JP2005521676A5 - - Google Patents
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- Publication number
- JP2005521676A5 JP2005521676A5 JP2003565474A JP2003565474A JP2005521676A5 JP 2005521676 A5 JP2005521676 A5 JP 2005521676A5 JP 2003565474 A JP2003565474 A JP 2003565474A JP 2003565474 A JP2003565474 A JP 2003565474A JP 2005521676 A5 JP2005521676 A5 JP 2005521676A5
- Authority
- JP
- Japan
- Prior art keywords
- compound according
- alkyl
- cycloalkyl
- aryl
- tert
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 150000001875 compounds Chemical class 0.000 claims 85
- 125000000217 alkyl group Chemical group 0.000 claims 53
- 125000000753 cycloalkyl group Chemical group 0.000 claims 51
- 125000003118 aryl group Chemical group 0.000 claims 30
- -1 NR c R d Chemical group 0.000 claims 29
- 125000004423 acyloxy group Chemical group 0.000 claims 19
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 claims 19
- 125000001589 carboacyl group Chemical group 0.000 claims 18
- 125000003545 alkoxy group Chemical group 0.000 claims 16
- 125000005843 halogen group Chemical group 0.000 claims 13
- 125000004093 cyano group Chemical group *C#N 0.000 claims 12
- 125000005505 thiomorpholino group Chemical group 0.000 claims 12
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 11
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims 10
- 125000000876 trifluoromethoxy group Chemical group FC(F)(F)O* 0.000 claims 10
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims 10
- 125000001424 substituent group Chemical group 0.000 claims 8
- 229910052757 nitrogen Inorganic materials 0.000 claims 7
- 239000000203 mixture Substances 0.000 claims 6
- 150000003839 salts Chemical class 0.000 claims 5
- 125000004573 morpholin-4-yl group Chemical group N1(CCOCC1)* 0.000 claims 4
- 125000001401 1,2,4-triazol-4-yl group Chemical group N=1N=C([H])N([*])C=1[H] 0.000 claims 3
- 102000003840 Opioid Receptors Human genes 0.000 claims 3
- 108090000137 Opioid Receptors Proteins 0.000 claims 3
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 3
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 3
- 241000124008 Mammalia Species 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 230000000694 effects Effects 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 125000000587 piperidin-1-yl group Chemical group [H]C1([H])N(*)C([H])([H])C([H])([H])C([H])([H])C1([H])[H] 0.000 claims 2
- 125000002112 pyrrolidino group Chemical group [*]N1C([H])([H])C([H])([H])C([H])([H])C1([H])[H] 0.000 claims 2
- LFWAVNRDCVJWNS-UHFFFAOYSA-N 3-(3-tert-butylphenyl)-4-(3-methoxyphenyl)-1,2,4-triazole Chemical compound COC1=CC=CC(N2C(=NN=C2)C=2C=C(C=CC=2)C(C)(C)C)=C1 LFWAVNRDCVJWNS-UHFFFAOYSA-N 0.000 claims 1
- XAUBIRVVXYSHLW-UHFFFAOYSA-N 3-(4-tert-butylphenyl)-4-(3-methoxyphenyl)-1,2,4-triazole Chemical compound COC1=CC=CC(N2C(=NN=C2)C=2C=CC(=CC=2)C(C)(C)C)=C1 XAUBIRVVXYSHLW-UHFFFAOYSA-N 0.000 claims 1
- LXPRIRPPEBBCBL-UHFFFAOYSA-N 3-(5-tert-butyl-2-methoxyphenyl)-4-(3-methoxyphenyl)-1,2,4-triazole Chemical compound COC1=CC=CC(N2C(=NN=C2)C=2C(=CC=C(C=2)C(C)(C)C)OC)=C1 LXPRIRPPEBBCBL-UHFFFAOYSA-N 0.000 claims 1
- KMHZSWOKFAORBT-UHFFFAOYSA-N 5-(4-tert-butylphenyl)-4-(3-methoxyphenyl)-n,n-dimethyl-1,2,4-triazol-3-amine Chemical compound COC1=CC=CC(N2C(=NN=C2N(C)C)C=2C=CC(=CC=2)C(C)(C)C)=C1 KMHZSWOKFAORBT-UHFFFAOYSA-N 0.000 claims 1
