JP2018513832A5 - - Google Patents
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- Publication number
- JP2018513832A5 JP2018513832A5 JP2017541855A JP2017541855A JP2018513832A5 JP 2018513832 A5 JP2018513832 A5 JP 2018513832A5 JP 2017541855 A JP2017541855 A JP 2017541855A JP 2017541855 A JP2017541855 A JP 2017541855A JP 2018513832 A5 JP2018513832 A5 JP 2018513832A5
- Authority
- JP
- Japan
- Prior art keywords
- optionally substituted
- compound according
- hydrogen
- pharmaceutically acceptable
- pharmaceutical composition
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 0 C*(C)N(C1C(*)C1)C(N=C(C1)C1*=C)=C Chemical compound C*(C)N(C1C(*)C1)C(N=C(C1)C1*=C)=C 0.000 description 3
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510157772 | 2015-04-03 | ||
| CN201510157772.0 | 2015-04-03 | ||
| PCT/CN2016/077519 WO2016155593A1 (zh) | 2015-04-03 | 2016-03-28 | 4'-硫代核苷的新型化合物及其制备方法、药物组合物和应用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018513832A JP2018513832A (ja) | 2018-05-31 |
| JP2018513832A5 true JP2018513832A5 (https=) | 2019-03-28 |
| JP6769000B2 JP6769000B2 (ja) | 2020-10-14 |
Family
ID=57004251
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017541855A Expired - Fee Related JP6769000B2 (ja) | 2015-04-03 | 2016-03-28 | ４’−チオヌクレオシドの新規な化合物、並びにその調製方法、その医薬組成物及びその用途 |
Country Status (8)
| Country | Link |
|---|---|
| US (2) | US10662214B2 (https=) |
| EP (1) | EP3279207B1 (https=) |
| JP (1) | JP6769000B2 (https=) |
| CN (2) | CN109553651B (https=) |
| AU (1) | AU2016240117C1 (https=) |
| CA (1) | CA2975990A1 (https=) |
| EA (1) | EA034375B1 (https=) |
| WO (1) | WO2016155593A1 (https=) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2013241341B2 (en) | 2012-03-28 | 2016-09-08 | Fujifilm Corporation | Salt of 1-(2-deoxy-2-fluoro-4-thio-beta-D-arabinofuranosyl)cytosine |
| DK2883866T3 (da) | 2012-08-13 | 2019-05-13 | Fujifilm Corp | MELLEMPRODUKT TIL SYNTESE AF 1-(2-DEOXY-2-FLUOR-4-THIO-beta-D- ARABINOFURANOSYL)CYTOSIN, MELLEMPRODUKT TIL SYNTESE AF THIONUKLEOSID OG FREMGANGSMÅDER TIL FREMSTILLING AF DISSE MELLEMPRODUKTER |
| TWI678373B (zh) | 2014-10-31 | 2019-12-01 | 日商富士軟片股份有限公司 | 硫代核苷衍生物或其鹽及醫藥組合物 |
| US10662214B2 (en) * | 2015-04-03 | 2020-05-26 | Sichuan Keiun-Biotech Biopharmaceutical Co., Ltd. | Compound of 4′-thionucleoside, as well as preparation method therefor, pharmaceutical composition thereof and application thereof |
| EP3508205B1 (en) | 2016-08-31 | 2022-05-18 | FUJIFILM Corporation | Anti-tumor agent, anti-tumor effect enhancer, and anti-tumor kit |
| JP2020502043A (ja) * | 2016-12-22 | 2020-01-23 | シチュアン ケルン−バイオテック バイオファーマシューティカル カンパニー リミテッド | ４’−チオ−２’−フルオロヌクレオシドホスファミド化合物の固体形態及びそのための調製方法及びその使用 |
| WO2019001292A1 (zh) * | 2017-06-29 | 2019-01-03 | 四川科伦博泰生物医药股份有限公司 | 4'-硫代核苷的新型化合物的制备方法和此制备方法中的中间体 |
| US11266674B2 (en) * | 2017-09-01 | 2022-03-08 | Sichuan Kelun-Biotech Biopharmaceutical Co., Ltd. | Pharmaceutical composition for tumor treatment or prevention, method, and use thereof |
