JP2004525965A5 - - Google Patents
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- JP2004525965A5 JP2004525965A5 JP2002581420A JP2002581420A JP2004525965A5 JP 2004525965 A5 JP2004525965 A5 JP 2004525965A5 JP 2002581420 A JP2002581420 A JP 2002581420A JP 2002581420 A JP2002581420 A JP 2002581420A JP 2004525965 A5 JP2004525965 A5 JP 2004525965A5
- Authority
- JP
- Japan
- Prior art keywords
- benzo
- dihydro
- phenyl
- diazepin
- trifluoromethyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 150000001875 compounds Chemical class 0.000 claims 36
- 125000000217 alkyl group Chemical group 0.000 claims 24
- -1 chloro, cyano, phenyl Chemical group 0.000 claims 22
- 125000003545 alkoxy group Chemical group 0.000 claims 21
- 125000004093 cyano group Chemical group *C#N 0.000 claims 6
- 229910052736 halogen Inorganic materials 0.000 claims 6
- 150000002367 halogens Chemical group 0.000 claims 6
- AZIZBYRGIGKTLW-UHFFFAOYSA-N 1,4-diazepin-2-one Chemical compound O=C1C=NC=CC=N1 AZIZBYRGIGKTLW-UHFFFAOYSA-N 0.000 claims 5
- 229910052739 hydrogen Inorganic materials 0.000 claims 5
- 239000001257 hydrogen Substances 0.000 claims 5
- 125000001462 1-pyrrolyl group Chemical group [*]N1C([H])=C([H])C([H])=C1[H] 0.000 claims 4
- YNAVUWVOSKDBBP-UHFFFAOYSA-N Morpholine Chemical compound C1COCCN1 YNAVUWVOSKDBBP-UHFFFAOYSA-N 0.000 claims 4
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 4
- 238000000034 method Methods 0.000 claims 4
- 239000002253 acid Substances 0.000 claims 3
- 125000003282 alkyl amino group Chemical group 0.000 claims 3
- JFDZBHWFFUWGJE-UHFFFAOYSA-N benzonitrile Chemical compound N#CC1=CC=CC=C1 JFDZBHWFFUWGJE-UHFFFAOYSA-N 0.000 claims 3
- 239000003814 drug Substances 0.000 claims 3
- 150000002431 hydrogen Chemical class 0.000 claims 3
- 150000003839 salts Chemical class 0.000 claims 3
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 claims 2
- 208000024827 Alzheimer disease Diseases 0.000 claims 2
- 208000028698 Cognitive impairment Diseases 0.000 claims 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 2
- 208000012902 Nervous system disease Diseases 0.000 claims 2
- 208000025966 Neurological disease Diseases 0.000 claims 2
- 208000028017 Psychotic disease Diseases 0.000 claims 2
- 230000001154 acute effect Effects 0.000 claims 2
- 230000001684 chronic effect Effects 0.000 claims 2
- 208000010877 cognitive disease Diseases 0.000 claims 2
- 125000001153 fluoro group Chemical group F* 0.000 claims 2