- 125000004429 atom Chemical group 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 230000002401 inhibitory effect Effects 0.000 claims 1
- 125000000959 isobutyl group Chemical group [H]C([H])([H])C([H])(C([H])([H])[H])C([H])([H])* 0.000 claims 1
- 238000013160 medical therapy Methods 0.000 claims 1
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims 1
- UZKWTJUDCOPSNM-UHFFFAOYSA-N methoxybenzene Substances CCCCOC=C UZKWTJUDCOPSNM-UHFFFAOYSA-N 0.000 claims 1
- 125000004108 n-butyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 0 *C(Nc1cc(*)ccc1)=N* Chemical compound *C(Nc1cc(*)ccc1)=N* 0.000 description 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US35499002P | 2002-02-07 | 2002-02-07 | |
| PCT/US2003/003746 WO2003066050A1 (en) | 2002-02-07 | 2003-02-07 | Opioid receptor active 4-(3-hydroxyphenyl) or 4-(3-alkoxyphenyl)-1,2,4-triazole compounds |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2005521676A JP2005521676A (ja) | 2005-07-21 |
| JP2005521676A5 true JP2005521676A5 (https=) | 2006-02-02 |
Family
ID=27734448
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003565474A Pending JP2005521676A (ja) | 2002-02-07 | 2003-02-07 | オピオイドレセプター作動性４−（３−ヒドロキシフェニル）または４−（３−アルコキシフェニル）−１，２，４−トリアゾール化合物 |
Country Status (10)
| Country | Link |
|---|---|
| US (3) | US7045520B2 (https=) |
| EP (1) | EP1485088B1 (https=) |
| JP (1) | JP2005521676A (https=) |
| AT (1) | ATE403426T1 (https=) |
| AU (1) | AU2003210916B9 (https=) |
| CA (1) | CA2475767A1 (https=) |
| DE (1) | DE60322680D1 (https=) |
| ES (1) | ES2311711T3 (https=) |
| MX (1) | MXPA04007719A (https=) |
| WO (1) | WO2003066050A1 (https=) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE403426T1 (de) * | 2002-02-07 | 2008-08-15 | Univ Missouri | Opioid-rezeptor-aktive 4-(3-hydroxyphenyl) oder 4-(3-alkoxyphenyl)-1,2,4-triazol-verbindungen |
| WO2006055760A1 (en) * | 2004-11-18 | 2006-05-26 | Synta Pharmaceuticals Corp. | Triazole compounds that modulate hsp90 activity |
| WO2006124687A1 (en) * | 2005-05-12 | 2006-11-23 | University Of Medicine And Dentistry Of New Jersey | Opioid receptor subtype-selective agents |
| WO2008064310A2 (en) * | 2006-11-22 | 2008-05-29 | University Of Medicine And Dentistry Of New Jersey | Mixed opioid receptor active compounds |
| EP2509961B1 (en) | 2009-12-11 | 2016-03-09 | Autifony Therapeutics Limited | Imidazolidinedione derivatives |
| EA023768B1 (ru) | 2010-12-06 | 2016-07-29 | Отифони Терапеутикс Лимитед | ПРОИЗВОДНЫЕ ГИДАНТОИНА, ПОЛЕЗНЫЕ В КАЧЕСТВЕ ИНГИБИТОРОВ Kv3-КАНАЛОВ |
| JP6133790B2 (ja) | 2011-02-18 | 2017-05-24 | ザ スクリプス リサーチ インスティテュート | ミエリン形成細胞運命へのオリゴデンドロサイト前駆細胞の定方向分化 |
| CN103596943B (zh) | 2011-06-07 | 2016-10-12 | 奥蒂福尼疗法有限公司 | 用作kv3抑制剂的乙内酰脲衍生物 |
| EP2757881A4 (en) * | 2011-09-15 | 2014-11-12 | Univ Kansas | KAPPA OPIATE RECEPTOR EFFECTORS AND USES THEREOF |
| EP2613277A1 (en) * | 2012-01-06 | 2013-07-10 | MathPharm GmbH | Method and system for indentifying compounds that bind and preferably activate a target opioid receptor in a pH-dependent manner |
| WO2013134562A1 (en) | 2012-03-09 | 2013-09-12 | Inception 2, Inc. | Triazolone compounds and uses thereof |
| US9669030B2 (en) | 2012-05-22 | 2017-06-06 | Autifony Therapeutics Limited | Hydantoin derivatives as Kv3 inhibitors |
