ZA200507486B - Nitrogenous heterocyclic derivative having 2,6-disubstituted styryl - Google Patents
Nitrogenous heterocyclic derivative having 2,6-disubstituted styrylInfo
- Publication number
- ZA200507486B ZA200507486B ZA200507486A ZA200507486A ZA200507486B ZA 200507486 B ZA200507486 B ZA 200507486B ZA 200507486 A ZA200507486 A ZA 200507486A ZA 200507486 A ZA200507486 A ZA 200507486A ZA 200507486 B ZA200507486 B ZA 200507486B
- Authority
- ZA
- South Africa
- Prior art keywords
- heterocyclic derivative
- nitrogenous heterocyclic
- disubstituted styryl
- styryl
- disubstituted
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/10—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms
- C07D211/12—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms with only hydrogen atoms attached to the ring nitrogen atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4465—Non condensed piperidines, e.g. piperocaine only substituted in position 4
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D211/30—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by doubly bound oxygen or sulfur atoms or by two oxygen or sulfur atoms singly bound to the same carbon atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/38—Halogen atoms or nitro radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2003061758 | 2003-03-07 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZA200507486B true ZA200507486B (en) | 2007-03-28 |
Family
ID=32958970
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA200507486A ZA200507486B (en) | 2003-03-07 | 2004-03-05 | Nitrogenous heterocyclic derivative having 2,6-disubstituted styryl |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US8044206B2 (xx) |
| EP (1) | EP1602645A4 (xx) |
| JP (1) | JP4610480B2 (xx) |
| KR (1) | KR20050114641A (xx) |
| CN (1) | CN100516040C (xx) |
| AU (1) | AU2004218115A1 (xx) |
| BR (1) | BRPI0408136A (xx) |
| CA (1) | CA2517081A1 (xx) |
| MX (1) | MXPA05009290A (xx) |
| NO (1) | NO20054607L (xx) |
| RU (1) | RU2333200C2 (xx) |
| WO (1) | WO2004078715A1 (xx) |
| ZA (1) | ZA200507486B (xx) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2333200C2 (ru) | 2003-03-07 | 2008-09-10 | Астеллас Фарма Инк. | Азотсодержащие гетероциклические производные, содержащие 2,6-дизамещенный стирил |
| AR046276A1 (es) | 2003-10-07 | 2005-11-30 | Renovis Inc | Derivados de amida como ligandos de canales ionicos y composiciones farmaceuticas y metodos que los utilizan. |
| CA2578604A1 (en) * | 2004-09-01 | 2006-03-09 | Astellas Pharma Inc. | Piperidine derivative or pharmaceutically acceptable salt thereof |
| US20080300243A1 (en) * | 2005-02-28 | 2008-12-04 | Kelly Michael G | Amide Derivatives as Ion-Channel Ligands and Pharmaceutical Compositions and Methods of Using the Same |
| US7576099B2 (en) | 2005-02-28 | 2009-08-18 | Renovis, Inc. | Amide derivatives as ion-channel ligands and pharmaceutical compositions and methods of using the same |
| NZ564759A (en) * | 2005-06-30 | 2011-08-26 | Prosidion Ltd | GPCR agonists |
| GB201106817D0 (en) | 2011-04-21 | 2011-06-01 | Astex Therapeutics Ltd | New compound |
| US8772277B2 (en) | 2011-08-04 | 2014-07-08 | Takeda Pharmaceutical Company Limited | Nitrogen-containing heterocyclic compound |
| GB201218862D0 (en) | 2012-10-19 | 2012-12-05 | Astex Therapeutics Ltd | Bicyclic heterocycle compounds and their uses in therapy |
| US9980973B2 (en) | 2012-10-19 | 2018-05-29 | Astex Therapeutics Limited | Bicyclic heterocycle compounds and their uses in therapy |
| GB201218850D0 (en) | 2012-10-19 | 2012-12-05 | Astex Therapeutics Ltd | Bicyclic heterocycle compounds and their uses in therapy |
