HUP9904265A2 - Fokozott biológiai hasznosulású gombaellenes gyógyászati készítmény - Google Patents
Fokozott biológiai hasznosulású gombaellenes gyógyászati készítményInfo
- Publication number
- HUP9904265A2 HUP9904265A2 HU9904265A HUP9904265A HUP9904265A2 HU P9904265 A2 HUP9904265 A2 HU P9904265A2 HU 9904265 A HU9904265 A HU 9904265A HU P9904265 A HUP9904265 A HU P9904265A HU P9904265 A2 HUP9904265 A2 HU P9904265A2
- Authority
- HU
- Hungary
- Prior art keywords
- weight
- agent
- triazol
- diluent
- surfactant
- Prior art date
Links
- 230000000843 anti-fungal effect Effects 0.000 title abstract 2
- 229940121375 antifungal agent Drugs 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 239000003795 chemical substances by application Substances 0.000 abstract 4
- 150000001875 compounds Chemical class 0.000 abstract 3
- 230000001772 anti-angiogenic effect Effects 0.000 abstract 2
- 239000011230 binding agent Substances 0.000 abstract 2
- 239000003085 diluting agent Substances 0.000 abstract 2
- 239000004094 surface-active agent Substances 0.000 abstract 2
- 125000003626 1,2,4-triazol-1-yl group Chemical group [*]N1N=C([H])N=C1[H] 0.000 abstract 1
- ZFXIRAHGUYKOBW-UHFFFAOYSA-N 1-(oxo-$l^{3}-sulfanyl)ethane Chemical compound CC[S]=O ZFXIRAHGUYKOBW-UHFFFAOYSA-N 0.000 abstract 1
- GOOHAUXETOMSMM-UHFFFAOYSA-N Propylene oxide Chemical compound CC1CO1 GOOHAUXETOMSMM-UHFFFAOYSA-N 0.000 abstract 1
- 239000011149 active material Substances 0.000 abstract 1
- 239000003429 antifungal agent Substances 0.000 abstract 1
- 239000002775 capsule Substances 0.000 abstract 1
- 239000002552 dosage form Substances 0.000 abstract 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 239000000825 pharmaceutical preparation Substances 0.000 abstract 1
- 229920000642 polymer Polymers 0.000 abstract 1
- 239000004575 stone Substances 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4866—Organic macromolecular compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/2031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyethylene oxide, poloxamers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
A találmány tárgya egy (A) képletű (-)-(2R-cisz)-4-{4-[4-{4-[{5-(2,4-diflűőr-fenil)-tetrahidrő-5-[(1H-1,2,4-triazől-1-il)-metil]-3-fűril}-metőxi]-fenil}-1-piperazinil]-fenil}-2,4-dihidrő-2-[(S)-1-etil-2(9)-hidrőxi-prőpil]-3H-1,2,4-triazől-3-őn gőmbaellenes vegyületet,legalább egy nemiőnős felületaktív anyagőt és egy hígítószerttartalmazó gőmbaellenes gyógyszerkészítmény. A készítmény tartalmazhattővábbá egy szétesést elősegítő anyagőt, egy kötőanyagőt és egysíkősítóanyagőt is. A felületaktív anyag célszerűen az etilkén-őxidnakés prőpilén-őxidnak az (I) általánős képlettel szemléltetett kémiaiszerkezetű blőkk-kőpőlimerje, ahől a = 10 és 110 közötti egész szám, b= 20 és 60 közötti egész szám. A gyógyszerkészítmény lehet agőmbaellenes vegyületet 50 mg és 200 mg közötti mennyiségbentartalmazó kapszűla vagy tabletta adagőlási főrmában, amely agőmbaellenes vegyületet 18 és 50 tömeg% közötti, a nemiőnősfelületaktív anyagőt 9 és 50 tömeg% közötti, a hígítószert 12 és 60tömeg% közötti, a szétesést elősegítő anyagőt 4 és 10 tömeg% közötti,a kötőanyagőt 3 és 6 tömeg% közötti, a síkősítóanyagőt 0,3 és 1,5tömeg% közötti mennyiségben tartalmazza. ŕ