- 206010027175 memory impairment Diseases 0.000 claims 2
- 230000002265 prevention Effects 0.000 claims 2
- 238000007363 ring formation reaction Methods 0.000 claims 2
- 201000000980 schizophrenia Diseases 0.000 claims 2
- BRNULMACUQOKMR-UHFFFAOYSA-N thiomorpholine Chemical compound C1CSCCN1 BRNULMACUQOKMR-UHFFFAOYSA-N 0.000 claims 2
- QDKZHQGXPVFLHU-UHFFFAOYSA-N 1,5-benzodiazepin-2-one Chemical compound O=C1C=CN=C2C=CC=CC2=N1 QDKZHQGXPVFLHU-UHFFFAOYSA-N 0.000 claims 1
- KOZJGDMRNUDJER-UHFFFAOYSA-N 3-[2-oxo-8-(3-phenylpyrrol-1-yl)-1,3-dihydro-1,5-benzodiazepin-4-yl]benzonitrile Chemical compound C1=C2NC(=O)CC(C=3C=C(C=CC=3)C#N)=NC2=CC=C1N(C=1)C=CC=1C1=CC=CC=C1 KOZJGDMRNUDJER-UHFFFAOYSA-N 0.000 claims 1
- DJNCHHLJNKAOEQ-UHFFFAOYSA-N 4-(2-chlorophenyl)-1-[4-(3-cyanophenyl)-2-oxo-1,3-dihydro-1,5-benzodiazepin-8-yl]pyrrole-3-carbonitrile Chemical compound ClC1=CC=CC=C1C1=CN(C=2C=C3NC(=O)CC(=NC3=CC=2)C=2C=C(C=CC=2)C#N)C=C1C#N DJNCHHLJNKAOEQ-UHFFFAOYSA-N 0.000 claims 1
- KJFSUONZDZKWIS-UHFFFAOYSA-N 4-(3-imidazol-1-ylphenyl)-7-methyl-8-(trifluoromethyl)-1,3-dihydro-1,5-benzodiazepin-2-one Chemical compound C1C(=O)NC=2C=C(C(F)(F)F)C(C)=CC=2N=C1C(C=1)=CC=CC=1N1C=CN=C1 KJFSUONZDZKWIS-UHFFFAOYSA-N 0.000 claims 1
- ZMKXDWYSWILRNU-UHFFFAOYSA-N 4-(3-imidazol-1-ylphenyl)-8-pyrrol-1-yl-1,3-dihydro-1,5-benzodiazepin-2-one Chemical compound C1=C2NC(=O)CC(C=3C=C(C=CC=3)N3C=NC=C3)=NC2=CC=C1N1C=CC=C1 ZMKXDWYSWILRNU-UHFFFAOYSA-N 0.000 claims 1
- XSGXUFLAJGGFLE-UHFFFAOYSA-N 4-(3-iodophenyl)-8-pyrrol-1-yl-1,3-dihydro-1,5-benzodiazepin-2-one Chemical compound IC1=CC=CC(C=2CC(=O)NC3=CC(=CC=C3N=2)N2C=CC=C2)=C1 XSGXUFLAJGGFLE-UHFFFAOYSA-N 0.000 claims 1
- SRKGMKKYVLEGFO-UHFFFAOYSA-N 4-[3-(1,3-oxazol-2-yl)phenyl]-8-pyrrol-1-yl-1,3-dihydro-1,5-benzodiazepin-2-one Chemical compound C1=C2NC(=O)CC(C=3C=C(C=CC=3)C=3OC=CN=3)=NC2=CC=C1N1C=CC=C1 SRKGMKKYVLEGFO-UHFFFAOYSA-N 0.000 claims 1
- CNSZNKCNRBFDTH-UHFFFAOYSA-N 4-[3-(3-methyl-1,2-oxazol-5-yl)phenyl]-7-morpholin-4-yl-8-(trifluoromethyl)-1,3-dihydro-1,5-benzodiazepin-2-one Chemical compound O1N=C(C)C=C1C1=CC=CC(C=2CC(=O)NC3=CC(=C(N4CCOCC4)C=C3N=2)C(F)(F)F)=C1 CNSZNKCNRBFDTH-UHFFFAOYSA-N 0.000 claims 1
- VLPCKCKTCMYPOC-UHFFFAOYSA-N 4-[3-(3-methyl-1,2-oxazol-5-yl)phenyl]-8-pyrrol-1-yl-1,3-dihydro-1,5-benzodiazepin-2-one Chemical compound O1N=C(C)C=C1C1=CC=CC(C=2CC(=O)NC3=CC(=CC=C3N=2)N2C=CC=C2)=C1 VLPCKCKTCMYPOC-UHFFFAOYSA-N 0.000 claims 1
