JP2015514063A5 - - Google Patents
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- Publication number
- JP2015514063A5 JP2015514063A5 JP2015500716A JP2015500716A JP2015514063A5 JP 2015514063 A5 JP2015514063 A5 JP 2015514063A5 JP 2015500716 A JP2015500716 A JP 2015500716A JP 2015500716 A JP2015500716 A JP 2015500716A JP 2015514063 A5 JP2015514063 A5 JP 2015514063A5
- Authority
- JP
- Japan
- Prior art keywords
- optionally substituted
- alkyl
- halo
- compound according
- ring
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 125000000217 alkyl group Chemical group 0.000 claims 53
- 150000001875 compounds Chemical class 0.000 claims 27
- 125000001475 halogen functional group Chemical group 0.000 claims 20
- 125000000623 heterocyclic group Chemical group 0.000 claims 15
- 229910019142 PO4 Inorganic materials 0.000 claims 14
- 150000002148 esters Chemical class 0.000 claims 14
- 235000021317 phosphate Nutrition 0.000 claims 14
- 239000000651 prodrug Substances 0.000 claims 13
- 229940002612 prodrug Drugs 0.000 claims 13
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 claims 9
- KXDHJXZQYSOELW-UHFFFAOYSA-M Carbamate Chemical compound NC([O-])=O KXDHJXZQYSOELW-UHFFFAOYSA-M 0.000 claims 9
- QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 claims 9
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 claims 9
- 239000010452 phosphate Substances 0.000 claims 9
- 150000003839 salts Chemical class 0.000 claims 9
- 125000003601 C2-C6 alkynyl group Chemical group 0.000 claims 8
- 229920006395 saturated elastomer Polymers 0.000 claims 8
- 125000006272 (C3-C7) cycloalkyl group Chemical group 0.000 claims 6
- 150000004657 carbamic acid derivatives Chemical class 0.000 claims 5
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 5
- 150000003013 phosphoric acid derivatives Chemical class 0.000 claims 5
- 150000003467 sulfuric acid derivatives Chemical class 0.000 claims 5
- 208000035143 Bacterial infection Diseases 0.000 claims 4
- 208000022362 bacterial infectious disease Diseases 0.000 claims 4
- 125000002619 bicyclic group Chemical group 0.000 claims 4
- 208000015181 infectious disease Diseases 0.000 claims 4
- 150000003333 secondary alcohols Chemical class 0.000 claims 4
- 150000003509 tertiary alcohols Chemical class 0.000 claims 4
- 125000006570 (C5-C6) heteroaryl group Chemical group 0.000 claims 3
- HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 claims 3
- 201000001178 Bacterial Pneumonia Diseases 0.000 claims 3
- 125000006273 (C1-C3) alkyl group Chemical group 0.000 claims 2
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 claims 2
- 125000001313 C5-C10 heteroaryl group Chemical group 0.000 claims 2
- 125000003545 alkoxy group Chemical group 0.000 claims 2
- 125000003118 aryl group Chemical group 0.000 claims 2
- ZADPBFCGQRWHPN-UHFFFAOYSA-N boronic acid Chemical compound OBO ZADPBFCGQRWHPN-UHFFFAOYSA-N 0.000 claims 2
- -1 boronic acid ester Chemical class 0.000 claims 2
- 229910052799 carbon Inorganic materials 0.000 claims 2
