JP2013544276A5 - - Google Patents
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- Publication number
- JP2013544276A5 JP2013544276A5 JP2013541445A JP2013541445A JP2013544276A5 JP 2013544276 A5 JP2013544276 A5 JP 2013544276A5 JP 2013541445 A JP2013541445 A JP 2013541445A JP 2013541445 A JP2013541445 A JP 2013541445A JP 2013544276 A5 JP2013544276 A5 JP 2013544276A5
- Authority
- JP
- Japan
- Prior art keywords
- pharmaceutically acceptable
- acceptable salt
- optionally substituted
- alkyl
- phenyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000003839 salts Chemical class 0.000 claims 14
- 150000001875 compounds Chemical class 0.000 claims 12
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims 4
- 125000000623 heterocyclic group Chemical group 0.000 claims 4
- 229910052739 hydrogen Inorganic materials 0.000 claims 4
- 239000001257 hydrogen Substances 0.000 claims 4
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 4
- 125000004432 carbon atom Chemical group C* 0.000 claims 3
- 125000006273 (C1-C3) alkyl group Chemical group 0.000 claims 2
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 claims 2
- 125000006570 (C5-C6) heteroaryl group Chemical group 0.000 claims 2
- 208000035143 Bacterial infection Diseases 0.000 claims 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 2
- 208000022362 bacterial infectious disease Diseases 0.000 claims 2
- 229910052799 carbon Inorganic materials 0.000 claims 2
- 150000002431 hydrogen Chemical class 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- 150000003852 triazoles Chemical class 0.000 claims 2
- -1 (1- (2-aminothiazol-4-yl) -2-(((2S, 3R) -2-((3-((1,5-dihydroxy- 4-oxo-1,4-dihydropyridin-2-yl) methyl) ureido) methyl) -4-oxo-1-sulfoazetidin-3-yl) amino) -2-oxoethylidene) amino Chemical group 0.000 claims 1
- ZCQWOFVYLHDMMC-UHFFFAOYSA-N Oxazole Chemical group C1=COC=N1 ZCQWOFVYLHDMMC-UHFFFAOYSA-N 0.000 claims 1
- CZPWVGJYEJSRLH-UHFFFAOYSA-N Pyrimidine Chemical group C1=CN=CN=C1 CZPWVGJYEJSRLH-UHFFFAOYSA-N 0.000 claims 1
- FZWLAAWBMGSTSO-UHFFFAOYSA-N Thiazole Chemical group C1=CSC=N1 FZWLAAWBMGSTSO-UHFFFAOYSA-N 0.000 claims 1
- 239000002253 acid Substances 0.000 claims 1
- 125000000753 cycloalkyl group Chemical group 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 125000000842 isoxazolyl group Chemical group 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 1
- BKPWVBVFGRYCBH-FMDKYWOUSA-N Nc1nc(/C(/C(N[C@@H]([C@@H](CNC(NCC(N(C=C2O)O)=CC2=O)=O)N2S(O)(=O)=O)C2=O)=O)=N/OC2(CCCC2)C(O)=O)c[s]1 Chemical compound Nc1nc(/C(/C(N[C@@H]([C@@H](CNC(NCC(N(C=C2O)O)=CC2=O)=O)N2S(O)(=O)=O)C2=O)=O)=N/OC2(CCCC2)C(O)=O)c[s]1 BKPWVBVFGRYCBH-FMDKYWOUSA-N 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US41757510P | 2010-11-29 | 2010-11-29 | |
| US61/417,575 | 2010-11-29 | ||
| PCT/IB2011/055104 WO2012073138A1 (en) | 2010-11-29 | 2011-11-15 | Monobactams |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013544276A JP2013544276A (ja) | 2013-12-12 |