- ZDQNHJAROPROLE-UHFFFAOYSA-N 4-[3-[2-(hydroxymethyl)-5-methyl-1,3-thiazol-4-yl]phenyl]-7-methyl-8-(trifluoromethyl)-1,3-dihydro-1,5-benzodiazepin-2-one Chemical compound S1C(CO)=NC(C=2C=C(C=CC=2)C=2CC(=O)NC3=CC(=C(C)C=C3N=2)C(F)(F)F)=C1C ZDQNHJAROPROLE-UHFFFAOYSA-N 0.000 claims 1
- RJNFOFBZNNRQNC-UHFFFAOYSA-N 4-[3-[4-(hydroxymethyl)-1,3-oxazol-2-yl]phenyl]-8-pyrrol-1-yl-1,3-dihydro-1,5-benzodiazepin-2-one Chemical compound OCC1=COC(C=2C=C(C=CC=2)C=2CC(=O)NC3=CC(=CC=C3N=2)N2C=CC=C2)=N1 RJNFOFBZNNRQNC-UHFFFAOYSA-N 0.000 claims 1
- NPEZFSNOQFPSSH-UHFFFAOYSA-N 4-[3-[4-(hydroxymethyl)-1,3-thiazol-2-yl]phenyl]-8-pyrrol-1-yl-1,3-dihydro-1,5-benzodiazepin-2-one Chemical compound OCC1=CSC(C=2C=C(C=CC=2)C=2CC(=O)NC3=CC(=CC=C3N=2)N2C=CC=C2)=N1 NPEZFSNOQFPSSH-UHFFFAOYSA-N 0.000 claims 1
- NYXFGEQQLGOZMF-UHFFFAOYSA-N 4-[3-[5-[(cyclopropylamino)methyl]triazol-1-yl]phenyl]-7-ethoxy-8-(trifluoromethyl)-1,3-dihydro-1,5-benzodiazepin-2-one Chemical compound C1C(=O)NC=2C=C(C(F)(F)F)C(OCC)=CC=2N=C1C(C=1)=CC=CC=1N1N=NC=C1CNC1CC1 NYXFGEQQLGOZMF-UHFFFAOYSA-N 0.000 claims 1
- WMLMNBINHLZFDW-UHFFFAOYSA-N 4-[3-[5-[(cyclopropylamino)methyl]triazol-1-yl]phenyl]-7-methyl-8-(trifluoromethyl)-1,3-dihydro-1,5-benzodiazepin-2-one Chemical compound C1C(=O)NC=2C=C(C(F)(F)F)C(C)=CC=2N=C1C(C=1)=CC=CC=1N1N=NC=C1CNC1CC1 WMLMNBINHLZFDW-UHFFFAOYSA-N 0.000 claims 1
- NHGJLWKIZLSRKG-UHFFFAOYSA-N 4-[7-ethoxy-2-oxo-8-(trifluoromethyl)-1,3-dihydro-1,5-benzodiazepin-4-yl]pyridine-2-carbonitrile Chemical compound C1C(=O)NC=2C=C(C(F)(F)F)C(OCC)=CC=2N=C1C1=CC=NC(C#N)=C1 NHGJLWKIZLSRKG-UHFFFAOYSA-N 0.000 claims 1
- CPFQVRMETORQSM-UHFFFAOYSA-N 4-[7-methyl-2-oxo-8-(trifluoromethyl)-1,3-dihydro-1,5-benzodiazepin-4-yl]pyridine-2-carbonitrile Chemical compound C1C(=O)NC=2C=C(C(F)(F)F)C(C)=CC=2N=C1C1=CC=NC(C#N)=C1 CPFQVRMETORQSM-UHFFFAOYSA-N 0.000 claims 1
- MSXOSLFRXQXVGU-UHFFFAOYSA-N 4-[7-morpholin-4-yl-2-oxo-8-(trifluoromethyl)-1,3-dihydro-1,5-benzodiazepin-4-yl]pyridine-2-carbonitrile Chemical compound FC(F)(F)C1=CC=2NC(=O)CC(C=3C=C(N=CC=3)C#N)=NC=2C=C1N1CCOCC1 MSXOSLFRXQXVGU-UHFFFAOYSA-N 0.000 claims 1
- KUMADDIKXWCDPV-UHFFFAOYSA-N 7-chloro-4-(3-imidazol-1-ylphenyl)-8-(trifluoromethyl)-1,3-dihydro-1,5-benzodiazepin-2-one Chemical compound N=1C=2C=C(Cl)C(C(F)(F)F)=CC=2NC(=O)CC=1C(C=1)=CC=CC=1N1C=CN=C1 KUMADDIKXWCDPV-UHFFFAOYSA-N 0.000 claims 1
- BAEZFZTUGYMZBO-UHFFFAOYSA-N 7-chloro-4-[3-(1,2,4-triazol-1-yl)phenyl]-8-(trifluoromethyl)-1,3-dihydro-1,5-benzodiazepin-2-one Chemical compound N=1C=2C=C(Cl)C(C(F)(F)F)=CC=2NC(=O)CC=1C(C=1)=CC=CC=1N1C=NC=N1 BAEZFZTUGYMZBO-UHFFFAOYSA-N 0.000 claims 1