- 125000004432 carbon atom Chemical group C* 0.000 claims 2
- 125000000753 cycloalkyl group Chemical group 0.000 claims 2
- 125000002950 monocyclic group Chemical group 0.000 claims 2
- 239000002243 precursor Substances 0.000 claims 2
- ITMCEJHCFYSIIV-UHFFFAOYSA-M triflate Chemical compound [O-]S(=O)(=O)C(F)(F)F ITMCEJHCFYSIIV-UHFFFAOYSA-M 0.000 claims 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims 1
- 101001035951 Homo sapiens Hyaluronan-binding protein 2 Proteins 0.000 claims 1
- 102100039238 Hyaluronan-binding protein 2 Human genes 0.000 claims 1
- 208000036209 Intraabdominal Infections Diseases 0.000 claims 1
- 206010057190 Respiratory tract infections Diseases 0.000 claims 1
- 125000003342 alkenyl group Chemical group 0.000 claims 1
- 125000000304 alkynyl group Chemical group 0.000 claims 1
- 239000008280 blood Substances 0.000 claims 1
- 210000004369 blood Anatomy 0.000 claims 1
- 230000008878 coupling Effects 0.000 claims 1
- 238000010168 coupling process Methods 0.000 claims 1
- 238000005859 coupling reaction Methods 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 239000002271 gyrase inhibitor Substances 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 208000019206 urinary tract infection Diseases 0.000 claims 1
- 0 C*(C)(C(*)(*)O)N Chemical compound C*(C)(C(*)(*)O)N 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261614044P | 2012-03-22 | 2012-03-22 | |
| US61/614,044 | 2012-03-22 | ||
| PCT/AU2013/000286 WO2013138860A1 (en) | 2012-03-22 | 2013-03-21 | Antibacterial compounds |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2015514063A JP2015514063A (ja) | 2015-05-18 |
| JP2015514063A5 true JP2015514063A5 (https=) | 2016-05-12 |
Family
ID=49212365
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015500716A Pending JP2015514063A (ja) | 2012-03-22 | 2013-03-21 | 抗菌化合物 |
Country Status (6)
| Country | Link |
|---|---|
| US (3) | US9604976B2 (https=) |
| EP (1) | EP2828257B1 (https=) |
| JP (1) | JP2015514063A (https=) |
| CN (1) | CN104302645A (https=) |
| HK (1) | HK1206031A1 (https=) |
| WO (1) | WO2013138860A1 (https=) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8476281B2 (en) | 2011-01-14 | 2013-07-02 | Vertex Pharmaceuticals Incorporated | Solid forms of gyrase inhibitor (R)-1-ethyl-3-[6-fluoro-5-[2-(1-hydroxy-1-methyl-ethyl)pyrimidin-5-yl]-7-(tetrahydrofuran-2-yl)-1H-benzimidazol-2-yl]urea |
| RU2609259C2 (ru) | 2011-01-14 | 2017-01-31 | Сперо Тринем, Инк. | Пиримидиновые ингибиторы гиразы и топоизомеразы iv |
| KR101882172B1 (ko) | 2011-01-14 | 2018-07-26 | 스페로 트리넴, 인코포레이티드 | 자이라제 및 토포이소머라제 ⅳ 억제제의 제조방법 |
| CN103702994B (zh) | 2011-06-20 | 2016-03-23 | 沃泰克斯药物股份有限公司 | 旋转酶和拓扑异构酶抑制剂的磷酸酯 |
| WO2013138860A1 (en) * | 2012-03-22 | 2013-09-26 | Biota Europe Limited | Antibacterial compounds |
| WO2014014845A1 (en) | 2012-07-18 | 2014-01-23 | Vertex Pharmaceuticals Incorporated | Combination therapy comprising|1 -ethyl-3-[5-[2-{1 -hydroxy-1 -methyl-ethyl}pyrimidin-5-yl]-7-(tetra hydrofuran-2-|yl}-1 h-benzimidazol-2-yl]urea and derivatives thereof to treat mycobacterium|diseases |