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US65532996A | 1996-05-24 | 1996-05-24 | |
| PCT/US1997/019388 WO1998007429A2 (en) | 1996-05-24 | 1997-05-21 | Antifungal composition with enhanced bioavailability |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| HUP9904265A2 true HUP9904265A2 (hu) | 2000-04-28 |
| HUP9904265A3 HUP9904265A3 (en) | 2000-05-29 |
| HU221371B1 HU221371B1 (en) | 2002-09-28 |
Family
ID=24628452
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HU9904265A HU221371B1 (en) | 1996-05-24 | 1997-05-21 | Antifungal pharmaceutical composition with enhanced bioavailability |
Country Status (28)
| Country | Link |
|---|---|
| EP (1) | EP0914127B1 (hu) |
| JP (1) | JP3366648B2 (hu) |
| KR (1) | KR100307427B1 (hu) |
| CN (1) | CN1121860C (hu) |
| AR (1) | AR007250A1 (hu) |
| AT (1) | ATE213632T1 (hu) |
| AU (1) | AU719109B2 (hu) |
| BR (1) | BR9711167A (hu) |
| CA (1) | CA2255663C (hu) |
| CO (1) | CO4840511A1 (hu) |
| CZ (1) | CZ293586B6 (hu) |
| DE (1) | DE69710729T2 (hu) |
| ES (1) | ES2169440T3 (hu) |
| HK (1) | HK1017855A1 (hu) |
| HU (1) | HU221371B1 (hu) |
| ID (1) | ID16956A (hu) |
| IL (1) | IL126979A (hu) |
| MY (1) | MY118988A (hu) |
| NO (1) | NO316997B1 (hu) |
| NZ (1) | NZ332699A (hu) |
| PE (1) | PE68898A1 (hu) |
| PL (1) | PL188401B1 (hu) |
| RU (1) | RU2207119C2 (hu) |
| SK (1) | SK281818B6 (hu) |
| TR (1) | TR199802424T2 (hu) |
| TW (1) | TW504390B (hu) |
| WO (1) | WO1998007429A2 (hu) |
| ZA (1) | ZA974428B (hu) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2157731B1 (es) * | 1998-07-21 | 2002-05-01 | Liconsa Liberacion Controlada | Preparacion farmaceutica oral de un compuesto de actividad antifungica y procedimiento para su preparacion. |
| EP1175205B1 (en) | 1999-11-12 | 2006-06-14 | Abbott Laboratories | Solid dispersion comprising ritonavir, fenofibrate or griseofulvin |
| DE10026698A1 (de) | 2000-05-30 | 2001-12-06 | Basf Ag | Selbstemulgierende Wirkstoffformulierung und Verwendung dieser Formulierung |
| DK1413331T3 (da) * | 2001-01-26 | 2007-12-10 | Schering Corp | Kombinationer af peroxisomproliferatoraktiveret receptor (PPAR)-aktivatoren fenofibrat og sterolabsorptionsinhibitoren ezetimib til vaskulære indikationer |
| WO2004066981A1 (en) * | 2003-01-29 | 2004-08-12 | Sun Pharmaceutical Industries Limited | Oral controlled release pharmaceutical composition containing metaxalone as active agent |
| US8025899B2 (en) | 2003-08-28 | 2011-09-27 | Abbott Laboratories | Solid pharmaceutical dosage form |
| SG190117A1 (en) | 2010-11-01 | 2013-06-28 | Rib X Pharmaceuticals Inc | Pharmaceutical compositions |
| RU2450807C1 (ru) * | 2011-05-11 | 2012-05-20 | Общество с ограниченной ответственностью фирма "Вита" | Стабилизированный фармацевтический состав с противогрибковым действием |
| CN103845292A (zh) * | 2012-11-29 | 2014-06-11 | 正大天晴药业集团股份有限公司 | 泊沙康唑微丸及其制备方法 |
| US9763934B2 (en) * | 2014-03-05 | 2017-09-19 | Professional Compounding Centers Of America | Synergistic effect of poloxamer-based composition and itraconazole on fungus and yeast |
