JP2004520292A5 - - Google Patents
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- Publication number
- JP2004520292A5 JP2004520292A5 JP2002547905A JP2002547905A JP2004520292A5 JP 2004520292 A5 JP2004520292 A5 JP 2004520292A5 JP 2002547905 A JP2002547905 A JP 2002547905A JP 2002547905 A JP2002547905 A JP 2002547905A JP 2004520292 A5 JP2004520292 A5 JP 2004520292A5
- Authority
- JP
- Japan
- Prior art keywords
- imidazole
- alkyl
- phenylethynyl
- methyl
- compound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP00126615 | 2000-12-04 | ||
| PCT/EP2001/013714 WO2002046166A1 (en) | 2000-12-04 | 2001-11-26 | Phenylethenyl or phenylethinyl derivatives as glutamate receptor antagonists |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007325072A Division JP2008169206A (ja) | 2000-12-04 | 2007-12-17 | グルタメート受容体アンタゴニストとしてのフェニルエテニルまたはフェニルエチニル誘導体 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2004520292A JP2004520292A (ja) | 2004-07-08 |
| JP2004520292A5 true JP2004520292A5 (https=) | 2005-05-26 |
| JP4077317B2 JP4077317B2 (ja) | 2008-04-16 |
Family
ID=8170567
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002547905A Expired - Fee Related JP4077317B2 (ja) | 2000-12-04 | 2001-11-26 | グルタメート受容体アンタゴニストとしてのフェニルエテニルまたはフェニルエチニル誘導体 |
| JP2007325072A Pending JP2008169206A (ja) | 2000-12-04 | 2007-12-17 | グルタメート受容体アンタゴニストとしてのフェニルエテニルまたはフェニルエチニル誘導体 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007325072A Pending JP2008169206A (ja) | 2000-12-04 | 2007-12-17 | グルタメート受容体アンタゴニストとしてのフェニルエテニルまたはフェニルエチニル誘導体 |
Country Status (31)
| Country | Link |
|---|---|
| US (4) | US6706707B2 (https=) |
| EP (1) | EP1349839B8 (https=) |
| JP (2) | JP4077317B2 (https=) |
| KR (1) | KR100515549B1 (https=) |
| CN (1) | CN1257894C (https=) |
| AR (1) | AR035401A1 (https=) |
| AT (1) | ATE288898T1 (https=) |
| AU (2) | AU2956702A (https=) |
| BG (1) | BG107877A (https=) |
| BR (1) | BR0115871A (https=) |
| CA (1) | CA2430696C (https=) |
| CZ (1) | CZ20031795A3 (https=) |
| DE (1) | DE60108900T2 (https=) |
| DK (1) | DK1349839T3 (https=) |
| EC (1) | ECSP034640A (https=) |
| ES (1) | ES2248410T3 (https=) |
| HR (1) | HRP20030429A2 (https=) |
| HU (1) | HUP0400570A3 (https=) |
| IL (2) | IL155999A0 (https=) |
| MA (1) | MA26971A1 (https=) |
| MX (1) | MXPA03004862A (https=) |
| NO (1) | NO324326B1 (https=) |
| NZ (1) | NZ525917A (https=) |
| PL (1) | PL366222A1 (https=) |
| PT (1) | PT1349839E (https=) |
| RS (1) | RS43903A (https=) |
| RU (1) | RU2284323C9 (https=) |
| SI (1) | SI1349839T1 (https=) |
| SK (1) | SK8402003A3 (https=) |
| WO (1) | WO2002046166A1 (https=) |
| ZA (1) | ZA200303870B (https=) |
Families Citing this family (51)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0128996D0 (en) | 2001-12-04 | 2002-01-23 | Novartis Ag | Organic compounds |
| AU2003264018A1 (en) | 2002-08-09 | 2004-02-25 | Astrazeneca Ab | Compounds having an activity at metabotropic glutamate receptors |
| MXPA05001592A (es) * | 2002-08-09 | 2005-05-05 | Astrazeneca Ab | Oxadiazoles como moduladores de receptor-5 de glutamato metabotropico. |
| IL166510A0 (en) | 2002-08-09 | 2006-01-15 | Nps Pharma Inc | 1,2,4"oxadiazole as modulators of metabotropic glutamate receptor-5 |
| ITMI20030151A1 (it) * | 2003-01-30 | 2004-07-31 | Recordati Ind Chimica E Farma Ceutica S P A | Uso di antagonisti selettivi del recettore mglu5 per il trattamento di disfunzioni neuromuscolari del tratto urinario inferiore. |
