EP2625178A4 - Bacteria topoisomerase ii inhibiting 2-ethylcarbamoylamino-1, 3-benzothiazol-5-yls - Google Patents
Bacteria topoisomerase ii inhibiting 2-ethylcarbamoylamino-1, 3-benzothiazol-5-ylsInfo
- Publication number
- EP2625178A4 EP2625178A4 EP11830125.8A EP11830125A EP2625178A4 EP 2625178 A4 EP2625178 A4 EP 2625178A4 EP 11830125 A EP11830125 A EP 11830125A EP 2625178 A4 EP2625178 A4 EP 2625178A4
- Authority
- EP
- European Patent Office
- Prior art keywords
- ethylcarbamoylamino
- yls
- benzothiazol
- inhibiting
- topoisomerase
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N47/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid
- A01N47/08—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid the carbon atom having one or more single bonds to nitrogen atoms
- A01N47/28—Ureas or thioureas containing the groups >N—CO—N< or >N—CS—N<
- A01N47/36—Ureas or thioureas containing the groups >N—CO—N< or >N—CS—N< containing the group >N—CO—N< directly attached to at least one heterocyclic ring; Thio analogues thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Dentistry (AREA)
- Engineering & Computer Science (AREA)
- Plant Pathology (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Environmental Sciences (AREA)
- Pest Control & Pesticides (AREA)
- Agronomy & Crop Science (AREA)
- General Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Communicable Diseases (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Oncology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US39116310P | 2010-10-08 | 2010-10-08 | |
PCT/AU2011/001284 WO2012045124A1 (en) | 2010-10-08 | 2011-10-07 | Bacteria topoisomerase ii inhibiting 2-ethylcarbamoylamino-1, 3-benzothiazol-5-yls |
Publications (2)
Publication Number | Publication Date |
---|---|
EP2625178A1 EP2625178A1 (en) | 2013-08-14 |
EP2625178A4 true EP2625178A4 (en) | 2014-04-30 |
Family
ID=45925612
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP11830125.8A Withdrawn EP2625178A4 (en) | 2010-10-08 | 2011-10-07 | Bacteria topoisomerase ii inhibiting 2-ethylcarbamoylamino-1, 3-benzothiazol-5-yls |
Country Status (6)
Country | Link |
---|---|
US (1) | US9181234B2 (en) |
EP (1) | EP2625178A4 (en) |
JP (1) | JP5864589B2 (en) |
CN (1) | CN103249732B (en) |
AU (1) | AU2011313820A1 (en) |
WO (1) | WO2012045124A1 (en) |
Families Citing this family (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2012097274A1 (en) | 2011-01-14 | 2012-07-19 | Vertex Pharmaceuticals Incorporation | Process of making gyrase and topoisomerase iv inhibitors |
RU2625305C2 (en) | 2011-01-14 | 2017-07-13 | Сперо Тринем, Инк. | Solid forms of gyrase inhibitor (r)-1-ethyl-3-[6-fluoro-5-[2-(1-hydroxy-1-methyl-ethyl) pyrimidin-5-yl]-7-(tetrahydrofuran-2-yl)-1h-benzimidazol-2-yl] urea |
AU2012205415B2 (en) | 2011-01-14 | 2017-02-02 | Spero Therapeutics, Inc. | Pyrimidine gyrase and topoisomerase IV inhibitors |
KR101897950B1 (en) | 2011-01-14 | 2018-09-12 | 스페로 트리넴, 인코포레이티드 | Solid forms of gyrase inhibitor (r)-1-ethyl-3-[5-[2-{1-hydroxy-1-methyl-ethyl}pyrimidin-5-yl]-7-(tetrahydrofuran-2-yl}-1h-benzimidazol-2-yl]urea |
TWI554515B (en) | 2011-06-20 | 2016-10-21 | 維泰克斯製藥公司 | Phosphate esters of gyrase and topoisomerase inhibitors |
US9604976B2 (en) * | 2012-03-22 | 2017-03-28 | Spero Gyrase, Inc. | Antibacterial compounds |
US9572809B2 (en) | 2012-07-18 | 2017-02-21 | Spero Trinem, Inc. | Combination therapy to treat Mycobacterium diseases |
US9018216B2 (en) | 2012-07-18 | 2015-04-28 | Vertex Pharmaceuticals Incorporated | Solid forms of (R)-2-(5-(2-(3-ethylureido)-6-fluoro-7-(tetrahydrofuran-2-yl)-1H-benzo[d]imidazol-5-yl)pyrimidin-2-yl)propan-2-yl dihydrogen phosphate and salts thereof |
CA2938459A1 (en) | 2014-02-03 | 2015-08-06 | Spero Gyrase, Inc. | Antibacterial compounds |
CN104230991A (en) * | 2014-08-25 | 2014-12-24 | 亿腾药业(泰州)有限公司 | Method for controlling palladium residue in fosaprepitant dimeglumine |
