JP2011529918A5 - - Google Patents
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- JP2011529918A5 JP2011529918A5 JP2011521361A JP2011521361A JP2011529918A5 JP 2011529918 A5 JP2011529918 A5 JP 2011529918A5 JP 2011521361 A JP2011521361 A JP 2011521361A JP 2011521361 A JP2011521361 A JP 2011521361A JP 2011529918 A5 JP2011529918 A5 JP 2011529918A5
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- JP
- Japan
- Prior art keywords
- compound
- aryl
- heteroaryl
- lower alkyl
- formula
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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- 0 *c1ccnc2ncn[n]12 Chemical compound *c1ccnc2ncn[n]12 0.000 description 69
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- RNHNZDUJRXROJA-UHFFFAOYSA-N Cc1c2[o]nnc2ncc1 Chemical compound Cc1c2[o]nnc2ncc1 RNHNZDUJRXROJA-UHFFFAOYSA-N 0.000 description 2
- QAIZVTQMYGHGTG-UHFFFAOYSA-N Cc1c2[s]cnc2ncc1 Chemical compound Cc1c2[s]cnc2ncc1 QAIZVTQMYGHGTG-UHFFFAOYSA-N 0.000 description 2
- VAXIBUZVPFRMHZ-UHFFFAOYSA-N Cc1c2[s]cnc2ncn1 Chemical compound Cc1c2[s]cnc2ncn1 VAXIBUZVPFRMHZ-UHFFFAOYSA-N 0.000 description 2
- IYMQFDVVSJBOCJ-UHFFFAOYSA-N Cc1c2[s]ncc2ncc1 Chemical compound Cc1c2[s]ncc2ncc1 IYMQFDVVSJBOCJ-UHFFFAOYSA-N 0.000 description 2
- QPBHBVWTNWOHRK-UHFFFAOYSA-N Cc1c2[s]ncc2ncn1 Chemical compound Cc1c2[s]ncc2ncn1 QPBHBVWTNWOHRK-UHFFFAOYSA-N 0.000 description 2
- WXVQCFALDUVKSC-UHFFFAOYSA-N Cc1cc(C)nc2ncn[n]12 Chemical compound Cc1cc(C)nc2ncn[n]12 WXVQCFALDUVKSC-UHFFFAOYSA-N 0.000 description 2
- KEFHNNMOFZXQJA-UHFFFAOYSA-N Cc1cc(Cl)nc2ncc[n]12 Chemical compound Cc1cc(Cl)nc2ncc[n]12 KEFHNNMOFZXQJA-UHFFFAOYSA-N 0.000 description 2
- GKGGEVRMITWKIA-UHFFFAOYSA-N Cc1nc(F)n[n]2c1ccc2 Chemical compound Cc1nc(F)n[n]2c1ccc2 GKGGEVRMITWKIA-UHFFFAOYSA-N 0.000 description 2
- CZODODSACGXIMA-UHFFFAOYSA-N Cc1ncn[n]2c1ccc2 Chemical compound Cc1ncn[n]2c1ccc2 CZODODSACGXIMA-UHFFFAOYSA-N 0.000 description 2
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- YZEJFPWHRCHRRI-UHFFFAOYSA-N Cc1ncn[n]2ncnc12 Chemical compound Cc1ncn[n]2ncnc12 YZEJFPWHRCHRRI-UHFFFAOYSA-N 0.000 description 2
- NKNFAJHOXKRJJK-UHFFFAOYSA-N Ic1ccnc2ccn[n]12 Chemical compound Ic1ccnc2ccn[n]12 NKNFAJHOXKRJJK-UHFFFAOYSA-N 0.000 description 2
- RINRRWDHGQAUGT-UHFFFAOYSA-N Ic1ncn[n]2c1ccc2 Chemical compound Ic1ncn[n]2c1ccc2 RINRRWDHGQAUGT-UHFFFAOYSA-N 0.000 description 2
- COIRNGWSWUWRGE-UHFFFAOYSA-N Ic1ncn[n]2nccc12 Chemical compound Ic1ncn[n]2nccc12 COIRNGWSWUWRGE-UHFFFAOYSA-N 0.000 description 2
- AYRXNHGVHILSDU-UHFFFAOYSA-N Ic1ncnc2c1[nH]nc2 Chemical compound Ic1ncnc2c1[nH]nc2 AYRXNHGVHILSDU-UHFFFAOYSA-N 0.000 description 2
- QWZFYLPTEFARKF-UHFFFAOYSA-N Ic1ncnc2c1[o]cc2 Chemical compound Ic1ncnc2c1[o]cc2 QWZFYLPTEFARKF-UHFFFAOYSA-N 0.000 description 2
- PEHVGBZKEYRQSX-UHFFFAOYSA-N Nc1c(cc[nH]2)c2ncn1 Chemical compound Nc1c(cc[nH]2)c2ncn1 PEHVGBZKEYRQSX-UHFFFAOYSA-N 0.000 description 2