| ES2316968T3 (es) | 2003-03-04 | 2009-04-16 | Addex Pharma Sa | Nuevos derivados de aminopiridina utilizados como antagonistas de mglur5. |
| CA2517081A1 (en) | 2003-03-07 | 2004-09-16 | Astellas Pharma Inc. | Nitrogen-containing heterocyclic derivatives having 2-6, disubtituted styryl |
| TWI292318B (en) | 2003-03-10 | 2008-01-11 | Hoffmann La Roche | Imidazol-4-yl-ethynyl-pyridine derivatives |
| JP2006521358A (ja) * | 2003-03-26 | 2006-09-21 | メルク エンド カムパニー インコーポレーテッド | 代謝調節型グルタミン酸受容体のベンズアミドモジュレータ |
| US7531529B2 (en) | 2003-06-05 | 2009-05-12 | Roche Palo Alto Llc | Imidazole derivatives |
| UA80888C2 (en) * | 2003-06-05 | 2007-11-12 | Hoffmann La Roche | Imidazole derivatives as glutmate receptor antagonists |
| WO2004111040A1 (en) * | 2003-06-12 | 2004-12-23 | F. Hoffmann-La Roche Ag | Heteroaryl-substituted imdazole derivatives as glutamate receptor antagonists |
| US7915424B2 (en) * | 2004-03-22 | 2011-03-29 | Eli Lilly And Company | Pyridyl derivatives and their use as mGlu5 antagonists |
| MY149038A (en) * | 2004-05-26 | 2013-07-15 | Eisai R&D Man Co Ltd | Cinnamide compound |
| EP1756086B1 (en) * | 2004-06-01 | 2008-06-04 | F.Hoffmann-La Roche Ag | Pyridin-4-yl-ethynyl-imidazoles and pyrazoles as mglu5 receptor antagonists |
| KR100907108B1 (ko) * | 2004-06-01 | 2009-07-09 | 에프. 호프만-라 로슈 아게 | Ｍｇｌｕ5 수용체 길항제로서 피리딘-4-일-에틴일-이미다졸및 피라졸 |
| GB0413605D0 (en) | 2004-06-17 | 2004-07-21 | Addex Pharmaceuticals Sa | Novel compounds |
| DE102004044884A1 (de) | 2004-09-14 | 2006-05-24 | Grünenthal GmbH | Substituierte bizyklische Imidazo-3-yl-amin-Verbindungen |
| CA2580119A1 (en) | 2004-10-26 | 2006-05-04 | Eisai R & D Management Co., Ltd. | Amorphous object of cinnamide compound |
| KR20070106690A (ko) * | 2004-12-27 | 2007-11-05 | 아스트라제네카 아베 | 피라졸론 화합물 및 대사성 글루타메이트 수용체길항제로서 그들의 용도 |
| CA2601098C (en) * | 2005-03-16 | 2011-07-05 | Aventis Pharmaceuticals Inc. | Dipyrazoles as central nervous system agents |
| DE602006012815D1 (de) | 2005-03-23 | 2010-04-22 | Hoffmann La Roche | Acetylenylpyrazolopyrimidinderivate als mglur2-antagonsten |
| GB0508319D0 (en) | 2005-04-25 | 2005-06-01 | Novartis Ag | Organic compounds |
| AU2006316005A1 (en) * | 2005-11-18 | 2007-05-24 | Eisai R & D Management Co., Ltd. | Process for production of cinnamamide derivative |
| EP1953151A4 (en) * | 2005-11-18 | 2010-06-02 | Eisai R&D Man Co Ltd | SALTS FROM A CYNNAMIDE COMPOUND OR SOLVATE THEREOF |
| RU2381225C1 (ru) * | 2005-11-24 | 2010-02-10 | Эйсай Ар Энд Ди Менеджмент Ко., Лтд. | Производное циннамида типа морфолина |
| TWI370130B (en) | 2005-11-24 | 2012-08-11 | Eisai R&D Man Co Ltd | Two cyclic cinnamide compound |
| EP1965780B1 (en) * | 2005-12-19 | 2017-03-08 | The University Of Liverpool | Propofol derivatives as analgesics |
| DE102005062985A1 (de) * | 2005-12-28 | 2007-07-05 | Grünenthal GmbH | Substituierte bis(hetero)aromatische N-Ethylpropiolamide und ihre Verwendung zur Herstellung von Arzneimitteln |
| TWI378091B (en) * | 2006-03-09 | 2012-12-01 | Eisai R&D Man Co Ltd | Multi-cyclic cinnamide derivatives |
| AR059955A1 (es) * | 2006-03-09 | 2008-05-14 | Eisai R&D Man Co Ltd | Compuestos policiclicos no peptidicos, medicamentos que los contienen, y usos para prevenir o tratar enfermedades causadas por la produccion de beta amiloide |
