ES2157731B1 - Preparacion farmaceutica oral de un compuesto de actividad antifungica y procedimiento para su preparacion. - Google Patents
Preparacion farmaceutica oral de un compuesto de actividad antifungica y procedimiento para su preparacion.Info
- Publication number
- ES2157731B1 ES2157731B1 ES009801539A ES9801539A ES2157731B1 ES 2157731 B1 ES2157731 B1 ES 2157731B1 ES 009801539 A ES009801539 A ES 009801539A ES 9801539 A ES9801539 A ES 9801539A ES 2157731 B1 ES2157731 B1 ES 2157731B1
- Authority
- ES
- Spain
- Prior art keywords
- preparation
- coating
- procedure
- compound
- oral pharmaceutical
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 150000001875 compounds Chemical class 0.000 title abstract 4
- 238000000034 method Methods 0.000 title abstract 4
- 239000008183 oral pharmaceutical preparation Substances 0.000 title abstract 2
- 238000002360 preparation method Methods 0.000 title abstract 2
- 230000001716 anti-fugal effect Effects 0.000 title 1
- 239000011248 coating agent Substances 0.000 abstract 5
- 238000000576 coating method Methods 0.000 abstract 5
- 230000000843 anti-fungal effect Effects 0.000 abstract 3
- 229920001477 hydrophilic polymer Polymers 0.000 abstract 2
- 239000002736 nonionic surfactant Substances 0.000 abstract 2
- 239000002356 single layer Substances 0.000 abstract 2
- 229940121375 antifungal agent Drugs 0.000 abstract 1
- 239000003429 antifungal agent Substances 0.000 abstract 1
- 238000001035 drying Methods 0.000 abstract 1
- 238000002663 nebulization Methods 0.000 abstract 1
- 239000002245 particle Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/167—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction with an outer layer or coating comprising drug; with chemically bound drugs or non-active substances on their surface
- A61K9/1676—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction with an outer layer or coating comprising drug; with chemically bound drugs or non-active substances on their surface having a drug-free core with discrete complete coating layer containing drug
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
Abstract
Preparación farmacéutica oral de un compuesto de actividad antifúngica y procedimiento para su preparación. Comprende un compuesto de actividad antifúngica como principio activo, un núcleo inerte y un recubrimiento que incluye dicho principio activo, y se caracteriza por el hecho de que dicho núcleo inerte presenta un tamaño de partícula comprendido entre 50-600 {mi}m, y por el hecho de que dicho recubrimiento comprende una única capa que se obtiene por nebulización, sobre dicho núcleo inerte, de una solución que comprende un compuesto de actividad antifúngica, un polímero hidrofílico y un agente tensioactivo no iónico. El procedimiento se lleva a cabo mediante un recubrimiento que comprende una única capa de los núcleos inertes de tamaño entre 50 y 600 {mi}m por nebulización de una solución compuesta por el agente antifúngico, el polímero hidrofílico y el agente tensioactivo no iónico a una velocidad de recubrimiento constante durante todo el proceso; y un solo secado de dicho recubrimiento en el mismo equipo.
Priority Applications (33)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ES009801539A ES2157731B1 (es) | 1998-07-21 | 1998-07-21 | Preparacion farmaceutica oral de un compuesto de actividad antifungica y procedimiento para su preparacion. |
PT99931261T PT1103252E (pt) | 1998-07-21 | 1999-07-20 | Preparacao farmaceutica oral de um composto com actividade antifungica e seu metodo de preparacao |
