ES2157731B1 - ORAL PHARMACEUTICAL PREPARATION OF AN ANTIFUNGIC ACTIVITY COMPOUND AND PROCEDURE FOR PREPARATION. - Google Patents

ORAL PHARMACEUTICAL PREPARATION OF AN ANTIFUNGIC ACTIVITY COMPOUND AND PROCEDURE FOR PREPARATION.

Info

Publication number
ES2157731B1
ES2157731B1 ES009801539A ES9801539A ES2157731B1 ES 2157731 B1 ES2157731 B1 ES 2157731B1 ES 009801539 A ES009801539 A ES 009801539A ES 9801539 A ES9801539 A ES 9801539A ES 2157731 B1 ES2157731 B1 ES 2157731B1
Authority
ES
Spain
Prior art keywords
preparation
coating
procedure
compound
oral pharmaceutical
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
ES009801539A
Other languages
Spanish (es)
Other versions
ES2157731A1 (en
Inventor
Darder Carlos Picornell
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Laboratorios Liconsa SA
Original Assignee
Liconsa Liberacion Controlada de Sustancias Activas SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=8304581&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ES2157731(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Liconsa Liberacion Controlada de Sustancias Activas SA filed Critical Liconsa Liberacion Controlada de Sustancias Activas SA
Priority to ES009801539A priority Critical patent/ES2157731B1/en
Priority to ES99931261T priority patent/ES2194480T3/en
Priority to CZ2001175A priority patent/CZ291938B6/en
Priority to HU0103708A priority patent/HU228895B1/en
Priority to CA002337509A priority patent/CA2337509C/en
Priority to EEP200100041A priority patent/EE04415B1/en
Priority to EP99931261A priority patent/EP1103252B1/en
Priority to SI9930282T priority patent/SI1103252T1/en
Priority to SK86-2001A priority patent/SK283279B6/en
Priority to DK99931261T priority patent/DK1103252T3/en
Priority to MXPA01000681A priority patent/MXPA01000681A/en
Priority to YUP-39/01A priority patent/RS50063B/en
Priority to PCT/ES1999/000230 priority patent/WO2000004881A1/en
Priority to US09/744,322 priority patent/US6737082B1/en
Priority to IL14091099A priority patent/IL140910A/en
Priority to BR9912300-2A priority patent/BR9912300A/en
Priority to RU2001104894/14A priority patent/RU2209628C2/en
Priority to PL99345625A priority patent/PL194740B1/en
Priority to PT99931261T priority patent/PT1103252E/en
Priority to KR1020017000783A priority patent/KR100572135B1/en
Priority to DE69905905T priority patent/DE69905905T2/en
Priority to NZ509886A priority patent/NZ509886A/en
Priority to TR2001/00177T priority patent/TR200100177T2/en
Priority to UA2001021260A priority patent/UA64009C2/en
Priority to AT99931261T priority patent/ATE234077T1/en
Priority to MEP-267/08A priority patent/MEP26708A/en
Priority to AU47821/99A priority patent/AU750730B2/en
Priority to JP2000560874A priority patent/JP4190732B2/en
Priority to NO20010289A priority patent/NO320054B1/en
Priority to ZA200101293A priority patent/ZA200101293B/en
Priority to BG105282A priority patent/BG65187B1/en
Priority to HR20010128A priority patent/HRP20010128B1/en
Publication of ES2157731A1 publication Critical patent/ES2157731A1/en
Priority to HK01108330A priority patent/HK1037531A1/en
Publication of ES2157731B1 publication Critical patent/ES2157731B1/en
Application granted granted Critical
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/167—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction with an outer layer or coating comprising drug; with chemically bound drugs or non-active substances on their surface
    • A61K9/1676—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction with an outer layer or coating comprising drug; with chemically bound drugs or non-active substances on their surface having a drug-free core with discrete complete coating layer containing drug
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics

