JP2020520946A5 - - Google Patents
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- Publication number
- JP2020520946A5 JP2020520946A5 JP2019564166A JP2019564166A JP2020520946A5 JP 2020520946 A5 JP2020520946 A5 JP 2020520946A5 JP 2019564166 A JP2019564166 A JP 2019564166A JP 2019564166 A JP2019564166 A JP 2019564166A JP 2020520946 A5 JP2020520946 A5 JP 2020520946A5
- Authority
- JP
- Japan
- Prior art keywords
- methyl
- trifluoromethoxy
- fluoro
- solvate
- compound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000001875 compounds Chemical class 0.000 claims description 38
- 239000012453 solvate Substances 0.000 claims description 14
- 150000003839 salts Chemical class 0.000 claims description 13
- 239000008194 pharmaceutical composition Substances 0.000 claims description 9
- 229910052739 hydrogen Inorganic materials 0.000 claims description 8
- 239000001257 hydrogen Substances 0.000 claims description 8
- 208000015181 infectious disease Diseases 0.000 claims description 8
- -1 pentanyl Chemical group 0.000 claims description 7
- 208000001490 Dengue Diseases 0.000 claims description 6
- 206010012310 Dengue fever Diseases 0.000 claims description 6
- 208000025729 dengue disease Diseases 0.000 claims description 6
- 125000000876 trifluoromethoxy group Chemical group FC(F)(F)O* 0.000 claims description 5
- 239000004480 active ingredient Substances 0.000 claims description 4
- 125000001153 fluoro group Chemical group F* 0.000 claims description 4
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims description 4
- 239000003085 diluting agent Substances 0.000 claims description 3
- 241000700605 Viruses Species 0.000 claims description 2
- 239000003443 antiviral agent Substances 0.000 claims description 2
- 125000001309 chloro group Chemical group Cl* 0.000 claims description 2
- 125000000753 cycloalkyl group Chemical group 0.000 claims description 2
- 201000010099 disease Diseases 0.000 claims description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 2
- 239000003814 drug Substances 0.000 claims description 2
- 239000000546 pharmaceutical excipient Substances 0.000 claims description 2
- 230000002265 prevention Effects 0.000 claims description 2
- 239000002904 solvent Substances 0.000 claims description 2
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims description 2
- 238000000034 method Methods 0.000 claims 9
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 8
- YMGUBTXCNDTFJI-UHFFFAOYSA-M cyclopropanecarboxylate Chemical compound [O-]C(=O)C1CC1 YMGUBTXCNDTFJI-UHFFFAOYSA-M 0.000 claims 6
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims 4
- JGFZNNIVVJXRND-UHFFFAOYSA-N N,N-Diisopropylethylamine (DIPEA) Chemical compound CCN(C(C)C)C(C)C JGFZNNIVVJXRND-UHFFFAOYSA-N 0.000 claims 4
- 125000004435 hydrogen atom Chemical class [H]* 0.000 claims 4
- 239000000203 mixture Substances 0.000 claims 4