IL14091099A IL140910A (en) | 1998-07-21 | 1999-07-20 | An oral pharmaceutical preparation of a compound with antifungal activity and a method of preparation |
HU0103708A HU228895B1 (en) | 1998-07-21 | 1999-07-20 | Pharmaceutical oral preparation of a compound having an antifungic activity, and preparation method |
KR1020017000783A KR100572135B1 (ko) | 1998-07-21 | 1999-07-20 | 항진균 활성을 갖는 화합물의 경구용 약제 및 이의 제조방법 |
EEP200100041A EE04415B1 (et) | 1998-07-21 | 1999-07-20 | Antimükootilist toimet omava ühendi farmatseutiline peroraalne preparaat ja selle valmistamismeetod |
EP99931261A EP1103252B1 (en) | 1998-07-21 | 1999-07-20 | Pharmaceutical oral preparation of a compound having an antifungic activity, and preparation method |
SI9930282T SI1103252T1 (en) | 1998-07-21 | 1999-07-20 | Pharmaceutical oral preparation of a compound having an antifungic activity, and preparation method |
SK86-2001A SK283279B6 (sk) | 1998-07-21 | 1999-07-20 | Orálny farmaceutický prostriedok protihubovo účinnej zlúčeniny a spôsob jeho prípravy |
DK99931261T DK1103252T3 (da) | 1998-07-21 | 1999-07-20 | Oral farmaceutisk sammensætning af en forbindelse med en afsvampningsaktivitet og fremgangsmåde til fremstilling deraf |
MXPA01000681A MXPA01000681A (es) | 1998-07-21 | 1999-07-20 | Preparacion farmaceutica oral de un compuesto de actividad antifungica y procedimiento para su preparacion. |
YUP-39/01A RS50063B (sr) | 1998-07-21 | 1999-07-20 | Oralni farmaceutski preparat sa fungicidnim dejstvom i postupak za njegovo pripremanje |
PCT/ES1999/000230 WO2000004881A1 (es) | 1998-07-21 | 1999-07-20 | Preparacion farmaceutica oral de un compuesto de actividad antifungica y procedimiento para su preparacion |
US09/744,322 US6737082B1 (en) | 1998-07-21 | 1999-07-20 | Pharmaceutical oral preparation of a compound having an antifungic activity, and preparation method |
CZ2001175A CZ291938B6 (cs) | 1998-07-21 | 1999-07-20 | Orální farmaceutický prostředek protihoubově účinné sloučeniny a způsob jeho přípravy |
BR9912300-2A BR9912300A (pt) | 1998-07-21 | 1999-07-20 | Composição farmacêutica oral de um composto tendo atividade antifúngica e método para a sua preparação |
RU2001104894/14A RU2209628C2 (ru) | 1998-07-21 | 1999-07-20 | Пероральная фармацевтическая композиция на основе соединения, имеющего антигрибковую активность, и способ ее получения |
PL99345625A PL194740B1 (pl) | 1998-07-21 | 1999-07-20 | Doustna kompozycja farmaceutyczna w postaci peletek zawierająca związek o działaniu przeciwgrzybicznym i sposób jej wytwarzania |
ES99931261T ES2194480T3 (es) | 1998-07-21 | 1999-07-20 | Preparacion farmaceutica oral de un compuesto de actividad antifungica y procedimiento para su preparacion. |
CA002337509A CA2337509C (en) | 1998-07-21 | 1999-07-20 | Pharmaceutical oral preparation of a compound having an antifungic activity, and preparation method |
DE69905905T DE69905905T2 (de) | 1998-07-21 | 1999-07-20 | Orale pharmazeutische zusammensetzung enthaltend einen wirkstoff mit antimykotischer wirkung und verfahren zu ihrer herstellung |
TR2001/00177T TR200100177T2 (tr) | 1998-07-21 | 1999-07-20 | Antifungal Aktiviteye sahip bir bileşimin oral farmasötik kompozisyonu ve bu kompozisyonun hazırlanış metodu. |
NZ509886A NZ509886A (en) | 1998-07-21 | 1999-07-20 | Pharmaceutical oral preparation of either itraconazole or saperconazole having antifungic activity |
UA2001021260A UA64009C2 (en) | 1998-07-21 | 1999-07-20 | Pharmaceutical composition comprising antifungal agent and method for its production |
AT99931261T ATE234077T1 (de) | 1998-07-21 | 1999-07-20 | Orale pharmazeutische zusammensetzung enthaltend einen wirkstoff mit antimykotischer wirkung und verfahren zu ihrer herstellung |