- VEFILPQJQRHUBK-UHFFFAOYSA-N Nc1c2[o]ncc2ncc1 Chemical compound Nc1c2[o]ncc2ncc1 VEFILPQJQRHUBK-UHFFFAOYSA-N 0.000 description 2
- WPFZGADUIUVTCF-UHFFFAOYSA-N Nc1ccnc2ccn[n]12 Chemical compound Nc1ccnc2ccn[n]12 WPFZGADUIUVTCF-UHFFFAOYSA-N 0.000 description 2
- QOXCEADXSTZKHA-UHFFFAOYSA-N Nc1ccnc2ncn[n]12 Chemical compound Nc1ccnc2ncn[n]12 QOXCEADXSTZKHA-UHFFFAOYSA-N 0.000 description 2
- HVWJATXZZQPVEL-UHFFFAOYSA-N Nc1ncnc2c1[o]cc2 Chemical compound Nc1ncnc2c1[o]cc2 HVWJATXZZQPVEL-UHFFFAOYSA-N 0.000 description 2
- VASAZSNMKDILTC-UHFFFAOYSA-O [NH3+]c1ccn[n]2nccc12 Chemical compound [NH3+]c1ccn[n]2nccc12 VASAZSNMKDILTC-UHFFFAOYSA-O 0.000 description 2
- KCSLHMLHJTWKLW-ZJUUUORDSA-N C[C@H](CCNC1)[C@H]1N(C)C=C=C Chemical compound C[C@H](CCNC1)[C@H]1N(C)C=C=C KCSLHMLHJTWKLW-ZJUUUORDSA-N 0.000 description 1
- DVKMEJAYUBJYIM-RQJHMYQMSA-N C[C@H](CCNC1)[C@H]1N(C)N Chemical compound C[C@H](CCNC1)[C@H]1N(C)N DVKMEJAYUBJYIM-RQJHMYQMSA-N 0.000 description 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US8570508P | 2008-08-01 | 2008-08-01 | |
| US61/085,705 | 2008-08-01 | ||
| US9856208P | 2008-09-19 | 2008-09-19 | |
| US61/098,562 | 2008-09-19 | ||
| PCT/US2009/052449 WO2010014930A2 (en) | 2008-08-01 | 2009-07-31 | Therapeutic agents |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2011529918A JP2011529918A (ja) | 2011-12-15 |
| JP2011529918A5 true JP2011529918A5 (https=) | 2012-09-06 |
Family
ID=41170025
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011521361A Pending JP2011529918A (ja) | 2008-08-01 | 2009-07-31 | Ｊａｋ３阻害剤としてのピペリジン誘導体 |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US20110165183A1 (https=) |
| EP (1) | EP2324020A2 (https=) |
| JP (1) | JP2011529918A (https=) |
| KR (1) | KR20110050654A (https=) |
| CN (1) | CN102171211A (https=) |
| AU (1) | AU2009276420A1 (https=) |
| BR (1) | BRPI0916931A2 (https=) |
| CA (1) | CA2732628A1 (https=) |
| IL (1) | IL210990A0 (https=) |
| MX (1) | MX2011001259A (https=) |
| NZ (1) | NZ590922A (https=) |
| RU (1) | RU2011105768A (https=) |
| WO (1) | WO2010014930A2 (https=) |
Families Citing this family (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2012107101A (ru) | 2009-07-31 | 2013-09-10 | Байокрист Фармасьютикалз, Инк. | Производные пирроло[1,2-в] пиридазина как ингибиторы янус-киназы |
| AU2011258005A1 (en) * | 2010-05-28 | 2013-01-17 | Biocryst Pharmaceuticals, Inc. | Heterocyclic compounds as Janus kinase inhibitors |
| CA2836417A1 (en) | 2011-05-17 | 2012-11-22 | Principia Biopharma Inc. | Azaindole derivatives as tyrosine kinase inhibitors |
| WO2013135671A1 (en) | 2012-03-13 | 2013-09-19 | Basf Se | Fungicidal pyrimidine compounds |
| ME03455B (me) | 2012-09-10 | 2020-01-20 | Principia Biopharma Inc | Jedinjenja pirazolopirimidina kao inhibitori kinaze |
| US9550785B2 (en) * | 2012-11-20 | 2017-01-24 | Glaxosmithkline Llc | Pyrrolopyrimidines as therapeutic agents for the treatment of diseases |