Abstract

Preparación farmacéutica oral de un compuesto de actividad antifúngica y procedimiento para su preparación. Comprende un compuesto de actividad antifúngica como principio activo, un núcleo inerte y un recubrimiento que incluye dicho principio activo, y se caracteriza por el hecho de que dicho núcleo inerte presenta un tamaño de partícula comprendido entre 50-600 {mi}m, y por el hecho de que dicho recubrimiento comprende una única capa que se obtiene por nebulización, sobre dicho núcleo inerte, de una solución que comprende un compuesto de actividad antifúngica, un polímero hidrofílico y un agente tensioactivo no iónico. El procedimiento se lleva a cabo mediante un recubrimiento que comprende una única capa de los núcleos inertes de tamaño entre 50 y 600 {mi}m por nebulización de una solución compuesta por el agente antifúngico, el polímero hidrofílico y el agente tensioactivo no iónico a una velocidad de recubrimiento constante durante todo el proceso; y un solo secado de dicho recubrimiento en el mismo equipo.Oral pharmaceutical preparation of a compound of antifungal activity and procedure for its preparation. It comprises a compound of antifungal activity as an active principle, an inert core and a coating that includes said active principle, and is characterized by the fact that said inert core has a particle size between 50-600 m, and by the fact that said coating comprises a single layer which is obtained by nebulizing, on said inert core, a solution comprising a compound of antifungal activity, a hydrophilic polymer and a non-ionic surfactant. The process is carried out by means of a coating comprising a single layer of the inert nuclei of size between 50 and 600 µm by nebulization of a solution composed of the antifungal agent, the hydrophilic polymer and the non-ionic surfactant at a constant coating speed throughout the process; and a single drying of said coating in the same equipment.

ES009801539A 1998-07-21 1998-07-21 ORAL PHARMACEUTICAL PREPARATION OF AN ANTIFUNGIC ACTIVITY COMPOUND AND PROCEDURE FOR PREPARATION. Expired - Fee Related ES2157731B1 (en)

Priority Applications (33)

Application Number Priority Date Filing Date Title
ES009801539A ES2157731B1 (en) 1998-07-21 1998-07-21 ORAL PHARMACEUTICAL PREPARATION OF AN ANTIFUNGIC ACTIVITY COMPOUND AND PROCEDURE FOR PREPARATION.
PT99931261T PT1103252E (en) 1998-07-21 1999-07-20 ORAL PHARMACEUTICAL PREPARATION OF A COMPOUND WITH ANTIFUNGAL ACTIVITY AND ITS PREPARATION METHOD
IL14091099A IL140910A (en) 1998-07-21 1999-07-20 Oral pharmaceutical composition of a compound having antifungal activity and a method for its preparation
HU0103708A HU228895B1 (en) 1998-07-21 1999-07-20 Pharmaceutical oral preparation of a compound having an antifungic activity, and preparation method
KR1020017000783A KR100572135B1 (en) 1998-07-21 1999-07-20 Oral medicaments for compounds with antifungal activity and preparation methods thereof
EEP200100041A EE04415B1 (en) 1998-07-21 1999-07-20 A pharmaceutical oral preparation of a compound having antimycotic activity and a process for its preparation
EP99931261A EP1103252B1 (en) 1998-07-21 1999-07-20 Pharmaceutical oral preparation of a compound having an antifungic activity, and preparation method
SI9930282T SI1103252T1 (en) 1998-07-21 1999-07-20 Pharmaceutical oral preparation of a compound having an antifungic activity, and preparation method
SK86-2001A SK283279B6 (en) 1998-07-21 1999-07-20 Pharmaceutical oral preparation of a compound having an antifungic activity, and preparation method
DK99931261T DK1103252T3 (en) 1998-07-21 1999-07-20 Oral pharmaceutical composition of a compound having a sponge activity and process for its preparation
MXPA01000681A MXPA01000681A (en) 1998-07-21 1999-07-20 Pharmaceutical oral preparation of a compound having an antifungic activity, and preparation method.
YUP-39/01A RS50063B (en) 1998-07-21 1999-07-20 Pharmaceutical oral preparation of a compound having an antifungici activity, and preparation method
PCT/ES1999/000230 WO2000004881A1 (en) 1998-07-21 1999-07-20 Pharmaceutical oral preparation of a compound having an antifungic activity, and preparation method
US09/744,322 US6737082B1 (en) 1998-07-21 1999-07-20 Pharmaceutical oral preparation of a compound having an antifungic activity, and preparation method
CZ2001175A CZ291938B6 (en) 1998-07-21 1999-07-20 Pharmaceutical preparation of antifungal active compound for oral administration and process for preparing thereof
BR9912300-2A BR9912300A (en) 1998-07-21 1999-07-20 Oral pharmaceutical composition of a compound having antifungal activity and method for its preparation
RU2001104894/14A RU2209628C2 (en) 1998-07-21 1999-07-20 Oral pharmaceutical composition based on antifungal compound and method for its preparing
PL99345625A PL194740B1 (en) 1998-07-21 1999-07-20 Pharmaceutical oral preparation of a compound having an antifungic activity, and preparation method
ES99931261T ES2194480T3 (en) 1998-07-21 1999-07-20 ORAL PHARMACEUTICAL PREPARATION OF AN ANTIFUNGIC ACTIVITY COMPOUND AND PROCEDURE FOR PREPARATION.
CA002337509A CA2337509C (en) 1998-07-21 1999-07-20 Pharmaceutical oral preparation of a compound having an antifungic activity, and preparation method
DE69905905T DE69905905T2 (en) 1998-07-21 1999-07-20 ORAL PHARMACEUTICAL COMPOSITION CONTAINING AN ACTIVE SUBSTANCE WITH ANTIMYCOTIC EFFECT AND METHOD FOR THE PRODUCTION THEREOF
TR2001/00177T TR200100177T2 (en) 1998-07-21 1999-07-20 Oral pharmaceutical composition of a composition with antifungal activity and method of preparation of this composition.
NZ509886A NZ509886A (en) 1998-07-21 1999-07-20 Pharmaceutical oral preparation of either itraconazole or saperconazole having antifungic activity
UA2001021260A UA64009C2 (en) 1998-07-21 1999-07-20 Pharmaceutical composition comprising antifungal agent and method for its production
AT99931261T ATE234077T1 (en) 1998-07-21 1999-07-20 ORAL PHARMACEUTICAL COMPOSITION CONTAINING AN ACTIVE SUBSTANCE WITH ANTIFUNGAL ACTION AND METHOD FOR THE PRODUCTION THEREOF
MEP-267/08A MEP26708A (en) 1998-07-21 1999-07-20 Pharmaceutical oral preparation of a compound having an antifungic activity, and preparation method
AU47821/99A AU750730B2 (en) 1998-07-21 1999-07-20 Pharmaceutical oral preparation of a compound having an antifungic activity, and preparation method
JP2000560874A JP4190732B2 (en) 1998-07-21 1999-07-20 Oral pharmaceutical composition containing antifungal active compound and process for producing the same
NO20010289A NO320054B1 (en) 1998-07-21 2001-01-17 Oral pharmaceutical composition having a compound having antifungal activity and a method for its preparation
ZA200101293A ZA200101293B (en) 1998-07-21 2001-02-15 Pharmaceutical oral preparation of a compound having an antifungic activity, and preparation method.
BG105282A BG65187B1 (en) 1998-07-21 2001-02-21 Pharmaceutical oral use preparation containing compounds with antifungicide effect, and method for preparation thereof
HR20010128A HRP20010128B1 (en) 1998-07-21 2001-02-21 Pharmaceutical oral preparation of a compound having an antifungic activity, and preparation method
HK01108330A HK1037531A1 (en) 1998-07-21 2001-11-27 Pharmaceutical oral preparation of a compound having an antifungic acitivity, and preparation method

