JP2001519346A5 - - Google Patents
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- Publication number
- JP2001519346A5 JP2001519346A5 JP2000514908A JP2000514908A JP2001519346A5 JP 2001519346 A5 JP2001519346 A5 JP 2001519346A5 JP 2000514908 A JP2000514908 A JP 2000514908A JP 2000514908 A JP2000514908 A JP 2000514908A JP 2001519346 A5 JP2001519346 A5 JP 2001519346A5
- Authority
- JP
- Japan
- Prior art keywords
- triazol
- phenyl
- wide
- medium
- following
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 125000004215 2,4-difluorophenyl group Chemical group [H]C1=C([H])C(*)=C(F)C([H])=C1F 0.000 claims 2
- 125000003682 3-furyl group Chemical group O1C([H])=C([*])C([H])=C1[H] 0.000 claims 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 2
- IOLCXVTUBQKXJR-UHFFFAOYSA-M potassium bromide Chemical compound [K+].[Br-] IOLCXVTUBQKXJR-UHFFFAOYSA-M 0.000 claims 2
- 238000000634 powder X-ray diffraction Methods 0.000 claims 2
- -1 1H-1,2,4-triazol-1-ylmethyl Chemical group 0.000 claims 1
- STTHYLJITRSSSN-JQWIXIFHSA-N C1(=CC=CC=C1)N1C(N(N=C1)[C@H]([C@H](C)O)CC)=O Chemical compound C1(=CC=CC=C1)N1C(N(N=C1)[C@H]([C@H](C)O)CC)=O STTHYLJITRSSSN-JQWIXIFHSA-N 0.000 claims 1
- 206010017533 Fungal infection Diseases 0.000 claims 1
- 241000124008 Mammalia Species 0.000 claims 1
- 208000031888 Mycoses Diseases 0.000 claims 1
- 230000000843 anti-fungal effect Effects 0.000 claims 1
- 229940121375 antifungal agent Drugs 0.000 claims 1
- 150000001875 compounds Chemical class 0.000 claims 1
- 239000013078 crystal Substances 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 238000002329 infrared spectrum Methods 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 239000008188 pellet Substances 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US94618397A | 1997-10-07 | 1997-10-07 | |
| US08/946,183 | 1997-10-07 | ||
| PCT/US1998/020476 WO1999018097A1 (en) | 1997-10-07 | 1998-10-05 | Crystalline antifungal polymorph |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008000110A Division JP2008106075A (ja) | 1997-10-07 | 2008-01-04 | 抗真菌性結晶性多形物 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2001519346A JP2001519346A (ja) | 2001-10-23 |
| JP2001519346A5 true JP2001519346A5 (https=) | 2005-09-02 |
Family
ID=25484068
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000514908A Withdrawn JP2001519346A (ja) | 1997-10-07 | 1998-10-05 | 抗真菌性結晶性多形物 |
| JP2008000110A Withdrawn JP2008106075A (ja) | 1997-10-07 | 2008-01-04 | 抗真菌性結晶性多形物 |
| JP2012114725A Pending JP2012153730A (ja) | 1997-10-07 | 2012-05-18 | 抗真菌性結晶性多形物 |
| JP2012114724A Pending JP2012153729A (ja) | 1997-10-07 | 2012-05-18 | 抗真菌性結晶性多形物 |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008000110A Withdrawn JP2008106075A (ja) | 1997-10-07 | 2008-01-04 | 抗真菌性結晶性多形物 |
| JP2012114725A Pending JP2012153730A (ja) | 1997-10-07 | 2012-05-18 | 抗真菌性結晶性多形物 |
| JP2012114724A Pending JP2012153729A (ja) | 1997-10-07 | 2012-05-18 | 抗真菌性結晶性多形物 |
Country Status (30)
| Country | Link |
|---|---|
| EP (1) | EP1021439B1 (https=) |
| JP (4) | JP2001519346A (https=) |
| KR (1) | KR100626109B1 (https=) |
| CN (1) | CN1125067C (https=) |
| AR (1) | AR015947A1 (https=) |
| AT (1) | ATE263163T1 (https=) |
| AU (1) | AU759982B2 (https=) |
| BR (1) | BR9812866A (https=) |
| CA (1) | CA2305803C (https=) |
| CO (1) | CO4970829A1 (https=) |
| CZ (1) | CZ299835B6 (https=) |
| DE (1) | DE69822859T2 (https=) |
| DK (1) | DK1021439T3 (https=) |
| ES (1) | ES2217594T3 (https=) |
| HU (1) | HU225233B1 (https=) |
