|
US20040014761A1
(en)
*
|
1997-10-28 |
2004-01-22 |
Place Virgil A. |
Treatment of female sexual dysfunction with phosphodiesterase inhibitors
|
|
US6403597B1
(en)
*
|
1997-10-28 |
2002-06-11 |
Vivus, Inc. |
Administration of phosphodiesterase inhibitors for the treatment of premature ejaculation
|
|
SK287161B6
(sk)
*
|
1997-11-12 |
2010-02-08 |
Bayer Healthcare Ag |
2-Fenylsubstituované imidazotriazinóny, spôsob ich výroby, liečivá obsahujúce tieto látky a ich použitie
|
|
DE19827640A1
(de)
|
1998-06-20 |
1999-12-23 |
Bayer Ag |
7-Alkyl- und Cycloalkyl-substituierte Imidazotriazinone
|
|
US7235625B2
(en)
|
1999-06-29 |
2007-06-26 |
Palatin Technologies, Inc. |
Multiple agent therapy for sexual dysfunction
|
|
DE19944161A1
(de)
*
|
1999-09-15 |
2001-03-22 |
Bayer Ag |
Neue Kombination zur Behandlung von sexueller Dysfunktion
|
|
CA2323008C
(en)
*
|
1999-10-11 |
2005-07-12 |
Pfizer Inc. |
Pharmaceutically active compounds
|
|
US20050070499A1
(en)
*
|
1999-11-08 |
2005-03-31 |
Pfizer Inc. |
Compounds for the treatment of female sexual dysfunction
|
|
IL139457A0
(en)
*
|
1999-11-08 |
2001-11-25 |
Pfizer |
Compounds for the treatment of female sexual dysfunction
|
|
CA2395548A1
(en)
|
1999-12-24 |
2001-07-05 |
Bayer Aktiengesellschaft |
Imidazo 1,3,5 triazinones and the use thereof
|
|
DE50008549D1
(de)
|
1999-12-24 |
2004-12-09 |
Bayer Healthcare Ag |
Triazolotriazinone und ihre verwendung
|
|
US6777416B2
(en)
|
1999-12-24 |
2004-08-17 |
Bayer Aktiengesellschaft |
Isoxazolo pyrimidinones and the use thereof
|
|
DE10010067A1
(de)
*
|
2000-03-02 |
2001-09-06 |
Bayer Ag |
Neue Imidazotriazinone und ihre Verwendung
|
|
WO2001078711A2
(en)
|
2000-04-19 |
2001-10-25 |
Lilly Icos, Llc. |
Pde-v inhibitors for treatment of parkinson's disease
|
|
US6821978B2
(en)
*
|
2000-09-19 |
2004-11-23 |
Schering Corporation |
Xanthine phosphodiesterase V inhibitors
|
|
ES2275729T3
(es)
*
|
2000-09-29 |
2007-06-16 |
Glaxo Group Limited |
Compuestos utiles en el tratamiento de enfermedades inflamatorias.
|
|
US6548508B2
(en)
|
2000-10-20 |
2003-04-15 |
Pfizer, Inc. |
Use of PDE V inhibitors for improved fecundity in mammals
|
|
US20020091129A1
(en)
*
|
2000-11-20 |
2002-07-11 |
Mitradev Boolell |
Treatment of premature ejaculation
|
|
DE10063108A1
(de)
*
|
2000-12-18 |
2002-06-20 |
Bayer Ag |
Verfahren zur Herstellung von Sulfonamid-substituierten Imidazotriazinonen
|
|
DE10063106A1
(de)
*
|
2000-12-18 |
2002-06-20 |
Bayer Ag |
Verfahren zur Herstellung von 2-(2-Ethoxyphenyl)-substituierten Imidazotriazinonen
|
|
DE10064105A1
(de)
|
2000-12-21 |
2002-06-27 |
Bayer Ag |
Neue Substituierte Imidazotriazinone
|
|
JP2004527476A
(ja)
|
2001-02-02 |
2004-09-09 |
ファイザー・インク |
真性糖尿病の処置
|
|
DE10107639A1
(de)
*
|
2001-02-15 |
2002-08-22 |
Bayer Ag |
2-Alkoxyphenyl-substituierte Imidazotriazinone
|
|
DE10108752A1
(de)
*
|
2001-02-23 |
2002-09-05 |
Bayer Ag |
Neue Substituierte Imidazotriazinone
|
|