| GB201218864D0 (en) | 2012-10-19 | 2012-12-05 | Astex Therapeutics Ltd | Bicyclic heterocycle compounds and their uses in therapy |
| CN105829310B (zh) | 2013-12-20 | 2019-04-12 | 阿斯特克斯治疗有限公司 | 双环杂环化合物及其治疗用途 |
| US9950989B2 (en) | 2014-02-14 | 2018-04-24 | Toa Eiyo Ltd. | Cyclic hydrocarbon compound |
| US10077289B2 (en) | 2015-03-31 | 2018-09-18 | Allergan, Inc. | Cyclosporins modified on the MeBmt sidechain by heterocyclic rings |
| CN108503579B (zh) * | 2018-03-28 | 2021-03-26 | 南京医科大学 | 芬太尼类似物及其应用 |
| CN114948953A (zh) * | 2021-06-29 | 2022-08-30 | 四川大学华西医院 | 一种杂原子取代芳香类化合物及其盐的用途 |
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| US3658797A (en) * | 1968-08-06 | 1972-04-25 | Lilly Co Eli | Novel 5-nitroimidazole antiparasitic agents |
| GB2069481B (en) | 1980-02-13 | 1983-07-27 | Farmos Oy | Substituted imidazole derivatives |
| GB2092569B (en) * | 1981-02-05 | 1984-09-19 | Farmos Oy | Substituted imidazole derivatives and their preparation and use |
| GB2101114B (en) | 1981-07-10 | 1985-05-22 | Farmos Group Ltd | Substituted imidazole derivatives and their preparation and use |
| FR2522325B1 (fr) | 1982-02-26 | 1985-08-09 | Delalande Sa | Nouveaux derives aryliques de la piperazine, de l'homopiperazine et de n,n'-dialkyl diamino-1,2 ethane, leur procede de preparation et leur application en therapeutique |
| JPS60193966A (ja) | 1984-03-13 | 1985-10-02 | Ss Pharmaceut Co Ltd | Ν−ニコチノイルピペラジン誘導体及びその製造法 |
| CN1030415A (zh) | 1987-02-20 | 1989-01-18 | 山之内制药株式会社 | 饱和的杂环碳酰胺衍生物和它的制备方法 |
| JPH0631230B2 (ja) | 1987-02-20 | 1994-04-27 | 山之内製薬株式会社 | 飽和ヘテロ環カルボン酸アミド誘導体 |
| JPH01316359A (ja) | 1988-03-23 | 1989-12-21 | Idemitsu Kosan Co Ltd | ピリジン誘導体および該誘導体を有効成分とする殺虫・殺ダニ剤 |
| DE69123052T2 (de) | 1990-06-07 | 1997-03-06 | Merrell Pharma Inc | Derivate des 1-piperidinyl-alkanoylarylsulfonamids |
| JPH04342579A (ja) | 1991-05-20 | 1992-11-30 | Hiroyoshi Hidaka | １−アリールスルホニルピペラジン類及び薬剤として許容され得るその酸付加塩 |
| EP0551617A3 (en) | 1991-12-13 | 1993-11-03 | Ube Industries | Cinnamyl piperazine derivatives method of manufacturing the same and agricultural/horticultural fungicides containing cinnamyl piperazine derivatives |
| JP3134552B2 (ja) | 1991-12-13 | 2001-02-13 | 宇部興産株式会社 | シンナミルピペラジン誘導体、その製法及び農園芸用殺菌剤 |
| US5240943A (en) | 1991-12-19 | 1993-08-31 | G. D. Searle & Co. | Benzopyran class iii antiarrhythmic agents |
| GB9226111D0 (en) | 1992-12-15 | 1993-02-10 | Smithkline Beecham Plc | Madicaments |
| WO1995024390A1 (en) | 1994-03-11 | 1995-09-14 | Smithkline Beecham Plc | Novel phenyl(-alkyl/alkoxy)-1-aminoalkyl-substituted piperidines and pyrrolidines as calcium channel antagonists |
| FR2726267B1 (fr) | 1994-10-26 | 1998-01-02 | Smithkline Beecham Lab | Nouveaux agents anti-arythmiques, compositions pharmaceutiques les contenant, et procede pour les preparer |
| AU717012B2 (en) | 1995-11-17 | 2000-03-16 | Merck & Co., Inc. | Novel substituted aryl compounds useful as modulators of acetylcholine receptors |
| TWI240627B (en) | 1996-04-26 | 2005-10-01 | Chugai Pharmaceutical Co Ltd | Erythropoietin solution preparation |
| TW544448B (en) * | 1997-07-11 | 2003-08-01 | Novartis Ag | Pyridine derivatives |
| CA2297732C (en) | 1997-08-14 | 2008-04-29 | F. Hoffmann-La Roche Ag | Heterocyclic vinylethers against neurological disorders |
| AU772477B2 (en) | 1998-08-28 | 2004-04-29 | Scios Inc. | Inhibitors of p38-alpha kinase |
| CA2371618A1 (en) | 1999-04-28 | 2000-11-09 | Yuji Ishihara | Cyclic amide compounds, their production and use |
| JP4829449B2 (ja) | 1999-07-28 | 2011-12-07 | アベンティス・ファーマスーティカルズ・インコーポレイテツド | 置換オキソアザヘテロシクリル化合物 |
