CO4840511A1 - Composicion antifungica que contiene (2r-cis)-4-[4-[4-[4- [[-5-(2,4-difluorofenil)tetrahidro-5-(1h-1,2,4-triazol-1- ilmetil)furan-3-il]metoxi]fenil]-1-piperazinil]fenil]2-4- dihidro-2-[(s)-1-etil-2(s)-hidroxipropil-3h-1,2,4- triazol-3-ona - Google Patents

Composicion antifungica que contiene (2r-cis)-4-[4-[4-[4- [[-5-(2,4-difluorofenil)tetrahidro-5-(1h-1,2,4-triazol-1- ilmetil)furan-3-il]metoxi]fenil]-1-piperazinil]fenil]2-4- dihidro-2-[(s)-1-etil-2(s)-hidroxipropil-3h-1,2,4- triazol-3-ona

Info

Publication number
CO4840511A1
CO4840511A1 CO97027673A CO97027673A CO4840511A1 CO 4840511 A1 CO4840511 A1 CO 4840511A1 CO 97027673 A CO97027673 A CO 97027673A CO 97027673 A CO97027673 A CO 97027673A CO 4840511 A1 CO4840511 A1 CO 4840511A1
Authority
CO
Colombia
Prior art keywords
triazol
fenil
difluorophenyl
furan
cis
Prior art date
Application number
CO97027673A
Other languages
English (en)
Inventor
Surendra A Sangekar
Winston A Vadino
Ping I Lee
Original Assignee
Schering Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Corp filed Critical Schering Corp
Publication of CO4840511A1 publication Critical patent/CO4840511A1/es

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4866—Organic macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/2031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyethylene oxide, poloxamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)

Abstract

Una composición farmacéutica que comprende:i) un agente antihongo que es (-)-(2R-cis)-4-[4-[4-[4-[[-5-(2,4-difluorofenil)te-trahidro-5-(1H-1,2,4-triazol-1-ilmetil)furan-3-il] metoxi]fenil]-1-piperazinil]fenil]2-4-dihidro-2-[(S)-1-etil-2(S)-hidroxipropil]-3H-1,2,4-triazol-3-ona;ii) por lo menos un surfactante no iónico; yiii) un diluyente. La composición permite al compuesto antihongo, que tiene una muy baja solubilidad en agua, mejorar la biodisponibilidad en mamíferos, tales como humanos.
CO97027673A 1996-05-24 1997-05-21 Composicion antifungica que contiene (2r-cis)-4-[4-[4-[4- [[-5-(2,4-difluorofenil)tetrahidro-5-(1h-1,2,4-triazol-1- ilmetil)furan-3-il]metoxi]fenil]-1-piperazinil]fenil]2-4- dihidro-2-[(s)-1-etil-2(s)-hidroxipropil-3h-1,2,4- triazol-3-ona CO4840511A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US65532996A 1996-05-24 1996-05-24

Publications (1)

Publication Number Publication Date
CO4840511A1 true CO4840511A1 (es) 1999-09-27

Family

ID=24628452

Family Applications (1)

Application Number Title Priority Date Filing Date
CO97027673A CO4840511A1 (es) 1996-05-24 1997-05-21 Composicion antifungica que contiene (2r-cis)-4-[4-[4-[4- [[-5-(2,4-difluorofenil)tetrahidro-5-(1h-1,2,4-triazol-1- ilmetil)furan-3-il]metoxi]fenil]-1-piperazinil]fenil]2-4- dihidro-2-[(s)-1-etil-2(s)-hidroxipropil-3h-1,2,4- triazol-3-ona

Country Status (28)