GB0107751D0
(en)
*
|
2001-03-28 |
2001-05-16 |
Pfizer Ltd |
Pharmaceutically active compounds
|
|
DE10118306A1
(de)
|
2001-04-12 |
2002-10-17 |
Bayer Ag |
Imidazotriazinonhaltige Zusammensetzungen zur nasalen Applikation
|
|
BR0209541A
(pt)
*
|
2001-05-09 |
2004-04-20 |
Bayer Healthcare Ag |
Uso das imidazotriazinonas 2-fenil-substituìdas
|
|
US7458374B2
(en)
|
2002-05-13 |
2008-12-02 |
Alexza Pharmaceuticals, Inc. |
Method and apparatus for vaporizing a compound
|
|
US7766013B2
(en)
|
2001-06-05 |
2010-08-03 |
Alexza Pharmaceuticals, Inc. |
Aerosol generating method and device
|
|
US20070122353A1
(en)
|
2001-05-24 |
2007-05-31 |
Hale Ron L |
Drug condensation aerosols and kits
|
|
US7090830B2
(en)
|
2001-05-24 |
2006-08-15 |
Alexza Pharmaceuticals, Inc. |
Drug condensation aerosols and kits
|
|
US7585493B2
(en)
|
2001-05-24 |
2009-09-08 |
Alexza Pharmaceuticals, Inc. |
Thin-film drug delivery article and method of use
|
|
GB0113344D0
(en)
|
2001-06-01 |
2001-07-25 |
Bayer Ag |
Novel heterocycles 3
|
|
US7087605B2
(en)
|
2001-06-01 |
2006-08-08 |
Bayer Aktiengesellschaft |
5-Ethyl-imidazotriazinones
|
|
DE10130167A1
(de)
*
|
2001-06-22 |
2003-01-02 |
Bayer Ag |
Imidazotriazine
|
|
DE10135815A1
(de)
*
|
2001-07-23 |
2003-02-06 |
Bayer Ag |
Verwendung von 2-Alkoxyphenyl-substituierten Imidazotriazinonen
|
|
DE60226615D1
(cs)
|
2001-08-28 |
2008-06-26 |
Schering Corp |
|
|
WO2003042216A1
(en)
*
|
2001-11-09 |
2003-05-22 |
Schering Corporation |
Polycyclic guanine derivative phosphodiesterase v inhibitors
|
|
GB0129274D0
(en)
*
|
2001-12-06 |
2002-01-23 |
Pfizer Ltd |
Novel kit
|
|
ES2294189T3
(es)
*
|
2001-12-13 |
2008-04-01 |
Asubio Pharma Co., Ltd. |
Derivados de pirazolopirimidinona que tienen accion inhibidora de pde7.
|
|
GB0130219D0
(en)
*
|
2001-12-18 |
2002-02-06 |
Pfizer Ltd |
Compounds for the treatment of sexual dysfunction
|
|
GB0209988D0
(en)
*
|
2002-05-01 |
2002-06-12 |
Bayer Ag |
Novel Heterocycles
|
|
DE10220570A1
(de)
|
2002-05-08 |
2003-11-20 |
Bayer Ag |
Carbamat-substituierte Pyrazolopyridine
|
|
WO2003101276A2
(en)
|
2002-05-22 |
2003-12-11 |
Virginia Commonwealth University |
Protective effects of pde-5 inhibitors
|
|
JP2005529927A
(ja)
*
|
2002-05-23 |
2005-10-06 |
ファイザー インコーポレイテッド |
新規な組み合わせ
|
|
EP1719772A1
(en)
|
2002-05-31 |
2006-11-08 |
Schering Corporation |
Process for preparing xanthine phosphodiesterase v inhibitors and precursors thereof
|
|
GB0214784D0
(en)
*
|
2002-06-26 |
2002-08-07 |
Pfizer Ltd |
Novel combination
|
|
DE10229778A1
(de)
*
|
2002-07-03 |
2004-01-29 |
Bayer Ag |
Neue Verwendung von Imidazotriazinonen
|
|
DE10230605A1
(de)
|
2002-07-08 |
2004-01-29 |
Bayer Ag |
Substituierte Imidazotriazine
|
|
DE10232113A1
(de)
*
|
2002-07-16 |
2004-01-29 |
Bayer Ag |
Vardenafil Hydrochlorid Trihydrat enthaltende Arzneimittel
|
|
GB0219961D0
(en)
|
2002-08-28 |
2002-10-02 |
Pfizer Ltd |
Oxytocin inhibitors
|
|
US7323462B2
(en)
|
2002-12-10 |