- OKALWKDYRBEXTK-UHFFFAOYSA-N 7-chloro-4-[3-(3-methyl-1,2-oxazol-5-yl)phenyl]-8-(trifluoromethyl)-1,3-dihydro-1,5-benzodiazepin-2-one Chemical compound O1N=C(C)C=C1C1=CC=CC(C=2CC(=O)NC3=CC(=C(Cl)C=C3N=2)C(F)(F)F)=C1 OKALWKDYRBEXTK-UHFFFAOYSA-N 0.000 claims 1
- PXTUROXJUIVEOU-UHFFFAOYSA-N 7-chloro-4-[3-(triazol-1-yl)phenyl]-8-(trifluoromethyl)-1,3-dihydro-1,5-benzodiazepin-2-one Chemical compound N=1C=2C=C(Cl)C(C(F)(F)F)=CC=2NC(=O)CC=1C(C=1)=CC=CC=1N1C=CN=N1 PXTUROXJUIVEOU-UHFFFAOYSA-N 0.000 claims 1
- QNDQOKDXZJHKLB-UHFFFAOYSA-N 7-ethoxy-4-[3-(triazol-1-yl)phenyl]-8-(trifluoromethyl)-1,3-dihydro-1,5-benzodiazepin-2-one Chemical compound C1C(=O)NC=2C=C(C(F)(F)F)C(OCC)=CC=2N=C1C(C=1)=CC=CC=1N1C=CN=N1 QNDQOKDXZJHKLB-UHFFFAOYSA-N 0.000 claims 1
- JGHOKBYVKJKPER-UHFFFAOYSA-N 7-ethoxy-4-[3-[5-[(2,2,2-trifluoroethylamino)methyl]triazol-1-yl]phenyl]-8-(trifluoromethyl)-1,3-dihydro-1,5-benzodiazepin-2-one Chemical compound C1C(=O)NC=2C=C(C(F)(F)F)C(OCC)=CC=2N=C1C(C=1)=CC=CC=1N1N=NC=C1CNCC(F)(F)F JGHOKBYVKJKPER-UHFFFAOYSA-N 0.000 claims 1
- WTFSUCJKQXRBRH-UHFFFAOYSA-N 7-methoxy-4-[3-(3-methyl-1,2-oxazol-5-yl)phenyl]-8-(trifluoromethyl)-1,3-dihydro-1,5-benzodiazepin-2-one Chemical compound C1C(=O)NC=2C=C(C(F)(F)F)C(OC)=CC=2N=C1C(C=1)=CC=CC=1C1=CC(C)=NO1 WTFSUCJKQXRBRH-UHFFFAOYSA-N 0.000 claims 1
- ILOJIYYHDKPLLX-UHFFFAOYSA-N 7-methyl-4-[3-(1,2,4-triazol-1-yl)phenyl]-8-(trifluoromethyl)-1,3-dihydro-1,5-benzodiazepin-2-one Chemical compound C1C(=O)NC=2C=C(C(F)(F)F)C(C)=CC=2N=C1C(C=1)=CC=CC=1N1C=NC=N1 ILOJIYYHDKPLLX-UHFFFAOYSA-N 0.000 claims 1
- KSFDHAWWRWUGAG-UHFFFAOYSA-N 7-methyl-4-[3-(3-methyl-1,2-oxazol-5-yl)phenyl]-8-(trifluoromethyl)-1,3-dihydro-1,5-benzodiazepin-2-one Chemical compound O1N=C(C)C=C1C1=CC=CC(C=2CC(=O)NC3=CC(=C(C)C=C3N=2)C(F)(F)F)=C1 KSFDHAWWRWUGAG-UHFFFAOYSA-N 0.000 claims 1
- JOYIPFAAAYEHOM-UHFFFAOYSA-N 7-methyl-4-[3-(triazol-1-yl)phenyl]-8-(trifluoromethyl)-1,3-dihydro-1,5-benzodiazepin-2-one Chemical compound C1C(=O)NC=2C=C(C(F)(F)F)C(C)=CC=2N=C1C(C=1)=CC=CC=1N1C=CN=N1 JOYIPFAAAYEHOM-UHFFFAOYSA-N 0.000 claims 1
- GBXAMFNGEMDBKL-UHFFFAOYSA-N 8-pyrrol-1-yl-4-[3-(triazol-1-yl)phenyl]-1,3-dihydro-1,5-benzodiazepin-2-one Chemical compound C1=C2NC(=O)CC(C=3C=C(C=CC=3)N3N=NC=C3)=NC2=CC=C1N1C=CC=C1 GBXAMFNGEMDBKL-UHFFFAOYSA-N 0.000 claims 1
