ES2157731A1 - Preparacion farmaceutica oral de un compuesto de anticidad antifungica y procedimiento para su preparacion. - Google Patents

Preparacion farmaceutica oral de un compuesto de anticidad antifungica y procedimiento para su preparacion.

Info

Publication number
ES2157731A1
ES2157731A1 ES009801539A ES9801539A ES2157731A1 ES 2157731 A1 ES2157731 A1 ES 2157731A1 ES 009801539 A ES009801539 A ES 009801539A ES 9801539 A ES9801539 A ES 9801539A ES 2157731 A1 ES2157731 A1 ES 2157731A1
Authority
ES
Spain
Prior art keywords
compound
preparation
antifungic
coat
activity
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
ES009801539A
Other languages
English (en)
Other versions
ES2157731B1 (es
Inventor
Darder Carlos Picornell
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Laboratorios Liconsa SA
Original Assignee
Liconsa Liberacion Controlada de Sustancias Activas SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=8304581&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ES2157731(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Liconsa Liberacion Controlada de Sustancias Activas SA filed Critical Liconsa Liberacion Controlada de Sustancias Activas SA
Priority to ES009801539A priority Critical patent/ES2157731B1/es
Priority to DE69905905T priority patent/DE69905905T2/de
Priority to RU2001104894/14A priority patent/RU2209628C2/ru
Priority to AU47821/99A priority patent/AU750730B2/en
Priority to ES99931261T priority patent/ES2194480T3/es
Priority to SK86-2001A priority patent/SK283279B6/sk
Priority to PT99931261T priority patent/PT1103252E/pt
Priority to YUP-39/01A priority patent/RS50063B/sr
Priority to EP99931261A priority patent/EP1103252B1/en
Priority to JP2000560874A priority patent/JP4190732B2/ja
Priority to KR1020017000783A priority patent/KR100572135B1/ko
Priority to UA2001021260A priority patent/UA64009C2/uk
Priority to MEP-267/08A priority patent/MEP26708A/xx
Priority to BR9912300-2A priority patent/BR9912300A/pt
Priority to CA002337509A priority patent/CA2337509C/en
Priority to SI9930282T priority patent/SI1103252T1/xx
Priority to IL14091099A priority patent/IL140910A/en
Priority to US09/744,322 priority patent/US6737082B1/en
Priority to AT99931261T priority patent/ATE234077T1/de
Priority to DK99931261T priority patent/DK1103252T3/da
Priority to MXPA01000681A priority patent/MXPA01000681A/es
Priority to PCT/ES1999/000230 priority patent/WO2000004881A1/es
Priority to HU0103708A priority patent/HU228895B1/hu
Priority to PL99345625A priority patent/PL194740B1/pl
Priority to NZ509886A priority patent/NZ509886A/xx
Priority to CZ2001175A priority patent/CZ291938B6/cs
Priority to EEP200100041A priority patent/EE04415B1/xx
Priority to TR2001/00177T priority patent/TR200100177T2/xx
Priority to NO20010289A priority patent/NO320054B1/no
Priority to ZA200101293A priority patent/ZA200101293B/en
Priority to BG105282A priority patent/BG65187B1/bg
Priority to HR20010128A priority patent/HRP20010128B1/xx
Publication of ES2157731A1 publication Critical patent/ES2157731A1/es
Priority to HK01108330A priority patent/HK1037531A1/xx
Publication of ES2157731B1 publication Critical patent/ES2157731B1/es
Application granted granted Critical
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/167—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction with an outer layer or coating comprising drug; with chemically bound drugs or non-active substances on their surface
    • A61K9/1676—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction with an outer layer or coating comprising drug; with chemically bound drugs or non-active substances on their surface having a drug-free core with discrete complete coating layer containing drug
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics

Abstract

Preparación farmacéutica oral de un compuesto de actividad antifúngica y procedimiento para su preparación. Comprende un compuesto de actividad antifúngica como principio activo, un núcleo inerte y un recubrimiento que incluye dicho principio activo, y se caracteriza por el hecho de que dicho núcleo inerte presenta un tamaño de partícula comprendido entre 50-600 {mi}m, y por el hecho de que dicho recubrimiento comprende una única capa que se obtiene por nebulización, sobre dicho núcleo inerte, de una solución que comprende un compuesto de actividad antifúngica, un polímero hidrofílico y un agente tensioactivo no iónico. El procedimiento se lleva a cabo mediante un recubrimiento que comprende una única capa de los núcleos inertes de tamaño entre 50 y 600 {mi}m por nebulización de una solución compuesta por el agente antifúngico, el polímero hidrofílico y el agente tensioactivo no iónico a una velocidad de recubrimiento constante durante todo el proceso; y un solo secado de dicho recubrimiento en el mismo equipo.
ES009801539A 1998-07-21 1998-07-21 Preparacion farmaceutica oral de un compuesto de actividad antifungica y procedimiento para su preparacion. Expired - Fee Related ES2157731B1 (es)

Priority Applications (33)

Application Number Priority Date Filing Date Title
ES009801539A ES2157731B1 (es) 1998-07-21 1998-07-21 Preparacion farmaceutica oral de un compuesto de actividad antifungica y procedimiento para su preparacion.
AT99931261T ATE234077T1 (de) 1998-07-21 1999-07-20 Orale pharmazeutische zusammensetzung enthaltend einen wirkstoff mit antimykotischer wirkung und verfahren zu ihrer herstellung
CA002337509A CA2337509C (en) 1998-07-21 1999-07-20 Pharmaceutical oral preparation of a compound having an antifungic activity, and preparation method
AU47821/99A AU750730B2 (en) 1998-07-21 1999-07-20 Pharmaceutical oral preparation of a compound having an antifungic activity, and preparation method
DK99931261T DK1103252T3 (da) 1998-07-21 1999-07-20 Oral farmaceutisk sammensætning af en forbindelse med en afsvampningsaktivitet og fremgangsmåde til fremstilling deraf
SK86-2001A SK283279B6 (sk) 1998-07-21 1999-07-20 Orálny farmaceutický prostriedok protihubovo účinnej zlúčeniny a spôsob jeho prípravy
PT99931261T PT1103252E (pt) 1998-07-21 1999-07-20 Preparacao farmaceutica oral de um composto com actividade antifungica e seu metodo de preparacao
YUP-39/01A RS50063B (sr) 1998-07-21 1999-07-20 Oralni farmaceutski preparat sa fungicidnim dejstvom i postupak za njegovo pripremanje
EP99931261A EP1103252B1 (en) 1998-07-21 1999-07-20 Pharmaceutical oral preparation of a compound having an antifungic activity, and preparation method
JP2000560874A JP4190732B2 (ja) 1998-07-21 1999-07-20 抗真菌活性化合物を含む経口医薬組成物およびその製法
KR1020017000783A KR100572135B1 (ko) 1998-07-21 1999-07-20 항진균 활성을 갖는 화합물의 경구용 약제 및 이의 제조방법
UA2001021260A UA64009C2 (en) 1998-07-21 1999-07-20 Pharmaceutical composition comprising antifungal agent and method for its production
MEP-267/08A MEP26708A (en) 1998-07-21 1999-07-20 Pharmaceutical oral preparation of a compound having an antifungic activity, and preparation method