2008-01-29 |
Pfizer Inc. |
Morpholine dopamine agonists
|
|
WO2004054560A1
(en)
|
2002-12-13 |
2004-07-01 |
Warner-Lambert Company Llc |
Alpha-2-delta ligand to treat lower urinary tract symptoms
|
|
WO2004087652A2
(en)
*
|
2003-04-01 |
2004-10-14 |
Smithkline Beecham Corporation |
Imidazotriazine compounds
|
|
WO2004096810A1
(en)
|
2003-04-29 |
2004-11-11 |
Pfizer Limited |
5,7-diaminopyrazolo`4,3-d!pyrimidines useful in the treatment of hypertension
|
|
US20040220186A1
(en)
*
|
2003-04-30 |
2004-11-04 |
Pfizer Inc. |
PDE9 inhibitors for treating type 2 diabetes,metabolic syndrome, and cardiovascular disease
|
|
JP2007516149A
(ja)
|
2003-05-21 |
2007-06-21 |
アレックザ ファーマシューティカルズ, インコーポレイテッド |
基板温度の均一性を制御する方法、および、内蔵式加熱ユニットおよびそれを使用する薬剤供給ユニット
|
|
WO2004103407A2
(en)
|
2003-05-22 |
2004-12-02 |
Altana Pharma Ag |
Composition comprising a pde4 inhibitor and a pde5 inhibitor
|
|
CN100374441C
(zh)
|
2003-06-06 |
2008-03-12 |
天津倍方科技发展有限公司 |
二氢吡咯[2,3-d]嘧啶-4-酮衍生物,其制备方法及其制药用途
|
|
JP2006219374A
(ja)
*
|
2003-06-13 |
2006-08-24 |
Daiichi Asubio Pharma Co Ltd |
Pde7阻害作用を有するイミダゾトリアジノン誘導体
|
|
US20050079548A1
(en)
*
|
2003-07-07 |
2005-04-14 |
Plexxikon, Inc. |
Ligand development using PDE4B crystal structures
|
|
US7291640B2
(en)
*
|
2003-09-22 |
2007-11-06 |
Pfizer Inc. |
Substituted triazole derivatives as oxytocin antagonists
|
|
BRPI0416202A
(pt)
*
|
2003-11-21 |
2006-12-26 |
Schering Corp |
formulações inibidoras de fosfodiesterase v
|
|
US7572799B2
(en)
*
|
2003-11-24 |
2009-08-11 |
Pfizer Inc |
Pyrazolo[4,3-d]pyrimidines as Phosphodiesterase Inhibitors
|
|
GB0327323D0
(en)
*
|
2003-11-24 |
2003-12-31 |
Pfizer Ltd |
Novel pharmaceuticals
|
|
BRPI0506994A
(pt)
|
2004-01-22 |
2007-07-03 |
Pfizer |
derivados de triazol que inibem a atividade antagonista da vasopressina
|
|
CA2562251C
(en)
*
|
2004-04-07 |
2009-04-28 |
Pfizer Inc. |
Pyrazolo'4,3-d pyrimidines
|
|
DE102004023069A1
(de)
|
2004-05-11 |
2005-12-08 |
Bayer Healthcare Ag |
Neue Darreichungsformen des PDE 5-Inhibitors Vardenafil
|
|
US7540286B2
(en)
|
2004-06-03 |
2009-06-02 |
Alexza Pharmaceuticals, Inc. |
Multiple dose condensation aerosol devices and methods of forming condensation aerosols
|
|
JP2008501617A
(ja)
*
|
2004-06-11 |
2008-01-24 |
アスビオファーマ株式会社 |
Pde7阻害作用を有するイミダゾトリアジノン誘導体
|
|
WO2006022714A1
(en)
|
2004-08-12 |
2006-03-02 |
Alexza Pharmaceuticals, Inc. |
Aerosol drug delivery device incorporating percussively activated heat packages
|
|
DE102005001989A1
(de)
*
|
2005-01-15 |
2006-07-20 |
Bayer Healthcare Ag |
Intravenöse Formulierungen von PDE-Inhibitoren
|
|
ZA200707505B
(en)
*
|
2005-02-18 |
2009-08-26 |
Surface Logix Inc |
Pharmacokinetically improved compounds
|
|
MX2007010142A
(es)
*
|
2005-02-18 |
2007-12-07 |
Surface Logix Inc |
Metodos para fabricar compuestos mejorados farmacocineticamente que comprenden residuos o grupos funcionales y composiciones farmaceuticas que comprenden dichos compuestos.
