|
JPS63276054A
(ja)
|
1987-05-07 |
1988-11-14 |
Hitachi Chem Co Ltd |
電子写真感光体
|
|
CA2009925C
(en)
|
1989-02-14 |
2002-10-01 |
Koichi Kondo |
Method for enhancement of chemiluminescence
|
|
EP0553009B1
(fr)
|
1992-01-23 |
1997-06-04 |
Institut Francais Du Petrole |
Catalyseur d'alkylation de paraffines
|
|
ATE205202T1
(de)
|
1992-03-13 |
2001-09-15 |
Merck Sharp & Dohme |
Imidazol-, triazol- und tetrazolderivate
|
|
US5348969A
(en)
|
1992-04-03 |
1994-09-20 |
Bristol-Myers Squibb Company |
Diphenyloxazolyl-oxazoles as platelet aggregation inhibitors
|
|
AU5118893A
(en)
|
1992-10-13 |
1994-05-09 |
Nippon Soda Co., Ltd. |
Oxazole and thiazole derivatives
|
|
ATE202571T1
(de)
|
1993-09-14 |
2001-07-15 |
Merck & Co Inc |
Humane protein-tyrosinphosphatase decodierende cdna
|
|
US5616601A
(en)
|
1994-07-28 |
1997-04-01 |
Gd Searle & Co |
1,2-aryl and heteroaryl substituted imidazolyl compounds for the treatment of inflammation
|
|
ES2247604T3
(es)
|
1995-06-12 |
2006-03-01 |
G.D. SEARLE & CO. |
Composiciones que comprenden un inhibidor de ciclooxigenasa-2 y un inhibidor de 5-lipoxigenasa.
|
|
US5700816A
(en)
|
1995-06-12 |
1997-12-23 |
Isakson; Peter C. |
Treatment of inflammation and inflammation-related disorders with a combination of a cyclooxygenase-2 inhibitor and a leukotriene A4 hydrolase inhibitor
|
|
US6388076B1
(en)
|
1995-06-19 |
2002-05-14 |
Ontogen Corporation |
Protein tyrosine phosphatase-inhibiting compounds
|
|
US5753687A
(en)
|
1995-06-19 |
1998-05-19 |
Ontogen Corporation |
Modulators of proteins with phosphotryrosine recognition units
|
|
JP3849157B2
(ja)
|
1995-08-01 |
2006-11-22 |
東ソー株式会社 |
2−イミダゾリン類の製造法
|
|
US6238902B1
(en)
|
1996-03-22 |
2001-05-29 |
Genentech, Inc. |
Protein tyrosine phosphatases
|
|
US5958957A
(en)
|
1996-04-19 |
1999-09-28 |
Novo Nordisk A/S |
Modulators of molecules with phosphotyrosine recognition units
|
|
JP2001506997A
(ja)
*
|
1996-12-16 |
2001-05-29 |
オントジエン・コーポレイシヨン |
ホスホチロシン認識ユニットを有する蛋白質の修飾物質
|
|
US5840721A
(en)
|
1997-07-09 |
1998-11-24 |
Ontogen Corporation |
Imidazole derivatives as MDR modulators
|
|
GB9715816D0
(en)
|
1997-07-25 |
1997-10-01 |
Black James Foundation |
Histamine H receptor ligands
|
|
FR2767527B1
(fr)
|
1997-08-25 |
1999-11-12 |
Pf Medicament |
Derives de piperazines indoliques, utiles comme medicaments et procede de preparation
|
|
EP1019364B1
(en)
|
1997-08-28 |
2004-06-09 |
Biovitrum Ab |
Inhibitors of protein tyrosine phosphatase
|
|
AU9253798A
(en)
|
1997-09-23 |
1999-04-12 |
Novo Nordisk A/S |
Modules of protein tyrosine phosphatases (ptpases)
|
|
US5972986A
(en)
|
1997-10-14 |
1999-10-26 |
G.D. Searle & Co. |
Method of using cyclooxygenase-2 inhibitors in the treatment and prevention of neoplasia
|
|
US6159944A
(en)
*
|
1998-02-27 |
2000-12-12 |
Synchroneuron, Llc |
Method for treating painful conditions of the anal region and compositions therefor
|
|
US20020002199A1
(en)
|
1998-03-12 |
2002-01-03 |
Lone Jeppesen |
Modulators of protein tyrosine phosphatases (ptpases)
|
|
US6262044B1
(en)
|
1998-03-12 |
2001-07-17 |
Novo Nordisk A/S |
Modulators of protein tyrosine phosphatases (PTPASES)
|
|
US6699896B1
(en)
|