| JP2013544276A5 true JP2013544276A5 (https=) | 2014-12-04 |
| JP5777725B2 JP5777725B2 (ja) | 2015-09-09 |
Family
ID=45315854
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013541445A Expired - Fee Related JP5777725B2 (ja) | 2010-11-29 | 2011-11-15 | モノバクタム |
Country Status (17)
| Country | Link |
|---|---|
| US (3) | US20120302542A1 (https=) |
| EP (1) | EP2646436B1 (https=) |
| JP (1) | JP5777725B2 (https=) |
| KR (1) | KR101514587B1 (https=) |
| CN (1) | CN103228652B (https=) |
| AR (1) | AR084001A1 (https=) |
| AU (1) | AU2011336209B2 (https=) |
| CA (1) | CA2815821C (https=) |
| DK (1) | DK2646436T3 (https=) |
| ES (1) | ES2542431T3 (https=) |
| IL (1) | IL226052A0 (https=) |
| MX (1) | MX2013005994A (https=) |
| SG (1) | SG190007A1 (https=) |
| TW (1) | TW201247661A (https=) |
| UY (1) | UY33754A (https=) |
| WO (1) | WO2012073138A1 (https=) |
| ZA (1) | ZA201304479B (https=) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2015099107A1 (ja) | 2013-12-26 | 2015-07-02 | 塩野義製薬株式会社 | 含窒素６員環誘導体およびそれらを含有する医薬組成物 |
| MX373444B (es) | 2014-03-24 | 2020-04-30 | Novartis Ag | Compuestos organicos de monobactam para el tratamiento de infecciones bacterianas. |
| PL3353175T3 (pl) * | 2015-09-23 | 2021-02-22 | Novartis Ag | Sole i postacie stałe antybiotyku monobaktamowego |
| CN105481812B (zh) * | 2015-11-30 | 2020-04-21 | 重庆天奕恒化科技有限公司 | 一种5-苄氧基-4-氧代-4h-吡喃-2-羧酸的制备方法 |
| US20180339983A1 (en) | 2015-12-15 | 2018-11-29 | Merck Sharp & Dohme Corp. | Biaryl monobactam compounds and methods of use thereof for the treatment of bacterial infections |
| CA3016341A1 (en) | 2016-03-07 | 2017-09-14 | Merck Sharp & Dohme Corp. | Bicyclic aryl monobactam compounds and methods of use thereof for the treatment of bacterial infections |
| US10047077B2 (en) | 2016-04-13 | 2018-08-14 | Skyline Antiinfectives, Inc. | Deuterated O-sulfated beta-lactam hydroxamic acids and deuterated N-sulfated beta-lactams |
| CN107641119B (zh) | 2016-07-21 | 2019-11-08 | 中国科学院上海药物研究所 | 单环β-内酰胺-铁载体轭合物及其制备方法和用途 |
| JP7235718B2 (ja) | 2017-08-02 | 2023-03-08 | ノバルティス アーゲー | モノバクタム系抗生物質およびその中間体を製造するための化学的方法 |
| EP3691639B1 (en) | 2017-10-02 | 2023-11-15 | Merck Sharp & Dohme LLC | Chromane monobactam compounds for the treatment of bacterial infections |
| US10513504B2 (en) | 2018-03-08 | 2019-12-24 | Apotex Inc. | Processes for the preparation of apalutamide and intermediates thereof |
| EP4046998B1 (en) * | 2019-11-22 | 2024-02-28 | Suzhou Erye Pharmaceutical Co., Ltd. | Sulfonylurea ring substituted monocyclic beta-lactam antibiotics |
| BR112022010924A2 (pt) | 2019-12-06 | 2022-09-06 | Vertex Pharma | Tetra-hidrofuranos substituídos como moduladores de canais de sódio |
| CN111303144B (zh) * | 2019-12-13 | 2020-11-27 | 苏州信诺维医药科技有限公司 | 一种治疗细菌感染的化合物 |