| DE102006011574A1 (de) | 2006-03-10 | 2007-10-31 | Grünenthal GmbH | Substituierte Imidazo[2,1-b]thiazol-Verbindungen und ihre Verwendung zur Herstellung von Arzneimitteln |
| AR062095A1 (es) * | 2006-07-28 | 2008-10-15 | Eisai R&D Man Co Ltd | Profarmaco de compuesto cinamida |
| ES2577391T3 (es) | 2006-12-21 | 2016-07-14 | F. Hoffmann-La Roche Ag | Polimorfos de un antagonista del receptor mglur5 |
| CL2008000582A1 (es) | 2007-02-28 | 2008-06-27 | Eisai R&D Man Co Ltd | Compuestos ciclicos derivados de oximorfolina condensados; farmacos que comprenden a dichos compuestos; y su uso para tratar enfermedad de alzheimer, demencia senil, sindrome de down o amiloidosis. |
| WO2008140111A1 (ja) * | 2007-05-16 | 2008-11-20 | Eisai R & D Management Co., Ltd. | シンナミド誘導体のワンポット製造方法 |
| ES2529648T3 (es) | 2007-08-31 | 2015-02-24 | Eisai R&D Management Co., Ltd. | Compuesto policíclico |
| US7935815B2 (en) * | 2007-08-31 | 2011-05-03 | Eisai R&D Management Co., Ltd. | Imidazoyl pyridine compounds and salts thereof |
| US20100317860A1 (en) * | 2008-01-28 | 2010-12-16 | Ikuo Kushida | Crystalline cinnamide compounds or salts thereof |
| US8323805B2 (en) | 2009-06-04 | 2012-12-04 | Nitto Denko Corporation | Emissive aryl-heteroaryl acetylenes |
| US8334287B2 (en) | 2009-07-17 | 2012-12-18 | Hoffmann-La Roche Inc. | Imidazoles |
| US8642626B2 (en) | 2010-07-29 | 2014-02-04 | Taisho Pharmaceutical Co., Ltd. | Ethinyl-pyrazole derivative |
| HUE040156T2 (hu) * | 2010-11-05 | 2019-02-28 | Oat Agrio Co Ltd | Etinilfenilamidinvegyület vagy sója, eljárás azok elõállítására, és fungicid mezõgazdasági és kertészeti alkalmazásra |
| WO2012172093A1 (en) * | 2011-06-17 | 2012-12-20 | Merz Pharma Gmbh & Co. Kgaa | Dihydroindolizine derivate as metabotropic glutamate receptor modulators |
| KR101291037B1 (ko) * | 2011-10-12 | 2013-08-01 | 사회복지법인 삼성생명공익재단 | 레스베라트롤 유도체와 스티릴-오각형 방향족 화합물 및 이들의 베타-아밀로이드 플라그에 대한 결합제 및 진단영상제의 용도 |
| WO2017117708A1 (en) | 2016-01-05 | 2017-07-13 | Hua Medicine (Shanghai) Ltd. | Pyrazole derivatives |
| US10669255B2 (en) | 2016-04-06 | 2020-06-02 | Hua Medicine (Shanghai) Ltd. | Pyrrole derivatives |
| AU2018208422B2 (en) | 2017-01-10 | 2021-11-11 | Bayer Aktiengesellschaft | Heterocyclene derivatives as pest control agents |
| CA3066711A1 (en) | 2017-07-31 | 2019-02-07 | Novartis Ag | Use of mavoglurant in the reduction of cocaine use or in preventing relapse into cocaine use |
| US12479816B2 (en) | 2019-02-08 | 2025-11-25 | University of Pittsburgh—of the Commonwealth System of Higher Education | 20-HETE formation inhibitors |
| JP2023504177A (ja) | 2019-12-02 | 2023-02-01 | エフ．ホフマン－ラ ロシュ アーゲー | アルキニル－（ヘテロアリール）－カルボキサミドｈｃｎ１阻害剤 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3303199A (en) | 1963-07-15 | 1967-02-07 | Geigy Chem Corp | Certain imidazolone derivatives and process for making same |
| US3341548A (en) | 1964-04-29 | 1967-09-12 | Hoffmann La Roche | Nitroimidazoles and their preparation |
| DE2035905A1 (de) * | 1970-07-20 | 1972-02-03 | Chemische Fabrik Stockhausen & Cie.,4150Krefeld | Imidazolverbindungen und deren Herstellungsverfahren |
| CA1174673A (en) | 1981-02-27 | 1984-09-18 | Walter Hunkeler | Imidazodiazepines |
| US4711962A (en) | 1984-10-18 | 1987-12-08 | Stauffer Chemical Company | Process for selective preparation of ratios of isomers formed on N-substitution of asymmetric imidazoles |
| EP0479903B1 (en) | 1989-06-30 | 1996-02-21 | E.I. Du Pont De Nemours And Company | Substituted imidazoles useful as angiotensin ii blockers |