1998-05-12 |
2004-03-02 |
Wyeth |
Oxazole-aryl-carboxylic acids useful in the treatment of insulin resistance and hyperglycemia
|
|
CA2331056A1
(en)
|
1998-05-12 |
1999-12-02 |
Wyeth |
2,3,5-substituted biphenyls useful in the treatment of insulin resistance and hyperglycemia
|
|
US20030194745A1
(en)
|
1998-06-26 |
2003-10-16 |
Mcdowell Robert S. |
Cysteine mutants and methods for detecting ligand binding to biological molecules
|
|
EP1119614B1
(en)
|
1998-07-24 |
2009-12-09 |
Merck Frosst Canada Ltd. |
Protein tyrosine phosphatase-1b (ptp-1b) deficient mice and uses thereof
|
|
US6174874B1
(en)
|
1998-09-21 |
2001-01-16 |
Merck Frosst Canada & Co. |
Phosphonic acids derivatives as inhibitors of protein tyrosine phosphate 1B (PTP-1B)
|
|
US6534056B1
(en)
|
1998-12-11 |
2003-03-18 |
Mcgill University |
Therapeutic and diagnostic uses of protein tyrosine phosphatase TC-PTP
|
|
JP4221129B2
(ja)
|
1999-02-15 |
2009-02-12 |
富士フイルム株式会社 |
含窒素ヘテロ環化合物、有機発光素子材料、有機発光素子
|
|
CA2372116A1
(en)
|
1999-05-14 |
2000-11-23 |
Claude Dufresne |
Phosphonic and carboxylic acid derivatives as inhibitors of protein tyrosine phosphatase-1b (ptp-1b)
|
|
ATE257827T1
(de)
|
1999-07-21 |
2004-01-15 |
Hoffmann La Roche |
Triazolderivate
|
|
WO2001016097A1
(en)
|
1999-08-27 |
2001-03-08 |
Sugen, Inc. |
Phosphate mimics and methods of treatment using phosphatase inhibitors
|
|
US6410556B1
(en)
|
1999-09-10 |
2002-06-25 |
Novo Nordisk A/S |
Modulators of protein tyrosine phosphateses (PTPases)
|
|
WO2001030757A1
(en)
|
1999-10-28 |
2001-05-03 |
Microcide Pharmaceuticals, Inc. |
Drug discharge pump inhibitors
|
|
US6624182B1
(en)
|
1999-11-25 |
2003-09-23 |
Ciba Specialty Chemicals Corporation |
Hydroxyphenylvinylthiazoles
|
|
US6486141B2
(en)
|
1999-12-22 |
2002-11-26 |
Merck Frosst Canada & Co. |
Phosphonic acid biaryl derivatives as inhibitors of protein tyrosine phosphatase 1B (PTP-1B)
|
|
JP2003518128A
(ja)
|
1999-12-22 |
2003-06-03 |
メルク フロスト カナダ アンド カンパニー |
タンパク質チロシンホスファターゼ1b(ptp−1b)のインヒビターとなる芳香族ホスホネート
|
|
US6777433B2
(en)
|
1999-12-22 |
2004-08-17 |
Merck Frosst Canada & Co. |
Protein tyrosine phosphatase 1B (PTP-1B) inhibitors containing two ortho-substituted aromatic phosphonates
|
|
CA2393363A1
(en)
|
1999-12-22 |
2001-06-28 |
Merck Frosst Canada & Co. |
Phosphonic acid derivatives as inhibitors of protein tyrosine phosphatase 1b (ptp-1b)
|
|
US6486142B2
(en)
|
1999-12-22 |
2002-11-26 |
Merck Frosst Canada & Co. |
Phosphonic acid derivatives as inhibitors of protein tyrosine phosphatase 1B (PTP-1B)
|
|
JP2003520049A
(ja)
|
2000-01-18 |
2003-07-02 |
ヒューマン ジノーム サイエンシーズ, インコーポレイテッド |
ヒトタンパク質であるチロシンホスファターゼのポリヌクレオチド、ポリペプチド、および抗体
|
|
TWI284639B
(en)
|
2000-01-24 |
2007-08-01 |
Shionogi & Co |
A compound having thrombopoietin receptor agonistic effect
|
|
US20020009762A1
(en)
|
2000-02-14 |
2002-01-24 |
Flint Andrew J. |
Assay for protein tyrosine phosphatases
|
|
US6498151B2
(en)
|
2000-03-22 |
2002-12-24 |
Merck Frosst Canada & Co. |
Aryldifluoromethylphosphonic acids with sulfur-containing substituents as PTP-1B inhibitors
|
|
US6627647B1
(en)
|
2000-03-23 |
2003-09-30 |
Boehringer Ingelheim Pharmaceuticals, Inc. |
