CN104302645A - 抗菌化合物 - Google Patents

抗菌化合物 Download PDF

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Publication number
CN104302645A
CN104302645A CN201380014971.5A CN201380014971A CN104302645A CN 104302645 A CN104302645 A CN 104302645A CN 201380014971 A CN201380014971 A CN 201380014971A CN 104302645 A CN104302645 A CN 104302645A
Authority
CN
China
Prior art keywords
base
ethyl
pyrimidine
benzothiazole
methyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201380014971.5A
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English (en)
Chinese (zh)
Inventor
C·J·鲁尼斯
J·T·帕尔默
G·R·W·皮特
L·C·阿克斯福德
D·戴维斯
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Biota Europe Ltd
Original Assignee
Biota Europe Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biota Europe Ltd filed Critical Biota Europe Ltd
Publication of CN104302645A publication Critical patent/CN104302645A/zh
Pending legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
    • C07F9/65583—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system each of the hetero rings containing nitrogen as ring hetero atom

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Dermatology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
CN201380014971.5A 2012-03-22 2013-03-21 抗菌化合物 Pending CN104302645A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261614044P 2012-03-22 2012-03-22
US61/614,044 2012-03-22
PCT/AU2013/000286 WO2013138860A1 (en) 2012-03-22 2013-03-21 Antibacterial compounds

Publications (1)

Publication Number Publication Date
CN104302645A true CN104302645A (zh) 2015-01-21

Family

ID=49212365

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201380014971.5A Pending CN104302645A (zh) 2012-03-22 2013-03-21 抗菌化合物

Country Status (6)

Country Link
US (3) US8906902B2 (https=)
EP (1) EP2828257B1 (https=)
JP (1) JP2015514063A (https=)
CN (1) CN104302645A (https=)
HK (1) HK1206031A1 (https=)
WO (1) WO2013138860A1 (https=)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8476281B2 (en) 2011-01-14 2013-07-02 Vertex Pharmaceuticals Incorporated Solid forms of gyrase inhibitor (R)-1-ethyl-3-[6-fluoro-5-[2-(1-hydroxy-1-methyl-ethyl)pyrimidin-5-yl]-7-(tetrahydrofuran-2-yl)-1H-benzimidazol-2-yl]urea
AU2012205415B2 (en) 2011-01-14 2017-02-02 Spero Therapeutics, Inc. Pyrimidine gyrase and topoisomerase IV inhibitors
CN103384665B (zh) 2011-01-14 2018-01-09 斯派罗吹耐姆公司 制备促旋酶和拓扑异构酶抑制剂的方法
CN103702994B (zh) 2011-06-20 2016-03-23 沃泰克斯药物股份有限公司 旋转酶和拓扑异构酶抑制剂的磷酸酯
WO2013138860A1 (en) * 2012-03-22 2013-09-26 Biota Europe Limited Antibacterial compounds
WO2014015105A1 (en) 2012-07-18 2014-01-23 Vertex Pharmaceuticals Incorporated Solid forms of (r)-2-(5-(2-(3-ethylureido)-6-fluoro-7-(tetrahydrofuran-2-yl)-1h-benzo[d]imidazol-5-yl)pyrimidin-2-yl)propan-2-yl dihydrogen phosphate and salts thereof
US9572809B2 (en) 2012-07-18 2017-02-21 Spero Trinem, Inc. Combination therapy to treat Mycobacterium diseases
MX2016010057A (es) * 2014-02-03 2017-04-27 Spero Gyrase Inc Compuestos antibacterianos.
UA121558C2 (uk) 2014-11-03 2020-06-25 Баєр Фарма Актіенгезеллшафт Гідроксіалкілзаміщені фенілтриазольні похідні та їх застосування
JP6911052B2 (ja) 2016-05-03 2021-07-28 バイエル ファーマ アクチエンゲゼルシャフト オキソアルキル置換フェニルトリアゾール誘導体およびその使用
US9988367B2 (en) 2016-05-03 2018-06-05 Bayer Pharma Aktiengesellschaft Amide-substituted pyridinyltriazole derivatives and uses thereof
US10702525B1 (en) 2019-09-04 2020-07-07 United Arab Emirates University Pyrimidine derivatives as anti-diabetic agents
CN115124544B (zh) * 2022-07-20 2023-06-23 四川抗菌素工业研究所金华分所 一种螺[四氢呋喃-3,3’-吲哚啉]骨架物及其晶型和其制备方法与用途
WO2026073439A1 (en) * 2024-10-04 2026-04-09 Para Therapeutics, Inc. Vps4 inhibitors and methods of use thereof

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101048381A (zh) * 2004-09-09 2007-10-03 中外制药株式会社 新型四氢咪唑衍生物及其用途
CN101472585A (zh) * 2006-06-22 2009-07-01 普罗利西斯有限公司 抗菌组合物
WO2009156966A1 (en) * 2008-06-25 2009-12-30 Ranbaxy Laboratories Limited Benzothiazoles and aza-analogues thereof use as antibacterial agents
CN102015700A (zh) * 2007-12-13 2011-04-13 生物区欧洲有限公司 抗菌稠合噻唑
CN102056932A (zh) * 2008-06-04 2011-05-11 阿斯利康(瑞典)有限公司 作为抗菌药的噻唑并[5,4-b]吡啶和唑[5,4-b]吡啶衍生物

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0724349D0 (en) 2007-12-13 2008-01-30 Prolysis Ltd Antibacterial agents
US8586582B2 (en) * 2008-11-11 2013-11-19 Xcovery Holding Company, Llc PI3K/mTOR kinase inhibitors
WO2012045124A1 (en) 2010-10-08 2012-04-12 Biota Europe Ltd Bacteria topoisomerase ii inhibiting 2-ethylcarbamoylamino-1, 3-benzothiazol-5-yls
CN104125947A (zh) * 2011-12-21 2014-10-29 生物区欧洲有限公司 杂环脲化合物
WO2013138860A1 (en) * 2012-03-22 2013-09-26 Biota Europe Limited Antibacterial compounds

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101048381A (zh) * 2004-09-09 2007-10-03 中外制药株式会社 新型四氢咪唑衍生物及其用途
CN101472585A (zh) * 2006-06-22 2009-07-01 普罗利西斯有限公司 抗菌组合物
CN102015700A (zh) * 2007-12-13 2011-04-13 生物区欧洲有限公司 抗菌稠合噻唑
CN102056932A (zh) * 2008-06-04 2011-05-11 阿斯利康(瑞典)有限公司 作为抗菌药的噻唑并[5,4-b]吡啶和唑[5,4-b]吡啶衍生物
WO2009156966A1 (en) * 2008-06-25 2009-12-30 Ranbaxy Laboratories Limited Benzothiazoles and aza-analogues thereof use as antibacterial agents

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
袁勇等: "新型合成抗菌药物研究新进展", 《中国新药杂志》 *

Also Published As

Publication number Publication date
JP2015514063A (ja) 2015-05-18
US9604976B2 (en) 2017-03-28
EP2828257B1 (en) 2017-07-26
US20170260178A1 (en) 2017-09-14
US8906902B2 (en) 2014-12-09
EP2828257A1 (en) 2015-01-28
EP2828257A4 (en) 2015-08-26
US20130252938A1 (en) 2013-09-26
HK1206031A1 (en) 2015-12-31
US20150329530A1 (en) 2015-11-19
WO2013138860A1 (en) 2013-09-26

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