- OCABOAQENCPTSP-UHFFFAOYSA-N 5-fluoro-6-(trifluoromethoxy)-1H-indole Chemical compound FC=1C=C2C=CNC2=CC=1OC(F)(F)F OCABOAQENCPTSP-UHFFFAOYSA-N 0.000 claims 3
- QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 claims 3
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 claims 3
- 125000001559 cyclopropyl group Chemical group [H]C1([H])C([H])([H])C1([H])* 0.000 claims 3
- 125000003854 p-chlorophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C([H])=C1Cl 0.000 claims 3
- LMDZBCPBFSXMTL-UHFFFAOYSA-N 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide Chemical compound CCN=C=NCCCN(C)C LMDZBCPBFSXMTL-UHFFFAOYSA-N 0.000 claims 2
- VHYFNPMBLIVWCW-UHFFFAOYSA-N 4-Dimethylaminopyridine Chemical compound CN(C)C1=CC=NC=C1 VHYFNPMBLIVWCW-UHFFFAOYSA-N 0.000 claims 2
- QBEUDXAREIDECL-UHFFFAOYSA-N 4-fluoro-5-(trifluoromethoxy)-2-(2-trimethylsilylethynyl)aniline Chemical compound FC1=CC(=C(N)C=C1OC(F)(F)F)C#C[Si](C)(C)C QBEUDXAREIDECL-UHFFFAOYSA-N 0.000 claims 2
- PJHUUSIPDVULCT-UHFFFAOYSA-N BrC1=C(C=C(C(=C1)F)OC(F)(F)F)[N+](=O)[O-] Chemical compound BrC1=C(C=C(C(=C1)F)OC(F)(F)F)[N+](=O)[O-] PJHUUSIPDVULCT-UHFFFAOYSA-N 0.000 claims 2
- AOQBVPPEXCRXAW-UHFFFAOYSA-N ethyl 2-(hydroxymethyl)cyclopropane-1-carboxylate Chemical compound CCOC(=O)C1CC1CO AOQBVPPEXCRXAW-UHFFFAOYSA-N 0.000 claims 2
- WMFOQBRAJBCJND-UHFFFAOYSA-M lithium hydroxide Inorganic materials [Li+].[OH-] WMFOQBRAJBCJND-UHFFFAOYSA-M 0.000 claims 2
- 238000003756 stirring Methods 0.000 claims 2
- 230000002194 synthesizing effect Effects 0.000 claims 2
- NNYYXTHPUFLAOQ-UHFFFAOYSA-N 2-bromo-4-fluoro-5-(trifluoromethoxy)aniline Chemical compound BrC1=C(N)C=C(C(=C1)F)OC(F)(F)F NNYYXTHPUFLAOQ-UHFFFAOYSA-N 0.000 claims 1
- YETHUNXROLCEGJ-UHFFFAOYSA-N 3-methoxy-5-nitrophenol Chemical compound COC1=CC(O)=CC([N+]([O-])=O)=C1 YETHUNXROLCEGJ-UHFFFAOYSA-N 0.000 claims 1
- 229960000549 4-dimethylaminophenol Drugs 0.000 claims 1
- GWDCINSZLONNLV-UHFFFAOYSA-N 5-fluoro-6-(trifluoromethoxy)-2,3-dihydro-1H-indole Chemical compound FC=1C=C2CCNC2=CC=1OC(F)(F)F GWDCINSZLONNLV-UHFFFAOYSA-N 0.000 claims 1
- IKHGUXGNUITLKF-UHFFFAOYSA-N Acetaldehyde Chemical compound CC=O IKHGUXGNUITLKF-UHFFFAOYSA-N 0.000 claims 1
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 claims 1
- 125000000217 alkyl group Chemical group 0.000 claims 1
- 230000003197 catalytic effect Effects 0.000 claims 1
- YMGUBTXCNDTFJI-UHFFFAOYSA-N cyclopropanecarboxylic acid Chemical compound OC(=O)C1CC1 YMGUBTXCNDTFJI-UHFFFAOYSA-N 0.000 claims 1
- MDWXTLNIZCHBJE-UHFFFAOYSA-N ethyl 2-formylcyclopropane-1-carboxylate Chemical compound CCOC(=O)C1CC1C=O MDWXTLNIZCHBJE-UHFFFAOYSA-N 0.000 claims 1
- 238000005984 hydrogenation reaction Methods 0.000 claims 1
- LPNYRYFBWFDTMA-UHFFFAOYSA-N potassium tert-butoxide Chemical compound [K+].CC(C)(C)[O-] LPNYRYFBWFDTMA-UHFFFAOYSA-N 0.000 claims 1
