JP2002541109A5 - - Google Patents
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- Publication number
- JP2002541109A5 JP2002541109A5 JP2000609073A JP2000609073A JP2002541109A5 JP 2002541109 A5 JP2002541109 A5 JP 2002541109A5 JP 2000609073 A JP2000609073 A JP 2000609073A JP 2000609073 A JP2000609073 A JP 2000609073A JP 2002541109 A5 JP2002541109 A5 JP 2002541109A5
- Authority
- JP
- Japan
- Prior art keywords
- pyrimidin
- dimethyl
- piperazin
- ethanol
- triazin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- -1 2- (4-methylpiperazin-1-yl) -pyrimid-4-yl Chemical group 0.000 claims 90
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N EtOH Substances CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims 57
- 150000001875 compounds Chemical class 0.000 claims 48
- 229940002612 prodrug Drugs 0.000 claims 34
- 239000000651 prodrug Substances 0.000 claims 34
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 claims 28
- 150000003839 salts Chemical class 0.000 claims 17
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 9
- 125000000229 (C1-C4)alkoxy group Chemical group 0.000 claims 7
- 125000002883 imidazolyl group Chemical group 0.000 claims 7
- 208000002249 Diabetes Complications Diseases 0.000 claims 6
- 206010012655 Diabetic complications Diseases 0.000 claims 6
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims 6
- 125000004356 hydroxy functional group Chemical group O* 0.000 claims 6
- 239000008194 pharmaceutical composition Substances 0.000 claims 6
- 125000004306 triazinyl group Chemical group 0.000 claims 6
- 125000006272 (C3-C7) cycloalkyl group Chemical group 0.000 claims 5
- 239000003814 drug Substances 0.000 claims 4
- 125000002757 morpholinyl group Chemical group 0.000 claims 4
- 125000000714 pyrimidinyl group Chemical group 0.000 claims 4
- 125000001425 triazolyl group Chemical group 0.000 claims 4
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 3
- 125000002777 acetyl group Chemical group [H]C([H])([H])C(*)=O 0.000 claims 3
- 229910052739 hydrogen Inorganic materials 0.000 claims 3
- 239000001257 hydrogen Substances 0.000 claims 3
- 239000012442 inert solvent Substances 0.000 claims 3
- AEOZCEMLLBCHQZ-HSHFZTNMSA-N (2r)-2-hydroxypropanimidamide;hydrochloride Chemical compound Cl.C[C@@H](O)C(N)=N AEOZCEMLLBCHQZ-HSHFZTNMSA-N 0.000 claims 2
- 125000004209 (C1-C8) alkyl group Chemical group 0.000 claims 2
- 125000004195 4-methylpiperazin-1-yl group Chemical group [H]C([H])([H])N1C([H])([H])C([H])([H])N(*)C([H])([H])C1([H])[H] 0.000 claims 2
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 claims 2
- 208000007342 Diabetic Nephropathies Diseases 0.000 claims 2
- 208000032131 Diabetic Neuropathies Diseases 0.000 claims 2
- 125000005466 alkylenyl group Chemical group 0.000 claims 2
- 206010012601 diabetes mellitus Diseases 0.000 claims 2
- 208000033679 diabetic kidney disease Diseases 0.000 claims 2
- CEIPQQODRKXDSB-UHFFFAOYSA-N ethyl 3-(6-hydroxynaphthalen-2-yl)-1H-indazole-5-carboximidate dihydrochloride Chemical compound Cl.Cl.C1=C(O)C=CC2=CC(C3=NNC4=CC=C(C=C43)C(=N)OCC)=CC=C21 CEIPQQODRKXDSB-UHFFFAOYSA-N 0.000 claims 2
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 2
