WO2004078732B1 - Produits n-aryl-heteroaromatiques, compositions les contenant et utilisation - Google Patents
Produits n-aryl-heteroaromatiques, compositions les contenant et utilisationInfo
- Publication number
- WO2004078732B1 WO2004078732B1 PCT/FR2004/000168 FR2004000168W WO2004078732B1 WO 2004078732 B1 WO2004078732 B1 WO 2004078732B1 FR 2004000168 W FR2004000168 W FR 2004000168W WO 2004078732 B1 WO2004078732 B1 WO 2004078732B1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- phenyl
- methyl
- piperazin
- pyrazol
- methanone
- Prior art date
Links
- SPGYTDHCZYNIEY-UHFFFAOYSA-N COc1cc2c(N)nc(N(CC3)CCN3C(c3ccn[n]3-c3ccccc3)=O)nc2cc1OC Chemical compound COc1cc2c(N)nc(N(CC3)CCN3C(c3ccn[n]3-c3ccccc3)=O)nc2cc1OC SPGYTDHCZYNIEY-UHFFFAOYSA-N 0.000 description 1
- HLDIOAAHVQLYGJ-UHFFFAOYSA-N Cc(cc1C(N(CC2)CCN2c2ccncc2)=O)n[n]1-c1cc2ccccc2cc1S(C)(=O)=O Chemical compound Cc(cc1C(N(CC2)CCN2c2ccncc2)=O)n[n]1-c1cc2ccccc2cc1S(C)(=O)=O HLDIOAAHVQLYGJ-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyrrole Compounds (AREA)
Abstract
Claims
Priority Applications (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
BR0407088-7A BRPI0407088A (pt) | 2003-01-28 | 2004-01-26 | Produtos n-aril-heteroaromáticos, composições contendo os mesmos e seu uso |
EP04705102A EP1590329A1 (fr) | 2003-01-28 | 2004-01-26 | Produits n-aryl-heteroaromatiques, compositions les contenant et utilisation |
MXPA05008099A MXPA05008099A (es) | 2003-01-28 | 2004-01-26 | Productos n-aril-heteroaromaticos, composiciones que los contienen y su utilizacion. |
JP2006505660A JP2006516656A (ja) | 2003-01-28 | 2004-01-26 | N−アリールヘテロ芳香族物質、それを含む組成物およびその用途 |
AU2004218260A AU2004218260A1 (en) | 2003-01-28 | 2004-01-26 | N-aryl heteroaromatic products, compositions containing same and use thereof |
CA002512243A CA2512243A1 (fr) | 2003-01-28 | 2004-01-26 | Produits n-aryl-heteroaromatiques, compositions les contenant et utilisation |
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR0300894A FR2850379B1 (fr) | 2003-01-28 | 2003-01-28 | Produits n-aryl-heteroaromatiques, compositions les contenant et utilisation |
FR0300894 | 2003-01-28 | ||
FR0313086 | 2003-11-07 | ||
FR0313086 | 2003-11-07 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2004078732A1 WO2004078732A1 (fr) | 2004-09-16 |
WO2004078732B1 true WO2004078732B1 (fr) | 2004-10-28 |
Family
ID=32963981
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/FR2004/000168 WO2004078732A1 (fr) | 2003-01-28 | 2004-01-26 | Produits n-aryl-heteroaromatiques, compositions les contenant et utilisation |
Country Status (7)
Country | Link |
---|---|
EP (1) | EP1590329A1 (fr) |
JP (1) | JP2006516656A (fr) |
AU (1) | AU2004218260A1 (fr) |
BR (1) | BRPI0407088A (fr) |
CA (1) | CA2512243A1 (fr) |
MX (1) | MXPA05008099A (fr) |
WO (1) | WO2004078732A1 (fr) |
Families Citing this family (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1620405A2 (fr) * | 2003-05-01 | 2006-02-01 | Abbott Laboratories | Pyrazole-amides et sulfonamides modulateurs des canaux sodiques |
RU2440996C2 (ru) * | 2005-01-25 | 2012-01-27 | Галенеа Корп. | Замещенные ариламины и их применение в качестве модуляторов 5-ht6-рецептора |
TW200800946A (en) * | 2005-08-15 | 2008-01-01 | Astrazeneca Ab | Substituted piperazines as metabotropic glutamate receptor antagonists |
EP2009011A1 (fr) * | 2006-04-14 | 2008-12-31 | Takeda Pharmaceutical Company Limited | Composé hétérocyclique azoté |