|
|
DE102005009241A1
(de)
*
|
2005-03-01 |
2006-09-07 |
Bayer Healthcare Ag |
Arzneiformen mit kontrollierter Bioverfügbarkeit
|
|
DE102005009240A1
(de)
|
2005-03-01 |
2006-09-07 |
Bayer Healthcare Ag |
Arzneiformen mit verbesserten pharmakokinetischen Eigenschaften
|
|
DE102005016345A1
(de)
*
|
2005-04-09 |
2006-10-12 |
Bayer Healthcare Ag |
Neue Verwendung von 2-Phenyl-substituierten Imidazotriazinon-Derivaten
|
|
KR101358479B1
(ko)
|
2005-04-19 |
2014-02-06 |
다케다 게엠베하 |
폐고혈압 치료용 로플루밀라스트
|
|
MX2007013215A
(es)
|
2005-05-12 |
2007-12-12 |
Pfizer |
Formas cristalinas anhidras de la n-[1-(2-etoxietil)-5-(n-etil-n- metilamino)-7-(4-metilpiridin-2-il-amino)-1h-pirazolo[4,3-d] pirimidina -3-carbonil] metanosulfonamida.
|
|
US20060264624A1
(en)
*
|
2005-05-20 |
2006-11-23 |
Alexander Heim-Riether |
Methods for synthesizing imidazotriazinones
|
|
US20070010525A1
(en)
*
|
2005-06-27 |
2007-01-11 |
Meyer Jackson |
Method and compositions for modulating neuropeptide hormone secretion
|
|
US20100222365A1
(en)
*
|
2005-08-10 |
2010-09-02 |
Pfizer Inc |
Substituted triazole deriviatives as oxytocin antagonists
|
|
US7678363B2
(en)
|
2005-08-26 |
2010-03-16 |
Braincells Inc |
Methods of treating psychiatric conditions comprising administration of muscarinic agents in combination with SSRIs
|
|
EP2258359A3
(en)
|
2005-08-26 |
2011-04-06 |
Braincells, Inc. |
Neurogenesis by muscarinic receptor modulation with sabcomelin
|
|
AU2006299232A1
(en)
*
|
2005-09-29 |
2007-04-12 |
Bayer Schering Pharma Aktiengesellschaft |
PDE inhibitors and combinations thereof for the treatment of urological disorders
|
|
US20070093493A1
(en)
*
|
2005-10-12 |
2007-04-26 |
Lilly Icos Llc |
Treatment of benign prostatic hypertrophy and lower urinary tract symptoms
|
|
CA2625153A1
(en)
|
2005-10-21 |
2007-04-26 |
Braincells, Inc. |
Modulation of neurogenesis by pde inhibition
|
|
JP2009513672A
(ja)
|
2005-10-31 |
2009-04-02 |
ブレインセルス,インコーポレイティド |
神経発生のgaba受容体媒介調節
|
|
GB0601951D0
(en)
|
2006-01-31 |
2006-03-15 |
Novartis Ag |
Organic compounds
|
|
CA2641013A1
(en)
*
|
2006-02-17 |
2007-08-30 |
Wyeth |
Methods for preparing sulfonamide substituted alcohols and intermediates thereof
|
|
EP1984347A1
(en)
*
|
2006-02-17 |
2008-10-29 |
Wyeth a Corporation of the State of Delaware |
Selective n-sulfonylation of 2-amino trifluoroalkyl substituted alcohols
|
|
US20100216734A1
(en)
|
2006-03-08 |
2010-08-26 |
Braincells, Inc. |
Modulation of neurogenesis by nootropic agents
|
|
US7977478B2
(en)
*
|
2006-03-13 |
2011-07-12 |
Dr. Reddy's Laboratories Limited |
Polymorphic forms of vardenafil
|
|
EP2586434B3
(en)
*
|
2006-03-17 |
2022-04-06 |
The Johns Hopkins University |
N-hydroxylsulfonamide derivatives as new physiologically useful nitroxyl donors
|
|
WO2007124045A2
(en)
*
|
2006-04-20 |
2007-11-01 |