| ID (1) | ID29290A (https=) |
| IL (1) | IL135331A (https=) |
| IN (1) | IN1998CH02232A (https=) |
| MX (1) | MX225999B (https=) |
| MY (1) | MY130126A (https=) |
| NO (1) | NO318827B1 (https=) |
| NZ (1) | NZ503662A (https=) |
| PE (1) | PE120499A1 (https=) |
| PH (1) | PH11998002606B1 (https=) |
| PL (1) | PL189317B1 (https=) |
| PT (1) | PT1021439E (https=) |
| SK (1) | SK285190B6 (https=) |
| TW (1) | TW589310B (https=) |
| WO (1) | WO1999018097A1 (https=) |
| ZA (1) | ZA989063B (https=) |
Families Citing this family (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2130540A1 (en) * | 2008-06-02 | 2009-12-09 | Sandoz AG | Pharmaceutical compositions containing a crystalline form of posaconazole |
| EP2141159A1 (en) * | 2008-07-03 | 2010-01-06 | Sandoz AG | A Crystalline form of posaconazole |
| WO2011003992A1 (en) | 2009-07-09 | 2011-01-13 | Sandoz Ag | A crystalline form of posaconazole |
| CN102906087B (zh) | 2010-05-19 | 2016-03-23 | 桑多斯股份公司 | 制备手性三唑酮的方法 |
| JP5955837B2 (ja) | 2010-05-19 | 2016-07-20 | サンド・アクチエンゲゼルシヤフト | ポサコナゾール及びポサコナゾール中間体の精製 |
| EP2571847B1 (en) | 2010-05-19 | 2016-09-21 | Sandoz AG | Process for the preparation of chiral hydrazides |
| AU2011254657B2 (en) | 2010-05-19 | 2016-02-04 | Sandoz Ag | Preparation of posaconazole intermediates |
| CA2838051C (en) | 2011-06-16 | 2019-09-24 | Sandoz Ag | Process for the preparation of a chiral compound |
| EP2758385B1 (en) * | 2011-09-19 | 2018-03-28 | MSN Laboratories Limited | Process for the preparation of triazole antifungal drug, its intermediates and polymorphs thereof |
| CA2919290A1 (en) | 2013-07-25 | 2015-01-29 | Sandoz Ag | Improved process for the preparation of crystalline form iv of posaconazole |
| ITMI20132117A1 (it) * | 2013-12-18 | 2015-06-19 | Djada Pharmaceutical Sa | Una forma cristallina di posaconazolo |
| ITMI20132114A1 (it) | 2013-12-18 | 2015-06-19 | Djada Pharmaceutical Sa | Una forma cristallina di posaconazolo |
| ITMI20132115A1 (it) * | 2013-12-18 | 2015-06-19 | Djada Pharmaceutical Sa | Una forma cristallina di posaconazolo |
| ITMI20132118A1 (it) * | 2013-12-18 | 2015-06-19 | Djada Pharmaceutical Sa | Una forma cristallina di posaconazolo |
| CN111825717A (zh) | 2014-10-21 | 2020-10-27 | 阿瑞雅德制药公司 | 5-氯-n4-[2-(二甲基磷酰基)苯基]-n2-{2-甲氧基-4-[4-(4-甲基哌嗪-1-基)哌啶-1-基]苯基}嘧啶-2,4-二胺的晶形 |
| CN104387374A (zh) * | 2014-10-21 | 2015-03-04 | 江苏恒盛药业有限公司 | 泊沙康唑晶型i的制备工艺 |
| CN104370894A (zh) * | 2014-10-21 | 2015-02-25 | 江苏恒盛药业有限公司 | 无定型泊沙康唑的制备工艺 |
| US11058682B2 (en) | 2015-08-08 | 2021-07-13 | Alfred E. Tiefenbacher (Gmbh & Co. Kg) | Gastro-resistant formulation containing posaconazole |
| CN108473467B (zh) | 2015-12-24 | 2021-08-13 | 武田药品工业株式会社 | 共结晶、其制造方法及含有共结晶的药物 |
| EP3210599B1 (en) | 2016-02-26 | 2024-08-28 | Alfred E. Tiefenbacher (GmbH & Co. KG) | Gastro-resistant formulation containing posaconazole and a polymeric precipitation inhibitor |
| CN105949278B (zh) * | 2016-03-30 | 2019-12-06 | 南京曼杰生物科技有限公司 | 一种取代的四氢呋喃水溶性衍生物及其应用 |
| WO2017032908A1 (en) | 2016-07-08 | 2017-03-02 | Synthon B.V. | Pharmaceutical composition comprising amorphous posaconazole |
| TR201620462A2 (tr) | 2016-12-31 | 2018-07-23 | Abdi Ibrahim Ilac Sanayi Ve Ticaret Anonim Sirketi | POSAKONAZOL İÇEREN FARMASÖTİK BİLEŞİMLER ve ÜRETİM YÖNTEMİ |
| TR201722493A2 (tr) | 2017-12-28 | 2019-07-22 | Sanovel Ilac Sanayi Ve Ticaret Anonim Sirketi | Posakonazol i̇çeren kati farmasöti̇k kompozi̇syon |
| WO2022034232A1 (en) | 2020-08-13 | 2022-02-17 | Alfred E. Tiefenbacher (Gmbh & Co. Kg) | Gastro-resistant high-strength formulation containing posaconazole |