| US5821937A (en) * | 1996-02-23 | 1998-10-13 | Netsuite Development, L.P. | Computer method for updating a network design |
| TW544448B (en) * | 1997-07-11 | 2003-08-01 | Novartis Ag | Pyridine derivatives |
| PL192029B1 (pl) * | 1997-08-14 | 2006-08-31 | Hoffmann La Roche | Zastosowanie heterocyklicznych eterów winylowych, nowe heterocykliczne etery winylowe, sposób ich wytwarzania i środek farmaceutyczny |
| US6377987B1 (en) * | 1999-04-30 | 2002-04-23 | Cisco Technology, Inc. | Mechanism for determining actual physical topology of network based on gathered configuration information representing true neighboring devices |
| EP1214303A1 (en) * | 1999-08-31 | 2002-06-19 | Merck & Co., Inc. | Heterocyclic compounds and methods of use thereof |
-
2001
- 2001-11-26 MX MXPA03004862A patent/MXPA03004862A/es active IP Right Grant
- 2001-11-26 EP EP01990437A patent/EP1349839B8/en not_active Expired - Lifetime
- 2001-11-26 AU AU2956702A patent/AU2956702A/xx active Pending
- 2001-11-26 BR BR0115871-6A patent/BR0115871A/pt not_active Application Discontinuation
- 2001-11-26 KR KR10-2003-7007421A patent/KR100515549B1/ko not_active Expired - Fee Related
- 2001-11-26 CA CA002430696A patent/CA2430696C/en not_active Expired - Fee Related
- 2001-11-26 IL IL15599901A patent/IL155999A0/xx unknown
- 2001-11-26 NZ NZ525917A patent/NZ525917A/en unknown
- 2001-11-26 PL PL01366222A patent/PL366222A1/xx unknown
- 2001-11-26 PT PT01990437T patent/PT1349839E/pt unknown
- 2001-11-26 CZ CZ20031795A patent/CZ20031795A3/cs unknown
- 2001-11-26 AT AT01990437T patent/ATE288898T1/de active
- 2001-11-26 ES ES01990437T patent/ES2248410T3/es not_active Expired - Lifetime
- 2001-11-26 HR HR20030429A patent/HRP20030429A2/hr not_active Application Discontinuation
- 2001-11-26 AU AU2002229567A patent/AU2002229567B2/en not_active Ceased
- 2001-11-26 WO PCT/EP2001/013714 patent/WO2002046166A1/en not_active Ceased
- 2001-11-26 HU HU0400570A patent/HUP0400570A3/hu unknown
- 2001-11-26 DK DK01990437T patent/DK1349839T3/da active
- 2001-11-26 RS YU43903A patent/RS43903A/sr unknown
- 2001-11-26 SI SI200130304T patent/SI1349839T1/xx unknown
- 2001-11-26 CN CNB018199933A patent/CN1257894C/zh not_active Expired - Fee Related
- 2001-11-26 RU RU2003119548/04A patent/RU2284323C9/ru not_active IP Right Cessation
- 2001-11-26 SK SK840-2003A patent/SK8402003A3/sk unknown
- 2001-11-26 DE DE60108900T patent/DE60108900T2/de not_active Expired - Lifetime
- 2001-11-26 JP JP2002547905A patent/JP4077317B2/ja not_active Expired - Fee Related
- 2001-11-28 US US09/996,641 patent/US6706707B2/en not_active Expired - Fee Related
- 2001-12-03 AR ARP010105602A patent/AR035401A1/es unknown
-
2003
- 2003-03-25 US US10/396,172 patent/US6972299B2/en not_active Expired - Fee Related
- 2003-04-04 US US10/407,929 patent/US6927232B2/en not_active Expired - Fee Related
- 2003-05-19 ZA ZA200303870A patent/ZA200303870B/en unknown
- 2003-05-19 IL IL155999A patent/IL155999A/en not_active IP Right Cessation
- 2003-06-03 NO NO20032503A patent/NO324326B1/no not_active IP Right Cessation
- 2003-06-03 EC EC2003004640A patent/ECSP034640A/es unknown
- 2003-06-04 BG BG107877A patent/BG107877A/bg unknown
- 2003-06-04 MA MA27192A patent/MA26971A1/fr unknown
-
2005
- 2005-01-18 US US11/037,904 patent/US20050131043A1/en not_active Abandoned
-
2007
- 2007-12-17 JP JP2007325072A patent/JP2008169206A/ja active Pending