Ampla Pharmaceuticals, Inc. |
Piperidine and piperazine compounds for use in the treatment of obesity, eating disorders and sexual dysfunction by potentiation of mc4 receptor activity
|
|
JP2009536667A
(ja)
|
2006-05-09 |
2009-10-15 |
ブレインセルス,インコーポレイティド |
5ht受容体介在性の神経新生
|
|
JP2009536669A
(ja)
|
2006-05-09 |
2009-10-15 |
ブレインセルス,インコーポレイティド |
アンジオテンシン調節による神経新生
|
|
SI2032521T1
(sl)
|
2006-06-27 |
2010-02-26 |
Sandoz Ag |
Nov postopek za pripravo soli
|
|
WO2008008398A2
(en)
*
|
2006-07-14 |
2008-01-17 |
Shionogi & Co., Ltd. |
Oxime compounds and the use thereof
|
|
CA2661483A1
(en)
*
|
2006-08-24 |
2008-02-28 |
Surface Logix, Inc. |
Pharmacokinetically improved 2-phenyl-substituted imidazotriazinone derivatives and their use
|
|
AR062501A1
(es)
|
2006-08-29 |
2008-11-12 |
Actelion Pharmaceuticals Ltd |
Composiciones terapeuticas
|
|
AU2007292848A1
(en)
|
2006-09-08 |
2008-03-13 |
Braincells, Inc. |
Combinations containing a 4-acylaminopyridine derivative
|
|
DE102006043443A1
(de)
*
|
2006-09-15 |
2008-03-27 |
Bayer Healthcare Ag |
Neue aza-bicyclische Verbindungen und ihre Verwendung
|
|
US20100184806A1
(en)
|
2006-09-19 |
2010-07-22 |
Braincells, Inc. |
Modulation of neurogenesis by ppar agents
|
|
US8314119B2
(en)
|
2006-11-06 |
2012-11-20 |
Abbvie Inc. |
Azaadamantane derivatives and methods of use
|
|
DK2101777T3
(en)
|
2006-12-12 |
2015-08-17 |
Gilead Sciences Inc |
COMPOSITION FOR TREATMENT OF PULMONAL HYPERTENSION
|
|
US20080194529A1
(en)
*
|
2007-02-12 |
2008-08-14 |
Auspex Pharmaceuticals, Inc. |
HIGHLY SELECTIVE and LONG-ACTING PDE5 MODULATORS
|
|
CA2677691C
(en)
|
2007-02-12 |
2012-07-31 |
David Bar-Or |
Reducing side effects of tramadol
|
|
CN101657101B
(zh)
*
|
2007-02-12 |
2013-12-11 |
Dmi生物科学公司 |
并存早泄和勃起功能障碍的治疗
|
|
WO2008112661A2
(en)
|
2007-03-09 |
2008-09-18 |
Alexza Pharmaceuticals, Inc. |
Heating unit for use in a drug delivery device
|
|
DE102007027067A1
(de)
|
2007-06-12 |
2008-12-18 |
Ratiopharm Gmbh |
Verfahren zur Herstellung eines Arzneimittels enthaltend Vardenafil Hydrochlorid Trihydrat
|
|
WO2008151734A1
(en)
*
|
2007-06-13 |
2008-12-18 |
Bayer Schering Pharma Aktiengesellschaft |
Pde inhibitors for the treatment of hearing impairment
|
|
WO2009030095A1
(en)
*
|
2007-09-06 |
2009-03-12 |
Topharman Shanghai Co., Ltd. |
Process for preparing vardenafil and its intermediates
|
|
EP2228370B1
(en)
|
2007-12-28 |
2012-05-23 |
Topharman Shanghai Co., Ltd. |
N-{1-[3-(2-ethoxy-5-(4-ethylpiperazinyl)benzenesulfonyl)-4,5-dihydro-5-oxo-1,2,4-triazin-6-yl]ethyl}butyramide, the preparation method and use thereof
|
|
US20090181975A1
(en)
*
|
2008-01-15 |
2009-07-16 |
Forest Laboratories Holdings Limited |
Nebivolol in the treatment of sexual dysfunction
|
|
DE102008063992A1
(de)
|
2008-12-19 |
2010-09-02 |
Lerner, Zinoviy, Dipl.-Ing. |
