MX2007015480A - Formulaciones de dosificacion solida de medicamentos narcoticos que tienen adsorcion bucal mejorada. - Google Patents

Formulaciones de dosificacion solida de medicamentos narcoticos que tienen adsorcion bucal mejorada.

Info

Publication number
MX2007015480A
MX2007015480A MX2007015480A MX2007015480A MX2007015480A MX 2007015480 A MX2007015480 A MX 2007015480A MX 2007015480 A MX2007015480 A MX 2007015480A MX 2007015480 A MX2007015480 A MX 2007015480A MX 2007015480 A MX2007015480 A MX 2007015480A
Authority
MX
Mexico
Prior art keywords
solid dosage
dosage formulations
narcotic drugs
adsorption
improved buccal
Prior art date
Application number
MX2007015480A
Other languages
English (en)
Inventor
Federico Stroppolo
Shahbaz Shoja-Ardalan
Original Assignee
Alpex Pharma S A
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alpex Pharma S A filed Critical Alpex Pharma S A
Publication of MX2007015480A publication Critical patent/MX2007015480A/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4468—Non condensed piperidines, e.g. piperocaine having a nitrogen directly attached in position 4, e.g. clebopride, fentanyl
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P23/00—Anaesthetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Abstract

Se describe una composicion farmaceutica en forma de una tableta adecuada para disolucion en la cavidad bucal, la composicion comprende: i) una cantidad eficaz de un ingrediente activo narcotico, y ii) una amina farmaceuticamente aceptable que tiene un pK de aproximadamente 8 o mayor, en donde la relacion molar de amina:ingrediente activo es de por lo menos aproximadamente 5:1.
MX2007015480A 2005-07-22 2006-07-21 Formulaciones de dosificacion solida de medicamentos narcoticos que tienen adsorcion bucal mejorada. MX2007015480A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US11/186,925 US20070020186A1 (en) 2005-07-22 2005-07-22 Solid dosage formulations of narcotic drugs having improved buccal adsorption
PCT/EP2006/007189 WO2007009806A2 (en) 2005-07-22 2006-07-21 Solid dosage formulations of narcotic drugs having improved buccal adsorption

Publications (1)

Publication Number Publication Date
MX2007015480A true MX2007015480A (es) 2008-04-29

Family

ID=37440618

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2007015480A MX2007015480A (es) 2005-07-22 2006-07-21 Formulaciones de dosificacion solida de medicamentos narcoticos que tienen adsorcion bucal mejorada.

Country Status (26)

