JP2011517457A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2011517457A5 JP2011517457A5 JP2011503076A JP2011503076A JP2011517457A5 JP 2011517457 A5 JP2011517457 A5 JP 2011517457A5 JP 2011503076 A JP2011503076 A JP 2011503076A JP 2011503076 A JP2011503076 A JP 2011503076A JP 2011517457 A5 JP2011517457 A5 JP 2011517457A5
- Authority
- JP
- Japan
- Prior art keywords
- oxepin
- thieno
- dihydrobenzo
- methyl
- carboxamide
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 0 *c(c(*)c1-2)c(*)c(*)c1OCCc1c-2[s]c(C(N(*)*)=O)c1 Chemical compound *c(c(*)c1-2)c(*)c(*)c1OCCc1c-2[s]c(C(N(*)*)=O)c1 0.000 description 4
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US4082708P | 2008-03-31 | 2008-03-31 | |
| US61/040,827 | 2008-03-31 | ||
| US10222008P | 2008-10-02 | 2008-10-02 | |
| US61/102,220 | 2008-10-02 | ||
| PCT/US2009/038795 WO2009123971A1 (en) | 2008-03-31 | 2009-03-30 | Benzopyran and benzoxepin pi3k inhibitor compounds and methods of use |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2011517457A JP2011517457A (ja) | 2011-06-09 |
| JP2011517457A5 true JP2011517457A5 (https=) | 2012-05-24 |
| JP5511786B2 JP5511786B2 (ja) | 2014-06-04 |
Family
ID=40790991
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011503076A Active JP5511786B2 (ja) | 2008-03-31 | 2009-03-30 | ベンゾピランおよびベンゾキセピンｐｉ３ｋ阻害剤化合物および使用方法 |
Country Status (21)
| Country | Link |
|---|---|
| US (4) | US7928248B2 (https=) |
| EP (1) | EP2276767B1 (https=) |
| JP (1) | JP5511786B2 (https=) |
| KR (1) | KR101626996B1 (https=) |
| CN (1) | CN102333779B (https=) |
| AR (1) | AR071112A1 (https=) |
| AU (1) | AU2009231885B2 (https=) |
| BR (1) | BRPI0910346A2 (https=) |
| CA (1) | CA2719032C (https=) |
| CL (1) | CL2009000780A1 (https=) |
| DK (1) | DK2276767T3 (https=) |
| ES (1) | ES2480994T3 (https=) |
| IL (1) | IL208359A (https=) |
| MX (1) | MX2010010659A (https=) |
| PE (1) | PE20091720A1 (https=) |
| PL (1) | PL2276767T3 (https=) |
| RU (1) | RU2506267C2 (https=) |
| SI (1) | SI2276767T1 (https=) |
| TW (1) | TWI443102B (https=) |
| WO (1) | WO2009123971A1 (https=) |
| ZA (1) | ZA201007218B (https=) |
Families Citing this family (58)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9029411B2 (en) | 2008-01-25 | 2015-05-12 | Millennium Pharmaceuticals, Inc. | Thiophenes and uses thereof |
| MX2010010659A (es) | 2008-03-31 | 2010-10-26 | Genentech Inc | Compuestos de benzopirano y benzoxepina, inhibidores de fosfoinoinositida 3-cinasas y metodos para utilizarlos. |
| WO2010090716A1 (en) | 2009-01-30 | 2010-08-12 | Millennium Pharmaceuticals, Inc. | Heteroaryls and their use as pi3k inhibitors |
| US9090601B2 (en) | 2009-01-30 | 2015-07-28 | Millennium Pharmaceuticals, Inc. | Thiazole derivatives |
| US8796314B2 (en) | 2009-01-30 | 2014-08-05 | Millennium Pharmaceuticals, Inc. | Heteroaryls and uses thereof |
| US20100233733A1 (en) * | 2009-02-10 | 2010-09-16 | Nodality, Inc., A Delaware Corporation | Multiple mechanisms for modulation of the pi3 kinase pathway |