| US9481679B2 (en) * | 2012-12-17 | 2016-11-01 | Sun Pharmaceutical Industries Limited | Process for the preparation of tofacitinib and intermediates thereof |
| WO2014102826A1 (en) * | 2012-12-28 | 2014-07-03 | Glenmark Pharmaceuticals Limited; | The present invention relates to process for the preparation of tofacitinib and intermediates thereof. |
| WO2015036058A1 (en) | 2013-09-16 | 2015-03-19 | Basf Se | Fungicidal pyrimidine compounds |
| WO2015036059A1 (en) | 2013-09-16 | 2015-03-19 | Basf Se | Fungicidal pyrimidine compounds |
| BR112016006319A2 (pt) * | 2013-09-27 | 2017-08-01 | Nimbus Iris Inc | inibidores de irak e usos dos mesmos |
| SI3539965T1 (sl) * | 2013-12-09 | 2021-07-30 | Unichem Laboratories Limited | Izboljšan postopek za pripravo (3R,4R)-(1-benzil-4-metilpiperidin-3-il)-metilamina |
| PT3107544T (pt) | 2014-02-21 | 2021-01-05 | Principia Biopharma Inc | Sais e forma sólida de um inibidor de btk |
| CN104860950A (zh) * | 2014-02-24 | 2015-08-26 | 重庆医药工业研究院有限责任公司 | 一种制备4-氯吡咯[2,3-d]并嘧啶的方法 |
| CN104059016A (zh) * | 2014-06-20 | 2014-09-24 | 湖南天地恒一制药有限公司 | 制备托法替布的中间体及所述中间体的制备方法 |
| KR101710127B1 (ko) * | 2014-08-29 | 2017-02-27 | 한화제약주식회사 | 야누스인산화효소 억제제로서의 치환된 N-(피롤리딘-3-일)-7H-피롤로[2,3-d]피리미딘-4-아민 |
| US10485797B2 (en) | 2014-12-18 | 2019-11-26 | Principia Biopharma Inc. | Treatment of pemphigus |
| CN105732637B (zh) * | 2014-12-30 | 2020-04-21 | 广东东阳光药业有限公司 | 杂芳化合物及其在药物中的应用 |
| EP3078665A1 (en) * | 2015-04-10 | 2016-10-12 | OLON S.p.A. | Efficient method for the preparation of tofacitinib citrate |
| RU2719477C2 (ru) * | 2015-06-22 | 2020-04-17 | Оно Фармасьютикал Ко., Лтд. | Соединение, ингибирующее brk |
| TW201718572A (zh) | 2015-06-24 | 2017-06-01 | 普林斯匹亞生物製藥公司 | 酪胺酸激酶抑制劑 |
| WO2017004134A1 (en) * | 2015-06-29 | 2017-01-05 | Nimbus Iris, Inc. | Irak inhibitors and uses thereof |
| CN105622616A (zh) * | 2016-02-25 | 2016-06-01 | 上海雅本化学有限公司 | 一种4-氯吡咯并嘧啶的制备方法 |
| MA45547A (fr) | 2016-06-29 | 2019-05-08 | Principia Biopharma Inc | Formulations à libération modifiée à base de 2-[3-[4-amino-3-(2-fluoro-4-phénoxy-phényl)pyrazolo[3,4-d]pyrimidine-1-yl]pipéridine-1-carbonyl]-4-méthyl-4-[4-(oxétane-3-yl)pipérazine-1-yl]pent-2-ènenitrile |
| GB201617758D0 (en) | 2016-10-20 | 2016-12-07 | Almac Discovery Limited | Pharmaceutical compounds |
| EP3782998B1 (en) * | 2018-04-16 | 2023-05-10 | Shenzhen TargetRx, Inc. | Substituted pyrrolotriazine compound, pharmaceutical composition thereof and use thereof |
| TWI877239B (zh) | 2019-10-14 | 2025-03-21 | 美商普林斯匹亞生物製藥公司 | 藉由投予(R)-2-[3-[4-胺基-3-(2-氟-4-苯氧基-苯基)吡唑并[3,4-d]嘧啶-1-基]哌啶-1-羰基]-4-甲基-4-[4-(氧呾-3-基)哌-1-基]戊-2-烯腈來治療免疫血小板減少症之方法 |
| JP2023511105A (ja) | 2020-01-22 | 2023-03-16 | プリンシピア バイオファーマ インコーポレイテッド | ２－［３－［４－アミノ－３－（２－フルオロ－４－フェノキシ－フェニル）－１ｈ－ピラゾロ［３，４－ｄ］ピリミジン－１－イル］ピペリジン－１－カルボニル］－４－メチル－４－［４－（オキセタン－３－イル）ピペラジン－１－イル］ペンタ－２－エンニトリルの結晶形態 |