BR9912300-2A BR9912300A (pt) 1998-07-21 1999-07-20 Composição farmacêutica oral de um composto tendo atividade antifúngica e método para a sua preparação
RU2001104894/14A RU2209628C2 (ru) 1998-07-21 1999-07-20 Пероральная фармацевтическая композиция на основе соединения, имеющего антигрибковую активность, и способ ее получения
SI9930282T SI1103252T1 (en) 1998-07-21 1999-07-20 Pharmaceutical oral preparation of a compound having an antifungic activity, and preparation method
IL14091099A IL140910A (en) 1998-07-21 1999-07-20 An oral pharmaceutical preparation of a compound with antifungal activity and a method of preparation
US09/744,322 US6737082B1 (en) 1998-07-21 1999-07-20 Pharmaceutical oral preparation of a compound having an antifungic activity, and preparation method
DE69905905T DE69905905T2 (de) 1998-07-21 1999-07-20 Orale pharmazeutische zusammensetzung enthaltend einen wirkstoff mit antimykotischer wirkung und verfahren zu ihrer herstellung
ES99931261T ES2194480T3 (es) 1998-07-21 1999-07-20 Preparacion farmaceutica oral de un compuesto de actividad antifungica y procedimiento para su preparacion.
MXPA01000681A MXPA01000681A (es) 1998-07-21 1999-07-20 Preparacion farmaceutica oral de un compuesto de actividad antifungica y procedimiento para su preparacion.
HU0103708A HU228895B1 (en) 1998-07-21 1999-07-20 Pharmaceutical oral preparation of a compound having an antifungic activity, and preparation method
PCT/ES1999/000230 WO2000004881A1 (es) 1998-07-21 1999-07-20 Preparacion farmaceutica oral de un compuesto de actividad antifungica y procedimiento para su preparacion
PL99345625A PL194740B1 (pl) 1998-07-21 1999-07-20 Doustna kompozycja farmaceutyczna w postaci peletek zawierająca związek o działaniu przeciwgrzybicznym i sposób jej wytwarzania
NZ509886A NZ509886A (en) 1998-07-21 1999-07-20 Pharmaceutical oral preparation of either itraconazole or saperconazole having antifungic activity
CZ2001175A CZ291938B6 (cs) 1998-07-21 1999-07-20 Orální farmaceutický prostředek protihoubově účinné sloučeniny a způsob jeho přípravy
EEP200100041A EE04415B1 (et) 1998-07-21 1999-07-20 Antimükootilist toimet omava ühendi farmatseutiline peroraalne preparaat ja selle valmistamismeetod
TR2001/00177T TR200100177T2 (tr) 1998-07-21 1999-07-20 Antifungal Aktiviteye sahip bir bileşimin oral farmasötik kompozisyonu ve bu kompozisyonun hazırlanış metodu.
NO20010289A NO320054B1 (no) 1998-07-21 2001-01-17 Oral farmasoytisk sammensetning med en forbindelse som har antisopp aktivitet og en metode for dens fremstilling
ZA200101293A ZA200101293B (en) 1998-07-21 2001-02-15 Pharmaceutical oral preparation of a compound having an antifungic activity, and preparation method.
BG105282A BG65187B1 (bg) 1998-07-21 2001-02-21 Фармацевтичен състав за орално приложение, съдържащ съединения с антифунгицидно действие, и метод за получаването му
HR20010128A HRP20010128B1 (en) 1998-07-21 2001-02-21 Pharmaceutical oral preparation of a compound having an antifungic activity, and preparation method
HK01108330A HK1037531A1 (en) 1998-07-21 2001-11-27 Pharmaceutical oral preparation of a compound having an antifungic acitivity, and preparation method