Neue aliphatisch substituierte Pyrazolopyridine und ihre Verwendung
|
|
JP2012513464A
(ja)
|
2008-12-23 |
2012-06-14 |
ザ トラスティーズ オブ コロンビア ユニヴァーシティ イン ザ シティ オブ ニューヨーク |
ホスホジエステラーゼ阻害剤及びその使用
|
|
US20100216805A1
(en)
|
2009-02-25 |
2010-08-26 |
Braincells, Inc. |
Modulation of neurogenesis using d-cycloserine combinations
|
|
GB0903493D0
(en)
|
2009-02-27 |
2009-04-08 |
Vantia Ltd |
New compounds
|
|
DE102009020888A1
(de)
|
2009-05-12 |
2010-11-18 |
Ratiopharm Gmbh |
Schmelztablette, enthaltend ein Vardenafil-Salz
|
|
AU2010280358A1
(en)
|
2009-08-07 |
2012-03-08 |
Ranbaxy Laboratories Limited |
Processes for the preparation of vardenafil
|
|
NZ625983A
(en)
|
2009-11-27 |
2016-02-26 |
Adverio Pharma Gmbh |
Method for producing methyl-{ 4,6-diamino-2-[1-(2-fluorobenzyl)-1h-pyrazolo[3,4-b]pyridino-3-yl]pyrimidino-5-yl} methyl carbamate and its purification for use thereof as pharmaceutical substance
|
|
UY33041A
(es)
|
2009-11-27 |
2011-06-30 |
Bayer Schering Pharma Aktienegesellschaft |
Procedimiento para la preparaciòn de {4,6-diamino-2-[1-(2-fluorobencil)-1h-pirazolo[3,4-b]piridin-3-il]pirimidin-5-il}carbamato de metilo y su purificaciòn para el uso como principio activo farmacèutico
|
|
WO2011075801A1
(pt)
|
2009-12-21 |
2011-06-30 |
Acef S.A. |
Cubebina, lignana dibenzilbutirolactólica, seus derivados semi-sintéticos e sintéticos, bem como outras lignanas e neolignanas como agente vasodilatador na terapia da disfunção erétil
|
|
PL390079A1
(pl)
|
2009-12-30 |
2011-07-04 |
Zakłady Farmaceutyczne POLPHARMA Spółka Akcyjna |
Sposób otrzymywania wardenafilu i jego izolacji jako soli z kwasem cytrynowym oraz krystaliczna postać tej soli
|
|
EP2556820A4
(en)
|
2010-04-05 |
2015-01-21 |
Sk Chemicals Co Ltd |
COMPOSITION CONTAINING PDE5 INHIBITOR FOR MITIGATION OF SKIN WRINKLES
|
|
DE102010021637A1
(de)
|
2010-05-26 |
2011-12-01 |
Bayer Schering Pharma Aktiengesellschaft |
Substituierte 5-Fluor-1H-Pyrazolopyridine und ihre Verwendung
|
|
CN102382129B
(zh)
*
|
2010-08-19 |
2014-02-26 |
山东轩竹医药科技有限公司 |
螺环取代的磷酸二酯酶抑制剂
|
|
CN102372730B
(zh)
*
|
2010-08-19 |
2014-03-26 |
山东轩竹医药科技有限公司 |
桥环取代的磷酸二酯酶抑制剂
|
|
CN103313988B
(zh)
|
2010-09-20 |
2016-06-08 |
论坛医药有限公司 |
咪唑并三嗪酮化合物
|
|
CN103180321A
(zh)
|
2010-09-23 |
2013-06-26 |
Abbvie公司 |
氮杂金刚烷衍生物的一水合物
|
|
EA201691759A1
(ru)
|
2010-10-15 |
2017-05-31 |
Джилид Сайэнс, Инк. |
Композиции и способы лечения легочной гипертензии
|
|
TWI462739B
(zh)
|
2010-11-02 |
2014-12-01 |
Univ Kaohsiung Medical |
Sildenafil-同族物四級銨哌嗪鹽類之製備及醫療用途
|
|
CN102134242B
(zh)
*
|
2011-01-21 |
2013-08-28 |
浙江大德药业集团有限公司 |
一种用于治疗阳痿的快速长效的化合物
|
|
MA37958B1
(fr)
|
2011-10-10 |
2018-10-31 |
H Lundbeck As |
Pde9i ayant un squelette imidazo pyrazinone
|
|
AT512084A1
(de)
|
2011-10-20 |
2013-05-15 |
Univ Wien Tech |
Diazabicyclo- und diazaspiro-alkanderivate als phosphodiesterase-5 inhibitoren
|
|
WO2013067309A1