Country Link
EP (1) EP0914127B1 (es)
JP (1) JP3366648B2 (es)
KR (1) KR100307427B1 (es)
CN (1) CN1121860C (es)
AR (1) AR007250A1 (es)
AT (1) ATE213632T1 (es)
AU (1) AU719109B2 (es)
BR (1) BR9711167A (es)
CA (1) CA2255663C (es)
CO (1) CO4840511A1 (es)
CZ (1) CZ293586B6 (es)
DE (1) DE69710729T2 (es)
ES (1) ES2169440T3 (es)
HK (1) HK1017855A1 (es)
HU (1) HU221371B1 (es)
ID (1) ID16956A (es)
IL (1) IL126979A (es)
MY (1) MY118988A (es)
NO (1) NO316997B1 (es)
NZ (1) NZ332699A (es)
PE (1) PE68898A1 (es)
PL (1) PL188401B1 (es)
RU (1) RU2207119C2 (es)
SK (1) SK281818B6 (es)
TR (1) TR199802424T2 (es)
TW (1) TW504390B (es)
WO (1) WO1998007429A2 (es)
ZA (1) ZA974428B (es)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2157731B1 (es) * 1998-07-21 2002-05-01 Liconsa Liberacion Controlada Preparacion farmaceutica oral de un compuesto de actividad antifungica y procedimiento para su preparacion.
ATE329579T1 (de) 1999-11-12 2006-07-15 Abbott Lab Feste dispersion mit ritonavir, fenofibrat oder griseofulvin
DE10026698A1 (de) 2000-05-30 2001-12-06 Basf Ag Selbstemulgierende Wirkstoffformulierung und Verwendung dieser Formulierung
KR100596257B1 (ko) * 2001-01-26 2006-07-03 쉐링 코포레이션 스테롤 흡수 억제제를 포함하는 조성물, 및 페록시솜 증식인자-활성화 수용체 활성화제와 스테롤 흡수 억제제를 포함하는 조성물 및 조합물
US20050163839A1 (en) * 2003-01-29 2005-07-28 Sun Pharmaceutical Industries Limited Oral controlled release pharmaceutical composition containing metaxalone as active agent
US8025899B2 (en) 2003-08-28 2011-09-27 Abbott Laboratories Solid pharmaceutical dosage form
CN103379917B (zh) 2010-11-01 2016-10-12 梅琳塔治疗公司 药物组合物
RU2450807C1 (ru) * 2011-05-11 2012-05-20 Общество с ограниченной ответственностью фирма "Вита" Стабилизированный фармацевтический состав с противогрибковым действием
CN103845292A (zh) * 2012-11-29 2014-06-11 正大天晴药业集团股份有限公司 泊沙康唑微丸及其制备方法
US9763934B2 (en) * 2014-03-05 2017-09-19 Professional Compounding Centers Of America Synergistic effect of poloxamer-based composition and itraconazole on fungus and yeast
TR201620462A2 (tr) 2016-12-31 2018-07-23 Abdi Ibrahim Ilac Sanayi Ve Ticaret Anonim Sirketi POSAKONAZOL İÇEREN FARMASÖTİK BİLEŞİMLER ve ÜRETİM YÖNTEMİ

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4791111A (en) * 1985-12-23 1988-12-13 Janssen Pharmaceutica, N.V. [[4-[4-(4-phenyl-1-piperazinyl)phenoxymethyl]-1,3-dioxolan-2-yl]methyl]-1H-imidazoles and 1H-1,2,4-triazoles having anti-microbial properties
US5039676A (en) * 1990-05-11 1991-08-13 Schering Corporation Tri- and tetra-substituted-oxetanes and tetrahydrofurans and intermediates thereof
DK0736030T3 (da) * 1993-12-21 2001-10-29 Schering Corp Fungicide tetrahydrofuraner

Also Published As

Publication number Publication date
PE68898A1 (es) 1998-11-10
IL126979A0 (en) 1999-09-22
ZA974428B (en) 1997-11-24
AU719109B2 (en) 2000-05-04
WO1998007429A3 (en) 1998-04-23
HUP9904265A2 (hu) 2000-04-28
AR007250A1 (es) 1999-10-27
WO1998007429A2 (en) 1998-02-26
ES2169440T3 (es) 2002-07-01
ID16956A (id) 1997-11-27
HK1017855A1 (en) 1999-12-03
SK281818B6 (sk) 2001-08-06
PL330480A1 (en) 1999-05-24
CN1228699A (zh) 1999-09-15
ATE213632T1 (de) 2002-03-15
JP3366648B2 (ja) 2003-01-14
KR100307427B1 (ko) 2001-12-28
HUP9904265A3 (en) 2000-05-29
IL126979A (en) 2000-10-31
BR9711167A (pt) 1999-08-17
AU5939998A (en) 1998-03-06
SK160898A3 (en) 1999-05-07
NO316997B1 (no) 2004-07-19
HU221371B1 (en) 2002-09-28
DE69710729D1 (de) 2002-04-04
CZ293586B6 (cs) 2004-06-16
KR20000065222A (ko) 2000-11-06
CA2255663A1 (en) 1998-02-26
CA2255663C (en) 2002-08-20
RU2207119C2 (ru) 2003-06-27
JP2000509720A (ja) 2000-08-02
TR199802424T2 (xx) 1999-03-22
NO985447D0 (no) 1998-11-23
PL188401B1 (pl) 2005-01-31
CN1121860C (zh) 2003-09-24
NZ332699A (en) 2000-01-28
DE69710729T2 (de) 2002-08-14
TW504390B (en) 2002-10-01
CZ379098A3 (cs) 1999-03-17
EP0914127B1 (en) 2002-02-27
NO985447L (no) 1998-11-23
MY118988A (en) 2005-02-28
EP0914127A2 (en) 1999-05-12

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