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES009801539A ES2157731B1 (es) 1998-07-21 1998-07-21 Preparacion farmaceutica oral de un compuesto de actividad antifungica y procedimiento para su preparacion.

Publications (2)

Publication Number Publication Date
ES2157731A1 true ES2157731A1 (es) 2001-08-16
ES2157731B1 ES2157731B1 (es) 2002-05-01

Family

ID=8304581

Family Applications (2)

Application Number Title Priority Date Filing Date
ES009801539A Expired - Fee Related ES2157731B1 (es) 1998-07-21 1998-07-21 Preparacion farmaceutica oral de un compuesto de actividad antifungica y procedimiento para su preparacion.
ES99931261T Expired - Lifetime ES2194480T3 (es) 1998-07-21 1999-07-20 Preparacion farmaceutica oral de un compuesto de actividad antifungica y procedimiento para su preparacion.

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES99931261T Expired - Lifetime ES2194480T3 (es) 1998-07-21 1999-07-20 Preparacion farmaceutica oral de un compuesto de actividad antifungica y procedimiento para su preparacion.

Country Status (31)

Country Link
US (1) US6737082B1 (es)
EP (1) EP1103252B1 (es)
JP (1) JP4190732B2 (es)
KR (1) KR100572135B1 (es)
AT (1) ATE234077T1 (es)
AU (1) AU750730B2 (es)
BG (1) BG65187B1 (es)
BR (1) BR9912300A (es)
CA (1) CA2337509C (es)
CZ (1) CZ291938B6 (es)
DE (1) DE69905905T2 (es)
DK (1) DK1103252T3 (es)
EE (1) EE04415B1 (es)
ES (2) ES2157731B1 (es)
HK (1) HK1037531A1 (es)
HR (1) HRP20010128B1 (es)
HU (1) HU228895B1 (es)
IL (1) IL140910A (es)
ME (1) MEP26708A (es)
MX (1) MXPA01000681A (es)
NO (1) NO320054B1 (es)
NZ (1) NZ509886A (es)
PL (1) PL194740B1 (es)
PT (1) PT1103252E (es)
RS (1) RS50063B (es)
RU (1) RU2209628C2 (es)
SK (1) SK283279B6 (es)
TR (1) TR200100177T2 (es)
UA (1) UA64009C2 (es)
WO (1) WO2000004881A1 (es)
ZA (1) ZA200101293B (es)

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US6248363B1 (en) * 1999-11-23 2001-06-19 Lipocine, Inc. Solid carriers for improved delivery of active ingredients in pharmaceutical compositions
CN1402629A (zh) 1999-12-23 2003-03-12 辉瑞产品公司 提供提高的药物浓度的药物组合物
FR2842736B1 (fr) * 2002-07-26 2005-07-22 Flamel Tech Sa Formulation pharmaceutique orale sous forme d'une pluralite de microcapsules permettant la liberation prolongee de principe(s) actif(s) peu soluble(s)
US20040115287A1 (en) * 2002-12-17 2004-06-17 Lipocine, Inc. Hydrophobic active agent compositions and methods
DK1438960T4 (da) * 2003-01-14 2013-03-25 Cimex Pharma Ag Sammensætning af itraconazol dispergeret i en hydrofil polymer med forhøjet biotilgængelighed
SI1438961T2 (sl) * 2003-01-14 2014-12-31 Cimex Pharma Ag Bioekvivalenten sestavek itrakonazola, dispergiranega v hidrofilnem polimeru
FR2852607B1 (fr) * 2003-03-20 2006-07-14 Procede de fabrication de microspheres de sucre de petite taille, les microspheres susceptibles d'etre obtenues par ce procede et leurs applications
BRPI0412734A (pt) * 2003-07-17 2006-09-26 Tibotec Pharm Ltd processo para preparação de partìculas que contêm um antiviral
FR2857591B1 (fr) * 2003-07-17 2007-11-02 Ethypharm Sa Particules comprenant un principe actif sous forme de co-precipite
FR2883179B1 (fr) 2005-03-18 2009-04-17 Ethypharm Sa Comprime enrobe
JP5435946B2 (ja) 2005-08-22 2014-03-05 ジョンズ ホプキンス ユニバーシティ 疾患を処置するためのヘッジホッグ経路アンタゴニスト
CN101283984B (zh) * 2007-04-12 2010-05-26 永胜药品工业股份有限公司 高生物使用率的经杀真菌剂和聚合物涂覆的核心微粒状物
US11304960B2 (en) 2009-01-08 2022-04-19 Chandrashekar Giliyar Steroidal compositions
EP2542222A2 (de) * 2010-03-05 2013-01-09 Basf Se Schmelzüberzogene arzneiformen
US9034858B2 (en) 2010-11-30 2015-05-19 Lipocine Inc. High-strength testosterone undecanoate compositions
US9358241B2 (en) 2010-11-30 2016-06-07 Lipocine Inc. High-strength testosterone undecanoate compositions
US20180153904A1 (en) 2010-11-30 2018-06-07 Lipocine Inc. High-strength testosterone undecanoate compositions
US20120148675A1 (en) 2010-12-10 2012-06-14 Basawaraj Chickmath Testosterone undecanoate compositions
US9498485B2 (en) 2014-08-28 2016-11-22 Lipocine Inc. Bioavailable solid state (17-β)-hydroxy-4-androsten-3-one esters
US20170246187A1 (en) 2014-08-28 2017-08-31 Lipocine Inc. (17-ß)-3-OXOANDROST-4-EN-17-YL TRIDECANOATE COMPOSITIONS AND METHODS OF THEIR PREPARATION AND USE
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RU2017141029A (ru) * 2015-05-25 2019-06-25 Сан Фармасьютикал Индастриз Лимитед Фармацевтическая пероральная композиция изотретиноина для применения один раз в сутки
AU2017310506B2 (en) 2016-08-11 2019-11-21 Dmk Pharmaceuticals Corporation Drug compositions
WO2018098501A1 (en) 2016-11-28 2018-05-31 Lipocine Inc. Oral testosterone undecanoate therapy
US11564910B2 (en) 2017-12-08 2023-01-31 Adamis Pharmaceuticals Corporation Drug compositions
WO2019208801A1 (ja) * 2018-04-27 2019-10-31 凸版印刷株式会社 徐放性複合粒子、徐放性複合粒子の製造方法、乾燥粉体及び壁紙
WO2023118082A1 (en) * 2021-12-22 2023-06-29 Palau Pharma, S.L.U. Multiparticulate albaconazole composition