- KEDCCDIPOFPVLE-UHFFFAOYSA-N COC1=CC2=C(C=C1C(F)(F)F)NCCC(=N2)C3=CC(=CC=C3)N4C=CN=N4 Chemical compound COC1=CC2=C(C=C1C(F)(F)F)NCCC(=N2)C3=CC(=CC=C3)N4C=CN=N4 KEDCCDIPOFPVLE-UHFFFAOYSA-N 0.000 claims 1
- 239000005973 Carvone Substances 0.000 claims 1
- 125000004453 alkoxycarbonyl group Chemical group 0.000 claims 1
- 125000004849 alkoxymethyl group Chemical group 0.000 claims 1
- 125000004390 alkyl sulfonyl group Chemical group 0.000 claims 1
- 125000004414 alkyl thio group Chemical group 0.000 claims 1
- 125000003277 amino group Chemical group 0.000 claims 1
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 claims 1
- 238000010511 deprotection reaction Methods 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 125000001301 ethoxy group Chemical group [H]C([H])([H])C([H])([H])O* 0.000 claims 1
- 125000004494 ethyl ester group Chemical group 0.000 claims 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 1
- 125000004029 hydroxymethyl group Chemical group [H]OC([H])([H])* 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 125000001424 substituent group Chemical group 0.000 claims 1
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 claims 1
- 125000004571 thiomorpholin-4-yl group Chemical group N1(CCSCC1)* 0.000 claims 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP01109126 | 2001-04-12 | ||
| PCT/EP2002/003643 WO2002083665A1 (en) | 2001-04-12 | 2002-04-02 | DIHYDRO-BENZO[b][1,4]DIAZEPIN-2-ONE DERIVATIVES AS MGLUR2 ANTAGONISTS I |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2004525965A JP2004525965A (ja) | 2004-08-26 |
| JP2004525965A5 true JP2004525965A5 (https=) | 2005-07-28 |
| JP4043953B2 JP4043953B2 (ja) | 2008-02-06 |
Family
ID=8177127
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002581420A Expired - Fee Related JP4043953B2 (ja) | 2001-04-12 | 2002-04-02 | ｍＧｌｕＲ２アンタゴニストＩとしてのジヒドロ−ベンゾ〔ｂ〕〔１，４〕ジアゼピン−２−オン誘導体 |
Country Status (37)
Families Citing this family (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE261945T1 (de) | 1999-10-15 | 2004-04-15 | Hoffmann La Roche | Benzodiazepinderivate und deren verwendung als metabotrope glutamatrezeptor antagonisten |
| ES2293287T3 (es) * | 2003-07-25 | 2008-03-16 | F. Hoffmann-La Roche Ag | Combinacion de antagonista de mglur2 y de inhibidor de ache para el tratamiento de trastornos neurologicos agudos y/o cronicos. |
| ES2309814T3 (es) | 2004-11-05 | 2008-12-16 | F. Hoffmann-La Roche Ag | Proceso para la obtencion de derivados del acido isonicotinico. |
