KR100515549B1 - 글루타메이트 수용체 길항제로서의 페닐에테닐 또는페닐에티닐 유도체 - Google Patents

글루타메이트 수용체 길항제로서의 페닐에테닐 또는페닐에티닐 유도체 Download PDF

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KR100515549B1
KR100515549B1 KR10-2003-7007421A KR20037007421A KR100515549B1 KR 100515549 B1 KR100515549 B1 KR 100515549B1 KR 20037007421 A KR20037007421 A KR 20037007421A KR 100515549 B1 KR100515549 B1 KR 100515549B1
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imidazole
phenylethynyl
methyl
alkyl
triazolyl
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KR20040025878A (ko
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무텔빈센트
피터스옌스-우베
비흐만유에르겐
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에프. 호프만-라 로슈 아게
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    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
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    • A61K31/33—Heterocyclic compounds
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
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    • C07D209/04—Indoles; Hydrogenated indoles
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    • C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
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    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D513/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains three hetero rings
    • C07D513/14—Ortho-condensed systems

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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
KR10-2003-7007421A 2000-12-04 2001-11-26 글루타메이트 수용체 길항제로서의 페닐에테닐 또는페닐에티닐 유도체 Expired - Fee Related KR100515549B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP00126615 2000-12-04
PCT/EP2001/013714 WO2002046166A1 (en) 2000-12-04 2001-11-26 Phenylethenyl or phenylethinyl derivatives as glutamate receptor antagonists
EP00126615.4 2004-12-04

Publications (2)

Publication Number Publication Date
KR20040025878A KR20040025878A (ko) 2004-03-26
KR100515549B1 true KR100515549B1 (ko) 2005-09-20

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KR10-2003-7007421A Expired - Fee Related KR100515549B1 (ko) 2000-12-04 2001-11-26 글루타메이트 수용체 길항제로서의 페닐에테닐 또는페닐에티닐 유도체

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Country Link
US (4) US6706707B2 (https=)
EP (1) EP1349839B8 (https=)
JP (2) JP4077317B2 (https=)
KR (1) KR100515549B1 (https=)
CN (1) CN1257894C (https=)
AR (1) AR035401A1 (https=)
AT (1) ATE288898T1 (https=)
AU (2) AU2956702A (https=)
BG (1) BG107877A (https=)
BR (1) BR0115871A (https=)
CA (1) CA2430696C (https=)
CZ (1) CZ20031795A3 (https=)
DE (1) DE60108900T2 (https=)
DK (1) DK1349839T3 (https=)
EC (1) ECSP034640A (https=)
ES (1) ES2248410T3 (https=)
HR (1) HRP20030429A2 (https=)
HU (1) HUP0400570A3 (https=)
IL (2) IL155999A0 (https=)
MA (1) MA26971A1 (https=)
MX (1) MXPA03004862A (https=)
NO (1) NO324326B1 (https=)
NZ (1) NZ525917A (https=)
PL (1) PL366222A1 (https=)
PT (1) PT1349839E (https=)
RS (1) RS43903A (https=)
RU (1) RU2284323C9 (https=)
SI (1) SI1349839T1 (https=)
SK (1) SK8402003A3 (https=)
WO (1) WO2002046166A1 (https=)
ZA (1) ZA200303870B (https=)

Cited By (1)

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KR101291037B1 (ko) * 2011-10-12 2013-08-01 사회복지법인 삼성생명공익재단 레스베라트롤 유도체와 스티릴-오각형 방향족 화합물 및 이들의 베타-아밀로이드 플라그에 대한 결합제 및 진단영상제의 용도

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BRPI0408136A (pt) 2003-03-07 2006-03-01 Astellas Pharma Inc derivados heterocìclicos contendo nitrogênio tendo estirila 2,6-dissubstituìda
TWI292318B (en) 2003-03-10 2008-01-11 Hoffmann La Roche Imidazol-4-yl-ethynyl-pyridine derivatives
CA2519954A1 (en) 2003-03-26 2004-10-14 Merck & Co., Inc. Benzamide modulators of metabotropic glutamate receptors
US7531529B2 (en) 2003-06-05 2009-05-12 Roche Palo Alto Llc Imidazole derivatives
UA80888C2 (en) * 2003-06-05 2007-11-12 Hoffmann La Roche Imidazole derivatives as glutmate receptor antagonists
KR100717914B1 (ko) * 2003-06-12 2007-05-11 에프. 호프만-라 로슈 아게 글루타메이트 수용체 길항제로서 헤테로아릴-치환된이미다졸 유도체
DE602005017129D1 (de) 2004-03-22 2009-11-26 Lilly Co Eli Pyridyl-derivate und ihre verwendung als mglu5-rezeptorantagonisten
RU2361872C2 (ru) * 2004-05-26 2009-07-20 Эйсай Ар Энд Ди Менеджмент Ко., Лтд. Циннамидное соединение
EP1756086B1 (en) * 2004-06-01 2008-06-04 F.Hoffmann-La Roche Ag Pyridin-4-yl-ethynyl-imidazoles and pyrazoles as mglu5 receptor antagonists
NZ551253A (en) * 2004-06-01 2010-07-30 Hoffmann La Roche Pyridin-4-yl-ethynyl-imidazoles and pyrazoles as MGLU5 receptor antagonists
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