(en)
|
2011-11-04 |
2013-05-10 |
Xion Pharmaceutical Corporation |
Methods and compositions for oral administration of melanocortin receptor agonist compounds
|
|
CZ303877B6
(cs)
|
2011-11-24 |
2013-06-05 |
Zentiva, K.S. |
Zpusob prípravy a izolace solí vardenafilu s kyselinami
|
|
WO2013106547A1
(en)
|
2012-01-10 |
2013-07-18 |
President And Fellows Of Harvard College |
Beta-cell replication promoting compounds and methods of their use
|
|
WO2013109738A1
(en)
|
2012-01-17 |
2013-07-25 |
The Trustees Of Columbia University In The City Of New York |
Novel phosphodiesterase inhibitors and uses thereof
|
|
BR112014018199A8
(pt)
|
2012-01-26 |
2021-03-02 |
H Lundbeck As |
inibidores da pde9 com cadeia principal imidazo triazinona, composição farmacêutica que os compreende, uso dos referidos inibidores e processo para sua preparação
|
|
CN104168895B
(zh)
|
2012-02-28 |
2020-02-21 |
首尔制药株式会社 |
包含西地那非作为活性成分的掩蔽苦味的高含量快速溶解膜
|
|
EP2828262A4
(en)
|
2012-03-19 |
2015-09-23 |
Forum Pharmaceuticals Inc |
IMIDAZOTRIAZINONVERBINDUNGEN
|
|
CN103374002B
(zh)
*
|
2012-04-19 |
2015-07-15 |
山东轩竹医药科技有限公司 |
磷酸二酯酶-5抑制剂
|
|
CZ307091B6
(cs)
|
2012-09-14 |
2018-01-10 |
Zentiva, K.S. |
Stabilní farmaceutický přípravek obsahující Vardenafil hydrochlorid
|
|
CN105025900B
(zh)
|
2012-12-04 |
2018-11-02 |
株式会社阿丽浱欧 |
包含5型磷酸二酯酶抑制剂的神经细胞的细胞凋亡抑制用组合物
|
|
KR101953735B1
(ko)
|
2012-12-14 |
2019-03-04 |
한미약품 주식회사 |
포스포다이에스터라제-5 억제제를 포함하는 츄정
|
|
BR112015019571A2
(pt)
|
2013-02-21 |
2017-07-18 |
Adverio Pharma Gmbh |
formas de {4,6-diamino-2-[1-(2-fluorobenzil)-1h-pirazolo[3,4-b]piridino-3-il]pirimidino-5-il}metilcarbamato de metila
|
|
CN104109164B
(zh)
*
|
2013-04-18 |
2016-05-25 |
广州朗圣药业有限公司 |
一种适合工业化的高纯度盐酸伐地那非三水合物的制备方法
|
|
US10899756B2
(en)
|
2013-07-17 |
2021-01-26 |
The Trustees Of Columbia University In The City Of New York |
Phosphodiesterase inhibitors and uses thereof
|
|
EP3082428A4
(en)
|
2013-12-09 |
2017-08-02 |
Respira Therapeutics, Inc. |
Pde5 inhibitor powder formulations and methods relating thereto
|
|
PL223869B1
(pl)
|
2013-12-16 |
2016-11-30 |
Starogardzkie Zakłady Farm Polpharma Spółka Akcyjna |
Sposób otrzymywania wardenafilu i jego soli
|
|
KR101645652B1
(ko)
|
2014-11-03 |
2016-08-08 |
(주)퓨젠바이오농업회사법인 |
세리포리아 락세라타에 의해 생산되는 세포외다당체를 유효성분으로 함유하는 성기능개선용 조성물
|
|
CN107810187B
(zh)
|
2015-07-07 |
2020-09-15 |
H.隆德贝克有限公司 |
用于治疗外周疾病的具有咪唑并三嗪酮骨架和咪唑并吡嗪酮骨架的pde9抑制剂
|
|
DK3377495T3
(da)
*
|
2015-11-16 |
2022-05-09 |
Topadur Pharma Ag |
2-phenyl-3,4-dihydropyrrolo[2,1-f] [1,2,4]triazinon-derivativer som phosphodiesterasehæmmere og anvendelser deraf
|
|
WO2017168174A1
(en)
|
2016-04-02 |
2017-10-05 |
N4 Pharma Uk Limited |
New pharmaceutical forms of sildenafil
|
|
RU2019121646A
(ru)
|
2016-12-14 |
2021-01-15 |
Респира Терапьютикс, Инк. |
Способы и композиции для лечения легочной гипертензии и других заболеваний легких