| AU2010268058A1 (en) * | 2009-07-02 | 2012-01-19 | Novartis Ag | 2-carboxamide cycloamino ureas useful as PI3K inhibitors |
| MY160064A (en) | 2009-09-28 | 2017-02-15 | Hoffmann La Roche | Benzoxazepin pi3k inhibitor compounds and methods of use |
| US8263633B2 (en) | 2009-09-28 | 2012-09-11 | F. Hoffman-La Roche Ag | Benzoxepin PI3K inhibitor compounds and methods of use |
| WO2011049625A1 (en) | 2009-10-20 | 2011-04-28 | Mansour Samadpour | Method for aflatoxin screening of products |
| US9216972B2 (en) * | 2009-10-29 | 2015-12-22 | Bristol-Myers Squibb Company | Tricyclic heterocyclic compounds |
| NZ599830A (en) | 2009-11-05 | 2014-08-29 | Rhizen Pharmaceuticals Sa | Novel kinase modulators |
| EA201290305A1 (ru) * | 2009-11-13 | 2012-12-28 | Мерк Сероно С.А. | Производные трициклического пиразоламина |
| WO2011063126A1 (en) * | 2009-11-18 | 2011-05-26 | Satoshi Ohtake | Highly dispersible powders, compositions and methods for preparation |
| US8859768B2 (en) | 2010-08-11 | 2014-10-14 | Millennium Pharmaceuticals, Inc. | Heteroaryls and uses thereof |
| TW201217365A (en) | 2010-08-11 | 2012-05-01 | Millennium Pharm Inc | Heteroaryls and uses thereof |
| WO2012021611A1 (en) | 2010-08-11 | 2012-02-16 | Millennium Pharmaceuticals, Inc. | Heteroaryls and uses thereof |
| TW201307309A (zh) * | 2010-10-13 | 2013-02-16 | Millennium Pharm Inc | 雜芳基化合物及其用途 |
| US9090628B2 (en) | 2011-03-21 | 2015-07-28 | Genentech, Inc. | Benzoxazepin compounds selective for PI3K P110 delta and methods of use |
| PH12013502240B1 (en) | 2011-05-04 | 2018-06-27 | Rhizen Pharmaceuticals Sa | Novel compounds as modulators of protein kinase |
| ES2715832T3 (es) | 2011-05-27 | 2019-06-06 | Lexicon Pharmaceuticals Inc | Inhibidores a base de 4H-tieno[3,2-c]-cromeno de pectina acetilesterasa de notum y métodos de utilización de los mismos |
| US9034866B2 (en) | 2012-02-17 | 2015-05-19 | Genentech, Inc. | Tricyclic compounds and methods of use therefor |
| US8940742B2 (en) * | 2012-04-10 | 2015-01-27 | Infinity Pharmaceuticals, Inc. | Heterocyclic compounds and uses thereof |
| KR20160027219A (ko) | 2012-05-23 | 2016-03-09 | 에프. 호프만-라 로슈 아게 | 내배엽 및 간세포를 수득하고 사용하는 조성물 및 방법 |
| RS56494B1 (sr) | 2012-07-04 | 2018-01-31 | Rhizen Pharmaceuticals S A | Selektivni inhibitori pi3k delta |
| US20150258127A1 (en) | 2012-10-31 | 2015-09-17 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods for preventing antiphospholipid syndrome (aps) |
| MX2015011438A (es) | 2013-03-13 | 2016-02-03 | Hoffmann La Roche | Procedimiento para preparar compuestos benzoxazepina. |
| CA2905123A1 (en) | 2013-03-15 | 2014-09-18 | Genentech, Inc. | Methods of treating cancer and preventing cancer drug resistance |
| KR20160061911A (ko) | 2013-04-08 | 2016-06-01 | 데니스 엠. 브라운 | 최적하 투여된 화학 화합물의 치료 효과 |
| PT3052485T (pt) | 2013-10-04 | 2021-10-22 | Infinity Pharmaceuticals Inc | Compostos heterocíclicos e suas utilizações |
| US9751888B2 (en) | 2013-10-04 | 2017-09-05 | Infinity Pharmaceuticals, Inc. | Heterocyclic compounds and uses thereof |