Country Link
US (3) US20070020186A1 (es)
EP (1) EP1906961B1 (es)
JP (1) JP5714797B2 (es)
KR (1) KR101326206B1 (es)
CN (1) CN101208091A (es)
AU (1) AU2006271870B2 (es)
BR (1) BRPI0613769A2 (es)
CA (1) CA2607360C (es)
CY (1) CY1117470T1 (es)
DK (1) DK1906961T3 (es)
ES (1) ES2569228T3 (es)
HR (1) HRP20160327T1 (es)
HU (1) HUE027354T2 (es)
IL (1) IL187387A (es)
MA (1) MA29744B1 (es)
MX (1) MX2007015480A (es)
NO (1) NO20080827L (es)
NZ (1) NZ563511A (es)
PL (1) PL1906961T3 (es)
RS (1) RS54670B1 (es)
RU (1) RU2408373C2 (es)
SI (1) SI1906961T1 (es)
TW (1) TW200727922A (es)
UA (1) UA90518C2 (es)
WO (1) WO2007009806A2 (es)
ZA (1) ZA200710406B (es)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8852638B2 (en) 2005-09-30 2014-10-07 Durect Corporation Sustained release small molecule drug formulation
US8497258B2 (en) 2005-11-12 2013-07-30 The Regents Of The University Of California Viscous budesonide for the treatment of inflammatory diseases of the gastrointestinal tract
US8865743B2 (en) 2006-01-06 2014-10-21 Acelrx Pharmaceuticals, Inc. Small volume oral transmucosal dosage forms containing sufentanil for treatment of pain
US8753308B2 (en) 2006-01-06 2014-06-17 Acelrx Pharmaceuticals, Inc. Methods for administering small volume oral transmucosal dosage forms using a dispensing device
US8252328B2 (en) * 2006-01-06 2012-08-28 Acelrx Pharmaceuticals, Inc. Bioadhesive drug formulations for oral transmucosal delivery
US8357114B2 (en) 2006-01-06 2013-01-22 Acelrx Pharmaceuticals, Inc. Drug dispensing device with flexible push rod
US9066847B2 (en) * 2007-01-05 2015-06-30 Aceirx Pharmaceuticals, Inc. Storage and dispensing devices for administration of oral transmucosal dosage forms
US8252329B2 (en) 2007-01-05 2012-08-28 Acelrx Pharmaceuticals, Inc. Bioadhesive drug formulations for oral transmucosal delivery
US8535714B2 (en) 2006-01-06 2013-09-17 Acelrx Pharmaceuticals, Inc. Small volume oral transmucosal dosage forms containing sufentanil for treatment of pain
US8202535B2 (en) * 2006-01-06 2012-06-19 Acelrx Pharmaceuticals, Inc. Small-volume oral transmucosal dosage forms
US9289583B2 (en) * 2006-01-06 2016-03-22 Acelrx Pharmaceuticals, Inc. Methods for administering small volume oral transmucosal dosage forms using a dispensing device
US20070260491A1 (en) * 2006-05-08 2007-11-08 Pamela Palmer System for delivery and monitoring of administration of controlled substances
US20070299687A1 (en) * 2006-06-23 2007-12-27 Pamela Palmer Inpatient system for patient-controlled delivery of oral transmucosal medications dosed as needed
JP2010531807A (ja) 2007-05-25 2010-09-30 トルマー セラピューティクス， インコーポレイテッド リスペリドン化合物の徐放送達製剤
US8945592B2 (en) 2008-11-21 2015-02-03 Acelrx Pharmaceuticals, Inc. Sufentanil solid dosage forms comprising oxygen scavengers and methods of using the same
US20110097401A1 (en) * 2009-06-12 2011-04-28 Meritage Pharma, Inc. Methods for treating gastrointestinal disorders
US9272044B2 (en) 2010-06-08 2016-03-01 Indivior Uk Limited Injectable flowable composition buprenorphine
GB2481017B (en) 2010-06-08 2015-01-07 Rb Pharmaceuticals Ltd Microparticle buprenorphine suspension
RU2476209C1 (ru) * 2012-02-29 2013-02-27 Станислав Анатольевич Кедик Имплантируемое лекарственное средство на основе налтрексона для лечения пациентов, зависимых от алкоголя или опиатов
ES2699806T3 (es) 2012-04-18 2019-02-12 SpecGx LLC Composiciones farmacéuticas, disuasivas del abuso, de liberación inmediata
CA2877774C (en) * 2012-07-12 2017-07-18 Mallinckrodt Llc Extended release, abuse deterrent pharmaceutical compositions
GB201404139D0 (en) 2014-03-10 2014-04-23 Rb Pharmaceuticals Ltd Sustained release buprenorphine solution formulations
MX2017008428A (es) 2014-12-23 2018-03-23 Acelrx Pharmaceuticals Inc Sistemas, dispositivos y métodos para dispensar formas de dosificación transmucosa oral.
MX2021002459A (es) 2018-09-25 2021-04-29 SpecGx LLC Formas de dosificacion en capsula disuasorias del abuso de liberacion inmediata.