- 125000001475 halogen functional group Chemical group 0.000 claims 2
- 125000004193 piperazinyl group Chemical group 0.000 claims 2
- 239000000600 sorbitol Substances 0.000 claims 2
- SXQFCVDSOLSHOQ-UWTATZPHSA-N (R)-(+)-Lactamide Chemical compound C[C@@H](O)C(N)=O SXQFCVDSOLSHOQ-UWTATZPHSA-N 0.000 claims 1
- CSDSSGBPEUDDEE-UHFFFAOYSA-N 2-formylpyridine Chemical compound O=CC1=CC=CC=N1 CSDSSGBPEUDDEE-UHFFFAOYSA-N 0.000 claims 1
- QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 claims 1
- 125000000217 alkyl group Chemical group 0.000 claims 1
- 125000006242 amine protecting group Chemical group 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 125000002962 imidazol-1-yl group Chemical group [*]N1C([H])=NC([H])=C1[H] 0.000 claims 1
- 230000002401 inhibitory effect Effects 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 229910052708 sodium Inorganic materials 0.000 claims 1
- 239000011734 sodium Substances 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US12743799P | 1999-04-01 | 1999-04-01 | |
| US60/127,437 | 1999-04-01 | ||
| PCT/IB2000/000296 WO2000059510A1 (en) | 1999-04-01 | 2000-03-16 | Aminopyrimidines as sorbitol dehydrogenase inhibitors |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2002541109A JP2002541109A (ja) | 2002-12-03 |
| JP3581103B2 JP3581103B2 (ja) | 2004-10-27 |
| JP2002541109A5 true JP2002541109A5 (https=) | 2005-08-04 |
Family
ID=22430114
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000609073A Expired - Fee Related JP3581103B2 (ja) | 1999-04-01 | 2000-03-16 | ソルビトールデヒドロゲナーゼ阻害薬としてのアミノピリミジン |
Country Status (41)
Families Citing this family (74)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PL350884A1 (en) * | 1999-04-01 | 2003-02-10 | Pfizer Prod Inc | Aminopyrimidines as sorbitol dehydrogenase inhibitors |
| CA2426592A1 (en) * | 2000-10-18 | 2002-04-25 | Pfizer Products Inc. | Combination of statins and sorbitol dehydrogenase inhibitors |
| SE0003795D0 (sv) * | 2000-10-20 | 2000-10-20 | Astrazeneca Ab | Pharmaceutically useful compounds |
| CA2430298A1 (en) * | 2000-11-30 | 2002-06-06 | Banavara Lakshman Mylari | Combination of gaba agonists and sorbitol dehydrogenase inhibitors |
| CA2433090A1 (en) * | 2000-12-27 | 2002-07-04 | Kyowa Hakko Kogyo Co., Ltd. | Dipeptidyl peptidase iv inhibitor |
| IL147696A0 (en) * | 2001-01-25 | 2002-08-14 | Pfizer Prod Inc | Combination therapy |
| EP1247809A3 (en) * | 2001-03-30 | 2003-12-17 | Pfizer Products Inc. | Triazine compounds useful as sorbitol dehydrogenase inhibitors |
| CA2448080A1 (en) | 2001-05-22 | 2002-11-28 | Neurogen Corporation | Melanin concentrating hormone receptor ligands: substituted 1-benzyl-4-aryl piperazine analogues |
| GB0127929D0 (en) * | 2001-11-21 | 2002-01-16 | Celltech R&D Ltd | Chemical compounds |
| EP1458374A2 (en) * | 2001-12-14 | 2004-09-22 | Novo Nordisk A/S | Compounds and uses thereof for decreasing activity of hormone-sensitive lipase |
| AU2003249369A1 (en) | 2002-06-21 | 2004-01-06 | Cellular Genomics, Inc. | Certain amino-substituted monocycles as kinase modulators |
| US7582635B2 (en) | 2002-12-24 | 2009-09-01 | Purdue Pharma, L.P. | Therapeutic agents useful for treating pain |