| MX382033B (es) | 2014-03-19 | 2025-03-13 | Infinity Pharmaceuticals Inc | Compuestos heterocíclicos para utilizarlos en el tratamiento de trastornos mediados por pi3k-gamma. |
| WO2016054491A1 (en) | 2014-10-03 | 2016-04-07 | Infinity Pharmaceuticals, Inc. | Heterocyclic compounds and uses thereof |
| JP6454419B2 (ja) | 2014-12-11 | 2019-01-16 | ナトコ ファーマ リミテッド | 抗癌剤としての７−（モルホリニル）−２−（Ｎ−ピペラジニル）メチルチエノ［２，３−ｃ］ピリジン誘導体 |
| WO2016157221A1 (en) | 2015-03-30 | 2016-10-06 | Jubilant Biosys Limited | Tricyclic fused derivatives of 1-(cyclo)alkyl pyridin-2-one useful for the treatment of cancer |
| WO2017048702A1 (en) | 2015-09-14 | 2017-03-23 | Infinity Pharmaceuticals, Inc. | Solid forms of isoquinolinone derivatives, process of making, compositions comprising, and methods of using the same |
| WO2017161116A1 (en) | 2016-03-17 | 2017-09-21 | Infinity Pharmaceuticals, Inc. | Isotopologues of isoquinolinone and quinazolinone compounds and uses thereof as pi3k kinase inhibitors |
| WO2017214269A1 (en) | 2016-06-08 | 2017-12-14 | Infinity Pharmaceuticals, Inc. | Heterocyclic compounds and uses thereof |
| UA124972C2 (uk) | 2016-07-29 | 2021-12-22 | Янссен Фармацевтика Нв | Способи лікування раку передміхурової залози |
| KR102482825B1 (ko) | 2016-09-02 | 2022-12-29 | 브리스톨-마이어스 스큅 컴퍼니 | 치환된 트리시클릭 헤테로시클릭 화합물 |
| TW201815787A (zh) | 2016-09-23 | 2018-05-01 | 美商基利科學股份有限公司 | 磷脂醯肌醇3-激酶抑制劑 |
| TW201813963A (zh) | 2016-09-23 | 2018-04-16 | 美商基利科學股份有限公司 | 磷脂醯肌醇3-激酶抑制劑 |
| TW201825465A (zh) | 2016-09-23 | 2018-07-16 | 美商基利科學股份有限公司 | 磷脂醯肌醇3-激酶抑制劑 |
| CA3070073A1 (en) | 2017-07-18 | 2019-01-24 | Nuvation Bio Inc. | 1,8-naphthyridinone compounds and uses thereof |
| CN111163780A (zh) | 2017-07-18 | 2020-05-15 | 诺维逊生物股份有限公司 | 作为腺苷拮抗剂的杂环化合物 |
| US11046646B2 (en) | 2017-08-09 | 2021-06-29 | Bristol-Myers Squibb Company | Alkylphenyl compounds |
| US11059784B2 (en) | 2017-08-09 | 2021-07-13 | Bristol-Myers Squibb Company | Oxime ether compounds |
| CN107805255B (zh) * | 2017-09-22 | 2020-06-16 | 中国药科大学 | 呋喃[3，2-b]吡啶-2(1H)-酮类化合物、制备方法和医药用途 |
| EP3762379A1 (en) | 2018-03-07 | 2021-01-13 | Bayer Aktiengesellschaft | Identification and use of erk5 inhibitors |
| CN110467629B (zh) * | 2018-05-09 | 2022-04-08 | 上海迪诺医药科技有限公司 | 苯醌衍生物、其药物组合物及应用 |
| AU2020208644A1 (en) | 2019-01-18 | 2021-08-26 | Nuvation Bio Inc. | Heterocyclic compounds as adenosine antagonists |
| WO2020150676A1 (en) | 2019-01-18 | 2020-07-23 | Nuvation Bio Inc. | 1,8-naphthyridinone compounds and uses thereof |
| CN114156414B (zh) * | 2021-11-30 | 2024-05-31 | 合肥工业大学 | 一种高效稳定CsPbI3无机钙钛矿电池的制备方法 |
| CN117209457B (zh) * | 2022-06-09 | 2025-08-15 | 四川师范大学 | 一种α-手性脒化合物的合成 |
| CN115403591A (zh) * | 2022-10-08 | 2022-11-29 | 河南师范大学 | 一种合成萘并噻吩并奥塞平并异喹啉酮类化合物的方法 |
| WO2025082467A1 (zh) * | 2023-10-19 | 2025-04-24 | 成都先导药物开发股份有限公司 | 一种免疫调节剂 |
| CN117736200A (zh) * | 2023-12-18 | 2024-03-22 | 西安交通大学 | 2-[(6H-二苯并[b,d]吡喃-3-基)氧]酰胺类衍生物及其制备方法和应用 |