| US12528804B2 (en) | 2021-03-31 | 2026-01-20 | Fedora Pharmaceuticals Inc. | Lactivicin compounds, their preparation and use as antibacterial agents |
| EP4685147A3 (en) | 2021-03-31 | 2026-04-15 | Fedora Pharmaceuticals Inc. | Lactivicin compounds, their preparation and use as antibacterial agents |
| KR102781293B1 (ko) * | 2021-05-07 | 2025-03-17 | 한국생명공학연구원 | 신규 사이드로포어 화합물 및 이를 이용한 금속 나노입자 복합체 |
| SMT202500481T1 (it) | 2021-06-04 | 2026-01-12 | Vertex Pharma | N-(idrossialchil(etero)aril)tetraidrofuran carbossammidi come modulatori di canali del sodio |
| JP7671398B2 (ja) * | 2021-11-18 | 2025-05-01 | メルク・シャープ・アンド・ドーム・エルエルシー | クロマンアミジンモノバクタム抗生物質 |
| GEAP202416514A (en) | 2021-11-18 | 2024-08-26 | Merck Sharp & Dohme Llc | Chromane amidine monobactam antibiotics |
| WO2023205463A1 (en) | 2022-04-22 | 2023-10-26 | Vertex Pharmaceuticals Incorporated | Heteroaryl compounds for the treatment of pain |
| CN115304594B (zh) * | 2022-10-12 | 2023-02-14 | 苏州二叶制药有限公司 | 磺酰脲环取代的化合物的盐型及其晶型 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH01502660A (ja) * | 1986-05-23 | 1989-09-14 | ジ・アップジョン・カンパニー | Ｎ―１置換スルホニルアミノカルボニル、ｃ―４置換モノバクタム類 |
| CA2783572C (en) | 2005-12-07 | 2016-08-09 | Basilea Pharmaceutica Ag | Useful combinations of monobactam antibiotics with beta-lactamase inhibitors |
| CN101679263B (zh) | 2007-03-28 | 2014-01-15 | 阿普泰克斯科技公司 | 去铁酮的氟化衍生物 |
| JP2012512863A (ja) | 2008-12-19 | 2012-06-07 | ファイザー・インク | モノカルバム |
-
2011
- 2011-11-15 DK DK11794237.5T patent/DK2646436T3/en active
- 2011-11-15 EP EP11794237.5A patent/EP2646436B1/en not_active Not-in-force
- 2011-11-15 WO PCT/IB2011/055104 patent/WO2012073138A1/en not_active Ceased
- 2011-11-15 JP JP2013541445A patent/JP5777725B2/ja not_active Expired - Fee Related
- 2011-11-15 SG SG2013031752A patent/SG190007A1/en unknown
- 2011-11-15 KR KR1020137016718A patent/KR101514587B1/ko not_active Expired - Fee Related
- 2011-11-15 AU AU2011336209A patent/AU2011336209B2/en not_active Ceased
- 2011-11-15 CN CN201180057264.5A patent/CN103228652B/zh not_active Expired - Fee Related
- 2011-11-15 CA CA2815821A patent/CA2815821C/en not_active Expired - Fee Related
- 2011-11-15 MX MX2013005994A patent/MX2013005994A/es active IP Right Grant
- 2011-11-15 ES ES11794237.5T patent/ES2542431T3/es active Active
- 2011-11-24 TW TW100143172A patent/TW201247661A/zh unknown
- 2011-11-25 AR ARP110104404A patent/AR084001A1/es not_active Application Discontinuation
- 2011-11-28 UY UY0001033754A patent/UY33754A/es not_active Application Discontinuation
- 2011-11-29 US US13/306,581 patent/US20120302542A1/en not_active Abandoned
-
2013
- 2013-02-27 US US13/778,670 patent/US20130252935A1/en not_active Abandoned
- 2013-04-29 IL IL226052A patent/IL226052A0/en unknown
- 2013-06-18 ZA ZA2013/04479A patent/ZA201304479B/en unknown
-
2015
- 2015-01-29 US US14/608,826 patent/US20150148326A1/en not_active Abandoned
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