CN100444842C (zh) * | 2006-11-30 | 2008-12-24 | 四川大学华西医院 | N-芳基杂环族化合物的制药用途 |
RU2501787C2 (ru) * | 2007-11-02 | 2013-12-20 | Метилджен Инк. | Ингибиторы гистондеацетилазы |
CN101597278B (zh) | 2008-06-04 | 2013-04-17 | 中国中化股份有限公司 | 酰胺类化合物及其制备与应用 |
WO2010001258A2 (fr) * | 2008-06-30 | 2010-01-07 | Centre National De La Recherche Scientifique | Inhibition de la croissance tumorale et de métastases |
JP2012501344A (ja) * | 2008-08-29 | 2012-01-19 | トレヴェンティス コーポレイション | アミロイド症を治療する組成物及び方法 |
ES2555260T3 (es) | 2010-06-15 | 2015-12-30 | Bayer Intellectual Property Gmbh | Derivados de diamida de ácido antranílico |
US9238643B2 (en) | 2010-09-06 | 2016-01-19 | Guangzhou Institutes Of Biomedicine And Health, Chinese Academy Of Sciences | Amide compounds |
PL2614052T3 (pl) * | 2010-09-08 | 2015-06-30 | Bristol Myers Squibb Co | Nowe analogi piperazyny jako środki przeciw wirusowi grypy o szerokim spektrum |
US9289365B2 (en) * | 2011-10-24 | 2016-03-22 | Avon Products, Inc. | Compositions and methods for stimulating collagen synthesis in the skin |
MX356846B (es) * | 2012-05-18 | 2018-06-18 | Vironova Influenza Ab | Compuestos de metanotiona que tienen actividad antiviral. |
US9676734B2 (en) | 2012-05-18 | 2017-06-13 | Vironova Influenza Ab | Compounds and methods |
SG10202001795XA (en) | 2014-03-07 | 2020-04-29 | Biocryst Pharm Inc | Human plasma kallikrein inhibitors |
EP3152198B1 (fr) * | 2014-06-09 | 2019-02-27 | Takeda Pharmaceutical Company Limited | Composés radiomarqués |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS61129129A (ja) * | 1984-11-28 | 1986-06-17 | Kureha Chem Ind Co Ltd | 抗腫瘍剤 |
TW312694B (fr) * | 1994-09-26 | 1997-08-11 | Daiichi Seiyaku Co | |
EP0850222B1 (fr) * | 1996-06-29 | 2003-05-28 | Samjin Pharmaceutical Co., Ltd. | Derives de piperazine et leur procede de preparation |
DE10035928A1 (de) * | 2000-07-21 | 2002-03-07 | Asta Medica Ag | Neue Heteroaryl-Derivate und deren Verwendung als Arzneimittel |
DE10035908A1 (de) * | 2000-07-21 | 2002-03-07 | Asta Medica Ag | Neue Heteroaryl-Derivate und deren Verwendung als Arzneimittel |
EA005934B1 (ru) * | 2001-07-05 | 2005-08-25 | Х. Лундбекк А/С | Замещённые анилиновые пиперидины в качестве селективных антагонистов мсн |
AU2003246571B2 (en) * | 2002-06-29 | 2008-06-26 | Zentaris Gmbh | Arylcarbonylpiperazines and heteroarylcarbonylpiperazines and the use thereof for treating benign and malignant tumour diseases |
-
2004
- 2004-01-26 WO PCT/FR2004/000168 patent/WO2004078732A1/fr not_active Application Discontinuation
- 2004-01-26 MX MXPA05008099A patent/MXPA05008099A/es not_active Application Discontinuation
- 2004-01-26 BR BR0407088-7A patent/BRPI0407088A/pt not_active Application Discontinuation
- 2004-01-26 EP EP04705102A patent/EP1590329A1/fr not_active Withdrawn
- 2004-01-26 AU AU2004218260A patent/AU2004218260A1/en not_active Abandoned
- 2004-01-26 CA CA002512243A patent/CA2512243A1/fr not_active Abandoned
- 2004-01-26 JP JP2006505660A patent/JP2006516656A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
JP2006516656A (ja) | 2006-07-06 |
AU2004218260A1 (en) | 2004-09-16 |
EP1590329A1 (fr) | 2005-11-02 |
CA2512243A1 (fr) | 2004-09-16 |
MXPA05008099A (es) | 2005-09-21 |
BRPI0407088A (pt) | 2006-01-24 |
WO2004078732A1 (fr) | 2004-09-16 |
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