| AR059898A1 (es) | 2006-03-15 | 2008-05-07 | Janssen Pharmaceutica Nv | Derivados de 3-ciano-piridona 1,4-disustituida y su uso como moduladores alostericos de los receptores mglur2 |
| TW200845978A (en) | 2007-03-07 | 2008-12-01 | Janssen Pharmaceutica Nv | 3-cyano-4-(4-tetrahydropyran-phenyl)-pyridin-2-one derivatives |
| TW200900065A (en) | 2007-03-07 | 2009-01-01 | Janssen Pharmaceutica Nv | 3-cyano-4-(4-pyridinyloxy-phenyl)-pyridin-2-one derivatives |
| ES2369866T3 (es) * | 2007-04-19 | 2011-12-07 | F. Hoffmann-La Roche Ag | Derivados de dihidro-benzo[b][1,4]diazepin-2-ona-sulfonamida. |
| PL2200985T3 (pl) | 2007-09-14 | 2011-12-30 | Ortho Mcneil Janssen Pharmaceuticals Inc | 1,3-Dipodstawione-4-(arylo-X-fenylo)-1H-pirydyn-2-ony |
| CN101801930B (zh) * | 2007-09-14 | 2013-01-30 | 奥梅-杨森制药有限公司 | 1,3-二取代的-4-苯基-1h-吡啶-2-酮 |
| SI2203439T1 (sl) | 2007-09-14 | 2011-05-31 | Ortho Mcneil Janssen Pharm | 1',3'-disubstituirani 4-fenil-3,4,5,6-tetrahidro-2H-1'H-(1,4')bipiridinil-2'-oni |
| CN101861316B (zh) | 2007-11-14 | 2013-08-21 | 奥梅-杨森制药有限公司 | 咪唑并[1,2-a]吡啶衍生物及其作为MGLUR2受体的正变构调节剂的用途 |
| EP2344470B1 (en) | 2008-09-02 | 2013-11-06 | Janssen Pharmaceuticals, Inc. | 3-azabicyclo[3.1.0]hexyl derivatives as modulators of metabotropic glutamate receptors |
| WO2010043396A1 (en) | 2008-10-16 | 2010-04-22 | Ortho-Mcneil-Janssen Pharmaceuticals, Inc. | Indole and benzomorpholine derivatives as modulators of metabotropic glutamate receptors |
| JP5690277B2 (ja) | 2008-11-28 | 2015-03-25 | ジャンセン ファーマシューティカルズ， インコーポレイテッド． | 代謝型グルタミン酸受容体の調節因子としてのインドールおよびベンゾオキサジン誘導体 |
| CN102439008B (zh) | 2009-05-12 | 2015-04-29 | 杨森制药有限公司 | 1,2,4-三唑并[4,3-a]吡啶衍生物及其用于治疗或预防神经和精神病症的用途 |
| MY153913A (en) | 2009-05-12 | 2015-04-15 | Janssen Pharmaceuticals Inc | 7-aryl-1,2,4-triazolo[4,3-a]pyridine derivatives and their use as positive allosteric modulators of mglur2 receptors |
| BRPI1010831A2 (pt) | 2009-05-12 | 2016-04-05 | Addex Pharmaceuticals Sa | derivados de 1,2,4-triazolo[4,3-a]piridina e seu como moduladores alostéricos positivos de receptores de mglur2 |
| US9271967B2 (en) | 2010-11-08 | 2016-03-01 | Janssen Pharmaceuticals, Inc. | 1,2,4-triazolo[4,3-a]pyridine derivatives and their use as positive allosteric modulators of mGluR2 receptors |
| ES2536433T3 (es) | 2010-11-08 | 2015-05-25 | Janssen Pharmaceuticals, Inc. | Derivados de 1,2,4-triazolo[4,3-a]piridina y su uso como moduladores alostéricos positivos de receptores mGluR2 |
