BRPI0408136A - derivados heterocìclicos contendo nitrogênio tendo estirila 2,6-dissubstituìda - Google Patents
derivados heterocìclicos contendo nitrogênio tendo estirila 2,6-dissubstituìdaInfo
- Publication number
- BRPI0408136A BRPI0408136A BRPI0408136-6A BRPI0408136A BRPI0408136A BR PI0408136 A BRPI0408136 A BR PI0408136A BR PI0408136 A BRPI0408136 A BR PI0408136A BR PI0408136 A BRPI0408136 A BR PI0408136A
- Authority
- BR
- Brazil
- Prior art keywords
- nitrogen
- containing heterocyclic
- disubstituted
- heterocyclic derivatives
- styryl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/10—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms
- C07D211/12—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms with only hydrogen atoms attached to the ring nitrogen atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4465—Non condensed piperidines, e.g. piperocaine only substituted in position 4
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D211/30—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by doubly bound oxygen or sulfur atoms or by two oxygen or sulfur atoms singly bound to the same carbon atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/38—Halogen atoms or nitro radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
Abstract
"DERIVADOS HETEROCìCLICOS CONTENDO NITROGêNIO TENDO ESTIRILA 2,6-DISSUBSTITUìDA". A presente invenção refere-se a um novo derivado heterocíclico contendo nitrogênio tendo estirila 2,6-dissubstituída e um sal farmaceuticamente aceitável do mesmo, e uma composição farmacêutica compreendendo o derivado heterocíclico contendo nitrogênio e um sal farmaceuticamente aceitável do mesmo, em particular, uma composição farmacêutica eficaz como um inibidor do canal de sódio, tendo uma excelente ação analgésica, especialmente sobre a dor neuropática, com efeitos colaterais minimizados.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2003061758 | 2003-03-07 | ||
PCT/JP2004/002842 WO2004078715A1 (ja) | 2003-03-07 | 2004-03-05 | 2,6-ジ置換スチリルを有する含窒素へテロ環誘導体 |
Publications (1)
Publication Number | Publication Date |
---|---|
BRPI0408136A true BRPI0408136A (pt) | 2006-03-01 |
Family
ID=32958970
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BRPI0408136-6A BRPI0408136A (pt) | 2003-03-07 | 2004-03-05 | derivados heterocìclicos contendo nitrogênio tendo estirila 2,6-dissubstituìda |
Country Status (13)
Country | Link |
---|---|
US (1) | US8044206B2 (pt) |
EP (1) | EP1602645A4 (pt) |
JP (1) | JP4610480B2 (pt) |
KR (1) | KR20050114641A (pt) |
CN (1) | CN100516040C (pt) |
AU (1) | AU2004218115A1 (pt) |
BR (1) | BRPI0408136A (pt) |
CA (1) | CA2517081A1 (pt) |
MX (1) | MXPA05009290A (pt) |
NO (1) | NO20054607L (pt) |
RU (1) | RU2333200C2 (pt) |
WO (1) | WO2004078715A1 (pt) |
ZA (1) | ZA200507486B (pt) |
Families Citing this family (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR20050114641A (ko) * | 2003-03-07 | 2005-12-06 | 아스텔라스세이야쿠 가부시키가이샤 | 2,6-이치환된 스티릴을 갖는 질소 함유 헤테로환 유도체 |
BRPI0415179A (pt) * | 2003-10-07 | 2006-11-28 | Renovis Inc | derivados de amida como ligandos de canal de ìon e composições farmacêuticas e métodos de empregar as mesmas |
KR20070050961A (ko) * | 2004-09-01 | 2007-05-16 | 아스텔라스세이야쿠 가부시키가이샤 | 피페리딘 유도체 또는 이의 제약학적으로 허용되는 염 |
US7576099B2 (en) | 2005-02-28 | 2009-08-18 | Renovis, Inc. | Amide derivatives as ion-channel ligands and pharmaceutical compositions and methods of using the same |