| MY150088A (en) | 2003-05-19 | 2013-11-29 | Irm Llc | Immunosuppressant compounds and compositions |
| EP1644367B1 (en) * | 2003-05-19 | 2015-10-14 | Novartis AG | Immunosuppressant compounds and compositions |
| WO2004111007A1 (en) * | 2003-06-12 | 2004-12-23 | Novo Nordisk A/S | 1-aryl-4-(aryloxycarbonyl)-piperazine derivatives for use as inhibitors of hormone sensitive lipase |
| CA2531619A1 (en) * | 2003-07-16 | 2005-01-27 | Neurogen Corporation | Biaryl piperazinyl-pyridine analogues |
| TWI290140B (en) * | 2003-08-25 | 2007-11-21 | Schering Corp | 2-Substituted benzimidazole derivatives as selective melanin concentrating hormone receptor antagonists for thr treatment of obesity and related disorders |
| ES2319539T3 (es) | 2003-09-17 | 2009-05-08 | Janssen Pharmaceutica Nv | Compuestos heterociclicos condensados como moduladores del receptor de serotonina. |
| WO2005037284A1 (en) * | 2003-10-15 | 2005-04-28 | Pfizer Products Inc. | Sorbitol dehydrogenase inhibitor and hypertensive agent combinations |
| US8455489B2 (en) * | 2003-11-10 | 2013-06-04 | Exelixis, Inc. | Substituted pyrimidine compositions and methods of use |
| WO2005110989A1 (en) * | 2004-04-07 | 2005-11-24 | Neurogen Corporation | Substituted 1-heteroaryl-4-substituted piperazine and piperidine analogues |
| WO2005110982A2 (en) * | 2004-04-07 | 2005-11-24 | Neurogen Corporation | Substituted 1-benzyl-4-substituted piperazine analogues |
| TW200609219A (en) * | 2004-06-17 | 2006-03-16 | Neurogen Corp | Aryl-substituted piperazine derivatives |
| MY145822A (en) * | 2004-08-13 | 2012-04-30 | Neurogen Corp | Substituted biaryl piperazinyl-pyridine analogues |
| GB0420831D0 (en) | 2004-09-17 | 2004-10-20 | Glaxo Group Ltd | Novel compounds |
| US20060128710A1 (en) * | 2004-12-09 | 2006-06-15 | Chih-Hung Lee | Antagonists to the vanilloid receptor subtype 1 (VR1) and uses thereof |
| TWI385164B (zh) * | 2005-02-17 | 2013-02-11 | Astellas Pharma Inc | Pyridyl non-aromatic nitrogen-containing heterocyclic-1-carboxylate derivatives (II) |
| US7402596B2 (en) | 2005-03-24 | 2008-07-22 | Renovis, Inc. | Bicycloheteroaryl compounds as P2X7 modulators and uses thereof |
| JP2008540443A (ja) * | 2005-05-04 | 2008-11-20 | バーテックス ファーマシューティカルズ インコーポレイテッド | イオンチャネルのモジュレーターとして有用なピリミジンおよびピラジン |
| JP5388574B2 (ja) | 2005-05-31 | 2014-01-15 | バーテックス ファーマシューティカルズ インコーポレイテッド | イオンチャネルのモジュレーターとして有用なヘテロ環式類 |
| US7598255B2 (en) | 2005-08-04 | 2009-10-06 | Janssen Pharmaceutica Nv | Pyrimidine compounds as serotonin receptor modulators |
| WO2007019083A1 (en) | 2005-08-04 | 2007-02-15 | Janssen Pharmaceutica N.V. | Pyrimidine compounds as serotonin receptor modulators |
| AU2006279312A1 (en) * | 2005-08-19 | 2007-02-22 | Elan Pharmaceuticals, Inc. | Bridged N-cyclic sulfonamido inhibitors of gamma secretase |
| US7825122B2 (en) | 2005-12-14 | 2010-11-02 | Amgen Inc. | Diaza heterocyclic sulfonamide derivatives and their uses |
| WO2008085316A1 (en) * | 2006-12-20 | 2008-07-17 | Merck & Co., Inc. | Bipiperidinyl compounds, compositions containing such compounds and methods of treatment |