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES009801539A ES2157731B1 (en) 1998-07-21 1998-07-21 ORAL PHARMACEUTICAL PREPARATION OF AN ANTIFUNGIC ACTIVITY COMPOUND AND PROCEDURE FOR PREPARATION.

Publications (2)

Publication Number Publication Date
ES2157731A1 ES2157731A1 (en) 2001-08-16
ES2157731B1 true ES2157731B1 (en) 2002-05-01

Family

ID=8304581

Family Applications (2)

Application Number Title Priority Date Filing Date
ES009801539A Expired - Fee Related ES2157731B1 (en) 1998-07-21 1998-07-21 ORAL PHARMACEUTICAL PREPARATION OF AN ANTIFUNGIC ACTIVITY COMPOUND AND PROCEDURE FOR PREPARATION.
ES99931261T Expired - Lifetime ES2194480T3 (en) 1998-07-21 1999-07-20 ORAL PHARMACEUTICAL PREPARATION OF AN ANTIFUNGIC ACTIVITY COMPOUND AND PROCEDURE FOR PREPARATION.

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES99931261T Expired - Lifetime ES2194480T3 (en) 1998-07-21 1999-07-20 ORAL PHARMACEUTICAL PREPARATION OF AN ANTIFUNGIC ACTIVITY COMPOUND AND PROCEDURE FOR PREPARATION.