Substituted 1-(4-aminophenyl)imidazoles and their use as anti-inflammatory agents
|
|
EP1284260A4
(en)
|
2000-05-22 |
2004-03-31 |
Takeda Chemical Industries Ltd |
TYROSIN PHOSPHATASE INHIBITORS
|
|
DE60135752D1
(en)
|
2000-07-06 |
2008-10-23 |
Array Biopharma Inc |
Tyrosinderivate als phosphatase inhibitoren
|
|
US20020099073A1
(en)
|
2000-07-07 |
2002-07-25 |
Andersen Henrik Sune |
Modulators of protein tyrosine phosphatases (PTPases)
|
|
US6613903B2
(en)
|
2000-07-07 |
2003-09-02 |
Novo Nordisk A/S |
Modulators of protein tyrosine phosphatases (PTPases)
|
|
US6627767B2
(en)
|
2000-08-29 |
2003-09-30 |
Abbott Laboratories |
Amino(oxo) acetic acid protein tyrosine phosphatase inhibitors
|
|
US6472545B2
(en)
|
2000-08-29 |
2002-10-29 |
Abbott Laboratories |
Protein tyrosine phosphatase inhibitors
|
|
US20020169157A1
(en)
|
2000-08-29 |
2002-11-14 |
Gang Liu |
Selective protein tyrosine phosphatatase inhibitors
|
|
US6972340B2
(en)
|
2000-08-29 |
2005-12-06 |
Abbott Laboratories |
Selective protein tyrosine phosphatatase inhibitors
|
|
US20020035137A1
(en)
|
2000-08-29 |
2002-03-21 |
Gang Liu |
Amino (oxo) acetic acid protein tyrosine phosphatase inhibitors
|
|
GB0022079D0
(en)
|
2000-09-08 |
2000-10-25 |
Inst Of Molecul & Cell Biology |
Novel protein tyrosine phosphatase inhibitor
|
|
JP2002114768A
(ja)
|
2000-10-11 |
2002-04-16 |
Japan Tobacco Inc |
2−(2,5−ジハロゲン−3,4−ジヒドロキシフェニル)アゾール化合物及びそれを含有してなる医薬組成物
|
|
US20030108883A1
(en)
|
2001-02-13 |
2003-06-12 |
Rondinone Cristina M. |
Methods for identifying compounds that inhibit or reduce PTP1B expression
|
|
US20030120073A1
(en)
|
2001-04-25 |
2003-06-26 |
Seto Christopher T. |
Alpha-ketocarboxylic acid based inhibitors of phosphoryl tyrosine phosphatases
|
|
JP2002322054A
(ja)
|
2001-04-26 |
2002-11-08 |
Dai Ichi Seiyaku Co Ltd |
薬剤排出ポンプ阻害薬
|
|
WO2002102813A1
(en)
|
2001-06-20 |
2002-12-27 |
Merck Frosst Canada & Co. |
Aryldifluoromethylphosphonic acids for treatment of diabetes
|
|
US20030064979A1
(en)
|
2001-06-29 |
2003-04-03 |
Hansen Thomas Kruse |
Method of inhibiting PTP 1B and /or T-cell PTP and/or other PTPases with an Asp residue at position 48
|
|
US20030170660A1
(en)
|
2001-07-11 |
2003-09-11 |
Sondergaard Helle Bach |
P387L variant in protein tyrosine phosphatase-1B is associated with type 2 diabetes and impaired serine phosphorylation of PTP-1B in vitro
|
|
JP2005507932A
(ja)
|
2001-10-12 |
2005-03-24 |
バイエル・フアーマシユーチカルズ・コーポレーシヨン |
肥満の処置のためのフェニル置換5−員窒素含有複素環
|
|
WO2003032982A1
(en)
|
2001-10-19 |
2003-04-24 |
Transtech Pharma, Inc. |
Bis-heteroaryl alkanes as therapeutic agents
|
|
JP2005508968A
(ja)
|
2001-10-19 |
2005-04-07 |
トランス テック ファーマ,インコーポレイテッド |
PTP阻害剤としてのβ−カルボリン誘導体
|
|
JP2003231679A
(ja)
|
2001-12-03 |
2003-08-19 |
Japan Tobacco Inc |
アゾール化合物及びその医薬用途
|
|
AU2002349705A1
(en)
|
2001-12-03 |
2003-06-17 |
Japan Tobacco Inc. |
Azole compound and medicinal use thereof
|
|
US6642381B2
(en)
|
2001-12-27 |
2003-11-04 |
Hoffman-La Roche Inc. |
Pyrimido[5,4-e][1,2,4]triazine-5,7-diamine compounds as protein tyrosine phosphatase inhibitors
|
|
US20030180827A1
(en)
|
2002-01-04 |
2003-09-25 |
Aventis Pharma Deutschland Gmbh. |