| CA2685266C (en) * | 2007-04-27 | 2014-01-28 | Purdue Pharma L.P. | Trpv1 antagonists and uses thereof for the treatment of prevention of pain, ui and ulcer, ibd, or ibs in an animal |
| MX2009011601A (es) | 2007-04-27 | 2009-11-10 | Purdue Pharma Lp | Agentes terapeuticos utiles para tratar el dolor. |
| SI2178858T1 (sl) * | 2007-08-02 | 2012-03-30 | Recordati Ireland Ltd | Nove heterociklične spojine kot mGlu antagonisti |
| KR20110014974A (ko) * | 2008-03-31 | 2011-02-14 | 썬 파마슈티컬 인더스트리스 리미티드 | 모르피난 유사체의 개선된 제조 방법 |
| US8703962B2 (en) * | 2008-10-24 | 2014-04-22 | Purdue Pharma L.P. | Monocyclic compounds and their use as TRPV1 ligands |
| US8759362B2 (en) * | 2008-10-24 | 2014-06-24 | Purdue Pharma L.P. | Bicycloheteroaryl compounds and their use as TRPV1 ligands |
| US8658648B2 (en) | 2008-12-05 | 2014-02-25 | Designmedix, Inc. | Modified chloroquines with single ring moiety or fused ring moiety |
| US20100317630A1 (en) * | 2009-02-04 | 2010-12-16 | Recordati Ireland Limited | Novel heterocyclic compounds as mglu5 antagonists |
| TWI482771B (zh) * | 2009-05-04 | 2015-05-01 | Du Pont | 磺醯胺殺線蟲劑 |
| CN101619063B (zh) * | 2009-06-02 | 2011-08-10 | 华中师范大学 | 具有抗肿瘤活性的3,7,8-多取代吡啶并[4,3-d]嘧啶衍生物及制备 |
| WO2011029633A1 (en) * | 2009-09-14 | 2011-03-17 | Recordati Ireland Limited | Heterocyclic mglu5 antagonists |
| AR080375A1 (es) | 2010-03-05 | 2012-04-04 | Sanofi Aventis | Procedimiento para la preparacion de 2-(cicloheximetil)-n-{2-[(2s)-1-metilpirrolidin-2-il] etil}-1,2,3,4-tetrahidroisoquinolina- 7-sulfonamida |
| US10065960B2 (en) | 2010-04-02 | 2018-09-04 | Ogeda Sa | NK-3 receptor selective antagonist compounds, pharmaceutical composition and methods for use in NK-3 receptors mediated disorders |
| PL2552920T3 (pl) | 2010-04-02 | 2017-08-31 | Ogeda Sa | Nowe wybiórcze związki antagonistów receptora NK-3, farmaceutyczne kompozycje i sposoby do zastosowania w zaburzeniach pośredniczonych przez receptory NK-3 |
| US8921373B2 (en) | 2010-06-22 | 2014-12-30 | Shionogi & Co., Ltd. | Compounds having TRPV1 antagonistic activity and uses thereof |
| US8883791B2 (en) | 2010-09-29 | 2014-11-11 | Intervet Inc. | N-heteroaryl compounds with cyclic bridging unit for the treatment of parasitic diseases |
| CN102572513A (zh) * | 2010-12-13 | 2012-07-11 | 财团法人资讯工业策进会 | 网络协定电视互动系统、装置及其互动方法 |
| PE20141531A1 (es) | 2011-06-22 | 2014-10-23 | Purdue Pharma Lp | Antagonistas de trpv1 que incluyen sustituyentes dihidroxi y sus usos |
| AU2012293417A1 (en) | 2011-08-10 | 2013-05-02 | Purdue Pharma L.P. | TRPV1 antagonists including dihydroxy substituent and uses thereof |
| DK2763992T3 (en) * | 2011-10-03 | 2016-04-25 | Euroscreen Sa | NOVEL CHIRAL N-acyl-5,6,7, (8-substituted) -tetrahydro [1,2,4] triazolo [4,3-a] pyrazines as selective NK-3 receptor antagonists, PHARMACEUTICAL COMPOSITION AND METHODS FOR THE use in the NK-3 receptor mediated diseases |
| PT2822936T (pt) | 2012-03-07 | 2021-12-02 | Univ Of Delhi | Derivados da aminoquinolina e suas utilizações |
| CN103073506B (zh) * | 2013-01-31 | 2015-03-11 | 京博农化科技股份有限公司 | 一种2-羟基-4,6-二甲基嘧啶盐酸盐的合成方法 |
| WO2014141110A2 (en) * | 2013-03-14 | 2014-09-18 | Curadev Pharma Pvt. Ltd. | Aminonitriles as kynurenine pathway inhibitors |