| CN117736199A (zh) * | 2023-12-18 | 2024-03-22 | 西安交通大学 | 一种3位含氧基取代的6H-二苯并[b,d]吡喃类衍生物及其制备方法和应用 |
Family Cites Families (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8504702D0 (en) * | 1985-02-23 | 1985-03-27 | Zyma Sa | Tricyclic compounds |
| FR2677356B1 (fr) * | 1991-06-05 | 1995-03-17 | Sanofi Sa | Derives heterocycliques d'acylamino-2 thiazoles-5 substitues, leur preparation et compositions pharmaceutiques en contenant. |
| EP0638071B1 (en) * | 1992-12-28 | 1997-04-09 | Eisai Co., Ltd. | Heterocyclic carbonic acid derivatives which bind to retinoid receptors (rar) |
| US5985799A (en) * | 1995-11-17 | 1999-11-16 | E.I. Du Pont De Nemours And Company | Tricyclic herbicidal heterocycles |
| DE19831878C2 (de) * | 1998-07-17 | 2001-05-17 | Aventis Pharma Gmbh | Polycyclische Thiazolidin-2-yliden Amine, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel |
| DE19908538A1 (de) * | 1999-02-26 | 2000-08-31 | Aventis Pharma Gmbh | Polycyclische 2-Amino-Thiazol Systeme, Verfahren zu ihrer Herstellung und Arzneimittel enthaltend diese Verbindungen |
| DE19908535A1 (de) * | 1999-02-26 | 2000-08-31 | Aventis Pharma Gmbh | Verwendung von polycyclischen Thiazol-Systemen zur Herstellung von Medikamenten zur Prophylaxe oder Behandlung von Obesitas |
| DE19908537A1 (de) * | 1999-02-26 | 2000-08-31 | Aventis Pharma Gmbh | Verwendung von polycyclischen 2-Amino-Thiazol Systemen zur Herstellung von Medikamenten zur Prophylaxe oder Behandlung von Obesitas |
| DE19908533A1 (de) * | 1999-02-26 | 2000-08-31 | Aventis Pharma Gmbh | Polycyclische Thiazol-Systeme, Verfahren zu ihrer Herstellung und Arzneimittel enthaltend diese Verbindungen |
| US7273880B2 (en) * | 1999-06-30 | 2007-09-25 | H. Lunbeck A/S | Selective NPY (Y5) antagonists |
| WO2001064675A1 (en) | 2000-03-03 | 2001-09-07 | Novartis Ag | Condensed thiazolamines and their use as neuropeptide y5 antagonists |
| US20040198791A1 (en) * | 2001-06-05 | 2004-10-07 | Yoshinari Sato | Fused imidazole derivative |
| BR0312780A (pt) * | 2002-07-19 | 2005-05-03 | Pharmacia Corp | Compostos de tiofeno-carboxamida substituìda para o tratamento de inflamação |
| JP2006516990A (ja) * | 2003-02-07 | 2006-07-13 | ワーナー−ランバート カンパニー リミティド ライアビリティー カンパニー | 抗菌剤として使用するための、三環式の環でｎ置換したオキサゾリジノン誘導体 |
| EP2343303A1 (de) * | 2004-10-07 | 2011-07-13 | Boehringer Ingelheim International GmbH | PI3-Kinase Inhibitoren |
| CN101039667A (zh) * | 2004-10-15 | 2007-09-19 | 辉瑞大药厂 | 双相性精神障碍和相关症状的治疗 |
| RU2281947C1 (ru) * | 2005-07-05 | 2006-08-20 | Общество С Ограниченной Ответственностью "Исследовательский Институт Химического Разнообразия" | Аннелированные карбамоилазагетероциклы, фокусированная библиотека, фармацевтическая композиция и способ получения |
| CA2659956C (en) * | 2006-08-04 | 2016-01-05 | Lewis C. Cantley | Inhibitors of pyruvate kinase and methods of treating disease |
| US8779154B2 (en) * | 2006-09-26 | 2014-07-15 | Qinglin Che | Fused ring compounds for inflammation and immune-related uses |