Family Cites Families (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5785989A (en) 1985-05-01 1998-07-28 University Utah Research Foundation Compositions and methods of manufacturing of oral dissolvable medicaments
US5464632C1 (en) 1991-07-22 2001-02-20 Prographarm Lab Rapidly disintegratable multiparticular tablet
DE69331839T2 (de) 1992-01-29 2002-12-12 Takeda Chemical Industries Ltd Schnellösliche Tablette und ihre Herstellung
US5576014A (en) 1994-01-31 1996-11-19 Yamanouchi Pharmaceutical Co., Ltd Intrabuccally dissolving compressed moldings and production process thereof
US5888534A (en) 1995-06-13 1999-03-30 Pentech Pharmaceuticals, Inc. Controlled release of drugs delivered by sublingual or buccal administration
US5624677A (en) 1995-06-13 1997-04-29 Pentech Pharmaceuticals, Inc. Controlled release of drugs delivered by sublingual or buccal administration
GB9517062D0 (en) 1995-08-18 1995-10-25 Scherer Ltd R P Pharmaceutical compositions
CA2259418A1 (en) * 1996-07-11 1998-01-22 Farmarc Nederland B.V. Pharmaceutical composition containing acid addition salt of basic drug
JP3770666B2 (ja) * 1996-09-20 2006-04-26 株式会社ティ・ティ・エス技術研究所 経粘膜吸収製剤用組成物
EP0839526A3 (en) 1996-10-31 1999-01-07 Takeda Chemical Industries, Ltd. Solid pharmaceutical preparation with fast buccal disintegration or dissolution
US6024981A (en) 1997-04-16 2000-02-15 Cima Labs Inc. Rapidly dissolving robust dosage form
ATE323467T1 (de) 1997-07-25 2006-05-15 Alpex Pharma Sa Verfahren zur herstellung eines granulates, geeignet zur herstellung schnell-freisetzender, im mund löslicher tabletten
US5869098A (en) 1997-08-20 1999-02-09 Fuisz Technologies Ltd. Fast-dissolving comestible units formed under high-speed/high-pressure conditions
US20030082107A1 (en) * 1997-10-01 2003-05-01 Dugger Harry A. Buccal, polar and non-polar spray or capsule containing drugs for treating an infectious disease or cancer
US6974590B2 (en) 1998-03-27 2005-12-13 Cima Labs Inc. Sublingual buccal effervescent
US6200604B1 (en) * 1998-03-27 2001-03-13 Cima Labs Inc. Sublingual buccal effervescent
US6350470B1 (en) 1998-04-29 2002-02-26 Cima Labs Inc. Effervescent drug delivery system for oral administration
US6270790B1 (en) 1998-08-18 2001-08-07 Mxneil-Ppc, Inc. Soft, convex shaped chewable tablets having reduced friability
US6680071B1 (en) 1999-03-03 2004-01-20 R. P. Scherer Technologies, Inc. Opioid agonist in a fast dispersing dosage form
JP2000281589A (ja) * 1999-03-26 2000-10-10 T T S Gijutsu Kenkyusho:Kk 経粘膜吸収助剤
US6210699B1 (en) 1999-04-01 2001-04-03 Watson Pharmaceuticals, Inc. Oral transmucosal delivery of drugs or any other ingredients via the inner buccal cavity
US6264981B1 (en) 1999-10-27 2001-07-24 Anesta Corporation Oral transmucosal drug dosage using solid solution
US20030104041A1 (en) * 1999-12-16 2003-06-05 Tsung-Min Hsu Transdermal and topical administration of drugs using basic permeation enhancers
US20020013331A1 (en) * 2000-06-26 2002-01-31 Williams Robert O. Methods and compositions for treating pain of the mucous membrane
US6733781B2 (en) 2000-12-06 2004-05-11 Wyeth Fast dissolving tablet
WO2003078437A1 (en) * 2002-03-20 2003-09-25 The University Of Queensland Methods and compositions comprising nitric oxide donors and opioid analgesics
US20030215502A1 (en) * 2002-03-20 2003-11-20 Elan Pharma International Limited Fast dissolving dosage forms having reduced friability
US20040253307A1 (en) * 2003-02-04 2004-12-16 Brian Hague Sugar-free oral transmucosal solid dosage forms and uses thereof
US20040202698A1 (en) * 2003-04-02 2004-10-14 The Procter & Gamble Company Drug delivery systems comprising an encapsulated active ingredient
EP1620075B1 (en) * 2003-05-07 2020-06-24 Samyang Biopharmaceuticals Corporation Highly plastic granules for making fast melting tablets
BRPI0418228B8 (pt) * 2003-12-31 2021-05-25 Cima Labs Inc forma de dosagem, e, método de preparação de um tablete para administração bucal, gengival ou sublingual de fentanil