| CA2383524C (en) | 1999-08-31 | 2010-09-28 | Merck & Co., Inc. | Thiazolyl alkynyl compounds and methods of use thereof |
| JP4282048B2 (ja) * | 2000-01-20 | 2009-06-17 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | 新規ピペリジン化合物およびその医薬 |
| HUP0204496A3 (en) * | 2000-01-20 | 2004-07-28 | Eisai Co Ltd | Novel piperidine compounds and pharmaceutical compositions containing the same and process for preparation the same |
| EP1268454A1 (en) | 2000-03-31 | 2003-01-02 | Bristol-Myers Squibb Pharma Company | Succinoylamino heterocycles as inhibitors of a-beta protein production |
| CN1257894C (zh) | 2000-12-04 | 2006-05-31 | 弗·哈夫曼-拉罗切有限公司 | 作为谷氨酸受体拮抗剂的苯基乙烯基或苯基乙炔基衍生物 |
| JP3953424B2 (ja) | 2001-02-21 | 2007-08-08 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ | 抗うつ薬としてのイソキサゾリン誘導体 |
| US6949655B2 (en) | 2001-06-14 | 2005-09-27 | David Lauffer | Acyclic piperidine derivatives |
| EP1422782B1 (en) | 2001-07-06 | 2011-01-12 | Nippon Kayaku Kabushiki Kaisha | Photoelectric conversion element sensitized with methine dyes |
| CN1941694B (zh) | 2001-07-17 | 2011-04-20 | 夏普株式会社 | 生成用于检测在处理期间加密数据的虚假改造的数据的设备及方法 |
| US6995144B2 (en) * | 2002-03-14 | 2006-02-07 | Eisai Co., Ltd. | Nitrogen containing heterocyclic compounds and medicines containing the same |
| CN2562229Y (zh) * | 2002-07-23 | 2003-07-23 | 昆山新力精密五金有限公司 | 散热器中的散热叶片之装置 |
| AU2003248122A1 (en) | 2002-07-25 | 2004-02-16 | Kotobuki Pharmaceutical Co., Ltd. | Sodium channel inhibitor |
| WO2004037817A1 (ja) | 2002-10-25 | 2004-05-06 | Mitsubishi Pharma Corporation | Ｎ−オキシド化合物 |
| RU2333200C2 (ru) | 2003-03-07 | 2008-09-10 | Астеллас Фарма Инк. | Азотсодержащие гетероциклические производные, содержащие 2,6-дизамещенный стирил |
| CA2578604A1 (en) * | 2004-09-01 | 2006-03-09 | Astellas Pharma Inc. | Piperidine derivative or pharmaceutically acceptable salt thereof |
-
2004
- 2004-03-05 RU RU2005131014/04A patent/RU2333200C2/ru not_active IP Right Cessation
- 2004-03-05 MX MXPA05009290A patent/MXPA05009290A/es not_active Application Discontinuation
- 2004-03-05 KR KR1020057016695A patent/KR20050114641A/ko not_active Application Discontinuation
- 2004-03-05 ZA ZA200507486A patent/ZA200507486B/xx unknown
- 2004-03-05 JP JP2005503134A patent/JP4610480B2/ja not_active Expired - Fee Related
- 2004-03-05 US US10/548,197 patent/US8044206B2/en not_active Expired - Fee Related
- 2004-03-05 BR BRPI0408136-6A patent/BRPI0408136A/pt not_active IP Right Cessation
- 2004-03-05 CA CA002517081A patent/CA2517081A1/en not_active Abandoned
- 2004-03-05 CN CNB2004800059211A patent/CN100516040C/zh not_active Expired - Fee Related
- 2004-03-05 WO PCT/JP2004/002842 patent/WO2004078715A1/ja active Application Filing
- 2004-03-05 EP EP04717835A patent/EP1602645A4/en not_active Withdrawn
- 2004-03-05 AU AU2004218115A patent/AU2004218115A1/en not_active Abandoned
-
2005
- 2005-10-06 NO NO20054607A patent/NO20054607L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| JP4610480B2 (ja) | 2011-01-12 |
| CA2517081A1 (en) | 2004-09-16 |
| JPWO2004078715A1 (ja) | 2006-06-08 |
| CN1756740A (zh) | 2006-04-05 |
| WO2004078715A1 (ja) | 2004-09-16 |
| KR20050114641A (ko) | 2005-12-06 |
| EP1602645A1 (en) | 2005-12-07 |
| RU2005131014A (ru) | 2006-05-10 |
| MXPA05009290A (es) | 2006-05-31 |
| NO20054607D0 (no) | 2005-10-06 |
| RU2333200C2 (ru) | 2008-09-10 |
| NO20054607L (no) | 2005-12-06 |
| CN100516040C (zh) | 2009-07-22 |
| US20070099956A1 (en) | 2007-05-03 |
| US8044206B2 (en) | 2011-10-25 |
| EP1602645A4 (en) | 2008-12-03 |
| AU2004218115A1 (en) | 2004-09-16 |
| BRPI0408136A (pt) | 2006-03-01 |
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