- JUJWROOIHBZHMG-UHFFFAOYSA-N pyridine Substances C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 claims 1
- 239000000725 suspension Substances 0.000 claims 1
- QKSQWQOAUQFORH-UHFFFAOYSA-N tert-butyl n-[(2-methylpropan-2-yl)oxycarbonylimino]carbamate Chemical compound CC(C)(C)OC(=O)N=NC(=O)OC(C)(C)C QKSQWQOAUQFORH-UHFFFAOYSA-N 0.000 claims 1
- CWMFRHBXRUITQE-UHFFFAOYSA-N trimethylsilylacetylene Chemical compound C[Si](C)(C)C#C CWMFRHBXRUITQE-UHFFFAOYSA-N 0.000 claims 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 description 2
- 150000002431 hydrogen Chemical class 0.000 description 2
- 0 COc1cc(NC(C(N2c3cc(OC(F)(F)F)ccc3CC2)=O)c(cc2)ccc2Cl)cc(OC2C(C3)C3C(*)=**2)c1 Chemical compound COc1cc(NC(C(N2c3cc(OC(F)(F)F)ccc3CC2)=O)c(cc2)ccc2Cl)cc(OC2C(C3)C3C(*)=**2)c1 0.000 description 1
- 239000000969 carrier Substances 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP17172237.4 | 2017-05-22 | ||
| EP17172237 | 2017-05-22 | ||
| PCT/EP2018/063028 WO2018215315A1 (en) | 2017-05-22 | 2018-05-18 | Substituted indoline derivatives as dengue viral replication inhibitors |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2020520946A JP2020520946A (ja) | 2020-07-16 |
| JP2020520946A5 true JP2020520946A5 (https=) | 2021-05-06 |
| JP7203764B2 JP7203764B2 (ja) | 2023-01-13 |
Family
ID=58745157
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019564166A Active JP7203764B2 (ja) | 2017-05-22 | 2018-05-18 | デングウイルス複製阻害剤としての置換インドリン誘導体 |
Country Status (25)
| Country | Link |
|---|---|
| US (2) | US11407715B2 (https=) |
| EP (1) | EP3630723B1 (https=) |
| JP (1) | JP7203764B2 (https=) |
| KR (1) | KR102625988B1 (https=) |
| CN (1) | CN110691773B (https=) |
| AR (1) | AR111878A1 (https=) |
| AU (1) | AU2018274100B2 (https=) |
| BR (1) | BR112019024195A2 (https=) |
| CA (1) | CA3060583C (https=) |
| CL (1) | CL2019003294A1 (https=) |
| CO (1) | CO2019012035A2 (https=) |
| CR (1) | CR20190530A (https=) |
| EA (1) | EA201992782A1 (https=) |
| EC (1) | ECSP19083640A (https=) |
| ES (1) | ES2929667T3 (https=) |
| IL (1) | IL270726B2 (https=) |
| MA (1) | MA48943A (https=) |
| MX (1) | MX393586B (https=) |
| NI (1) | NI201900119A (https=) |
| PE (1) | PE20200604A1 (https=) |
| PH (1) | PH12019502559A1 (https=) |
| TW (1) | TWI758480B (https=) |
| UA (1) | UA125407C2 (https=) |
| UY (1) | UY37742A (https=) |
| WO (1) | WO2018215315A1 (https=) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB201116559D0 (en) | 2011-09-26 | 2011-11-09 | Univ Leuven Kath | Novel viral replication inhibitors |
| JOP20160086B1 (ar) | 2015-05-08 | 2021-08-17 | 2 Katholieke Univ Leuven Ku Leuven Research And Development | مشتقات اندول مستبدلة احاديا او ثنائيا بصفتها مانعات للتكاثر الفيروسي لحمى الفنك |
| JOP20160198B1 (ar) | 2015-09-16 | 2022-03-14 | Janssen Pharmaceuticals Inc | مشتقات اندول مستبدلة احاديا او ثنائيا بصفتها مانعات للتكاثر الفيروسي لحمى الفنك |