MEP-267/08A MEP26708A (en) | 1998-07-21 | 1999-07-20 | Pharmaceutical oral preparation of a compound having an antifungic activity, and preparation method |
AU47821/99A AU750730B2 (en) | 1998-07-21 | 1999-07-20 | Pharmaceutical oral preparation of a compound having an antifungic activity, and preparation method |
JP2000560874A JP4190732B2 (ja) | 1998-07-21 | 1999-07-20 | 抗真菌活性化合物を含む経口医薬組成物およびその製法 |
NO20010289A NO320054B1 (no) | 1998-07-21 | 2001-01-17 | Oral farmasoytisk sammensetning med en forbindelse som har antisopp aktivitet og en metode for dens fremstilling |
ZA200101293A ZA200101293B (en) | 1998-07-21 | 2001-02-15 | Pharmaceutical oral preparation of a compound having an antifungic activity, and preparation method. |
BG105282A BG65187B1 (bg) | 1998-07-21 | 2001-02-21 | Фармацевтичен състав за орално приложение, съдържащ съединения с антифунгицидно действие, и метод за получаването му |
HR20010128A HRP20010128B1 (en) | 1998-07-21 | 2001-02-21 | Pharmaceutical oral preparation of a compound having an antifungic activity, and preparation method |
HK01108330A HK1037531A1 (en) | 1998-07-21 | 2001-11-27 | Pharmaceutical oral preparation of a compound having an antifungic acitivity, and preparation method |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ES009801539A ES2157731B1 (es) | 1998-07-21 | 1998-07-21 | Preparacion farmaceutica oral de un compuesto de actividad antifungica y procedimiento para su preparacion. |
Publications (2)
Publication Number | Publication Date |
---|---|
ES2157731A1 ES2157731A1 (es) | 2001-08-16 |
ES2157731B1 true ES2157731B1 (es) | 2002-05-01 |
Family
ID=8304581
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES009801539A Expired - Fee Related ES2157731B1 (es) | 1998-07-21 | 1998-07-21 | Preparacion farmaceutica oral de un compuesto de actividad antifungica y procedimiento para su preparacion. |
ES99931261T Expired - Lifetime ES2194480T3 (es) | 1998-07-21 | 1999-07-20 | Preparacion farmaceutica oral de un compuesto de actividad antifungica y procedimiento para su preparacion. |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES99931261T Expired - Lifetime ES2194480T3 (es) | 1998-07-21 | 1999-07-20 | Preparacion farmaceutica oral de un compuesto de actividad antifungica y procedimiento para su preparacion. |
Country Status (31)
Country | Link |
---|---|
US (1) | US6737082B1 (es) |
EP (1) | EP1103252B1 (es) |
JP (1) | JP4190732B2 (es) |
KR (1) | KR100572135B1 (es) |
AT (1) | ATE234077T1 (es) |
AU (1) | AU750730B2 (es) |
BG (1) | BG65187B1 (es) |
BR (1) | BR9912300A (es) |
CA (1) | CA2337509C (es) |
CZ (1) | CZ291938B6 (es) |
DE (1) | DE69905905T2 (es) |
DK (1) | DK1103252T3 (es) |
EE (1) | EE04415B1 (es) |
ES (2) | ES2157731B1 (es) |
HK (1) | HK1037531A1 (es) |
HR (1) | HRP20010128B1 (es) |
HU (1) | HU228895B1 (es) |
IL (1) | IL140910A (es) |
ME (1) | MEP26708A (es) |
MX (1) | MXPA01000681A (es) |
NO (1) | NO320054B1 (es) |
NZ (1) | NZ509886A (es) |
PL (1) | PL194740B1 (es) |
PT (1) | PT1103252E (es) |
RS (1) | RS50063B (es) |
RU (1) | RU2209628C2 (es) |
SK (1) | SK283279B6 (es) |
TR (1) | TR200100177T2 (es) |
UA (1) | UA64009C2 (es) |
WO (1) | WO2000004881A1 (es) |
ZA (1) | ZA200101293B (es) |
Families Citing this family (28)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1997027764A1 (en) * | 1996-01-31 | 1997-08-07 | South Alabama Medical Science Foundation | Food and vitamin preparations containing the natural isomer of reduced folates |
US6248363B1 (en) * | 1999-11-23 | 2001-06-19 | Lipocine, Inc. | Solid carriers for improved delivery of active ingredients in pharmaceutical compositions |
