-25 | Chiang Lillian W | Methods of Treating Neuropathic Pain with Agonists of PPAR-gamma |
| EP3721880B1 (en) | 2010-09-01 | 2022-02-02 | Thomas Jefferson University | Composition and method for muscle repair and regeneration |
| AU2012272642B2 (en) | 2011-06-24 | 2017-09-07 | Gri Bio, Inc. | Prevention and treatment of inflammatory conditions |
| AR086745A1 (es) | 2011-06-27 | 2014-01-22 | Parion Sciences Inc | 3,5-diamino-6-cloro-n-(n-(4-(4-(2-(hexil(2,3,4,5,6-pentahidroxihexil)amino)etoxi)fenil)butil)carbamimidoil)pirazina-2-carboxamida |
| US20140155381A1 (en) * | 2011-07-29 | 2014-06-05 | Erkan Baloglu | Compounds and methods |
| SG10201708931XA (en) | 2012-12-17 | 2017-12-28 | Parion Sciences Inc | Chloro-pyrazine carboxamide derivatives useful for the treatment of diseases favoured by insufficient mucosal hydration |
| RU2018138195A (ru) | 2012-12-17 | 2018-12-18 | Пэрион Сайенсиз, Инк. | Соединения 3,5-диамино-6-хлор-n-(n-(4- фенилбутил)карбамимидоил)пиразин-2-карбоксамида |
| WO2015026990A2 (en) | 2013-08-20 | 2015-02-26 | University Of Washington Through Its Center For Commercialization | Novel and specific inhibitors of cytochrome p450 26 retinoic acid hydrolase |
| US10500232B2 (en) | 2013-08-26 | 2019-12-10 | The J. David Gladstone Ins., a testamentary trust established under the Will of J. David Gladstone | Small molecule cellular reprogramming to generate neuronal cells |
| US9102633B2 (en) | 2013-12-13 | 2015-08-11 | Parion Sciences, Inc. | Arylalkyl- and aryloxyalkyl-substituted epithelial sodium channel blocking compounds |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR0139216B1 (ko) * | 1988-04-11 | 1998-05-01 | 제임스 엠. 캐내지 | 레티노이드 유사활성을 갖는 페놀 또는 벤조산의 테트랄린 에스테르 |
| ES2212797T3 (es) * | 1993-08-19 | 2004-08-01 | Janssen Pharmaceutica N.V. | Derivados de dihidrobenzopirano vasoconstrictores. |
| CA2129773C (en) * | 1993-09-02 | 2007-05-01 | Michael Klaus | Aromatic carboxylic acid derivatives |
| US5498795A (en) * | 1994-12-29 | 1996-03-12 | Allergan, Inc. | Acetylenes disubstituted with hydroxyaryl and aryl or heteroaryl groups having retinoid-like biological activity |
| DK0728742T3 (da) * | 1995-02-24 | 2000-04-17 | Hoffmann La Roche | Hidtil ukendte retinoider |
| US5807900A (en) * | 1995-03-31 | 1998-09-15 | Hoffmann-La Roche, Inc. | Method for identifying compounds having increased activity for the repair of skin photodamage |
| TW418186B (en) * | 1995-06-05 | 2001-01-11 | Bristol Myers Squibb Co | Retinoid-like compounds |
| US5624957A (en) * | 1995-06-06 | 1997-04-29 | Bristol-Myers Squibb Company | Rary-specific retinobenzoic acid derivatives |
| FR2739557B1 (fr) * | 1995-10-09 | 1997-11-14 | Cird Galderma | Utilisation d'un ligand agoniste specifique rar-gamma |
| US5726191A (en) * | 1995-11-16 | 1998-03-10 | Hoffmann-La Roche Inc. | Aromatic carboxylic acid esters |
| FR2747041B1 (fr) | 1996-04-05 | 1998-05-22 | Cird Galderma | Utilisation de derives benzonaphtaleniques pour la fabrication de medicaments destines au traitement des neuropathies |
| EP1030662B1 (en) * | 1997-11-12 | 2006-08-02 | F. Hoffmann-La Roche Ag | Treatment of t-helper cell type 2 mediated immune diseases with retinoid antagonists |