US20080300243A1 (en) * | 2005-02-28 | 2008-12-04 | Kelly Michael G | Amide Derivatives as Ion-Channel Ligands and Pharmaceutical Compositions and Methods of Using the Same |
AU2006264649A1 (en) * | 2005-06-30 | 2007-01-11 | Prosidion Limited | GPCR agonists |
GB201106817D0 (en) | 2011-04-21 | 2011-06-01 | Astex Therapeutics Ltd | New compound |
TW201311679A (zh) | 2011-08-04 | 2013-03-16 | Takeda Pharmaceutical | 含氮雜環化合物 |
GB201218850D0 (en) | 2012-10-19 | 2012-12-05 | Astex Therapeutics Ltd | Bicyclic heterocycle compounds and their uses in therapy |
US9980973B2 (en) | 2012-10-19 | 2018-05-29 | Astex Therapeutics Limited | Bicyclic heterocycle compounds and their uses in therapy |
GB201218862D0 (en) | 2012-10-19 | 2012-12-05 | Astex Therapeutics Ltd | Bicyclic heterocycle compounds and their uses in therapy |
GB201218864D0 (en) | 2012-10-19 | 2012-12-05 | Astex Therapeutics Ltd | Bicyclic heterocycle compounds and their uses in therapy |
MY186311A (en) | 2013-12-20 | 2021-07-08 | Astex Therapeutics Ltd | Bicyclic heterocycle compounds and their uses in therapy |
RU2676328C2 (ru) * | 2014-02-14 | 2018-12-28 | Тоа Эйо Лтд. | Циклическое углеводородное соединение |
WO2016160362A1 (en) | 2015-03-31 | 2016-10-06 | Allergan, Inc. | Cyclosporins modified on the mebmt sidechain by heterocyclic rings |
CN108503579B (zh) * | 2018-03-28 | 2021-03-26 | 南京医科大学 | 芬太尼类似物及其应用 |
CN114948953A (zh) * | 2021-06-29 | 2022-08-30 | 四川大学华西医院 | 一种杂原子取代芳香类化合物及其盐的用途 |
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KR20050114641A (ko) | 2003-03-07 | 2005-12-06 | 아스텔라스세이야쿠 가부시키가이샤 | 2,6-이치환된 스티릴을 갖는 질소 함유 헤테로환 유도체 |
KR20070050961A (ko) * | 2004-09-01 | 2007-05-16 | 아스텔라스세이야쿠 가부시키가이샤 | 피페리딘 유도체 또는 이의 제약학적으로 허용되는 염 |
-
2004
- 2004-03-05 KR KR1020057016695A patent/KR20050114641A/ko not_active Application Discontinuation
- 2004-03-05 RU RU2005131014/04A patent/RU2333200C2/ru not_active IP Right Cessation
- 2004-03-05 CN CNB2004800059211A patent/CN100516040C/zh not_active Expired - Fee Related
- 2004-03-05 CA CA002517081A patent/CA2517081A1/en not_active Abandoned
- 2004-03-05 ZA ZA200507486A patent/ZA200507486B/xx unknown
- 2004-03-05 EP EP04717835A patent/EP1602645A4/en not_active Withdrawn
- 2004-03-05 JP JP2005503134A patent/JP4610480B2/ja not_active Expired - Fee Related
- 2004-03-05 BR BRPI0408136-6A patent/BRPI0408136A/pt not_active IP Right Cessation
- 2004-03-05 MX MXPA05009290A patent/MXPA05009290A/es not_active Application Discontinuation
- 2004-03-05 US US10/548,197 patent/US8044206B2/en not_active Expired - Fee Related
- 2004-03-05 WO PCT/JP2004/002842 patent/WO2004078715A1/ja active Application Filing
- 2004-03-05 AU AU2004218115A patent/AU2004218115A1/en not_active Abandoned
-
2005
- 2005-10-06 NO NO20054607A patent/NO20054607L/no not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
NO20054607D0 (no) | 2005-10-06 |
CN1756740A (zh) | 2006-04-05 |
AU2004218115A1 (en) | 2004-09-16 |
JPWO2004078715A1 (ja) | 2006-06-08 |
CA2517081A1 (en) | 2004-09-16 |
EP1602645A4 (en) | 2008-12-03 |
MXPA05009290A (es) | 2006-05-31 |
RU2333200C2 (ru) | 2008-09-10 |
KR20050114641A (ko) | 2005-12-06 |
ZA200507486B (en) | 2007-03-28 |
NO20054607L (no) | 2005-12-06 |
EP1602645A1 (en) | 2005-12-07 |
RU2005131014A (ru) | 2006-05-10 |
WO2004078715A1 (ja) | 2004-09-16 |
US8044206B2 (en) | 2011-10-25 |
JP4610480B2 (ja) | 2011-01-12 |
US20070099956A1 (en) | 2007-05-03 |
CN100516040C (zh) | 2009-07-22 |
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