| US9018216B2 (en) | 2012-07-18 | 2015-04-28 | Vertex Pharmaceuticals Incorporated | Solid forms of (R)-2-(5-(2-(3-ethylureido)-6-fluoro-7-(tetrahydrofuran-2-yl)-1H-benzo[d]imidazol-5-yl)pyrimidin-2-yl)propan-2-yl dihydrogen phosphate and salts thereof |
| US20170007615A1 (en) * | 2014-02-03 | 2017-01-12 | Biota Europe Ltd | Antibacterial Compounds |
| SI3215498T1 (sl) | 2014-11-03 | 2018-11-30 | Bayer Pharma Aktiengesellschaft | Hidroksialkil-substituirani derivati feniltriazola in njihove uporabe |
| US9988367B2 (en) | 2016-05-03 | 2018-06-05 | Bayer Pharma Aktiengesellschaft | Amide-substituted pyridinyltriazole derivatives and uses thereof |
| WO2017191115A1 (en) | 2016-05-03 | 2017-11-09 | Bayer Pharma Aktiengesellschaft | Oxoalkyl-substituted phenyltriazole derivatives and uses thereof |
| US10702525B1 (en) | 2019-09-04 | 2020-07-07 | United Arab Emirates University | Pyrimidine derivatives as anti-diabetic agents |
| CN115124544B (zh) * | 2022-07-20 | 2023-06-23 | 四川抗菌素工业研究所金华分所 | 一种螺[四氢呋喃-3,3’-吲哚啉]骨架物及其晶型和其制备方法与用途 |
| WO2026073439A1 (en) * | 2024-10-04 | 2026-04-09 | Para Therapeutics, Inc. | Vps4 inhibitors and methods of use thereof |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8470829B2 (en) | 2004-09-09 | 2013-06-25 | Chugai Seiyaku Kabushiki Kaisha | Imidazolidine derivative and use thereof |
| GB0724349D0 (en) * | 2007-12-13 | 2008-01-30 | Prolysis Ltd | Antibacterial agents |
| GB0612428D0 (en) * | 2006-06-22 | 2006-08-02 | Prolysis Ltd | Antibacterial agents |
| GB0724342D0 (en) * | 2007-12-13 | 2008-01-30 | Prolysis Ltd | Anitbacterial compositions |
| AU2009254928A1 (en) * | 2008-06-04 | 2009-12-10 | Astrazeneca Ab | Thiazolo [5, 4-B] pyridine and oxazolo [5, 4-B] pyridine derivatives as antibacterial agents |
| EP2321309A1 (en) | 2008-06-25 | 2011-05-18 | Ranbaxy Laboratories Limited | Benzothiazoles and aza-analogues thereof use as antibacterial agents |
| AU2009314544C1 (en) * | 2008-11-11 | 2015-11-12 | Xcovery Holding Company Llc | PI3K/mTOR kinase inhibitors |
| EP2625178A4 (en) * | 2010-10-08 | 2014-04-30 | Biota Europe Ltd | BACTERIA TOPOISOMERASE II FOR INHIBITING 2-ETHYL CARBAMOYLAMINE-1,3-BENZOTHIAZOL-5-YLENE |
| WO2013091011A1 (en) * | 2011-12-21 | 2013-06-27 | Biota Europe Ltd | Heterocyclic urea compounds |
| WO2013138860A1 (en) * | 2012-03-22 | 2013-09-26 | Biota Europe Limited | Antibacterial compounds |
-
2013
- 2013-03-21 WO PCT/AU2013/000286 patent/WO2013138860A1/en not_active Ceased
- 2013-03-21 US US14/384,237 patent/US9604976B2/en not_active Expired - Fee Related
- 2013-03-21 EP EP13764012.4A patent/EP2828257B1/en not_active Not-in-force
- 2013-03-21 US US13/848,118 patent/US8906902B2/en not_active Expired - Fee Related
- 2013-03-21 CN CN201380014971.5A patent/CN104302645A/zh active Pending
- 2013-03-21 JP JP2015500716A patent/JP2015514063A/ja active Pending
- 2013-03-21 HK HK15106715.4A patent/HK1206031A1/xx unknown
-
2017
- 2017-03-27 US US15/470,419 patent/US20170260178A1/en not_active Abandoned