| US20240390363A1 (en) | 2021-11-25 | 2024-11-28 | Alfred E. Tiefenbacher (Gmbh & Co. Kg) | Granules containing posaconazole |
| EP4091604B1 (en) | 2021-11-25 | 2024-04-03 | Alfred E. Tiefenbacher (GmbH & Co. KG) | Granules containing posaconazole |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL103558A0 (en) * | 1991-10-30 | 1993-03-15 | Schering Corp | Tri-substituted tetrahydrofuran antifungals |
| PL181193B1 (pl) * | 1993-12-21 | 2001-06-29 | Schering Corp | Nowe pochodne tetrahydrofuranowe o działaniu przeciwgrzybicznym, kompozycja farmaceutyczna do leczenia infekcji grzybiczych oraz sposób wytwarzania tych związków |
| SG48386A1 (en) * | 1994-01-24 | 1998-04-17 | Janssen Pharmaceutica Nv | Watersoluble azole antifungals |
| US5625064A (en) * | 1995-04-19 | 1997-04-29 | Schering Corporation | Process for the preparation of triazolones |
| HUP9701690A3 (en) * | 1995-06-02 | 1998-04-28 | Schering Corp Kenilwort | Tetrahydrofuran derivatives as antifungals and pharmaceutical compositions containing the same |
-
1998
- 1998-10-05 KR KR20007003709A patent/KR100626109B1/ko not_active Expired - Lifetime
- 1998-10-05 AT AT98951994T patent/ATE263163T1/de active
- 1998-10-05 AR ARP980104957A patent/AR015947A1/es not_active Application Discontinuation
- 1998-10-05 DK DK98951994T patent/DK1021439T3/da active
- 1998-10-05 EP EP98951994A patent/EP1021439B1/en not_active Expired - Lifetime
- 1998-10-05 HU HU0004899A patent/HU225233B1/hu unknown
- 1998-10-05 ID IDW20000632A patent/ID29290A/id unknown
- 1998-10-05 CO CO98057733A patent/CO4970829A1/es unknown
- 1998-10-05 PE PE1998000942A patent/PE120499A1/es not_active IP Right Cessation
- 1998-10-05 PL PL98339659A patent/PL189317B1/pl unknown
- 1998-10-05 ES ES98951994T patent/ES2217594T3/es not_active Expired - Lifetime
- 1998-10-05 ZA ZA989063A patent/ZA989063B/xx unknown
- 1998-10-05 WO PCT/US1998/020476 patent/WO1999018097A1/en not_active Ceased
- 1998-10-05 JP JP2000514908A patent/JP2001519346A/ja not_active Withdrawn
- 1998-10-05 CZ CZ20001264A patent/CZ299835B6/cs not_active IP Right Cessation
- 1998-10-05 SK SK512-2000A patent/SK285190B6/sk not_active IP Right Cessation
- 1998-10-05 CN CN98811886A patent/CN1125067C/zh not_active Expired - Lifetime
- 1998-10-05 BR BR9812866-3A patent/BR9812866A/pt not_active Application Discontinuation
- 1998-10-05 PT PT98951994T patent/PT1021439E/pt unknown
- 1998-10-05 DE DE69822859T patent/DE69822859T2/de not_active Expired - Lifetime
- 1998-10-05 IL IL13533198A patent/IL135331A/xx not_active IP Right Cessation
- 1998-10-05 NZ NZ503662A patent/NZ503662A/xx not_active IP Right Cessation
- 1998-10-05 CA CA002305803A patent/CA2305803C/en not_active Expired - Lifetime
- 1998-10-05 AU AU97803/98A patent/AU759982B2/en not_active Expired
- 1998-10-06 MY MYPI98004576A patent/MY130126A/en unknown
- 1998-10-06 IN IN2232CH1998 patent/IN1998CH02232A/en unknown
- 1998-10-06 TW TW087116562A patent/TW589310B/zh not_active IP Right Cessation
- 1998-10-06 PH PH11998002606A patent/PH11998002606B1/en unknown
-
2000
- 2000-04-06 MX MXPA00003404 patent/MX225999B/es active IP Right Grant
- 2000-04-06 NO NO20001779A patent/NO318827B1/no not_active IP Right Cessation
-
2008
- 2008-01-04 JP JP2008000110A patent/JP2008106075A/ja not_active Withdrawn
-
2012
- 2012-05-18 JP JP2012114725A patent/JP2012153730A/ja active Pending
- 2012-05-18 JP JP2012114724A patent/JP2012153729A/ja active Pending
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