| US6083973A (en) * | 1998-03-09 | 2000-07-04 | Syntex (U.S.A.) Inc. | Methods for inhibiting mucin secretion using RAR α selective antagonists |
| AU4225500A (en) * | 1999-04-14 | 2000-11-14 | Allergan Sales, Inc. | Methods and compositions for the treatment and prevention of lung disease |
| AU4222400A (en) | 1999-04-14 | 2000-11-14 | Allergan Sales, Inc. | Methods and compositions for the treatment and prevention of lung disease |
| AU4228000A (en) * | 1999-04-14 | 2000-11-14 | Allergan Sales, Inc. | Methods and compositions for the treatment and prevention of lung disease |
| MXPA02000828A (es) * | 1999-08-02 | 2002-07-30 | Hoffmann La Roche | Nuevos antagonistas retinoiides selectivos. |
| US6479670B1 (en) * | 1999-08-25 | 2002-11-12 | Hoffmann-La Roche Inc. | Selective retinoid acid receptor agonists |
-
2000
- 2000-10-12 JO JO2000172A patent/JO2178B1/en active
- 2000-10-13 JP JP2001532746A patent/JP4074458B2/ja not_active Expired - Fee Related
- 2000-10-13 DK DK00972754T patent/DK1225878T3/da active
- 2000-10-13 EP EP00972754A patent/EP1225878B1/en not_active Expired - Lifetime
- 2000-10-13 AU AU11374/01A patent/AU777325B2/en not_active Ceased
- 2000-10-13 ES ES00972754T patent/ES2274810T3/es not_active Expired - Lifetime
- 2000-10-13 CZ CZ20021657A patent/CZ20021657A3/cs unknown
- 2000-10-13 AT AT00972754T patent/ATE344661T1/de active
- 2000-10-13 BR BR0015225-0A patent/BR0015225A/pt not_active Application Discontinuation
- 2000-10-13 TR TR2002/01071T patent/TR200201071T2/xx unknown
- 2000-10-13 CA CA002387844A patent/CA2387844C/en not_active Expired - Fee Related
- 2000-10-13 PL PL00357499A patent/PL357499A1/xx not_active Application Discontinuation
- 2000-10-13 DE DE60031790T patent/DE60031790T2/de not_active Expired - Lifetime
- 2000-10-13 PT PT00972754T patent/PT1225878E/pt unknown
- 2000-10-13 KR KR10-2002-7004950A patent/KR100485581B1/ko not_active Expired - Fee Related
- 2000-10-13 WO PCT/EP2000/010076 patent/WO2001030326A1/en not_active Ceased
- 2000-10-13 HR HR20020329A patent/HRP20020329A2/xx not_active Application Discontinuation
- 2000-10-13 RU RU2002110289/04A patent/RU2257383C2/ru not_active IP Right Cessation
- 2000-10-13 HU HU0203295A patent/HUP0203295A3/hu unknown
- 2000-10-13 RS YUP-290/02A patent/RS50165B/sr unknown
- 2000-10-13 IL IL14915100A patent/IL149151A0/xx not_active IP Right Cessation
- 2000-10-13 MX MXPA02003843A patent/MXPA02003843A/es active IP Right Grant
- 2000-10-13 NZ NZ518118A patent/NZ518118A/en not_active IP Right Cessation
- 2000-10-13 CN CNB008145466A patent/CN1201730C/zh not_active Expired - Fee Related
- 2000-10-17 MY MYPI20004872A patent/MY129001A/en unknown
- 2000-10-17 PE PE2000001108A patent/PE20010678A1/es not_active Application Discontinuation
- 2000-10-17 AR ARP000105436A patent/AR029648A1/es unknown
- 2000-10-18 US US09/691,967 patent/US6300350B1/en not_active Expired - Fee Related
- 2000-11-08 TW TW089121961A patent/TWI288639B/zh active
-
2002
- 2002-04-02 ZA ZA200202576A patent/ZA200202576B/en unknown
- 2002-04-18 NO NO20021823A patent/NO328738B1/no not_active IP Right Cessation
- 2002-04-19 MA MA26610A patent/MA26835A1/fr unknown
-
2007
- 2007-01-18 CY CY20071100077T patent/CY1105941T1/el unknown
- 2007-07-17 JP JP2007185746A patent/JP4850791B2/ja not_active Expired - Fee Related