JP2009536195A5 - - Google Patents
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- Publication number
- JP2009536195A5 JP2009536195A5 JP2009509484A JP2009509484A JP2009536195A5 JP 2009536195 A5 JP2009536195 A5 JP 2009536195A5 JP 2009509484 A JP2009509484 A JP 2009509484A JP 2009509484 A JP2009509484 A JP 2009509484A JP 2009536195 A5 JP2009536195 A5 JP 2009536195A5
- Authority
- JP
- Japan
- Prior art keywords
- formulation
- ionizing radiation
- container
- proton pump
- pump inhibitor
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 238000009472 formulation Methods 0.000 claims 24
- 239000000203 mixture Substances 0.000 claims 24
- 230000005865 ionizing radiation Effects 0.000 claims 11
- 239000002253 acid Substances 0.000 claims 8
- 229940126409 proton pump inhibitor Drugs 0.000 claims 8
- 239000000612 proton pump inhibitor Substances 0.000 claims 8
- 238000000034 method Methods 0.000 claims 7
- 239000007787 solid Substances 0.000 claims 6
- 125000000217 alkyl group Chemical group 0.000 claims 5
- 150000001875 compounds Chemical class 0.000 claims 5
- 238000010894 electron beam technology Methods 0.000 claims 5
- 230000005855 radiation Effects 0.000 claims 5
- 125000003545 alkoxy group Chemical group 0.000 claims 4
- 229910052739 hydrogen Inorganic materials 0.000 claims 4
- 150000002431 hydrogen Chemical group 0.000 claims 4
- 239000001257 hydrogen Substances 0.000 claims 4
- 239000000546 pharmaceutical excipient Substances 0.000 claims 4
- 231100000987 absorbed dose Toxicity 0.000 claims 3
- 229910052736 halogen Inorganic materials 0.000 claims 3
- 150000002367 halogens Chemical group 0.000 claims 3
- 238000004519 manufacturing process Methods 0.000 claims 3
- 238000002360 preparation method Methods 0.000 claims 3
- 239000002904 solvent Substances 0.000 claims 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 3
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 230000007935 neutral effect Effects 0.000 claims 2
- 159000000001 potassium salts Chemical class 0.000 claims 2
- 150000003839 salts Chemical class 0.000 claims 2
- 208000018522 Gastrointestinal disease Diseases 0.000 claims 1
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims 1
- 125000005083 alkoxyalkoxy group Chemical group 0.000 claims 1
- 125000004453 alkoxycarbonyl group Chemical group 0.000 claims 1
- 125000004448 alkyl carbonyl group Chemical group 0.000 claims 1
- 125000004414 alkyl thio group Chemical group 0.000 claims 1
- 125000003710 aryl alkyl group Chemical group 0.000 claims 1
- 125000003785 benzimidazolyl group Chemical group N1=C(NC2=C1C=CC=C2)* 0.000 claims 1
- 125000004432 carbon atom Chemical group C* 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 125000006165 cyclic alkyl group Chemical group 0.000 claims 1
- 125000001316 cycloalkyl alkyl group Chemical group 0.000 claims 1
- 125000004663 dialkyl amino group Chemical group 0.000 claims 1
- 229910052731 fluorine Inorganic materials 0.000 claims 1
- 239000011737 fluorine Substances 0.000 claims 1
- 125000001153 fluoro group Chemical group F* 0.000 claims 1
- 125000004438 haloalkoxy group Chemical group 0.000 claims 1
- 239000007788 liquid Substances 0.000 claims 1
- 229910052757 nitrogen Inorganic materials 0.000 claims 1
- 150000002829 nitrogen Chemical group 0.000 claims 1
- 125000002971 oxazolyl group Chemical group 0.000 claims 1
- 238000007911 parenteral administration Methods 0.000 claims 1
- 239000002245 particle Substances 0.000 claims 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 1
- 125000002071 phenylalkoxy group Chemical group 0.000 claims 1
- -1 piperidino, morpholino Chemical group 0.000 claims 1
- 125000000168 pyrrolyl group Chemical group 0.000 claims 1
- 229910052708 sodium Inorganic materials 0.000 claims 1
- 239000011734 sodium Substances 0.000 claims 1
- 159000000000 sodium salts Chemical class 0.000 claims 1
- 239000008247 solid mixture Substances 0.000 claims 1
- 239000007921 spray Substances 0.000 claims 1
- 230000001954 sterilising effect Effects 0.000 claims 1
- 125000004950 trifluoroalkyl group Chemical group 0.000 claims 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US79905806P | 2006-05-09 | 2006-05-09 | |
| PCT/SE2007/000440 WO2007129961A1 (en) | 2006-05-09 | 2007-05-07 | Parenteral formulation comprising proton pump inhibitor sterilized in its final container by ionizing radiation |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2009536195A JP2009536195A (ja) | 2009-10-08 |