| JO3633B1 (ar) | 2015-09-16 | 2020-08-27 | Katholieke Univ Leuven Ku Leuven Research & Development | مشتقات اندول مستبدلة احاديا او ثنائيا بصفتها مانعات للتكاثر الفيروسي لحمى الفنك |
| MX2018011788A (es) | 2016-03-31 | 2019-05-20 | Janssen Pharmaceuticals Inc | Derivados de indolina sustituidos como inhibidores de la replicacion virica de dengue. |
| HRP20210847T1 (hr) | 2016-03-31 | 2021-07-23 | Janssen Pharmaceuticals, Inc. | Supstituirani derivati indola kao inhibitori replikacije denga virusa |
| KR102359766B1 (ko) | 2016-04-01 | 2022-02-07 | 얀센 파마슈티칼즈, 인코포레이티드 | 뎅기 바이러스 복제 억제제로서 치환된 인돌 화합물 유도체 |
| JOP20170069B1 (ar) | 2016-04-01 | 2021-08-17 | 1 Janssen Pharmaceuticals Inc | مشتقات اندولين مستبدلة بصفتها مانعات للتكاثر الفيروسي لحمى الفنك |
| JOP20180026A1 (ar) | 2017-03-31 | 2019-01-30 | Univ Leuven Kath | مشتقات اندولين مستبدلة بصفتها مانعات للتكاثر الفيروسي لحمى الفنك |
| JOP20180025B1 (ar) | 2017-03-31 | 2021-08-17 | Janssen Pharmaceuticals Inc | مشتقات اندولين مستبدلة بصفتها مانعات للتكاثر الفيروسي لحمى الفنك |
| CN110753682B (zh) | 2017-05-22 | 2023-06-30 | 杨森制药公司 | 作为登革热病毒复制抑制剂的经取代的吲哚啉衍生物 |
| PE20260044A1 (es) * | 2023-06-05 | 2026-01-09 | Zydus Lifesciences Ltd | Compuestos novedosos para tratar infecciones virales |
| WO2025248536A1 (en) * | 2024-05-29 | 2025-12-04 | Zydus Lifesciences Limited | Novel oxime derivatives to treat viral infections |
Family Cites Families (43)
| Publication number | Priority date | Publication date | Assignee | Title |
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| ES2241178T3 (es) | 1997-10-27 | 2005-10-16 | Eli Lilly And Company | Profarmacos de ester de morlino-n-etilo de inhibidores indolicos de spla 2. |
| GB0110832D0 (en) | 2001-05-03 | 2001-06-27 | Virogen Ltd | Antiviral compounds |
| US20050074457A1 (en) | 2001-12-12 | 2005-04-07 | Adeela Kamal | Assays and implements for determining and modulating hsp90 binding activity |
| GB0215293D0 (en) | 2002-07-03 | 2002-08-14 | Rega Foundation | Viral inhibitors |
| ZA200705872B (en) | 2005-01-14 | 2008-09-25 | Genelabs Tecnologies Inc | Indole derivatives for treating viral infections |
| JP2008530124A (ja) | 2005-02-09 | 2008-08-07 | ミジェニックス インコーポレイテッド | フラビウイルス感染症を処置または予防するための組成物および方法 |
| AU2009256390A1 (en) | 2008-06-03 | 2009-12-10 | Siga Technologies, Inc. | Small molecule inhibitors for the treatment or prevention of dengue virus infection |
| JP5559174B2 (ja) * | 2008-08-19 | 2014-07-23 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ | 冷感−メントール受容体拮抗剤 |
| TWI453207B (zh) | 2008-09-08 | 2014-09-21 | Signal Pharm Llc | 胺基三唑并吡啶，其組合物及使用其之治療方法 |
| EP2393359A4 (en) | 2009-02-09 | 2012-10-03 | Enanta Pharm Inc | COMPOUND DIBENZIMIDAZOLE DERIVATIVES |
| GB0910003D0 (en) | 2009-06-11 | 2009-07-22 | Univ Leuven Kath | Novel compounds for the treatment of neurodegenerative diseases |