EP3250572B1 (en) | 2015-01-28 | 2020-08-26 | Shanghai Fudan-Zhangjiang Bio-Pharmaceutical Co., Ltd. | Substituted imidazo [1, 2-a]pyridin-2-ylamine compounds, and pharmaceutical compositions and methods of use thereof |
CN106167486B (en) * | 2015-05-22 | 2019-06-14 | 北京四环制药有限公司 | Monocycle class gyrase and topoisomerase I V inhibitor |
SI3436461T1 (en) | 2016-03-28 | 2024-03-29 | Incyte Corporation | Pyrrolotriazine compounds as tam inhibitors |
CN110267960B (en) * | 2017-01-18 | 2022-04-26 | 阿雷生物药品公司 | Substituted pyrazolo [1,5-a ] pyrazine compounds as RET kinase inhibitors |
JPWO2018174288A1 (en) | 2017-03-24 | 2020-01-23 | 大正製薬株式会社 | 2 (1H) -quinolinone derivatives |
WO2019057946A1 (en) | 2017-09-25 | 2019-03-28 | F. Hoffmann-La Roche Ag | Multi-cyclic aromatic compounds as factor d inhibitors |
CA3085366A1 (en) | 2017-12-22 | 2019-06-27 | Petra Pharma Corporation | Aminopyridine derivatives as phosphatidylinositol phosphate kinase inhibitors |
WO2022032644A1 (en) * | 2020-08-14 | 2022-02-17 | 上海复旦张江生物医药股份有限公司 | Method for preparing substituted imidazo[1,2-a]pyridin-2-ylamide compound, and intermediate thereof |
CN115073358B (en) * | 2022-07-21 | 2023-09-26 | 安徽德诺医药股份有限公司 | Preparation method of N-benzyl-4-ethyl piperidine formate |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
PT100905A (en) * | 1991-09-30 | 1994-02-28 | Eisai Co Ltd | BICYCLE HYGIENEOUS HETEROCYCLIC COMPOUNDS CONTAINING BENZENE, CYCLOHEXAN OR PYRIDINE AND PYRIMIDINE, PYRIDINE OR IMIDAZOLE SUBSTITUTES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM |
PT1341769E (en) * | 2000-12-15 | 2007-12-31 | Vertex Pharma | Bacterial gyrase inhibitors and uses thereof |
US7618974B2 (en) * | 2003-01-31 | 2009-11-17 | Vertex Pharmaceuticals Incorporated | Gyrase inhibitors and uses thereof |
US7569591B2 (en) * | 2003-01-31 | 2009-08-04 | Vertex Pharmaceuticals Incorporated | Gyrase inhibitors and uses thereof |
US8404852B2 (en) * | 2003-01-31 | 2013-03-26 | Vertex Pharmaceuticals Incorporated | Gyrase inhibitors and uses thereof |
CA2648748A1 (en) * | 2006-04-14 | 2007-10-25 | Takeda Pharmaceutical Company Limited | Nitrogen-containing heterocyclic compound |
GB0724342D0 (en) * | 2007-12-13 | 2008-01-30 | Prolysis Ltd | Anitbacterial compositions |
WO2009156966A1 (en) | 2008-06-25 | 2009-12-30 | Ranbaxy Laboratories Limited | Benzothiazoles and aza-analogues thereof use as antibacterial agents |
WO2010100144A1 (en) * | 2009-03-04 | 2010-09-10 | Merck Serono S.A. | Fused bicyclic compounds as inhibitors for pi3 kinase |
-
2011
- 2011-10-07 AU AU2011313820A patent/AU2011313820A1/en not_active Abandoned
- 2011-10-07 WO PCT/AU2011/001284 patent/WO2012045124A1/en active Application Filing
- 2011-10-07 EP EP11830125.8A patent/EP2625178A4/en not_active Withdrawn
- 2011-10-07 JP JP2013532015A patent/JP5864589B2/en not_active Expired - Fee Related
- 2011-10-07 CN CN201180059188.1A patent/CN103249732B/en not_active Expired - Fee Related
- 2011-10-07 US US13/268,154 patent/US9181234B2/en not_active Expired - Fee Related
Non-Patent Citations (2)
Title |
---|
No further relevant documents disclosed * |
See also references of WO2012045124A1 * |
Also Published As
Publication number | Publication date |
---|---|
EP2625178A1 (en) | 2013-08-14 |
JP2013542204A (en) | 2013-11-21 |
US20120088750A1 (en) | 2012-04-12 |
CN103249732A (en) | 2013-08-14 |
AU2011313820A1 (en) | 2013-04-11 |
US9181234B2 (en) | 2015-11-10 |
WO2012045124A1 (en) | 2012-04-12 |
JP5864589B2 (en) | 2016-02-17 |
CN103249732B (en) | 2016-08-10 |
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Legal Events
Date | Code | Title | Description |
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RIC1 | Information provided on ipc code assigned before grant |
Ipc: A61K 31/428 20060101ALI20140324BHEP Ipc: C07D 417/14 20060101AFI20140324BHEP Ipc: C07D 413/14 20060101ALI20140324BHEP Ipc: C07D 403/14 20060101ALI20140324BHEP Ipc: C07D 471/04 20060101ALI20140324BHEP Ipc: A61K 31/429 20060101ALI20140324BHEP Ipc: A61P 31/04 20060101ALI20140324BHEP |
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