| MX2018002611A (es) | 2018-01-29 | 2019-07-30 | Fujifilm Corp | Agente antitumoral para cancer del tracto biliar y metodo para tratar cancer del tracto biliar. |
| CA3097003A1 (en) * | 2018-04-19 | 2019-10-24 | Southern Research Institute | 4'-thio-nucleotide and -nucleoside prodrugs for the treatment of cancer |
| WO2020108343A1 (zh) * | 2018-11-28 | 2020-06-04 | 四川科伦博泰生物医药股份有限公司 | 以4'-硫代核苷类化合物为活性成分的口服药物组合物、其制备方法及其用途 |
| CN114341149A (zh) * | 2019-07-30 | 2022-04-12 | 匹诺生物股份有限公司 | 用于治疗癌症的二核苷酸化合物及其医学用途 |
| EP4138843A4 (en) | 2020-04-23 | 2024-07-10 | Southern Research Institute | COMPOSITION FOR THE TREATMENT OF BLOOD CANCER USING 4'-THIO-5-AZA-2'-DEOXYCYTIDINE AND USES THEREOF |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5128458A (en) | 1990-04-20 | 1992-07-07 | Southern Research Institute | 2',3'-dideoxy-4'-thioribonucleosides as antiviral agents |
| JPH1087687A (ja) | 1996-04-09 | 1998-04-07 | Yamasa Shoyu Co Ltd | ５−置換−１−（２−デオキシ−２−フルオロ−４−チオ−β−Ｄ−アラビノフラノシル）ウラシル |
| DK0841344T3 (da) * | 1996-04-09 | 2002-12-23 | Yamasa Corp | 1-(2-Desoxy-2-fluor-4-thio-Beta-D-arabinofuranosyl)cytosiner |
| GB0317009D0 (en) * | 2003-07-21 | 2003-08-27 | Univ Cardiff | Chemical compounds |
| WO2005027962A1 (en) | 2003-09-18 | 2005-03-31 | Isis Pharmaceuticals, Inc. | 4’-thionucleosides and oligomeric compounds |
| US7888330B2 (en) * | 2005-11-09 | 2011-02-15 | Wayne State University | Phosphoramidate derivatives of FAU |
| GB201016855D0 (en) * | 2010-10-06 | 2010-11-17 | Nucana Biomed Ltd | Chemical compounds |
| US20140315850A1 (en) * | 2011-07-19 | 2014-10-23 | Nanjing Molecular Research, Inc. | 2',3'-Dideoxy-2'-alpha-Fluoro-2'-beta-C-Methylnucleosides and Prodrugs Thereof |
| WO2014124430A1 (en) * | 2013-02-11 | 2014-08-14 | Emory University | Nucleotide and nucleoside therapeutic compositions and uses related thereto |
| US10005779B2 (en) * | 2013-06-05 | 2018-06-26 | Idenix Pharmaceuticals Llc | 1′,4′-thio nucleosides for the treatment of HCV |
| TWI678373B (zh) | 2014-10-31 | 2019-12-01 | 日商富士軟片股份有限公司 | 硫代核苷衍生物或其鹽及醫藥組合物 |
| US10662214B2 (en) * | 2015-04-03 | 2020-05-26 | Sichuan Keiun-Biotech Biopharmaceutical Co., Ltd. | Compound of 4′-thionucleoside, as well as preparation method therefor, pharmaceutical composition thereof and application thereof |
-
2016
- 2016-03-28 US US15/558,620 patent/US10662214B2/en active Active
- 2016-03-28 CN CN201811577363.6A patent/CN109553651B/zh active Active
- 2016-03-28 JP JP2017541855A patent/JP6769000B2/ja not_active Expired - Fee Related
- 2016-03-28 WO PCT/CN2016/077519 patent/WO2016155593A1/zh not_active Ceased
- 2016-03-28 EA EA201791535A patent/EA034375B1/ru unknown
- 2016-03-28 CA CA2975990A patent/CA2975990A1/en not_active Abandoned
- 2016-03-28 AU AU2016240117A patent/AU2016240117C1/en not_active Ceased
- 2016-03-28 CN CN201680001812.5A patent/CN106661077B/zh active Active
- 2016-03-28 EP EP16771348.6A patent/EP3279207B1/en active Active
-
2020
- 2020-04-17 US US16/851,217 patent/US20200262860A1/en not_active Abandoned
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