Country Status (31)

Country Link
US (1) US6737082B1 (en)
EP (1) EP1103252B1 (en)
JP (1) JP4190732B2 (en)
KR (1) KR100572135B1 (en)
AT (1) ATE234077T1 (en)
AU (1) AU750730B2 (en)
BG (1) BG65187B1 (en)
BR (1) BR9912300A (en)
CA (1) CA2337509C (en)
CZ (1) CZ291938B6 (en)
DE (1) DE69905905T2 (en)
DK (1) DK1103252T3 (en)
EE (1) EE04415B1 (en)
ES (2) ES2157731B1 (en)
HK (1) HK1037531A1 (en)
HR (1) HRP20010128B1 (en)
HU (1) HU228895B1 (en)
IL (1) IL140910A (en)
ME (1) MEP26708A (en)
MX (1) MXPA01000681A (en)
NO (1) NO320054B1 (en)
NZ (1) NZ509886A (en)
PL (1) PL194740B1 (en)
PT (1) PT1103252E (en)
RS (1) RS50063B (en)
RU (1) RU2209628C2 (en)
SK (1) SK283279B6 (en)
TR (1) TR200100177T2 (en)
UA (1) UA64009C2 (en)
WO (1) WO2000004881A1 (en)
ZA (1) ZA200101293B (en)

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JP5435946B2 (en) 2005-08-22 2014-03-05 ジョンズ ホプキンス ユニバーシティ Hedgehog pathway antagonists for treating diseases
CN101283984B (en) * 2007-04-12 2010-05-26 永胜药品工业股份有限公司 Core particle object coated by fungicide and polymer with high biological usage
US11304960B2 (en) 2009-01-08 2022-04-19 Chandrashekar Giliyar Steroidal compositions
JP2013521249A (en) * 2010-03-05 2013-06-10 ビーエーエスエフ ソシエタス・ヨーロピア Pharmaceutical form coated with melt
US9034858B2 (en) 2010-11-30 2015-05-19 Lipocine Inc. High-strength testosterone undecanoate compositions
US9358241B2 (en) 2010-11-30 2016-06-07 Lipocine Inc. High-strength testosterone undecanoate compositions
US20180153904A1 (en) 2010-11-30 2018-06-07 Lipocine Inc. High-strength testosterone undecanoate compositions
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Also Published As

Publication number Publication date
CA2337509C (en) 2005-12-27
CZ291938B6 (en) 2003-06-18
BG105282A (en) 2001-11-30
UA64009C2 (en) 2004-02-16
PT1103252E (en) 2003-07-31
IL140910A0 (en) 2002-02-10
ATE234077T1 (en) 2003-03-15
HUP0103708A2 (en) 2002-02-28
NO320054B1 (en) 2005-10-17
ES2194480T3 (en) 2003-11-16
KR20010070990A (en) 2001-07-28
JP4190732B2 (en) 2008-12-03
IL140910A (en) 2004-03-28
NO20010289D0 (en) 2001-01-17
RS50063B (en) 2009-01-22
NO20010289L (en) 2001-03-07
AU4782199A (en) 2000-02-14
HRP20010128B1 (en) 2003-12-31
CA2337509A1 (en) 2000-02-03
SK283279B6 (en) 2003-05-02
US6737082B1 (en) 2004-05-18
DE69905905T2 (en) 2004-03-04
MEP26708A (en) 2010-06-10
TR200100177T2 (en) 2001-07-23
EE200100041A (en) 2002-06-17
AU750730B2 (en) 2002-07-25
HRP20010128A2 (en) 2002-12-31
BR9912300A (en) 2001-04-17
RU2209628C2 (en) 2003-08-10
BG65187B1 (en) 2007-06-29
JP2002521323A (en) 2002-07-16
SK862001A3 (en) 2001-08-06
PL345625A1 (en) 2002-01-02
ZA200101293B (en) 2001-08-21
HUP0103708A3 (en) 2002-07-29
EP1103252B1 (en) 2003-03-12
PL194740B1 (en) 2007-06-29
HK1037531A1 (en) 2002-02-15
EE04415B1 (en) 2005-02-15
HU228895B1 (en) 2013-06-28
CZ2001175A3 (en) 2001-05-16
NZ509886A (en) 2002-09-27
EP1103252A1 (en) 2001-05-30
DE69905905D1 (en) 2003-04-17
MXPA01000681A (en) 2002-04-24
YU3901A (en) 2003-08-29
DK1103252T3 (en) 2003-07-14
WO2000004881A1 (en) 2000-02-03
KR100572135B1 (en) 2006-04-19
ES2157731A1 (en) 2001-08-16

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