| TR201620462A2 (tr) | 2016-12-31 | 2018-07-23 | Abdi Ibrahim Ilac Sanayi Ve Ticaret Anonim Sirketi | POSAKONAZOL İÇEREN FARMASÖTİK BİLEŞİMLER ve ÜRETİM YÖNTEMİ |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4791111A (en) * | 1985-12-23 | 1988-12-13 | Janssen Pharmaceutica, N.V. | [[4-[4-(4-phenyl-1-piperazinyl)phenoxymethyl]-1,3-dioxolan-2-yl]methyl]-1H-imidazoles and 1H-1,2,4-triazoles having anti-microbial properties |
| US5039676A (en) * | 1990-05-11 | 1991-08-13 | Schering Corporation | Tri- and tetra-substituted-oxetanes and tetrahydrofurans and intermediates thereof |
| CZ294823B6 (cs) * | 1993-12-21 | 2005-03-16 | Schering Corporation | Fungicidní tetrahydrofurany |
-
1997
- 1997-05-21 NZ NZ332699A patent/NZ332699A/xx not_active IP Right Cessation
- 1997-05-21 SK SK1608-98A patent/SK281818B6/sk not_active IP Right Cessation
- 1997-05-21 PE PE1997000400A patent/PE68898A1/es not_active Application Discontinuation
- 1997-05-21 TW TW086106780A patent/TW504390B/zh not_active IP Right Cessation
- 1997-05-21 KR KR1019980709501A patent/KR100307427B1/ko not_active IP Right Cessation
- 1997-05-21 CA CA002255663A patent/CA2255663C/en not_active Expired - Fee Related
- 1997-05-21 BR BR9711167A patent/BR9711167A/pt not_active IP Right Cessation
- 1997-05-21 DE DE69710729T patent/DE69710729T2/de not_active Expired - Lifetime
- 1997-05-21 HU HU9904265A patent/HU221371B1/hu not_active IP Right Cessation
- 1997-05-21 EP EP97949341A patent/EP0914127B1/en not_active Expired - Lifetime
- 1997-05-21 CN CN97196513A patent/CN1121860C/zh not_active Expired - Fee Related
- 1997-05-21 IL IL12697997A patent/IL126979A/xx not_active IP Right Cessation
- 1997-05-21 WO PCT/US1997/019388 patent/WO1998007429A2/en active IP Right Grant
- 1997-05-21 ES ES97949341T patent/ES2169440T3/es not_active Expired - Lifetime
- 1997-05-21 CO CO97027673A patent/CO4840511A1/es unknown
- 1997-05-21 TR TR1998/02424T patent/TR199802424T2/xx unknown
- 1997-05-21 RU RU98123611/14A patent/RU2207119C2/ru not_active IP Right Cessation
- 1997-05-21 AU AU59399/98A patent/AU719109B2/en not_active Ceased
- 1997-05-21 PL PL97330480A patent/PL188401B1/pl not_active IP Right Cessation
- 1997-05-21 ID IDP971708A patent/ID16956A/id unknown
- 1997-05-21 ZA ZA9704428A patent/ZA974428B/xx unknown
- 1997-05-21 CZ CZ19983790A patent/CZ293586B6/cs not_active IP Right Cessation
- 1997-05-21 JP JP50544798A patent/JP3366648B2/ja not_active Expired - Fee Related
- 1997-05-21 AT AT97949341T patent/ATE213632T1/de not_active IP Right Cessation
- 1997-05-22 MY MYPI97002234A patent/MY118988A/en unknown
- 1997-05-22 AR ARP970102173A patent/AR007250A1/es active IP Right Grant
-
1998
- 1998-11-23 NO NO19985447A patent/NO316997B1/no not_active IP Right Cessation
-
1999
- 1999-07-13 HK HK99103016A patent/HK1017855A1/xx not_active IP Right Cessation
Also Published As
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| HC9A | Change of name, address |
Owner name: MERCK SHARP & DOHME CORP., US Free format text: FORMER OWNER(S): SCHERING CORP., US |
|
| MM4A | Lapse of definitive patent protection due to non-payment of fees |