| US8993604B2 (en) | 2009-06-30 | 2015-03-31 | Siga Technologies, Inc. | Treatment and prevention of dengue virus infections |
| US7948798B1 (en) | 2009-07-22 | 2011-05-24 | Marvell International Ltd. | Mixed multi-level cell and single level cell storage device |
| CA2785563C (en) | 2010-01-15 | 2019-05-14 | Gilead Sciences, Inc. | Inhibitors of flaviviridae viruses |
| EP2552211A4 (en) | 2010-03-26 | 2013-10-23 | Glaxo Group Ltd | INDAZOLYL-PYRIMIDINE AS KINASEHEMMER |
| JP5716205B2 (ja) | 2011-03-29 | 2015-05-13 | 学校法人日本大学 | グルコシダーゼ活性阻害用組成物及びそのスクリーニング方法 |
| GB201116559D0 (en) | 2011-09-26 | 2011-11-09 | Univ Leuven Kath | Novel viral replication inhibitors |
| EP2624519A4 (en) * | 2011-09-30 | 2014-04-23 | Huawei Tech Co Ltd | NETWORKING METHOD AND DEVICE |
| GB201305376D0 (en) | 2013-03-25 | 2013-05-08 | Univ Leuven Kath | Novel viral replication inhibitors |
| KR102290189B1 (ko) | 2013-10-23 | 2021-08-17 | 얀센 사이언시즈 아일랜드 언리미티드 컴퍼니 | 카르복스아미드 유도체 및 ｂ형 간염 치료용 의약으로서의 이의 용도 |
| CN116987080A (zh) | 2014-01-31 | 2023-11-03 | 百时美施贵宝公司 | 作为因子xia抑制剂的具有杂环p2′基团的大环化合物 |
| ME03344B (me) | 2014-10-01 | 2019-10-20 | Janssen Pharmaceuticals Inc | Mono- ili di-supstituisani indoli kao inнibitori replikacije denga virusa |
| NO2721243T3 (https=) | 2014-10-01 | 2018-10-20 | ||
| AU2015326930B2 (en) * | 2014-10-01 | 2020-03-26 | Janssen Pharmaceuticals, Inc. | Mono- or di-substituted indole derivatives as dengue viral replication inhibitors |
| PH12017501272B1 (en) | 2015-01-16 | 2023-01-11 | Janssen Pharmaceuticals Inc | Indole derivatives as dengue viral replication inhibitors |
| AR103680A1 (es) | 2015-02-23 | 2017-05-24 | Lilly Co Eli | Inhibidores selectivos de bace1 |
| JOP20160086B1 (ar) | 2015-05-08 | 2021-08-17 | 2 Katholieke Univ Leuven Ku Leuven Research And Development | مشتقات اندول مستبدلة احاديا او ثنائيا بصفتها مانعات للتكاثر الفيروسي لحمى الفنك |
| JOP20160198B1 (ar) | 2015-09-16 | 2022-03-14 | Janssen Pharmaceuticals Inc | مشتقات اندول مستبدلة احاديا او ثنائيا بصفتها مانعات للتكاثر الفيروسي لحمى الفنك |
| JO3633B1 (ar) | 2015-09-16 | 2020-08-27 | Katholieke Univ Leuven Ku Leuven Research & Development | مشتقات اندول مستبدلة احاديا او ثنائيا بصفتها مانعات للتكاثر الفيروسي لحمى الفنك |
| MX374683B (es) | 2015-11-03 | 2025-03-04 | Zoetis Services Llc | Compuestos polimericos sol-gel y sus usos. |
| HRP20210847T1 (hr) | 2016-03-31 | 2021-07-23 | Janssen Pharmaceuticals, Inc. | Supstituirani derivati indola kao inhibitori replikacije denga virusa |
| ES2804580T3 (es) | 2016-03-31 | 2021-02-08 | Takeda Pharmaceuticals Co | Compuesto heterocíclico |
| MX2018011788A (es) * | 2016-03-31 | 2019-05-20 | Janssen Pharmaceuticals Inc | Derivados de indolina sustituidos como inhibidores de la replicacion virica de dengue. |
| MY210545A (en) | 2016-04-01 | 2025-09-30 | Kite Pharma Inc | Chimeric receptors to flt3 and methods of use thereof |