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WO1997044014A1 (en) * 1996-05-20 1997-11-27 Janssen Pharmaceutica N.V. Antifungal compositions with improved bioavailability
WO1998007429A2 (en) * 1996-05-24 1998-02-26 Schering Corporation Antifungal composition with enhanced bioavailability
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Also Published As

Publication number Publication date
HUP0103708A2 (hu) 2002-02-28
ES2194480T3 (es) 2003-11-16
YU3901A (sh) 2003-08-29
NZ509886A (en) 2002-09-27
HUP0103708A3 (en) 2002-07-29
JP2002521323A (ja) 2002-07-16
KR20010070990A (ko) 2001-07-28
NO320054B1 (no) 2005-10-17
BG65187B1 (bg) 2007-06-29
ATE234077T1 (de) 2003-03-15
ZA200101293B (en) 2001-08-21
HRP20010128B1 (en) 2003-12-31
PL194740B1 (pl) 2007-06-29
CA2337509A1 (en) 2000-02-03
NO20010289L (no) 2001-03-07
US6737082B1 (en) 2004-05-18
EP1103252B1 (en) 2003-03-12
ES2157731B1 (es) 2002-05-01
IL140910A (en) 2004-03-28
EE200100041A (et) 2002-06-17
PT1103252E (pt) 2003-07-31
DK1103252T3 (da) 2003-07-14
HRP20010128A2 (en) 2002-12-31
DE69905905D1 (de) 2003-04-17
BG105282A (en) 2001-11-30
RU2209628C2 (ru) 2003-08-10
DE69905905T2 (de) 2004-03-04
KR100572135B1 (ko) 2006-04-19
TR200100177T2 (tr) 2001-07-23
NO20010289D0 (no) 2001-01-17
AU4782199A (en) 2000-02-14
SK283279B6 (sk) 2003-05-02
IL140910A0 (en) 2002-02-10
CZ291938B6 (cs) 2003-06-18
MEP26708A (en) 2010-06-10
MXPA01000681A (es) 2002-04-24
AU750730B2 (en) 2002-07-25
HK1037531A1 (en) 2002-02-15
EP1103252A1 (en) 2001-05-30
PL345625A1 (en) 2002-01-02
UA64009C2 (en) 2004-02-16
EE04415B1 (et) 2005-02-15
CZ2001175A3 (en) 2001-05-16
WO2000004881A1 (es) 2000-02-03
SK862001A3 (en) 2001-08-06
JP4190732B2 (ja) 2008-12-03
BR9912300A (pt) 2001-04-17
RS50063B (sr) 2009-01-22
HU228895B1 (en) 2013-06-28
CA2337509C (en) 2005-12-27

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