| MX2010010659A (es) | 2008-03-31 | 2010-10-26 | Genentech Inc | Compuestos de benzopirano y benzoxepina, inhibidores de fosfoinoinositida 3-cinasas y metodos para utilizarlos. |
-
2009
- 2009-03-30 MX MX2010010659A patent/MX2010010659A/es active IP Right Grant
- 2009-03-30 JP JP2011503076A patent/JP5511786B2/ja active Active
- 2009-03-30 RU RU2010143319/04A patent/RU2506267C2/ru not_active IP Right Cessation
- 2009-03-30 WO PCT/US2009/038795 patent/WO2009123971A1/en not_active Ceased
- 2009-03-30 BR BRPI0910346A patent/BRPI0910346A2/pt not_active IP Right Cessation
- 2009-03-30 CA CA2719032A patent/CA2719032C/en not_active Expired - Fee Related
- 2009-03-30 KR KR1020107024488A patent/KR101626996B1/ko not_active Expired - Fee Related
- 2009-03-30 ES ES09726963.3T patent/ES2480994T3/es active Active
- 2009-03-30 SI SI200930981T patent/SI2276767T1/sl unknown
- 2009-03-30 PE PE2009000466A patent/PE20091720A1/es not_active Application Discontinuation
- 2009-03-30 TW TW098110447A patent/TWI443102B/zh not_active IP Right Cessation
- 2009-03-30 DK DK09726963.3T patent/DK2276767T3/da active
- 2009-03-30 US US12/414,403 patent/US7928248B2/en active Active
- 2009-03-30 EP EP09726963.3A patent/EP2276767B1/en active Active
- 2009-03-30 PL PL09726963T patent/PL2276767T3/pl unknown
- 2009-03-30 CL CL2009000780A patent/CL2009000780A1/es unknown
- 2009-03-30 AR ARP090101126A patent/AR071112A1/es not_active Application Discontinuation
- 2009-03-30 CN CN200980120112.8A patent/CN102333779B/zh active Active
- 2009-03-30 AU AU2009231885A patent/AU2009231885B2/en not_active Ceased
-
2010
- 2010-10-03 IL IL208359A patent/IL208359A/en not_active IP Right Cessation
- 2010-10-08 ZA ZA2010/07218A patent/ZA201007218B/en unknown
-
2011
- 2011-01-31 US US13/018,068 patent/US8399690B2/en active Active
-
2013
- 2013-01-10 US US13/738,846 patent/US8846762B2/en active Active
-
2014
- 2014-07-29 US US14/446,154 patent/US9309265B2/en active Active
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| RU2506267C2 (ru) | Бензопирановые и бензоксепиновые ингибиторы рi3k и их применение | |
| JP2011517457A5 (https=) | ||
| US11524938B2 (en) | Aromatic sulfonamide derivatives | |
| TWI902864B (zh) | 新穎二唑系選擇性ｈｄａｃ６抑制劑及其用途 | |
| RU2015104301A (ru) | Бензоксепиновые ингибиторы р13 и способы применения | |
| JP2004525965A5 (https=) | ||
| JP2007523182A5 (https=) | ||
| JP2008526723A5 (https=) | ||
| RU2006130683A (ru) | Производные 3-замещенного 1, 5-дифенилпиразола, полезные в качестве св1 модуляторов | |
| KR20130004316A (ko) | 비스아릴-결합된 아릴트리아졸론 및 그의 용도 | |
| RU2016141646A (ru) | Ингибиторы trka киназы, основанные на них композиции и способы | |
| EA010132B1 (ru) | Производные триазола в качестве антагонистов вазопрессина | |
| EA029718B1 (ru) | Бифтордиоксалан-аминобензимидазольные ингибиторы киназы для лечения рака, аутоиммунного воспаления и нарушений цнс | |
| RU2006135482A (ru) | Терапевтические агенты | |
| US9650377B2 (en) | Diazepinone derivatives | |
| EA040608B1 (ru) | Ароматические сульфонамидные производные |