| HK1223096A1 (zh) * | 2013-09-25 | 2017-07-21 | Vertex Pharmaceuticals Incorporated | 用作par-2信號通路抑制劑的咪唑並噠嗪 |
| TWI651310B (zh) | 2014-02-20 | 2019-02-21 | 日商日本煙草產業股份有限公司 | 三化合物及其醫藥用途 |
| FR3022784B1 (fr) * | 2014-06-26 | 2017-09-08 | Ecole Normale Superieure Lyon | Sondes moleculaires activables hydrosolubles, intermediaires pour leur synthese et procedes de detection associes |
| WO2016046398A1 (en) | 2014-09-25 | 2016-03-31 | Euroscreen Sa | Novel chiral synthesis of n-acyl-(3-substituted)-(8-substituted)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazines |
| JP2017529401A (ja) * | 2014-09-26 | 2017-10-05 | チャーンジョウ インシュヨン ファーマシューティカル カンパニー，リミティド | Ｎｓ４ｂ阻害剤としてのベンゾフラン類似体 |
| SI3215498T1 (sl) | 2014-11-03 | 2018-11-30 | Bayer Pharma Aktiengesellschaft | Hidroksialkil-substituirani derivati feniltriazola in njihove uporabe |
| KR20180037270A (ko) | 2015-08-17 | 2018-04-11 | 니뽄 다바코 산교 가부시키가이샤 | 히드록시트리아진 화합물 및 그의 의약 용도 |
| JP2018525429A (ja) | 2015-08-28 | 2018-09-06 | アッヴィ・インコーポレイテッド | Ｓ１ｐ調節剤としての縮合複素環化合物 |
| CA3006683A1 (en) * | 2015-12-22 | 2017-06-29 | Jiangsu Hengrui Medicine Co., Ltd. | Benzopiperidine derivative, preparation method thereof and medical use thereof |
| WO2017191115A1 (en) | 2016-05-03 | 2017-11-09 | Bayer Pharma Aktiengesellschaft | Oxoalkyl-substituted phenyltriazole derivatives and uses thereof |
| US9988367B2 (en) | 2016-05-03 | 2018-06-05 | Bayer Pharma Aktiengesellschaft | Amide-substituted pyridinyltriazole derivatives and uses thereof |
| CA3056890A1 (en) | 2017-03-17 | 2018-09-20 | Regents Of The University Of Colorado, A Body Corporate | Indazole inhibitors of fructokinase (khk) and methods of use in treating khk-mediated disorders or diseases |
| IL272246B2 (en) | 2017-07-28 | 2026-01-01 | Applied Therapeutics Inc | History of 2-(4-oxo/thioketone/azo-3-((substituted)benzo[d]thiazol-2-yl)methyl)- 3,4-dihydrothieno[3,4-d]pyridazin-1-yl)acetic acid for use as an aldose reductase inhibitor for the treatment of galactosemia or prevention of galactosemia-related complications |
| CN110872302B (zh) * | 2018-08-31 | 2022-09-27 | 沈阳中化农药化工研发有限公司 | 含嘧啶的螺环类化合物及其用途 |
| CA3132136A1 (en) | 2019-04-01 | 2020-10-08 | Andrew Wasmuth | Inhibitors of aldose reductase |
| JP2022531466A (ja) * | 2019-05-07 | 2022-07-06 | ユニバーシティ オブ マイアミ | 遺伝性ニューロパチーおよび関連障害の処置および検出 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3905364A1 (de) | 1989-02-22 | 1990-08-23 | Hoechst Ag | Substituierte pyrimidin-derivate, verfahren zu ihrer herstellung und ihre verwendung als tool |
| DE4025387A1 (de) * | 1990-08-10 | 1992-02-13 | Hoechst Ag | Substituierte pyrimidin-derivate, verfahren zu ihrer herstellung und ihre verwendung als reagenzien |
| US5728704A (en) | 1992-09-28 | 1998-03-17 | Pfizer Inc. | Substituted pyridmidines for control of diabetic complications |
| PT791355E (pt) * | 1996-02-29 | 2002-08-30 | Pfizer | Metodo para diminuir os daos associados com a isquemia nos tecidos |
| IT1285601B1 (it) | 1996-03-08 | 1998-06-18 | Bonfiglioli Riduttori Spa | Riduttore angolare a piu' stadi |
| PL350884A1 (en) * | 1999-04-01 | 2003-02-10 | Pfizer Prod Inc | Aminopyrimidines as sorbitol dehydrogenase inhibitors |
-
2000
- 2000-03-16 PL PL00350884A patent/PL350884A1/xx not_active Application Discontinuation