| AU2011328203B2 (en) | 2010-11-08 | 2015-03-19 | Janssen Pharmaceuticals, Inc. | 1,2,4-triazolo[4,3-a]pyridine derivatives and their use as positive allosteric modulators of mGluR2 receptors |
| EP2602248A1 (en) | 2011-12-05 | 2013-06-12 | University Of Leicester | Novel pyrrole compounds |
| CN104736140A (zh) | 2012-10-23 | 2015-06-24 | 霍夫曼-拉罗奇有限公司 | 用于治疗自闭症的mGlu2/3拮抗剂 |
| JP5654715B1 (ja) * | 2013-02-28 | 2015-01-14 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | テトラヒドロイミダゾ［１，５−ｄ］［１，４］オキサゼピン誘導体（ＴＥＴＲＡＨＹＤＲＯＩＭＩＤＡＺＯ［１，５−ｄ］［１，４］ＯＸＡＺＥＰＩＮＥＤＥＲＩＶＡＴＩＶＥ） |
| JO3368B1 (ar) | 2013-06-04 | 2019-03-13 | Janssen Pharmaceutica Nv | مركبات 6، 7- ثاني هيدرو بيرازولو [5،1-a] بيرازين- 4 (5 يد)- اون واستخدامها بصفة منظمات تفارغية سلبية لمستقبلات ميجلور 2 |
| JO3367B1 (ar) | 2013-09-06 | 2019-03-13 | Janssen Pharmaceutica Nv | مركبات 2،1، 4- ثلاثي زولو [3،4-a] بيريدين واستخدامها بصفة منظمات تفارغية موجبة لمستقبلات ميجلور 2 |
| MX386697B (es) | 2014-01-21 | 2025-03-19 | Janssen Pharmaceutica Nv | Combinaciones que comprenden agonistas ortostericos o moduladores alostericos positivos del receptor glutamatergico metabotropico de subtipo 2 y su uso |
| ME03518B (me) | 2014-01-21 | 2020-04-20 | Janssen Pharmaceutica Nv | Kombinacije koje obuhvataju pozitivne alosterične modulatore ili ortosterične agoniste metabotropnog glutamatergičnog receptora podtipa 2 i njihova primjena |
| JP2017513844A (ja) | 2014-04-23 | 2017-06-01 | エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ | 知的障害の処置のためのｍＧｌｕ２／３アンタゴニスト |
| WO2015191630A1 (en) * | 2014-06-10 | 2015-12-17 | Sanford-Burnham Medical Research Institute | Metabotropic glutamate receptor negative allosteric modulators (nams) and uses thereof |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SU953819A1 (ru) * | 1980-08-25 | 1991-09-23 | Физико-химический институт АН УССР | 1-(Гидразинокарбонил)алкил-1,2-дигидро-3Н-1,4-бенздиазепин-2-оны, обладающие транквилизирующими и противосудорожными свойствами |
| MXPA02001340A (es) * | 1999-08-05 | 2004-07-16 | Prescient Neuropharma Inc | Compuestos novedosos 1,4-benzodiazepina y derivados de los mismos. |
| BR0014859A (pt) * | 1999-10-15 | 2002-07-16 | Hoffmann La Roche | Derivados de benzodiazepina |
| ATE261945T1 (de) * | 1999-10-15 | 2004-04-15 | Hoffmann La Roche | Benzodiazepinderivate und deren verwendung als metabotrope glutamatrezeptor antagonisten |
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