EE200200357A (et) | 1999-12-23 | 2003-10-15 | Pfizer Products Inc. | Ravimaine suurenenud kontsentratsioone andvad farmatseutilised kompositsioonid |
FR2842736B1 (fr) | 2002-07-26 | 2005-07-22 | Flamel Tech Sa | Formulation pharmaceutique orale sous forme d'une pluralite de microcapsules permettant la liberation prolongee de principe(s) actif(s) peu soluble(s) |
US20040115287A1 (en) * | 2002-12-17 | 2004-06-17 | Lipocine, Inc. | Hydrophobic active agent compositions and methods |
ATE357234T1 (de) * | 2003-01-14 | 2007-04-15 | Cimex Pharma Ag | Zusammensetzung in form eines festen dispersion enthaltend itraconazol und ein hydrophilisches polymer mit einer verbesserten bioverfügbarkeit |
SI1438961T2 (sl) * | 2003-01-14 | 2014-12-31 | Cimex Pharma Ag | Bioekvivalenten sestavek itrakonazola, dispergiranega v hidrofilnem polimeru |
FR2852607B1 (fr) * | 2003-03-20 | 2006-07-14 | Procede de fabrication de microspheres de sucre de petite taille, les microspheres susceptibles d'etre obtenues par ce procede et leurs applications | |
FR2857591B1 (fr) * | 2003-07-17 | 2007-11-02 | Ethypharm Sa | Particules comprenant un principe actif sous forme de co-precipite |
BRPI0412734A (pt) * | 2003-07-17 | 2006-09-26 | Tibotec Pharm Ltd | processo para preparação de partìculas que contêm um antiviral |
FR2883179B1 (fr) | 2005-03-18 | 2009-04-17 | Ethypharm Sa | Comprime enrobe |
JP5435946B2 (ja) | 2005-08-22 | 2014-03-05 | ジョンズ ホプキンス ユニバーシティ | 疾患を処置するためのヘッジホッグ経路アンタゴニスト |
CN101283984B (zh) * | 2007-04-12 | 2010-05-26 | 永胜药品工业股份有限公司 | 高生物使用率的经杀真菌剂和聚合物涂覆的核心微粒状物 |
US11304960B2 (en) | 2009-01-08 | 2022-04-19 | Chandrashekar Giliyar | Steroidal compositions |
JP2013521249A (ja) * | 2010-03-05 | 2013-06-10 | ビーエーエスエフ ソシエタス・ヨーロピア | 融解物で被覆された医薬形態 |
US9034858B2 (en) | 2010-11-30 | 2015-05-19 | Lipocine Inc. | High-strength testosterone undecanoate compositions |
US9358241B2 (en) | 2010-11-30 | 2016-06-07 | Lipocine Inc. | High-strength testosterone undecanoate compositions |
US20180153904A1 (en) | 2010-11-30 | 2018-06-07 | Lipocine Inc. | High-strength testosterone undecanoate compositions |
US20120148675A1 (en) | 2010-12-10 | 2012-06-14 | Basawaraj Chickmath | Testosterone undecanoate compositions |
WO2016033556A1 (en) | 2014-08-28 | 2016-03-03 | Lipocine Inc. | BIOAVAILABLE SOLID STATE (17-β)-HYDROXY-4-ANDROSTEN-3-ONE ESTERS |
WO2016033549A2 (en) | 2014-08-28 | 2016-03-03 | Lipocine Inc. | (17-ß)-3-OXOANDROST-4-EN-17-YL TRIDECANOATE COMPOSITIONS AND METHODS OF THEIR PREPARATION AND USE |
MA40982A (fr) * | 2014-11-19 | 2017-09-26 | Biogen Ma Inc | Formulation de bille pharmaceutique comprenant du fumarate de diméthyle |
CA2987177A1 (en) * | 2015-05-25 | 2016-12-01 | Sun Pharmaceutical Industries Limited | Once-daily oral pharmaceutical composition of isotretinoin |
CA3033065A1 (en) | 2016-08-11 | 2018-02-15 | Adamis Pharmaceuticals Corporation | Drug compositions |
US20180147215A1 (en) | 2016-11-28 | 2018-05-31 | Lipocine Inc. | Oral testosterone undecanoate therapy |
WO2019113493A1 (en) | 2017-12-08 | 2019-06-13 | Adamis Pharmaceuticals Corporation | Drug compositions |
WO2019208801A1 (ja) * | 2018-04-27 | 2019-10-31 | 凸版印刷株式会社 | 徐放性複合粒子、徐放性複合粒子の製造方法、乾燥粉体及び壁紙 |
WO2023118082A1 (en) * | 2021-12-22 | 2023-06-29 | Palau Pharma, S.L.U. | Multiparticulate albaconazole composition |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4267179A (en) * | 1978-06-23 | 1981-05-12 | Janssen Pharmaceutica, N.V. | Heterocyclic derivatives of (4-phenylpiperazin-1-yl-aryloxymethyl-1,3-dioxolan-2-yl)methyl-1H-imidazoles and 1H-1,2,4-triazoles |