- 2000-03-16 EE EEP200100509A patent/EE200100509A/xx unknown
- 2000-03-16 HK HK02107025.2A patent/HK1045461A1/zh unknown
- 2000-03-16 MX MXPA01009871A patent/MXPA01009871A/es active IP Right Grant
- 2000-03-16 ID IDW00200102357A patent/ID30489A/id unknown
- 2000-03-16 TR TR2001/02810T patent/TR200102810T2/xx unknown
- 2000-03-16 HU HU0201011A patent/HUP0201011A3/hu unknown
- 2000-03-16 CZ CZ20013465A patent/CZ20013465A3/cs unknown
- 2000-03-16 EP EP00909565A patent/EP1185275A1/en not_active Withdrawn
- 2000-03-16 IL IL14536400A patent/IL145364A0/xx unknown
- 2000-03-16 EA EA200100933A patent/EA004656B1/ru not_active IP Right Cessation
- 2000-03-16 AP APAP/P/2001/002281A patent/AP2001002281A0/en unknown
- 2000-03-16 OA OA1200100249A patent/OA11856A/en unknown
- 2000-03-16 AU AU31845/00A patent/AU768720B2/en not_active Ceased
- 2000-03-16 CN CN00807825A patent/CN1351497A/zh active Pending
- 2000-03-16 HR HR20010716A patent/HRP20010716A2/hr not_active Application Discontinuation
- 2000-03-16 BR BR0009433-1A patent/BR0009433A/pt not_active IP Right Cessation
- 2000-03-16 UA UA2001096634A patent/UA71951C2/uk unknown
- 2000-03-16 JP JP2000609073A patent/JP3581103B2/ja not_active Expired - Fee Related
- 2000-03-16 KR KR1020017012626A patent/KR20020005653A/ko not_active Abandoned
- 2000-03-16 WO PCT/IB2000/000296 patent/WO2000059510A1/en not_active Ceased
- 2000-03-16 YU YU71101A patent/YU71101A/sh unknown
- 2000-03-16 NZ NZ514144A patent/NZ514144A/en unknown
- 2000-03-16 CA CA002366858A patent/CA2366858A1/en not_active Abandoned
- 2000-03-16 SK SK1353-2001A patent/SK13532001A3/sk unknown
- 2000-03-16 AP AP2005003199A patent/AP2005003199A0/xx unknown
- 2000-03-29 MA MA25941A patent/MA26727A1/fr unknown
- 2000-03-29 HN HN2000000040A patent/HN2000000040A/es unknown
- 2000-03-29 US US09/538,039 patent/US6414149B1/en not_active Expired - Fee Related
- 2000-03-29 DZ DZ000060A patent/DZ3037A1/xx active
- 2000-03-29 TN TNTNSN00065A patent/TNSN00065A1/fr unknown
- 2000-03-30 MY MYPI20001279A patent/MY136039A/en unknown
- 2000-03-30 PE PE2000000276A patent/PE20001601A1/es not_active Application Discontinuation
- 2000-03-30 UY UY26089A patent/UY26089A1/es not_active Application Discontinuation
- 2000-03-30 AR ARP000101427A patent/AR020562A1/es unknown
- 2000-03-31 GT GT200000038A patent/GT200000038A/es unknown
- 2000-03-31 PA PA20008493201A patent/PA8493201A1/es unknown
-
2001
- 2001-09-18 IS IS6076A patent/IS6076A/is unknown
- 2001-09-25 NO NO20014642A patent/NO20014642L/no not_active Application Discontinuation
- 2001-10-01 CR CR6471A patent/CR6471A/es not_active Application Discontinuation
- 2001-10-01 ZA ZA200108039A patent/ZA200108039B/en unknown
- 2001-10-23 BG BG106038A patent/BG106038A/xx unknown
-
2002
- 2002-02-28 US US10/087,869 patent/US6602875B2/en not_active Expired - Fee Related
-
2003
- 2003-03-10 US US10/384,424 patent/US6660740B1/en not_active Expired - Fee Related
- 2003-08-21 US US10/645,401 patent/US6869943B2/en not_active Expired - Fee Related
-
2004
- 2004-08-12 US US10/918,812 patent/US6936600B2/en not_active Expired - Fee Related
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