Also Published As

Publication number Publication date
US20070020187A1 (en) 2007-01-25
TW200727922A (en) 2007-08-01
US8574552B2 (en) 2013-11-05
KR20080030608A (ko) 2008-04-04
ZA200710406B (en) 2008-11-26
JP2009502761A (ja) 2009-01-29
HRP20160327T1 (hr) 2016-05-20
JP5714797B2 (ja) 2015-05-07
ES2569228T3 (es) 2016-05-09
US20070020186A1 (en) 2007-01-25
RS54670B1 (en) 2016-08-31
EP1906961A2 (en) 2008-04-09
NZ563511A (en) 2011-03-31
AU2006271870A1 (en) 2007-01-25
HUE027354T2 (en) 2016-09-28
PL1906961T3 (pl) 2016-07-29
SI1906961T1 (sl) 2016-09-30
RU2007149044A (ru) 2009-06-27
CN101208091A (zh) 2008-06-25
EP1906961B1 (en) 2016-03-23
BRPI0613769A2 (pt) 2011-02-01
NO20080827L (no) 2008-02-15
KR101326206B1 (ko) 2013-11-08
WO2007009806A3 (en) 2007-04-05
CA2607360A1 (en) 2007-01-25
UA90518C2 (ru) 2010-05-11
MA29744B1 (fr) 2008-09-01
CY1117470T1 (el) 2017-04-26
DK1906961T3 (en) 2016-05-02
US20140018392A1 (en) 2014-01-16
IL187387A (en) 2016-10-31
CA2607360C (en) 2014-02-18
IL187387A0 (en) 2008-02-09
WO2007009806A2 (en) 2007-01-25
AU2006271870B2 (en) 2011-11-24
RU2408373C2 (ru) 2011-01-10
US10258693B2 (en) 2019-04-16

Similar Documents

Publication Publication Date Title
MX2007015480A (es) Formulaciones de dosificacion solida de medicamentos narcoticos que tienen adsorcion bucal mejorada.
HUP0302319A3 (en) Pharmaceutical composition for oral administration of active ingredient
TW200505498A (en) Sugar-free oral transmucosal solid dosage forms and uses thereof
HK1096034A1 (en) A solid dosage form comprising a fibrate
NO993520D0 (no) Doseringsformer og fremgangsmåte for å bedre erektil dysfunksjon
MY148773A (en) Galenic formulations of organic compounds
WO2003047519A3 (en) 'compressed annular tablet with molded triturate tablet for oral and intraoral'
AU2003274681A8 (en) Dosage form comprising high dose high soluble active ingredient as modified release and low dose active ingredient as immediate release
GEP20074208B (en) Substituted amides active at the cannabinoid-1 receptor
BG66093B1 (bg) Състави с контролирано освобождаване, съдържащи нимесулид
WO2004032909A3 (en) Stabilized pharmaceutical composition containing basic excipients
WO2008023016A3 (en) Galenic formulations of aliskiren
IL159217A0 (en) An oral pharmaceutical formulation comprising a basic pharmaceutically active ingredient having ph-dependent solubility, a process for the manufacture thereof and use thereof in medicine
WO2002024203A3 (en) Controlled release formulations for oral administration
IL165786A0 (en) Ibuprofen suspension
ATE287264T1 (de) Oral anzuwendende buprenorphinhaltige arzneimittel
IL158668A0 (en) Deuterated 3-piperidinopropiophenone and medicaments containing said compounds
WO2002011694A3 (en) COMPOSITIONS AND DOSAGE FORMS FOR APPLICATION IN ORAL CAVITY IN THE TREATMENT OF MYCOSIS
TW200638927A (en) Bambuterol and integrin inhibitor combination
MXPA06000332A (es) Nueva composicion farmaceutica solida que comprende amisulprida.
IL179177A (en) A pharmaceutical product including acyclovir and delivery compound, dosage unit, use of acyclovir in the preparation of the pharmaceutical product, use of the pharmaceutical product in the preparation of a drug and a method for the preparation of the pharmaceutical product
WO2005120518A3 (en) Use of atp analogues for treatment of cardiovascular diseases
ATE460934T1 (de) Pharmazeutische zubereitungen von ciprofloxacin
AP1530A (en) Pharmaceutical composition for intramuscular injection containing loxoprofen.
BE2016C017I2 (es)

Legal Events

Date Code Title Description
FG Grant or registration