JP2011527299A5 - - Google Patents

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Publication number
JP2011527299A5
JP2011527299A5 JP2011517026A JP2011517026A JP2011527299A5 JP 2011527299 A5 JP2011527299 A5 JP 2011527299A5 JP 2011517026 A JP2011517026 A JP 2011517026A JP 2011517026 A JP2011517026 A JP 2011517026A JP 2011527299 A5 JP2011527299 A5 JP 2011527299A5
Authority
JP
Japan
Prior art keywords
compound
pharmaceutical composition
inhibiting
hcv
hcv replication
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2011517026A
Other languages
English (en)
Japanese (ja)
Other versions
JP2011527299A (ja
JP5426671B2 (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/EP2009/004942 external-priority patent/WO2010003658A1/en
Publication of JP2011527299A publication Critical patent/JP2011527299A/ja
Publication of JP2011527299A5 publication Critical patent/JP2011527299A5/ja
Application granted granted Critical
Publication of JP5426671B2 publication Critical patent/JP5426671B2/ja
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

JP2011517026A 2008-07-08 2009-07-08 Ｃ型肝炎ウイルス阻害剤として有用な大環状インドール誘導体 Expired - Fee Related JP5426671B2 (ja)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
EP08159965 2008-07-08
EP08159965.6 2008-07-08
EP08160254.2 2008-07-11
EP08160254 2008-07-11
EP08161743 2008-08-04
EP08161743.3 2008-08-04
PCT/EP2009/004942 WO2010003658A1 (en) 2008-07-08 2009-07-08 Macrocyclic indole derivatives useful as hepatitis c virus inhibitors

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2013176771A Division JP5808370B2 (ja) 2008-07-08 2013-08-28 Ｃ型肝炎ウイルス阻害剤として有用な大環状インドール誘導体

Publications (3)

Publication Number Publication Date
JP2011527299A JP2011527299A (ja) 2011-10-27
JP2011527299A5 true JP2011527299A5 (https=) 2013-10-17
JP5426671B2 JP5426671B2 (ja) 2014-02-26

Family

ID=40972916

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2011517026A Expired - Fee Related JP5426671B2 (ja) 2008-07-08 2009-07-08 Ｃ型肝炎ウイルス阻害剤として有用な大環状インドール誘導体
JP2013176771A Active JP5808370B2 (ja) 2008-07-08 2013-08-28 Ｃ型肝炎ウイルス阻害剤として有用な大環状インドール誘導体

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2013176771A Active JP5808370B2 (ja) 2008-07-08 2013-08-28 Ｃ型肝炎ウイルス阻害剤として有用な大環状インドール誘導体

Country Status (31)

Country Link
US (2) US8921355B2 (https=)
EP (1) EP2310396B1 (https=)
JP (2) JP5426671B2 (https=)
KR (1) KR101640374B1 (https=)
CN (1) CN102089314B (https=)
AP (1) AP2743A (https=)
AR (1) AR072726A1 (https=)
AU (1) AU2009267389B8 (https=)
BR (1) BRPI0915887B8 (https=)
CA (1) CA2729307C (https=)
CL (1) CL2011000032A1 (https=)
CO (1) CO6351793A2 (https=)
CR (1) CR20110076A (https=)
DK (1) DK2310396T3 (https=)
EA (1) EA019008B1 (https=)
EC (1) ECSP11010750A (https=)
ES (1) ES2651038T3 (https=)
HN (1) HN2011000072A (https=)
HR (1) HRP20171892T1 (https=)
HU (1) HUE035244T2 (https=)
IL (1) IL210086A (https=)
LT (1) LT2310396T (https=)
MX (1) MX2011000276A (https=)
NI (1) NI201100010A (https=)
NO (1) NO2310396T3 (https=)
NZ (2) NZ603343A (https=)
SI (1) SI2310396T1 (https=)
SV (1) SV2011003796A (https=)
TW (1) TWI454476B (https=)
UY (1) UY31973A (https=)
WO (1) WO2010003658A1 (https=)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2008339917B2 (en) 2007-12-24 2013-02-07 Tibotec Pharmaceuticals Macrocyclic indoles as hepatitis C virus inhibitors
TWI454476B (zh) 2008-07-08 2014-10-01 Tibotec Pharm Ltd 用作ｃ型肝炎病毒抑制劑之巨環吲哚衍生物
UA108211C2 (uk) * 2009-11-04 2015-04-10 Янссен Рід Айрленд Бензімідазолімідазольні похідні
CA2796243A1 (en) 2010-04-13 2011-10-20 Janssen Pharmaceuticals, Inc. Combination of a macrocyclic inhibitor of hcv, a non-nucleoside and a nucleoside
US9127010B2 (en) * 2010-06-24 2015-09-08 Janssen Sciences Ireland Uc Preparation of 13-cyclohexyl-3-methoxy-6-[methyl-(2-{2-[methyl-(sulphamoyl)-amino]-ethoxy}-ethyl)-carbamoyl]-7H-indolo-[2,1-a]-[2]-benzazepine-10-carboxylic acid
ES2655942T3 (es) 2011-09-02 2018-02-22 Novartis Ag Sal de colina de un compuesto anti-inflamatorio de ciclobutenodiona sustituida
US8716275B2 (en) * 2011-10-20 2014-05-06 Bristol-Myers Squibb Company Compound for the treatment of hepatitis C
EP2890378A2 (en) 2012-08-31 2015-07-08 Janssen Pharmaceuticals, Inc. Combination of a macrocyclic protease inhibitor of hcv, a non-nucleoside hcv inhibitor and ritonavir
WO2014152275A1 (en) * 2013-03-14 2014-09-25 Concert Pharmaceuticals, Inc. Deuterium modified derivatives of the ns5b polymerase inhibitor tmc647055
US10450263B2 (en) 2017-02-10 2019-10-22 Southern Research Institute Benzo annulenes as antiviral agents
KR101974388B1 (ko) 2017-06-23 2019-05-02 (주)에니켐텍 알킬 디에틸렌 트리아민 유도체 및 이의 제조방법
WO2019133574A2 (en) * 2017-12-26 2019-07-04 Southern Research Institute Benzoannulene derivatives as antiviral agents
US12274700B1 (en) 2020-10-30 2025-04-15 Accencio LLC Methods of treating symptoms of coronavirus infection with RNA polymerase inhibitors
US12060148B2 (en) 2022-08-16 2024-08-13 Honeywell International Inc. Ground resonance detection and warning system and method
CN116425782A (zh) * 2023-03-22 2023-07-14 烟台盛凯伦化学科技有限公司 一种5-乙酰基-2-氟苯硼酸频哪醇酯的制备方法

