CN1257894C - 作为谷氨酸受体拮抗剂的苯基乙烯基或苯基乙炔基衍生物 - Google Patents

作为谷氨酸受体拮抗剂的苯基乙烯基或苯基乙炔基衍生物 Download PDF

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Publication number
CN1257894C
CN1257894C CNB018199933A CN01819993A CN1257894C CN 1257894 C CN1257894 C CN 1257894C CN B018199933 A CNB018199933 A CN B018199933A CN 01819993 A CN01819993 A CN 01819993A CN 1257894 C CN1257894 C CN 1257894C
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China
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imidazole
phenylethynyl
methyl
alkyl
compound
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Expired - Fee Related
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CNB018199933A
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Chinese (zh)
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CN1478080A (zh
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V·穆泰尔
J－U·佩雷斯
J·维赫曼
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F Hoffmann La Roche AG
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F Hoffmann La Roche AG
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    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
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    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
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    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
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    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/91—Nitro radicals
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    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/91—Nitro radicals
    • C07D233/92—Nitro radicals attached in position 4 or 5
    • C07D233/94—Nitro radicals attached in position 4 or 5 with hydrocarbon radicals, substituted by oxygen or sulfur atoms, attached to other ring members
    • C—CHEMISTRY; METALLURGY
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07D513/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains three hetero rings
    • C07D513/14—Ortho-condensed systems

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  • Animal Behavior & Ethology (AREA)
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  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurology (AREA)
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  • Biomedical Technology (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Addiction (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Epidemiology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychology (AREA)
  • Virology (AREA)
  • AIDS & HIV (AREA)
  • Ophthalmology & Optometry (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Molecular Biology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Vascular Medicine (AREA)
  • Rheumatology (AREA)
  • Otolaryngology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CNB018199933A 2000-12-04 2001-11-26 作为谷氨酸受体拮抗剂的苯基乙烯基或苯基乙炔基衍生物 Expired - Fee Related CN1257894C (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP00126615 2000-12-04
EP00126615.4 2004-12-04

Publications (2)

Publication Number Publication Date
CN1478080A CN1478080A (zh) 2004-02-25
CN1257894C true CN1257894C (zh) 2006-05-31

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CNB018199933A Expired - Fee Related CN1257894C (zh) 2000-12-04 2001-11-26 作为谷氨酸受体拮抗剂的苯基乙烯基或苯基乙炔基衍生物

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Country Link
US (4) US6706707B2 (https=)
EP (1) EP1349839B8 (https=)
JP (2) JP4077317B2 (https=)
KR (1) KR100515549B1 (https=)
CN (1) CN1257894C (https=)
AR (1) AR035401A1 (https=)
AT (1) ATE288898T1 (https=)
AU (2) AU2956702A (https=)
BG (1) BG107877A (https=)
BR (1) BR0115871A (https=)
CA (1) CA2430696C (https=)
CZ (1) CZ20031795A3 (https=)
DE (1) DE60108900T2 (https=)
DK (1) DK1349839T3 (https=)
EC (1) ECSP034640A (https=)
ES (1) ES2248410T3 (https=)
HR (1) HRP20030429A2 (https=)
HU (1) HUP0400570A3 (https=)
IL (2) IL155999A0 (https=)
MA (1) MA26971A1 (https=)
MX (1) MXPA03004862A (https=)
NO (1) NO324326B1 (https=)
NZ (1) NZ525917A (https=)
PL (1) PL366222A1 (https=)
PT (1) PT1349839E (https=)
RS (1) RS43903A (https=)
RU (1) RU2284323C9 (https=)
SI (1) SI1349839T1 (https=)
SK (1) SK8402003A3 (https=)
WO (1) WO2002046166A1 (https=)
ZA (1) ZA200303870B (https=)

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CA2517083A1 (en) 2003-03-04 2004-09-16 Addex Pharmaceuticals Sa Novel aminopyridine derivatives as mglur5 antagonists
BRPI0408136A (pt) 2003-03-07 2006-03-01 Astellas Pharma Inc derivados heterocìclicos contendo nitrogênio tendo estirila 2,6-dissubstituìda
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DE602005017129D1 (de) 2004-03-22 2009-11-26 Lilly Co Eli Pyridyl-derivate und ihre verwendung als mglu5-rezeptorantagonisten
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