| US9422252B2 (en) | 2012-05-22 | 2016-08-23 | Autifony Therapeutics Limited | Triazoles as Kv3 inhibitors |
| AU2013363398B2 (en) | 2012-12-20 | 2017-06-01 | Tempest Therapeutics, Inc. | Triazolone compounds and uses thereof |
| ES2656012T3 (es) | 2013-02-06 | 2018-02-22 | Bayer Cropscience Aktiengesellschaft | Derivados de pirazol sustituidos con halógeno como pesticidas |
| US9776976B2 (en) | 2013-09-06 | 2017-10-03 | Inception 2, Inc. | Triazolone compounds and uses thereof |
| AU2014375265B2 (en) | 2014-01-03 | 2018-11-01 | Elanco Animal Health Gmbh | Novel pyrazolyl-heteroarylamides as pesticides |
| EP3268353B1 (de) | 2015-03-10 | 2020-09-09 | Bayer Animal Health GmbH | Pyrazolyl-derivate als schädlingsbekämpfungsmittel |
| CN108369222B (zh) * | 2015-08-31 | 2021-06-04 | 明尼苏达大学董事会 | 阿片受体调节剂及其用途 |
| CN111574368B (zh) * | 2020-05-15 | 2023-03-28 | 西安瑞联新材料股份有限公司 | 一种5-叔丁基-2-羟基苯甲酸甲酯的合成方法 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2269938A2 (en) * | 1974-05-08 | 1975-12-05 | Delalande Sa | 5-Hydroxymethyl-3,4-diphenyl-1,2,4-triazoles - with anticholinergic, bronchodilator, antidepressant, analgesic, vasodilator activity, etc. |
| FR2488891A1 (fr) | 1980-08-22 | 1982-02-26 | Roussel Uclaf | Nouveaux derives du 4h-1,2,4-triazole, leur procede de preparation et leur application comme medicament |
| US4481360A (en) * | 1983-08-26 | 1984-11-06 | The Upjohn Company | 4H-1,2,4-Triazol-3-yl compounds |
| US5310724A (en) * | 1990-02-09 | 1994-05-10 | Fmc Corporation | Herbicidal substituted phenyl-1,2,4-triazol-5(1H)-thiones |
| US5108486A (en) * | 1990-02-09 | 1992-04-28 | Kanagawa Chemical Laboratory, Ltd. | Herbicidal substituted-phenyl-1,2,4-triazol-5(1H)-thiones and -ones |
| AU9297798A (en) * | 1997-09-16 | 1999-04-05 | G.D. Searle & Co. | Substituted 1,2,4-triazoles useful for inhibiting cholesteryl ester transfer protein activity |
| JP2000063363A (ja) | 1998-08-12 | 2000-02-29 | Yamanouchi Pharmaceut Co Ltd | 新規なトリアゾール誘導体 |
| HN1999000149A (es) * | 1998-09-09 | 2000-01-12 | Pfizer Prod Inc | Derivados de 4,4-biarilpiperidina |
| ATE403426T1 (de) * | 2002-02-07 | 2008-08-15 | Univ Missouri | Opioid-rezeptor-aktive 4-(3-hydroxyphenyl) oder 4-(3-alkoxyphenyl)-1,2,4-triazol-verbindungen |
-
2003
- 2003-02-07 AT AT03737705T patent/ATE403426T1/de not_active IP Right Cessation
- 2003-02-07 CA CA002475767A patent/CA2475767A1/en not_active Abandoned
- 2003-02-07 ES ES03737705T patent/ES2311711T3/es not_active Expired - Lifetime
- 2003-02-07 DE DE60322680T patent/DE60322680D1/de not_active Expired - Fee Related
- 2003-02-07 JP JP2003565474A patent/JP2005521676A/ja active Pending
- 2003-02-07 US US10/360,602 patent/US7045520B2/en not_active Expired - Fee Related
- 2003-02-07 AU AU2003210916A patent/AU2003210916B9/en not_active Ceased
- 2003-02-07 EP EP03737705A patent/EP1485088B1/en not_active Expired - Lifetime
- 2003-02-07 MX MXPA04007719A patent/MXPA04007719A/es active IP Right Grant
- 2003-02-07 WO PCT/US2003/003746 patent/WO2003066050A1/en not_active Ceased
-
2006
- 2006-01-23 US US11/337,366 patent/US7294720B2/en not_active Expired - Fee Related
-
2007
- 2007-09-18 US US11/857,193 patent/US7776898B2/en not_active Expired - Fee Related
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