| JP2009536195A5 true JP2009536195A5 (https=) | 2010-06-17 |
Family
ID=38667996
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009509484A Pending JP2009536195A (ja) | 2006-05-09 | 2007-05-07 | 最終容器中で電離放射線により滅菌されるプロトンポンプ阻害剤を含む非経口製剤 |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US20090111856A1 (https=) |
| EP (1) | EP2018151A4 (https=) |
| JP (1) | JP2009536195A (https=) |
| KR (1) | KR20090024674A (https=) |
| CN (1) | CN101442985A (https=) |
| AU (1) | AU2007248949B2 (https=) |
| BR (1) | BRPI0711048A2 (https=) |
| CA (1) | CA2649946A1 (https=) |
| MX (1) | MX2008014283A (https=) |
| NO (1) | NO20084914L (https=) |
| NZ (1) | NZ572007A (https=) |
| WO (1) | WO2007129961A1 (https=) |
| ZA (1) | ZA200808824B (https=) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10953115B2 (en) | 2012-05-09 | 2021-03-23 | Icrom S.R.L. | Production of sterile active pharmaceutical ingredients |
| GB2513172A (en) * | 2013-04-18 | 2014-10-22 | Nupharm Lab Ltd | Liquid dosage form and delivery system |
| CN103698430B (zh) * | 2013-12-24 | 2015-01-21 | 江苏正大丰海制药有限公司 | 一种埃索美拉唑钠和注射用埃索美拉唑钠中杂质含量检测方法 |
| CN105272965A (zh) * | 2014-07-03 | 2016-01-27 | 上海汇伦生命科技有限公司 | 一种埃索美拉唑钠的纯化方法 |
| GB201505347D0 (en) * | 2015-03-27 | 2015-05-13 | Salupont Consulting Ltd | Sterilisation of s-nitrosothiols |
| US11793748B1 (en) * | 2019-04-05 | 2023-10-24 | Good Health, Llc | Pharmaceutical compositions of aspirin for parenteral administration |
| US11666548B2 (en) * | 2020-06-05 | 2023-06-06 | Baxter International Inc. | Parenteral nutrition formulation |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL75400A (en) * | 1984-06-16 | 1988-10-31 | Byk Gulden Lomberg Chem Fab | Dialkoxypyridine methyl(sulfinyl or sulfonyl)benzimidazoles,processes for the preparation thereof and pharmaceutical compositions containing the same |
| US4678809A (en) * | 1985-02-01 | 1987-07-07 | Michael Phillips | Injectable fomulations of disulfiram for the treatment of alcoholism |
| DE4438360C2 (de) * | 1994-10-27 | 1999-05-20 | Schott Glas | Vorfüllbare partikelarme, sterile Einmalspritze für die Injektion von Präparaten und Verfahren zu ihrer Herstellung |
| IL133105A (en) * | 1997-06-04 | 2004-09-27 | Debio Rech Pharma Sa | Implants for controlled release of pharmaceutically active principles and method for making same |
| SE9903831D0 (sv) * | 1999-10-22 | 1999-10-22 | Astra Ab | Formulation of substituted benzimidazoles |
| PE20021017A1 (es) * | 2001-04-03 | 2002-11-24 | Pharmacia Corp | Composicion parenteral reconstituible |
| WO2003077916A1 (en) * | 2002-03-15 | 2003-09-25 | Altana Pharma Ag | Use of proton pump inhibitors for the treatment of noncardiac chest pain |
| DE60304726T2 (de) * | 2002-07-19 | 2007-08-09 | Winston Pharmaceuticals Llc, Newport Beach | Benzimidazolderivative und ihre verwendung als prodrugs für protonenpumpenhemmer |
| EP1556091A1 (en) * | 2002-10-04 | 2005-07-27 | Elan Pharma International Limited | Gamma irradiation of solid nanoparticulate active agents |
| CN1703198A (zh) * | 2002-10-25 | 2005-11-30 | 辉瑞产品公司 | 呈混悬剂形式的芳基杂环活性物质的贮库制剂 |
| ATE466579T1 (de) * | 2003-11-05 | 2010-05-15 | Lyka Labs Ltd | Verfahren zur herstellung von benzimidazolen |
| JP2005200409A (ja) * | 2003-12-17 | 2005-07-28 | Takeda Chem Ind Ltd | 注射剤 |
| TW200526268A (en) * | 2003-12-17 | 2005-08-16 | Takeda Pharmaceutical | Injectable composition |
-
2007
- 2007-05-07 BR BRPI0711048-0A patent/BRPI0711048A2/pt not_active IP Right Cessation
- 2007-05-07 AU AU2007248949A patent/AU2007248949B2/en not_active Ceased
- 2007-05-07 EP EP07748104A patent/EP2018151A4/en not_active Withdrawn
- 2007-05-07 WO PCT/SE2007/000440 patent/WO2007129961A1/en not_active Ceased
- 2007-05-07 US US12/299,684 patent/US20090111856A1/en not_active Abandoned
- 2007-05-07 JP JP2009509484A patent/JP2009536195A/ja active Pending
- 2007-05-07 NZ NZ572007A patent/NZ572007A/en not_active IP Right Cessation
- 2007-05-07 KR KR1020087027385A patent/KR20090024674A/ko not_active Withdrawn
- 2007-05-07 CN CNA2007800168871A patent/CN101442985A/zh active Pending
- 2007-05-07 MX MX2008014283A patent/MX2008014283A/es not_active Application Discontinuation
- 2007-05-07 CA CA002649946A patent/CA2649946A1/en not_active Abandoned
-
2008
- 2008-10-15 ZA ZA200808824A patent/ZA200808824B/xx unknown
- 2008-11-21 NO NO20084914A patent/NO20084914L/no not_active Application Discontinuation
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