US4916134A (en) * | 1987-03-25 | 1990-04-10 | Janssen Pharmacuetica N.V. | 4-[4-[4-[4-[[2-(2,4-difluorophenyl)-2-(1H-azolylmethyl)-1,3-dioxolan-4-yl]me]phenyl]-1-piperazinyl]phenyl]triazolones |
IE61651B1 (en) * | 1990-07-04 | 1994-11-16 | Zambon Spa | Programmed release oral solid pharmaceutical dosage form |
PH30929A (en) * | 1992-09-03 | 1997-12-23 | Janssen Pharmaceutica Nv | Beads having a core coated with an antifungal and a polymer. |
US5567441A (en) * | 1995-03-24 | 1996-10-22 | Andrx Pharmaceuticals Inc. | Diltiazem controlled release formulation |
AU722101B2 (en) * | 1996-05-20 | 2000-07-20 | Janssen Pharmaceutica N.V. | Antifungal compositions with improved bioavailability |
AU719109B2 (en) * | 1996-05-24 | 2000-05-04 | Merck Sharp & Dohme Corp. | Antifungal composition with enhanced bioavailability |
PL330864A1 (en) * | 1996-06-28 | 1999-06-07 | Schering Corp | Orally administered composition containing antimycotic compounds of triazole |
DE19626924C2 (de) * | 1996-07-04 | 1999-08-19 | Epazon B V | Gerät zur Bereitstellung eines Atemgases |
SK284813B6 (sk) * | 1997-03-26 | 2005-12-01 | Janssen Pharmaceutica N. V. | Peleta obsahujúca itrakonazol, spôsob jej prípravy a farmaceutická dávková forma s jej obsahom |
-
1998
- 1998-07-21 ES ES009801539A patent/ES2157731B1/es not_active Expired - Fee Related
-
1999
- 1999-07-20 UA UA2001021260A patent/UA64009C2/uk unknown
- 1999-07-20 DE DE69905905T patent/DE69905905T2/de not_active Expired - Lifetime
- 1999-07-20 AU AU47821/99A patent/AU750730B2/en not_active Ceased
- 1999-07-20 ES ES99931261T patent/ES2194480T3/es not_active Expired - Lifetime
- 1999-07-20 AT AT99931261T patent/ATE234077T1/de active
- 1999-07-20 EE EEP200100041A patent/EE04415B1/xx not_active IP Right Cessation
- 1999-07-20 CA CA002337509A patent/CA2337509C/en not_active Expired - Fee Related
- 1999-07-20 SK SK86-2001A patent/SK283279B6/sk not_active IP Right Cessation
- 1999-07-20 PL PL99345625A patent/PL194740B1/pl not_active IP Right Cessation
- 1999-07-20 PT PT99931261T patent/PT1103252E/pt unknown
- 1999-07-20 JP JP2000560874A patent/JP4190732B2/ja not_active Expired - Fee Related
- 1999-07-20 IL IL14091099A patent/IL140910A/en not_active IP Right Cessation
- 1999-07-20 EP EP99931261A patent/EP1103252B1/en not_active Expired - Lifetime
- 1999-07-20 KR KR1020017000783A patent/KR100572135B1/ko not_active IP Right Cessation
- 1999-07-20 WO PCT/ES1999/000230 patent/WO2000004881A1/es not_active Application Discontinuation
- 1999-07-20 RU RU2001104894/14A patent/RU2209628C2/ru not_active IP Right Cessation
- 1999-07-20 HU HU0103708A patent/HU228895B1/hu not_active IP Right Cessation
- 1999-07-20 ME MEP-267/08A patent/MEP26708A/xx unknown
- 1999-07-20 TR TR2001/00177T patent/TR200100177T2/xx unknown
- 1999-07-20 BR BR9912300-2A patent/BR9912300A/pt not_active Application Discontinuation
- 1999-07-20 CZ CZ2001175A patent/CZ291938B6/cs not_active IP Right Cessation
- 1999-07-20 NZ NZ509886A patent/NZ509886A/xx not_active IP Right Cessation
- 1999-07-20 US US09/744,322 patent/US6737082B1/en not_active Expired - Fee Related
- 1999-07-20 RS YUP-39/01A patent/RS50063B/sr unknown
- 1999-07-20 MX MXPA01000681A patent/MXPA01000681A/es active IP Right Grant
- 1999-07-20 DK DK99931261T patent/DK1103252T3/da active
-
2001
- 2001-01-17 NO NO20010289A patent/NO320054B1/no not_active IP Right Cessation
- 2001-02-15 ZA ZA200101293A patent/ZA200101293B/en unknown
- 2001-02-21 HR HR20010128A patent/HRP20010128B1/xx not_active IP Right Cessation
- 2001-02-21 BG BG105282A patent/BG65187B1/bg unknown
- 2001-11-27 HK HK01108330A patent/HK1037531A1/xx not_active IP Right Cessation
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