Highly sensitive and continuous protein tyrosine phosphatase test using 6,8-difluoro-4-methylumbelliferyl phosphate
|
|
US20030215899A1
(en)
|
2002-02-13 |
2003-11-20 |
Ceptyr, Inc. |
Reversible oxidation of protein tyrosine phosphatases
|
|
US6784205B2
(en)
|
2002-03-01 |
2004-08-31 |
Sunesis Pharmaceuticals, Inc. |
Compounds that modulate the activity of PTP-1B and TC-PTP
|
|
DK1482931T3
(da)
|
2002-03-05 |
2011-12-19 |
Transtech Pharma Inc |
Mono- og bicycliske azolderivater der inhiberer interaktionen af ligander med RAGE
|
|
KR100868587B1
(ko)
|
2002-04-03 |
2008-11-12 |
노파르티스 아게 |
Ptpase 1b 억제제로서의 5-치환된1,1-디옥소-1,2,5-티아졸리딘-3-온 유도체
|
|
AU2003216579A1
(en)
|
2002-04-12 |
2003-10-27 |
Pfizer Inc. |
Imidazole compounds as anti-inflammatory and analgesic agents
|
|
JP4529342B2
(ja)
|
2002-04-23 |
2010-08-25 |
東ソー株式会社 |
環状アミジニウム有機酸塩の製造方法
|
|
JP2003313172A
(ja)
|
2002-04-23 |
2003-11-06 |
Tosoh Corp |
N−置換イミダゾール化合物の製造方法
|
|
US20040009956A1
(en)
|
2002-04-29 |
2004-01-15 |
Dehua Pei |
Inhibition of protein tyrosine phosphatases and SH2 domains by a neutral phosphotyrosine mimetic
|
|
US7399586B2
(en)
|
2002-05-23 |
2008-07-15 |
Ceptyr, Inc. |
Modulation of biological signal transduction by RNA interference
|
|
US6849761B2
(en)
|
2002-09-05 |
2005-02-01 |
Wyeth |
Substituted naphthoic acid derivatives useful in the treatment of insulin resistance and hyperglycemia
|
|
EP1402888A1
(en)
|
2002-09-18 |
2004-03-31 |
Jerini AG |
The use of substituted carbocyclic compounds as rotamases inhibitors
|
|
EP1594497B1
(en)
|
2002-12-30 |
2009-05-27 |
Vertex Pharmaceuticals Incorporated |
Sulfhydantoins as phosphate isosteres for use as phosphatase inhibitors in the treatment of cancer and autoimmune disorders
|
|
US7144911B2
(en)
|
2002-12-31 |
2006-12-05 |
Deciphera Pharmaceuticals Llc |
Anti-inflammatory medicaments
|
|
US7279576B2
(en)
|
2002-12-31 |
2007-10-09 |
Deciphera Pharmaceuticals, Llc |
Anti-cancer medicaments
|
|
WO2004071448A2
(en)
|
2003-02-12 |
2004-08-26 |
Transtech Pharma Inc. |
Substituted azole derivatives as inhibitors of protein tyrosine phosphatases
|
|
CA2514363A1
(en)
|
2003-02-12 |
2004-08-26 |
Transtech Pharma, Inc. |
Substituted azole derivatives as therapeutic agents
|
|
US20040167188A1
(en)
|
2003-02-14 |
2004-08-26 |
Zhili Xin |
Protein-tyrosine phosphatase inhibitors and uses thereof
|
|
WO2004089918A1
(ja)
|
2003-04-09 |
2004-10-21 |
Japan Tobacco Inc. |
複素芳香5員環化合物及びその医薬用途
|
|
US7141596B2
(en)
|
2003-10-08 |
2006-11-28 |
Incyte Corporation |
Inhibitors of proteins that bind phosphorylated molecules
|
|
CA2551909C
(en)
*
|
2004-02-12 |
2011-10-11 |
Transtech Pharma, Inc. |
Substituted azole derivatives, compositions, and methods of use
|
|
CA2629819A1
(en)
*
|
2005-12-08 |
2007-06-14 |
Novartis Ag |
1,2,5-thiazolidine derivatives useful for treating conditions mediated by protein tyrosine phosphatases (ptpase)
|
|
CA2630448A1
(en)
*
|
2005-12-08 |
2007-06-14 |
Novartis Ag |
1,1,3-trioxo-1,2,5-thiadiazolidines and their use as ptp-ases inhibitors
|
|
NZ569329A
(en)
*
|
2006-01-30 |
2011-09-30 |
Transtech Pharma Inc |
Substituted imidazole derivatives and their use as PTPase inhibitors
|