Family Cites Families (28)

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US6037157A (en) 1995-06-29 2000-03-14 Abbott Laboratories Method for improving pharmacokinetics
US5807876A (en) * 1996-04-23 1998-09-15 Vertex Pharmaceuticals Incorporated Inhibitors of IMPDH enzyme
US6054472A (en) * 1996-04-23 2000-04-25 Vertex Pharmaceuticals, Incorporated Inhibitors of IMPDH enzyme
US20050267836A1 (en) 1996-03-25 2005-12-01 Cfph, Llc Method and system for transacting with a trading application
HUP0004421A3 (en) 1996-04-23 2002-10-28 Vertex Pharmaceuticals Inc Cam Urea derivatives and pharmaceutical compositions containing them, use thereof for the treatment of deseases mediated by impdh enzyme
EP0966465B1 (en) 1997-03-14 2003-07-09 Vertex Pharmaceuticals Incorporated Inhibitors of impdh enzyme
AP1498A (en) * 1999-03-19 2005-11-21 Vertex Pharma Inhibitors of impdh enzyme.
US6891331B2 (en) 2000-08-30 2005-05-10 Matsushita Electric Industrial Co., Ltd. Plasma display unit and production method thereof
JP4902361B2 (ja) 2004-01-30 2012-03-21 メディヴィル・アクチエボラーグ Ｈｃｖｎｓ−３セリンプロテアーゼインヒビター
US7153848B2 (en) * 2004-08-09 2006-12-26 Bristol-Myers Squibb Company Inhibitors of HCV replication
PE20070211A1 (es) 2005-07-29 2007-05-12 Medivir Ab Compuestos macrociclicos como inhibidores del virus de hepatitis c
TW200800225A (en) 2005-09-02 2008-01-01 Tibotec Pharm Ltd Benzodiazepines as HCV inhibitors
US7399758B2 (en) * 2005-09-12 2008-07-15 Meanwell Nicholas A Cyclopropyl fused indolobenzazepine HCV NS5B inhibitors
GB0522881D0 (en) 2005-11-10 2005-12-21 Angeletti P Ist Richerche Bio Therapeutic compounds
WO2007092000A1 (en) 2006-02-06 2007-08-16 Bristol-Myers Squibb Company Inhibitors of hcv replication
US7456166B2 (en) * 2006-05-17 2008-11-25 Bristol-Myers Squibb Company Cyclopropyl fused indolobenzazepine HCV NS5B inhibitors
US7521443B2 (en) 2006-05-17 2009-04-21 Bristol-Myers Squibb Company Cyclopropyl fused indolobenzazepine HCV NS5B inhibitors
US7521441B2 (en) * 2006-05-22 2009-04-21 Bristol-Myers Squibb Company Cyclopropyl fused indolobenzazepine HCV NS5B inhibitors
US7521442B2 (en) * 2006-05-25 2009-04-21 Bristol-Myers Squibb Company Cyclopropyl fused indolobenzazepine HCV NS5B inhibitors
AP2009004812A0 (en) 2006-10-10 2009-04-30 Medivir Ab HCV nucleoside inhibitor
CN103224506A (zh) 2006-12-20 2013-07-31 P.安杰莱蒂分子生物学研究所 抗病毒的吲哚
AU2008277440A1 (en) * 2007-07-17 2009-01-22 Istituto Di Ricerche Di Biologia Molecolare P. Angeletti Spa Macrocyclic indole derivatives for the treatment of hepatitis C infections
TWI454476B (zh) * 2008-07-08 2014-10-01 Tibotec Pharm Ltd 用作ｃ型肝炎病毒抑制劑之巨環吲哚衍生物
AR073603A1 (es) 2008-09-18 2010-11-17 Ortho Mcneil Janssen Pharm Combinaciones sinergicas de un inhibidor macrociclico del vhc y un nucleosido
PT2401272T (pt) 2009-02-27 2017-02-28 Janssen Pharmaceuticals Inc Sal amorfo de um inibidor macrocíclico de hcv
CA2796243A1 (en) 2010-04-13 2011-10-20 Janssen Pharmaceuticals, Inc. Combination of a macrocyclic inhibitor of hcv, a non-nucleoside and a nucleoside
US9127010B2 (en) 2010-06-24 2015-09-08 Janssen Sciences Ireland Uc Preparation of 13-cyclohexyl-3-methoxy-6-[methyl-(2-{2-[methyl-(sulphamoyl)-amino]-ethoxy}-ethyl)-carbamoyl]-7H-indolo-[2,1-a]-[2]-benzazepine-10-carboxylic acid
EP2890378A2 (en) 2012-08-31 2015-07-08 Janssen Pharmaceuticals, Inc. Combination of a macrocyclic protease inhibitor of hcv, a non-nucleoside hcv inhibitor and ritonavir

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