UA90518C2 - Фармацевтическая композиция в форме таблетки, которая имеет улучшеное всасывание при трансбукальном введение, которая содержит наркотический активный ингредиент и амин - Google Patents

Фармацевтическая композиция в форме таблетки, которая имеет улучшеное всасывание при трансбукальном введение, которая содержит наркотический активный ингредиент и амин

Info

Publication number
UA90518C2
UA90518C2 UAA200713973A UAA200713973A UA90518C2 UA 90518 C2 UA90518 C2 UA 90518C2 UA A200713973 A UAA200713973 A UA A200713973A UA A200713973 A UAA200713973 A UA A200713973A UA 90518 C2 UA90518 C2 UA 90518C2
Authority
UA
Ukraine
Prior art keywords
active ingredient
amine
dissolution
pharmaceutical composition
buccal cavity
Prior art date
Application number
UAA200713973A
Other languages
English (en)
Ukrainian (uk)
Inventor
Федерико Стропполо
Шабаз Ардалан
Original Assignee
Альпекс Фарма С.А.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Альпекс Фарма С.А. filed Critical Альпекс Фарма С.А.
Publication of UA90518C2 publication Critical patent/UA90518C2/ru

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4468—Non condensed piperidines, e.g. piperocaine having a nitrogen directly attached in position 4, e.g. clebopride, fentanyl
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P23/00—Anaesthetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Abstract

Изобретение касается фармацевтической композиции в форме таблетки, пригодной для растворения в ротовой полости, причем вышеупомянутая композиция включает и) эффективное количество наркотического активного ингредиента и ии) фармацевтически приемлемый амин, который имеет рК приблизительно 8 или больше, в которой молярное соотношение амин : активный ингредиент представляет по крайней мере приблизительно 5:1.
UAA200713973A 2005-07-22 2006-07-21 Фармацевтическая композиция в форме таблетки, которая имеет улучшеное всасывание при трансбукальном введение, которая содержит наркотический активный ингредиент и амин UA90518C2 (ru)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US11/186,925 US20070020186A1 (en) 2005-07-22 2005-07-22 Solid dosage formulations of narcotic drugs having improved buccal adsorption

Publications (1)

Publication Number Publication Date
UA90518C2 true UA90518C2 (ru) 2010-05-11

Family

ID=37440618

Family Applications (1)

Application Number Title Priority Date Filing Date
UAA200713973A UA90518C2 (ru) 2005-07-22 2006-07-21 Фармацевтическая композиция в форме таблетки, которая имеет улучшеное всасывание при трансбукальном введение, которая содержит наркотический активный ингредиент и амин

Country Status (26)

Country Link
US (3) US20070020186A1 (ru)
EP (1) EP1906961B1 (ru)
JP (1) JP5714797B2 (ru)
KR (1) KR101326206B1 (ru)
CN (1) CN101208091A (ru)
AU (1) AU2006271870B2 (ru)
BR (1) BRPI0613769A2 (ru)
CA (1) CA2607360C (ru)
CY (1) CY1117470T1 (ru)
DK (1) DK1906961T3 (ru)
ES (1) ES2569228T3 (ru)
HR (1) HRP20160327T1 (ru)
HU (1) HUE027354T2 (ru)
IL (1) IL187387A (ru)
MA (1) MA29744B1 (ru)
MX (1) MX2007015480A (ru)
NO (1) NO20080827L (ru)
NZ (1) NZ563511A (ru)
PL (1) PL1906961T3 (ru)
RS (1) RS54670B1 (ru)
RU (1) RU2408373C2 (ru)
SI (1) SI1906961T1 (ru)
TW (1) TW200727922A (ru)
UA (1) UA90518C2 (ru)
WO (1) WO2007009806A2 (ru)
ZA (1) ZA200710406B (ru)

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US20070299687A1 (en) * 2006-06-23 2007-12-27 Pamela Palmer Inpatient system for patient-controlled delivery of oral transmucosal medications dosed as needed
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US8945592B2 (en) 2008-11-21 2015-02-03 Acelrx Pharmaceuticals, Inc. Sufentanil solid dosage forms comprising oxygen scavengers and methods of using the same
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GB2481017B (en) 2010-06-08 2015-01-07 Rb Pharmaceuticals Ltd Microparticle buprenorphine suspension
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RU2476209C1 (ru) * 2012-02-29 2013-02-27 Станислав Анатольевич Кедик Имплантируемое лекарственное средство на основе налтрексона для лечения пациентов, зависимых от алкоголя или опиатов
MX356111B (es) 2012-04-18 2018-05-15 SpecGx LLC Composiciones farmaceuticas disuasorias de abuso, de liberacion inmediata.
ES2698611T3 (es) 2012-07-12 2019-02-05 SpecGx LLC Composiciones farmacéuticas disuasorias del abuso y de liberación prolongada
GB201404139D0 (en) 2014-03-10 2014-04-23 Rb Pharmaceuticals Ltd Sustained release buprenorphine solution formulations
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EP3856160A4 (en) 2018-09-25 2022-07-06 SpecGx LLC ANTI-ABUSE IMMEDIATE RELEASE CAPSULES DOSAGE FORMS

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Also Published As

Publication number Publication date
CN101208091A (zh) 2008-06-25
ES2569228T3 (es) 2016-05-09
RU2408373C2 (ru) 2011-01-10
US10258693B2 (en) 2019-04-16
AU2006271870B2 (en) 2011-11-24
SI1906961T1 (sl) 2016-09-30
MX2007015480A (es) 2008-04-29
CA2607360A1 (en) 2007-01-25
PL1906961T3 (pl) 2016-07-29
EP1906961A2 (en) 2008-04-09
US20140018392A1 (en) 2014-01-16
DK1906961T3 (en) 2016-05-02
TW200727922A (en) 2007-08-01
HUE027354T2 (en) 2016-09-28
NZ563511A (en) 2011-03-31
JP5714797B2 (ja) 2015-05-07
AU2006271870A1 (en) 2007-01-25
CA2607360C (en) 2014-02-18
US20070020187A1 (en) 2007-01-25
RS54670B1 (en) 2016-08-31
MA29744B1 (fr) 2008-09-01
CY1117470T1 (el) 2017-04-26
HRP20160327T1 (hr) 2016-05-20
ZA200710406B (en) 2008-11-26
KR101326206B1 (ko) 2013-11-08
IL187387A0 (en) 2008-02-09
WO2007009806A3 (en) 2007-04-05
BRPI0613769A2 (pt) 2011-02-01
RU2007149044A (ru) 2009-06-27
EP1906961B1 (en) 2016-03-23
KR20080030608A (ko) 2008-04-04
US8574552B2 (en) 2013-11-05
JP2009502761A (ja) 2009-01-29
US20070020186A1 (en) 2007-01-25
NO20080827L (no) 2008-02-15
IL187387A (en) 2016-10-31
WO2007009806A2 (en) 2007-01-25

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