| PT3436079T (pt) | 2016-04-01 | 2021-10-06 | Kite Pharma Inc | Recetores de antigénios quiméricos e de células t e métodos de uso |
| EP3436457B1 (en) | 2016-04-01 | 2022-07-20 | Basf Se | Bicyclic compounds |
| KR102359766B1 (ko) | 2016-04-01 | 2022-02-07 | 얀센 파마슈티칼즈, 인코포레이티드 | 뎅기 바이러스 복제 억제제로서 치환된 인돌 화합물 유도체 |
| JOP20170069B1 (ar) | 2016-04-01 | 2021-08-17 | 1 Janssen Pharmaceuticals Inc | مشتقات اندولين مستبدلة بصفتها مانعات للتكاثر الفيروسي لحمى الفنك |
| KR20200068750A (ko) | 2016-04-01 | 2020-06-15 | 카이트 파마 인코포레이티드 | 키메라 수용체 및 그의 사용 방법 |
| AU2017241837B2 (en) | 2016-04-01 | 2021-07-22 | Signal Pharmaceuticals, Llc | Substituted aminopurine compounds, compositions thereof, and methods of treatment therewith |
| JOP20180026A1 (ar) | 2017-03-31 | 2019-01-30 | Univ Leuven Kath | مشتقات اندولين مستبدلة بصفتها مانعات للتكاثر الفيروسي لحمى الفنك |
| JOP20180025B1 (ar) | 2017-03-31 | 2021-08-17 | Janssen Pharmaceuticals Inc | مشتقات اندولين مستبدلة بصفتها مانعات للتكاثر الفيروسي لحمى الفنك |
| CN110753682B (zh) | 2017-05-22 | 2023-06-30 | 杨森制药公司 | 作为登革热病毒复制抑制剂的经取代的吲哚啉衍生物 |
-
2018
- 2018-05-18 EA EA201992782A patent/EA201992782A1/ru unknown
- 2018-05-18 CN CN201880033697.9A patent/CN110691773B/zh active Active
- 2018-05-18 UA UAA201912024A patent/UA125407C2/uk unknown
- 2018-05-18 AU AU2018274100A patent/AU2018274100B2/en active Active
- 2018-05-18 KR KR1020197036401A patent/KR102625988B1/ko active Active
- 2018-05-18 EP EP18728541.6A patent/EP3630723B1/en active Active
- 2018-05-18 PE PE2019002404A patent/PE20200604A1/es unknown
- 2018-05-18 MX MX2019013893A patent/MX393586B/es unknown
- 2018-05-18 WO PCT/EP2018/063028 patent/WO2018215315A1/en not_active Ceased
- 2018-05-18 TW TW107116924A patent/TWI758480B/zh not_active IP Right Cessation
- 2018-05-18 BR BR112019024195-7A patent/BR112019024195A2/pt active Search and Examination
- 2018-05-18 US US16/612,670 patent/US11407715B2/en active Active
- 2018-05-18 CR CR20190530A patent/CR20190530A/es unknown
- 2018-05-18 ES ES18728541T patent/ES2929667T3/es active Active
- 2018-05-18 JP JP2019564166A patent/JP7203764B2/ja active Active
- 2018-05-18 MA MA048943A patent/MA48943A/fr unknown
- 2018-05-18 CA CA3060583A patent/CA3060583C/en active Active
- 2018-05-21 AR ARP180101342A patent/AR111878A1/es not_active Application Discontinuation
- 2018-05-22 UY UY0001037742A patent/UY37742A/es unknown
-
2019
- 2019-10-28 CO CONC2019/0012035A patent/CO2019012035A2/es unknown
- 2019-11-15 CL CL2019003294A patent/CL2019003294A1/es unknown
- 2019-11-15 PH PH12019502559A patent/PH12019502559A1/en unknown
- 2019-11-18 IL IL270726A patent/IL270726B2/en unknown
- 2019-11-21 NI NI201900119A patent/NI201900119A/es unknown
- 2019-11-22 EC ECSENADI201983640A patent/ECSP19083640A/es unknown
-
2022
- 2022-06-16 US US17/842,367 patent/US11795149B2/en active Active
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