|
|
AU2018274599B9
(en)
|
2017-05-22 |
2022-04-07 |
Topadur Pharma Ag |
Novel dual mode of action soluble guanylate cyclase activators and phosphodiesterase inhibitors and uses thereof
|
|
CN107445964A
(zh)
*
|
2017-07-29 |
2017-12-08 |
合肥创新医药技术有限公司 |
一种盐酸伐地那非杂质的合成方法
|
|
CA3085219A1
(en)
|
2017-12-20 |
2019-06-27 |
Klaria Pharma Holding Ab |
Film formulation comprising vardenafil, method for its preparation, and use thereof
|
|
EP3746138A4
(en)
|
2018-02-02 |
2021-11-03 |
Alexza Pharmaceuticals, Inc. |
ELECTRIC CONDENSING AEROSOL DEVICE
|
|
EP4349403A3
(en)
|
2018-05-25 |
2024-06-05 |
Cardurion Pharmaceuticals, Inc. |
Monohydrate and crystalline forms of 6-[(3s,4s)-4-methyl-1- (pyrimidin-2-ylmethyl)pyrrolidin-3-yl]-3-tetrahydropyran-4-yl- 7h-imid azo [1,5- a] pyrazin-8-one
|
|
CN112997258A
(zh)
|
2018-06-14 |
2021-06-18 |
阿斯利康(英国)有限公司 |
用cGMP特异性磷酸二酯酶5抑制剂药物组合物治疗勃起功能障碍的方法
|
|
AU2019287546A1
(en)
|
2018-06-14 |
2021-01-21 |
Astrazeneca Uk Limited |
Methods for treating erectile dysfunction with a cGMP-specific phosphodiesterase 5 inhibitor pharmaceutical composition
|
|
BR112021003686A2
(pt)
|
2018-08-31 |
2021-05-18 |
Imara Inc. |
inibidores de pde9 para tratar doença falciforme
|
|
BR112021009958A2
(pt)
*
|
2018-11-28 |
2021-08-17 |
Topadur Pharma Ag |
modo duplo de ação de ativadores de guanilato ciclase solúveis e inibidores de fosfodiesterase e seus usos
|
|
EP3939954B1
(en)
|
2019-03-13 |
2025-07-23 |
Otsuka Pharmaceutical Co., Ltd. |
Method for introducing deuterated lower alkyl into amine moiety of compound containing secondary amine
|
|
US11590209B2
(en)
|
2020-01-21 |
2023-02-28 |
Palatin Technologies, Inc. |
Use of bremelanotide in patients with controlled hypertension
|
|
WO2021245192A1
(en)
|
2020-06-04 |
2021-12-09 |
Topadur Pharma Ag |
Novel dual mode of action soluble guanylate cyclase activators and phosphodiesterase inhibitors and uses thereof
|
|
JP2023552632A
(ja)
*
|
2020-12-11 |
2023-12-18 |
イルドン ファーマシューティカル カンパニー リミテッド |
アンドロゲン受容体及びホスホジエステラーゼ二重阻害剤としての新規化合物
|
|
US20240228501A1
(en)
*
|
2021-04-21 |
2024-07-11 |
Changchun Genescience Pharmaceutical Co., Ltd. |
Imidazole-containing condensed ring derivative, preparation method therefor, and application thereof in medicine
|
|
CN114085225A
(zh)
*
|
2021-06-04 |
2022-02-25 |
广东西捷药业有限公司 |
一种伐地那非类似物及其合成方法和应用
|
|
AU2022354094A1
(en)
|
2021-09-29 |
2024-02-15 |
Topadur Pharma Ag |
Topical compositions of 2-phenyl-3,4-dihydropyrrolo[2,l-f] [1,2,4]triazinone derivatives and uses thereof
|
|
KR20230129639A
(ko)
|
2022-03-02 |
2023-09-11 |
연세대학교 산학협력단 |
이중작용 pde5 억제제/질산유기에스터의 국소 혈류 증진을 위한 경피 투약 형태
|
|
KR20240154529A
(ko)
|
2022-03-02 |
2024-10-25 |
토파두르 파마 아게 |
국소 조성물 및 이들의 용도
|
|
WO2024173675A1
(en)
|
2023-02-16 |
2024-08-22 |
University Of Rochester |
Improving glymphatic-lymphatic efflux
|