| CN116768908B (zh) * | 2022-03-10 | 2025-11-18 | 石家庄迪斯凯威医药科技有限公司 | 一种含n多环化合物及其制备方法与用途 |
| CN117164519A (zh) * | 2023-08-18 | 2023-12-05 | 杭州小蓓医药科技有限公司 | 一种l-肌肽的合成方法 |
| CN117534603A (zh) * | 2023-11-10 | 2024-02-09 | 江苏海悦康医药科技有限公司 | 一种托法替布中间体的制备方法 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BR9911365A (pt) * | 1998-06-19 | 2001-03-13 | Pfizer Prod Inc | Compostos pirrolo[2,3-d]pirimidina |
| EP1382339B1 (en) * | 1999-12-10 | 2007-12-05 | Pfizer Products Inc. | Compositions containing pyrrolo ¬2,3-d pyrimidine derivatives |
| IL152771A0 (en) * | 2000-06-26 | 2003-06-24 | Pfizer Prod Inc | PYRROLO(2,3-d) PYRIMIDINE COMPOUNDS AS IMMUNOSUPPRESSIVE AGENTS |
| US7301023B2 (en) * | 2001-05-31 | 2007-11-27 | Pfizer Inc. | Chiral salt resolution |
| NZ539901A (en) * | 2002-11-26 | 2007-09-28 | Pfizer Prod Inc | Method of treatment of transplant rejection |
| EA008596B1 (ru) * | 2003-04-29 | 2007-06-29 | Пфайзер Инк. | 5,7-ДИАМИНОПИРАЗОЛО[4,3-d]ПИРИМИДИНЫ, ПОЛЕЗНЫЕ ПРИ ЛЕЧЕНИИ ГИПЕРТЕНЗИИ |
| JP2007512316A (ja) * | 2003-11-25 | 2007-05-17 | ファイザー・プロダクツ・インク | アテローム性動脈硬化症の治療方法 |
| AR054416A1 (es) * | 2004-12-22 | 2007-06-27 | Incyte Corp | Pirrolo [2,3-b]piridin-4-il-aminas y pirrolo [2,3-b]pirimidin-4-il-aminas como inhibidores de las quinasas janus. composiciones farmaceuticas. |
| WO2007007919A2 (en) * | 2005-07-14 | 2007-01-18 | Astellas Pharma Inc. | Heterocyclic janus kinase 3 inhibitors |
| NL2000291C2 (nl) * | 2005-11-10 | 2009-02-17 | Pfizer Prod Inc | 1-(1-(2-ethoxyethyl)-3-ethyl-7-(4-methylpyridin-2-ylamino)-1H- pyrazool(4,3-d)pyrimidine-5-yl)piperidine-4-carbonzuur en zouten daarvan. |
| TW201111385A (en) * | 2009-08-27 | 2011-04-01 | Biocryst Pharm Inc | Heterocyclic compounds as janus kinase inhibitors |
| RU2013120966A (ru) * | 2010-10-08 | 2014-11-20 | Эббви Инк. | ФУРО[3,2-d]ПИРИМИДИНОВЫЕ СОЕДИНЕНИЯ |
-
2009
- 2009-07-31 US US13/057,100 patent/US20110165183A1/en not_active Abandoned
- 2009-07-31 RU RU2011105768/04A patent/RU2011105768A/ru not_active Application Discontinuation
- 2009-07-31 MX MX2011001259A patent/MX2011001259A/es unknown
- 2009-07-31 CA CA2732628A patent/CA2732628A1/en not_active Abandoned
- 2009-07-31 AU AU2009276420A patent/AU2009276420A1/en not_active Abandoned
- 2009-07-31 NZ NZ590922A patent/NZ590922A/xx not_active IP Right Cessation
- 2009-07-31 KR KR1020117004724A patent/KR20110050654A/ko not_active Withdrawn
- 2009-07-31 WO PCT/US2009/052449 patent/WO2010014930A2/en not_active Ceased
- 2009-07-31 EP EP09791064A patent/EP2324020A2/en not_active Withdrawn
- 2009-07-31 BR BRPI0916931A patent/BRPI0916931A2/pt not_active IP Right Cessation
- 2009-07-31 CN CN2009801396041A patent/CN102171211A/zh active Pending
- 2009-07-31 JP JP2011521361A patent/JP2011529918A/ja active Pending
-
2011
- 2011-02-01 IL IL210990A patent/IL210990A0/en unknown
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